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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXA13
Z-value: 0.32
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Transcription factors associated with HOXA13
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_189839046 Show fit | 13.82 |
ENST00000304636.3
ENST00000317840.5 |
collagen, type III, alpha 1 |
|
| chr12_-_91539918 Show fit | 12.96 |
ENST00000548218.1
|
decorin |
|
| chr6_+_121756809 Show fit | 11.91 |
ENST00000282561.3
|
gap junction protein, alpha 1, 43kDa |
|
| chr3_-_123339418 Show fit | 10.06 |
ENST00000583087.1
|
myosin light chain kinase |
|
| chr3_-_123339343 Show fit | 9.60 |
ENST00000578202.1
|
myosin light chain kinase |
|
| chr12_-_91546926 Show fit | 8.10 |
ENST00000550758.1
|
decorin |
|
| chr3_-_112127981 Show fit | 6.93 |
ENST00000486726.2
|
RP11-231E6.1 |
|
| chr5_-_79287060 Show fit | 6.81 |
ENST00000512560.1
ENST00000509852.1 ENST00000512528.1 |
metaxin 3 |
|
| chr12_+_6309517 Show fit | 6.46 |
ENST00000382519.4
ENST00000009180.4 |
CD9 molecule |
|
| chr1_+_43766642 Show fit | 6.07 |
ENST00000372476.3
|
tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 33.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.8 | 21.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 2.8 | 11.1 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.1 | 6.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.6 | 6.5 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.2 | 6.1 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.1 | 5.8 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.6 | 5.6 | GO:0015705 | iodide transport(GO:0015705) |
| 0.3 | 5.6 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.8 | 5.3 | GO:0072564 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 21.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 20.3 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 1.2 | 13.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.8 | 11.9 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.4 | 11.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 6.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.3 | 6.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 5.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 5.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 4.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 3.9 | 19.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 1.0 | 13.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 1.9 | 11.1 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.1 | 10.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 6.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 6.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.4 | 6.2 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 6.1 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 1.9 | 5.6 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 31.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 23.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 13.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 6.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 6.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 5.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 3.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 3.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 21.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 18.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 17.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 13.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.7 | 11.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 6.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 6.2 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 4.6 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.3 | 4.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 3.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |