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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXA6
Z-value: 0.39
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Transcription factors associated with HOXA6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA6 | hg19_v2_chr7_-_27187393_27187393 | 0.18 | 6.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91576561 Show fit | 13.56 |
ENST00000547568.2
ENST00000552962.1 |
decorin |
|
| chr4_-_41884620 Show fit | 13.32 |
ENST00000504870.1
|
long intergenic non-protein coding RNA 682 |
|
| chr12_-_91576429 Show fit | 12.56 |
ENST00000552145.1
ENST00000546745.1 |
decorin |
|
| chr12_-_91576750 Show fit | 12.02 |
ENST00000228329.5
ENST00000303320.3 ENST00000052754.5 |
decorin |
|
| chr10_-_21786179 Show fit | 7.18 |
ENST00000377113.5
|
cancer susceptibility candidate 10 |
|
| chr3_-_114477787 Show fit | 5.43 |
ENST00000464560.1
|
zinc finger and BTB domain containing 20 |
|
| chr2_+_66662690 Show fit | 4.89 |
ENST00000488550.1
|
Meis homeobox 1 |
|
| chr3_-_114477962 Show fit | 4.60 |
ENST00000471418.1
|
zinc finger and BTB domain containing 20 |
|
| chr2_+_66662510 Show fit | 4.58 |
ENST00000272369.9
ENST00000407092.2 |
Meis homeobox 1 |
|
| chr7_-_27183263 Show fit | 4.46 |
ENST00000222726.3
|
homeobox A5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 38.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.3 | 14.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.5 | 11.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 10.2 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 1.7 | 8.6 | GO:1904075 | trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.6 | 7.8 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 6.2 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 1.3 | 5.1 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 1.5 | 4.5 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) |
| 0.1 | 4.4 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 38.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 20.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.2 | 8.6 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.7 | 7.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 4.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 3.7 | GO:0008328 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.0 | 3.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 3.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 2.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 38.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 16.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 12.1 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 10.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.1 | 8.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 8.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.6 | 7.8 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 6.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 6.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 6.0 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 16.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 10.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 2.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 38.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 8.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 4.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 3.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 3.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 2.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 2.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 2.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |