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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXA2_HOXB1

Z-value: 0.25

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
HOXA2
ENSG00000105996.5 homeobox A2
HOXB1
ENSG00000120094.6 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB1hg19_v2_chr17_-_46608272_466083850.413.4e-10Click!
HOXA2hg19_v2_chr7_-_27142290_271424300.261.1e-04Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_13835147 22.56 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr4_-_90757364 17.83 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr11_-_111782696 16.87 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chrX_-_13835461 16.34 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr6_+_151561085 15.64 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr14_-_21516590 15.43 ENST00000555026.1
NDRG2
NDRG family member 2
chr4_-_90756769 14.10 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr6_+_151561506 14.10 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_111782484 14.09 ENST00000533971.1
CRYAB
crystallin, alpha B
chr7_+_86273218 11.07 ENST00000361669.2
GRM3
glutamate receptor, metabotropic 3
chr16_+_15596123 7.63 ENST00000452191.2
C16orf45
chromosome 16 open reading frame 45
chr12_+_7023491 7.27 ENST00000541477.1
ENST00000229277.1
ENO2
enolase 2 (gamma, neuronal)
chr12_+_21679220 7.13 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr12_+_101988627 7.11 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
MYBPC1
myosin binding protein C, slow type
chr3_-_187388173 6.79 ENST00000287641.3
SST
somatostatin
chr9_-_101471479 6.34 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_+_12857043 6.34 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr16_-_49890016 5.89 ENST00000563137.2
ZNF423
zinc finger protein 423
chr20_+_34742650 5.52 ENST00000373945.1
ENST00000338074.2
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr19_-_49944806 5.37 ENST00000221485.3
SLC17A7
solute carrier family 17 (vesicular glutamate transporter), member 7
chr11_-_2162162 5.12 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_101988774 4.96 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
MYBPC1
myosin binding protein C, slow type
chr2_+_12857015 4.69 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr4_-_102267953 4.65 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr18_+_56887381 4.62 ENST00000256857.2
ENST00000529320.2
ENST00000420468.2
GRP
gastrin-releasing peptide
chr2_-_44588694 4.60 ENST00000409957.1
PREPL
prolyl endopeptidase-like
chr2_-_44588679 4.50 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr12_-_15038779 4.22 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr19_-_12997995 4.06 ENST00000264834.4
KLF1
Kruppel-like factor 1 (erythroid)
chr13_-_110438914 4.05 ENST00000375856.3
IRS2
insulin receptor substrate 2
chr6_+_32006042 3.77 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr5_-_125930929 3.75 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chrX_+_82763265 3.66 ENST00000373200.2
POU3F4
POU class 3 homeobox 4
chr8_-_143999259 3.22 ENST00000323110.2
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr13_+_52586517 3.14 ENST00000523764.1
ENST00000521508.1
ALG11
ALG11, alpha-1,2-mannosyltransferase
chr6_+_32006159 3.00 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr17_+_37824411 2.95 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr12_+_57610562 2.94 ENST00000349394.5
NXPH4
neurexophilin 4
chr12_-_49393092 2.89 ENST00000421952.2
DDN
dendrin
chr8_-_38008783 2.86 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr1_-_67390474 2.81 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
WDR78
WD repeat domain 78
chr12_-_58135903 2.76 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_+_189507460 2.75 ENST00000434928.1
TP63
tumor protein p63
chr2_+_68962014 2.74 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr1_-_109584716 2.64 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WDR47
WD repeat domain 47
chrX_+_41583408 2.52 ENST00000302548.4
GPR82
G protein-coupled receptor 82
chr17_+_37824217 2.40 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr10_+_95848824 2.39 ENST00000371385.3
ENST00000371375.1
PLCE1
phospholipase C, epsilon 1
chr1_-_109584768 2.39 ENST00000357672.3
WDR47
WD repeat domain 47
chrX_-_65253506 2.35 ENST00000427538.1
VSIG4
V-set and immunoglobulin domain containing 4
chr1_-_109584608 2.21 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WDR47
WD repeat domain 47
chr9_-_73029540 2.17 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr7_-_14029515 2.17 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr16_-_67427389 2.07 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
TPPP3
tubulin polymerization-promoting protein family member 3
chr1_-_223536679 2.05 ENST00000608996.1
SUSD4
sushi domain containing 4
chr17_-_46608272 2.05 ENST00000577092.1
ENST00000239174.6
HOXB1
homeobox B1
chr20_+_34802295 2.02 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chrX_-_47509887 1.97 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1
ELK1, member of ETS oncogene family
chr9_-_127269661 1.93 ENST00000373588.4
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr12_+_7282795 1.90 ENST00000266546.6
CLSTN3
calsyntenin 3
chr18_-_53070913 1.84 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr10_-_105615164 1.78 ENST00000355946.2
ENST00000369774.4
SH3PXD2A
SH3 and PX domains 2A
chr17_+_21729593 1.76 ENST00000581769.1
ENST00000584755.1
UBBP4
ubiquitin B pseudogene 4
chr17_-_37353950 1.65 ENST00000394310.3
ENST00000394303.3
ENST00000344140.5
CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr2_-_200323414 1.62 ENST00000443023.1
SATB2
SATB homeobox 2
chr11_+_57365150 1.59 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr10_+_89264625 1.54 ENST00000371996.4
ENST00000371994.4
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr7_+_79765071 1.53 ENST00000457358.2
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr6_-_112575838 1.50 ENST00000455073.1
LAMA4
laminin, alpha 4
chr17_+_58755184 1.49 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr8_-_143961236 1.48 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
chr8_+_23386305 1.48 ENST00000519973.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr6_-_112575687 1.42 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr17_+_48609903 1.35 ENST00000268933.3
EPN3
epsin 3
chr10_-_79397316 1.33 ENST00000372421.5
ENST00000457953.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr7_-_14029283 1.32 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr2_-_154335300 1.32 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr10_-_98945677 1.31 ENST00000266058.4
ENST00000371041.3
SLIT1
slit homolog 1 (Drosophila)
chr10_-_79397202 1.28 ENST00000372437.1
ENST00000372408.2
ENST00000372403.4
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_100995540 1.26 ENST00000370546.1
ENST00000404542.1
HPSE2
heparanase 2
chrX_+_95939711 1.17 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr19_+_52074502 1.14 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr8_+_143530791 1.02 ENST00000517894.1
BAI1
brain-specific angiogenesis inhibitor 1
chr12_+_57482877 1.00 ENST00000342556.6
ENST00000357680.4
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr6_-_112575912 0.99 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr11_+_68228186 0.97 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3
protein phosphatase 6, regulatory subunit 3
chr7_-_27170352 0.96 ENST00000428284.2
ENST00000360046.5
HOXA4
homeobox A4
chr10_+_18689637 0.85 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr6_+_29426230 0.84 ENST00000442615.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr9_-_26947453 0.81 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr17_+_37824700 0.81 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr17_+_39975544 0.81 ENST00000544340.1
FKBP10
FK506 binding protein 10, 65 kDa
chr20_+_52105495 0.79 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr19_+_47421933 0.76 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr2_+_135011731 0.75 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr17_-_42277203 0.68 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr3_+_148545586 0.68 ENST00000282957.4
ENST00000468341.1
CPB1
carboxypeptidase B1 (tissue)
chr10_-_100995603 0.68 ENST00000370552.3
ENST00000370549.1
HPSE2
heparanase 2
chr12_+_21168630 0.62 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr15_-_74501310 0.60 ENST00000423167.2
ENST00000432245.2
STRA6
stimulated by retinoic acid 6
chr3_+_189507523 0.58 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr19_-_41356347 0.58 ENST00000301141.5
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr7_-_27135591 0.57 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr1_-_43833628 0.56 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr15_-_74501360 0.55 ENST00000323940.5
STRA6
stimulated by retinoic acid 6
chrX_+_99899180 0.33 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr17_+_39975455 0.33 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr6_-_112575758 0.31 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr7_+_20370746 0.27 ENST00000222573.4
ITGB8
integrin, beta 8
chr19_+_35849723 0.26 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr2_-_200322723 0.26 ENST00000417098.1
SATB2
SATB homeobox 2
chr1_-_92351769 0.23 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr10_+_102891048 0.22 ENST00000467928.2
TLX1
T-cell leukemia homeobox 1
chr4_-_123542224 0.19 ENST00000264497.3
IL21
interleukin 21
chr9_+_140135665 0.19 ENST00000340384.4
TUBB4B
tubulin, beta 4B class IVb
chr8_+_23386557 0.12 ENST00000523930.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr4_-_5021164 0.10 ENST00000506508.1
ENST00000509419.1
ENST00000307746.4
CYTL1
cytokine-like 1
chr1_+_178062855 0.08 ENST00000448150.3
RASAL2
RAS protein activator like 2
chr14_+_22985251 0.03 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 70.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.2 11.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
2.0 29.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.8 5.4 GO:0042137 sequestering of neurotransmitter(GO:0042137)
1.7 31.0 GO:0007021 tubulin complex assembly(GO:0007021)
1.7 6.8 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
1.5 4.6 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.5 6.2 GO:0042418 epinephrine biosynthetic process(GO:0042418)
1.5 7.6 GO:1903976 negative regulation of glial cell migration(GO:1903976)
1.2 4.6 GO:0036343 psychomotor behavior(GO:0036343)
1.0 15.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.0 2.9 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.9 12.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.8 3.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.7 11.1 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.7 11.5 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.7 2.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.7 4.1 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.6 5.1 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.5 3.7 GO:0042426 choline catabolic process(GO:0042426)
0.5 1.6 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.5 1.9 GO:0007538 primary sex determination(GO:0007538)
0.5 2.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.4 1.8 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.4 1.1 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.3 0.6 GO:0021834 embryonic olfactory bulb interneuron precursor migration(GO:0021831) chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.3 2.2 GO:0051414 response to cortisol(GO:0051414)
0.2 1.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 9.1 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.2 1.9 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.2 2.3 GO:0034465 response to carbon monoxide(GO:0034465)
0.2 2.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 1.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 3.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 4.2 GO:0001502 cartilage condensation(GO:0001502)
0.2 3.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 2.0 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.2 6.3 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.6 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.1 0.9 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 1.5 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 0.8 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 5.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 5.4 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.0 GO:1902949 positive regulation of tau-protein kinase activity(GO:1902949)
0.1 2.3 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.1 0.6 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 2.8 GO:0003341 cilium movement(GO:0003341)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.6 GO:0021603 cranial nerve formation(GO:0021603)
0.1 0.3 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.1 2.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 4.1 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.0 2.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.8 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 1.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 2.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.9 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 1.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.5 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.1 GO:0030449 regulation of complement activation(GO:0030449)
0.0 2.8 GO:0042177 negative regulation of protein catabolic process(GO:0042177)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.9 31.0 GO:0097512 cardiac myofibril(GO:0097512)
1.2 7.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.0 31.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.7 5.4 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.5 4.6 GO:0005955 calcineurin complex(GO:0005955)
0.5 12.1 GO:0032982 myosin filament(GO:0032982)
0.4 2.9 GO:0030061 mitochondrial crista(GO:0030061)
0.2 2.1 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.8 GO:0005858 axonemal dynein complex(GO:0005858)
0.1 2.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 11.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 4.2 GO:0005605 basal lamina(GO:0005605)
0.1 42.7 GO:0045121 membrane raft(GO:0045121)
0.1 29.7 GO:0005938 cell cortex(GO:0005938)
0.1 15.4 GO:0030426 growth cone(GO:0030426)
0.1 0.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.8 GO:0002102 podosome(GO:0002102)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 1.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 4.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 8.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 3.3 GO:0060076 excitatory synapse(GO:0060076)
0.0 2.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 5.9 GO:0000790 nuclear chromatin(GO:0000790)
0.0 25.5 GO:0005856 cytoskeleton(GO:0005856)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 6.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.7 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 31.9 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
2.2 11.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
2.1 6.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
2.1 6.2 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
1.9 29.7 GO:0008179 adenylate cyclase binding(GO:0008179)
1.6 4.7 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
1.3 5.4 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
1.2 7.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.0 3.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.0 31.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.9 12.1 GO:0031432 titin binding(GO:0031432)
0.6 11.0 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.5 1.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 1.9 GO:0030305 heparanase activity(GO:0030305)
0.5 4.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.4 9.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.4 1.5 GO:0052827 inositol pentakisphosphate phosphatase activity(GO:0052827)
0.3 2.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 3.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 7.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 3.7 GO:0003680 AT DNA binding(GO:0003680)
0.2 1.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 9.2 GO:0005158 insulin receptor binding(GO:0005158)
0.2 3.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 1.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 2.9 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 4.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 2.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.6 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 6.3 GO:0005179 hormone activity(GO:0005179)
0.1 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.8 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 5.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 9.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 3.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.9 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 31.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 4.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 2.0 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 10.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 3.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.6 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 12.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 PID SHP2 PATHWAY SHP2 signaling
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 17.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 11.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 31.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 6.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 4.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 4.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 5.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 5.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 12.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 7.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 3.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 5.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 4.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 1.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 6.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.9 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling