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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXB13
Z-value: 0.56
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Transcription factors associated with HOXB13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB13 | hg19_v2_chr17_-_46806540_46806558 | 0.19 | 5.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_118401706 Show fit | 7.57 |
ENST00000411589.2
ENST00000442938.2 ENST00000359862.4 |
transmembrane protein 25 |
|
| chr3_-_195310802 Show fit | 5.72 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr18_-_52989217 Show fit | 5.32 |
ENST00000570287.2
|
transcription factor 4 |
|
| chr3_-_114790179 Show fit | 4.31 |
ENST00000462705.1
|
zinc finger and BTB domain containing 20 |
|
| chr1_+_84630645 Show fit | 4.18 |
ENST00000394839.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr2_-_51259292 Show fit | 3.80 |
ENST00000401669.2
|
neurexin 1 |
|
| chr18_-_52989525 Show fit | 3.69 |
ENST00000457482.3
|
transcription factor 4 |
|
| chr2_-_51259229 Show fit | 3.60 |
ENST00000405472.3
|
neurexin 1 |
|
| chr19_+_35634146 Show fit | 3.60 |
ENST00000586063.1
ENST00000270310.2 ENST00000588265.1 |
FXYD domain containing ion transport regulator 7 |
|
| chrM_+_12331 Show fit | 3.57 |
ENST00000361567.2
|
mitochondrially encoded NADH dehydrogenase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.0 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 1.5 | 7.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.9 | 7.4 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 1.9 | 5.7 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 4.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 1.3 | 3.8 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.1 | 3.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 3.6 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 1.1 | 3.4 | GO:0042938 | dipeptide transport(GO:0042938) |
| 0.0 | 3.4 | GO:0007045 | cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.4 | 7.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 7.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 5.7 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.1 | 5.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 5.0 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 3.8 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 3.1 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 2.1 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 1.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.5 | 7.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.5 | 7.4 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 5.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 4.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.6 | 3.8 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.1 | 3.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 3.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.4 | 3.4 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 3.4 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 7.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.9 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 7.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 3.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 2.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.7 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 1.2 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 1.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |