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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXA5

Z-value: 0.06

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Transcription factors associated with HOXA5

Gene Symbol Gene ID Gene Info
HOXA5
ENSG00000106004.4 homeobox A5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA5hg19_v2_chr7_-_27183263_27183287-0.187.3e-03Click!

Activity profile of HOXA5 motif

Sorted Z-values of HOXA5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_149889382 10.70 ENST00000369145.1
ENST00000369146.3
SV2A
synaptic vesicle glycoprotein 2A
chr20_+_4667094 10.54 ENST00000424424.1
ENST00000457586.1
PRNP
prion protein
chr20_+_4666882 8.99 ENST00000379440.4
ENST00000430350.2
PRNP
prion protein
chr14_+_93389425 8.15 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_+_35721106 7.65 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr15_-_73925651 7.37 ENST00000545878.1
ENST00000287226.8
ENST00000345330.4
NPTN
neuroplastin
chr6_-_116575226 6.87 ENST00000420283.1
TSPYL4
TSPY-like 4
chr6_-_154677900 5.92 ENST00000265198.4
ENST00000520261.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_+_84609944 5.34 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_33744256 4.72 ENST00000415002.2
ENST00000437761.2
ENST00000445143.2
CD59
CD59 molecule, complement regulatory protein
chr1_-_170043709 4.60 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
KIFAP3
kinesin-associated protein 3
chr14_+_65878565 4.28 ENST00000556518.1
ENST00000557164.1
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr2_+_102508955 4.28 ENST00000414004.2
FLJ20373
FLJ20373
chrX_+_55478538 4.25 ENST00000342972.1
MAGEH1
melanoma antigen family H, 1
chr3_+_238273 4.15 ENST00000256509.2
CHL1
cell adhesion molecule L1-like
chr11_-_33744487 3.68 ENST00000426650.2
CD59
CD59 molecule, complement regulatory protein
chr6_-_143266297 3.67 ENST00000367603.2
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr16_-_66764119 3.51 ENST00000569320.1
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr11_-_115375107 3.48 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr8_-_141774467 3.43 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr16_+_14927538 3.31 ENST00000287667.7
NOMO1
NODAL modulator 1
chr10_-_75226166 3.24 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chrX_+_54947229 3.18 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO
trophinin
chr16_-_18573396 3.11 ENST00000543392.1
ENST00000381474.3
ENST00000330537.6
NOMO2
NODAL modulator 2
chr10_-_127505167 2.82 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chr10_+_101089107 2.37 ENST00000446890.1
ENST00000370528.3
CNNM1
cyclin M1
chr3_-_79068594 2.34 ENST00000436010.2
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr7_-_99717463 2.32 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr10_+_18549645 2.28 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr6_+_13182751 2.23 ENST00000415087.1
PHACTR1
phosphatase and actin regulator 1
chr19_+_18794470 2.02 ENST00000321949.8
ENST00000338797.6
CRTC1
CREB regulated transcription coactivator 1
chr5_+_140723601 1.94 ENST00000253812.6
PCDHGA3
protocadherin gamma subfamily A, 3
chr11_+_12399071 1.63 ENST00000539723.1
ENST00000550549.1
PARVA
parvin, alpha
chr11_+_65686802 1.57 ENST00000376991.2
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr13_+_97874574 1.55 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
MBNL2
muscleblind-like splicing regulator 2
chr3_+_130569429 1.46 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_+_166095898 1.39 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr2_-_113594279 1.36 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr4_+_74606223 1.29 ENST00000307407.3
ENST00000401931.1
IL8
interleukin 8
chr14_+_78174414 1.28 ENST00000557342.1
ENST00000238688.5
ENST00000557623.1
ENST00000557431.1
ENST00000556831.1
ENST00000556375.1
ENST00000553981.1
SLIRP
SRA stem-loop interacting RNA binding protein
chrX_+_10124977 1.27 ENST00000380833.4
CLCN4
chloride channel, voltage-sensitive 4
chr20_-_34638841 1.18 ENST00000565493.1
LINC00657
long intergenic non-protein coding RNA 657
chr14_+_24025462 1.11 ENST00000556015.1
ENST00000554970.1
ENST00000554789.1
THTPA
thiamine triphosphatase
chr19_+_8455077 1.10 ENST00000328024.6
RAB11B
RAB11B, member RAS oncogene family
chr5_-_55412774 1.04 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr1_-_244006528 1.00 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr18_-_33709268 0.96 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chrX_+_99899180 0.93 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr2_+_74154032 0.93 ENST00000356837.6
DGUOK
deoxyguanosine kinase
chr17_+_19437132 0.91 ENST00000436810.2
ENST00000270570.4
ENST00000457293.1
ENST00000542886.1
ENST00000575023.1
ENST00000395585.1
SLC47A1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr7_-_99716952 0.89 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr22_-_41682172 0.88 ENST00000356244.3
RANGAP1
Ran GTPase activating protein 1
chr5_+_140552218 0.87 ENST00000231137.3
PCDHB7
protocadherin beta 7
chr12_+_74931551 0.84 ENST00000519948.2
ATXN7L3B
ataxin 7-like 3B
chr11_-_46722117 0.83 ENST00000311956.4
ARHGAP1
Rho GTPase activating protein 1
chr12_+_111051902 0.81 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chr1_-_182921119 0.81 ENST00000423786.1
SHCBP1L
SHC SH2-domain binding protein 1-like
chr12_+_111051832 0.80 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr11_+_9685604 0.77 ENST00000447399.2
ENST00000318950.6
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr3_+_179322481 0.76 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr5_+_66300446 0.66 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_197237352 0.62 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr11_-_6704513 0.60 ENST00000532203.1
ENST00000288937.6
MRPL17
mitochondrial ribosomal protein L17
chr18_+_13611431 0.59 ENST00000587757.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr4_-_164534657 0.57 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr1_+_171283331 0.57 ENST00000367749.3
FMO4
flavin containing monooxygenase 4
chr3_+_173116225 0.54 ENST00000457714.1
NLGN1
neuroligin 1
chr1_+_87012753 0.54 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr5_+_76326187 0.53 ENST00000312916.7
ENST00000506806.1
AGGF1
angiogenic factor with G patch and FHA domains 1
chr8_-_90769422 0.53 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr6_+_123100853 0.53 ENST00000356535.4
FABP7
fatty acid binding protein 7, brain
chr10_-_52645416 0.53 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr3_-_62358690 0.51 ENST00000475839.1
FEZF2
FEZ family zinc finger 2
chr1_+_177140633 0.50 ENST00000361539.4
BRINP2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr9_-_123342415 0.48 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr1_-_154150651 0.48 ENST00000302206.5
TPM3
tropomyosin 3
chr14_-_92413353 0.47 ENST00000556154.1
FBLN5
fibulin 5
chr21_-_35884573 0.45 ENST00000399286.2
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr10_-_7708918 0.41 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr5_+_69321074 0.41 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B (centromeric)
chr1_+_196743912 0.41 ENST00000367425.4
CFHR3
complement factor H-related 3
chr11_-_18610246 0.39 ENST00000379387.4
ENST00000541984.1
UEVLD
UEV and lactate/malate dehyrogenase domains
chr10_-_52645379 0.39 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr4_+_71063641 0.39 ENST00000514097.1
ODAM
odontogenic, ameloblast asssociated
chr3_+_12392971 0.39 ENST00000287820.6
PPARG
peroxisome proliferator-activated receptor gamma
chr5_+_140227357 0.36 ENST00000378122.3
PCDHA9
protocadherin alpha 9
chr8_-_122653630 0.35 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr4_-_152682129 0.34 ENST00000512306.1
ENST00000508611.1
ENST00000515812.1
ENST00000263985.6
PET112
PET112 homolog (yeast)
chr14_-_20801427 0.31 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr4_+_71296204 0.31 ENST00000413702.1
MUC7
mucin 7, secreted
chr6_+_29426230 0.25 ENST00000442615.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr7_+_26438187 0.24 ENST00000439120.1
ENST00000430548.1
ENST00000421862.1
ENST00000449537.1
ENST00000420774.1
ENST00000418758.2
AC004540.5
AC004540.5
chr20_+_58515417 0.23 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr14_-_92413727 0.20 ENST00000267620.10
FBLN5
fibulin 5
chr8_-_41166953 0.20 ENST00000220772.3
SFRP1
secreted frizzled-related protein 1
chr8_+_75262629 0.18 ENST00000434412.2
GDAP1
ganglioside induced differentiation associated protein 1
chr10_-_97200772 0.18 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr5_-_131879205 0.12 ENST00000231454.1
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr1_+_154229547 0.09 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr11_-_2162468 0.06 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_-_33446735 0.05 ENST00000460118.2
ENST00000335858.7
RAD51D
RAD51 paralog D
chr3_+_37035289 0.04 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr4_-_103749205 0.01 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr6_-_24666819 0.01 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.5 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
2.7 8.2 GO:2000705 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
2.5 7.4 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
2.1 8.4 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
1.5 4.6 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
1.4 4.3 GO:0036071 N-glycan fucosylation(GO:0036071)
1.2 10.7 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
1.1 5.3 GO:0097338 response to clozapine(GO:0097338)
0.9 3.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.8 2.3 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.7 2.8 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
0.7 2.0 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.5 1.4 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.4 1.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.4 3.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.4 2.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 1.3 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.3 4.7 GO:0015671 oxygen transport(GO:0015671)
0.3 1.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.3 0.8 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.3 3.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.3 0.5 GO:0099545 trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.3 0.8 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.2 1.5 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 0.9 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 0.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 4.2 GO:0035640 exploration behavior(GO:0035640)
0.1 1.6 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.1 0.9 GO:0046618 drug export(GO:0046618)
0.1 1.1 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 1.4 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.9 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.4 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1 0.4 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 1.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 3.5 GO:0051642 centrosome localization(GO:0051642)
0.1 0.9 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 0.3 GO:0070295 renal water absorption(GO:0070295)
0.1 0.2 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.1 1.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 3.1 GO:0031648 protein destabilization(GO:0031648)
0.1 3.2 GO:0007566 embryo implantation(GO:0007566)
0.0 0.6 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 7.6 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.0 0.6 GO:0042737 drug catabolic process(GO:0042737)
0.0 0.5 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.3 GO:0051026 chiasma assembly(GO:0051026)
0.0 4.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 1.3 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.5 GO:0060134 prepulse inhibition(GO:0060134)
0.0 1.9 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 2.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.0 GO:0051311 male meiosis chromosome segregation(GO:0007060) meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.6 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 27.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.2 4.6 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.6 10.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.6 7.4 GO:0060077 inhibitory synapse(GO:0060077)
0.6 8.2 GO:0042583 chromaffin granule(GO:0042583)
0.4 3.2 GO:0005955 calcineurin complex(GO:0005955)
0.3 0.9 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 5.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 2.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 3.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 3.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.6 GO:0036038 MKS complex(GO:0036038)
0.1 0.3 GO:0097679 other organism cytoplasm(GO:0097679)
0.1 1.4 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.8 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.8 GO:0097443 sorting endosome(GO:0097443)
0.1 0.7 GO:0071953 elastic fiber(GO:0071953)
0.0 4.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 3.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0072562 blood microparticle(GO:0072562)
0.0 2.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.0 GO:0005715 late recombination nodule(GO:0005715)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.8 GO:0045177 apical part of cell(GO:0045177)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 19.5 GO:1903135 cupric ion binding(GO:1903135)
1.8 7.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.4 4.3 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.4 2.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 4.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 5.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 3.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 2.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 8.4 GO:0001848 complement binding(GO:0001848)
0.2 3.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 3.4 GO:0008432 JUN kinase binding(GO:0008432)
0.2 0.9 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.2 3.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.9 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 2.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 4.6 GO:0019894 kinesin binding(GO:0019894)
0.1 2.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 1.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 4.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.1 GO:0031489 myosin V binding(GO:0031489)
0.0 2.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 6.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.1 GO:0002020 protease binding(GO:0002020)
0.0 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 5.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.6 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 9.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 19.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 6.9 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 8.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 0.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 4.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 21.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 5.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 4.6 REACTOME KINESINS Genes involved in Kinesins
0.2 4.3 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 3.4 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 2.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 3.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle