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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXB2_UNCX_HOXD3
Z-value: 0.70
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Transcription factors associated with HOXB2_UNCX_HOXD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD3 | hg19_v2_chr2_+_177015122_177015122, hg19_v2_chr2_+_177025619_177025619, hg19_v2_chr2_+_177028805_177028805 | -0.49 | 2.7e-14 | Click! |
| HOXB2 | hg19_v2_chr17_-_46623441_46623441 | 0.13 | 6.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_41593425 Show fit | 26.79 |
ENST00000239882.3
|
E74-like factor 1 (ets domain transcription factor) |
|
| chr2_-_136678123 Show fit | 26.17 |
ENST00000422708.1
|
aspartyl-tRNA synthetase |
|
| chr3_-_141747950 Show fit | 23.29 |
ENST00000497579.1
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chr6_-_32157947 Show fit | 22.02 |
ENST00000375050.4
|
pre-B-cell leukemia homeobox 2 |
|
| chr12_+_28410128 Show fit | 20.90 |
ENST00000381259.1
ENST00000381256.1 |
coiled-coil domain containing 91 |
|
| chr2_-_61697862 Show fit | 20.72 |
ENST00000398571.2
|
ubiquitin specific peptidase 34 |
|
| chr17_+_48823975 Show fit | 20.12 |
ENST00000513969.1
ENST00000503728.1 |
LUC7-like 3 (S. cerevisiae) |
|
| chr1_-_89357179 Show fit | 19.27 |
ENST00000448623.1
ENST00000418217.1 ENST00000370500.5 |
general transcription factor IIB |
|
| chr12_+_104337515 Show fit | 19.14 |
ENST00000550595.1
|
heat shock protein 90kDa beta (Grp94), member 1 |
|
| chr15_-_55562479 Show fit | 18.82 |
ENST00000564609.1
|
RAB27A, member RAS oncogene family |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB2_UNCX_HOXD3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 95.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 83.6 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.5 | 66.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 9.3 | 55.9 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.6 | 46.5 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.3 | 39.5 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.3 | 32.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.3 | 31.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 1.1 | 31.3 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 8.7 | 26.2 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 75.8 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.4 | 60.4 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 51.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 43.6 | GO:0005654 | nucleoplasm(GO:0005654) |
| 1.9 | 38.9 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 35.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 33.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 5.1 | 30.5 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.5 | 30.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.5 | 25.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 147.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 95.1 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.3 | 68.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.5 | 66.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 2.1 | 55.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 43.9 | GO:0003723 | RNA binding(GO:0003723) |
| 0.5 | 42.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 1.2 | 37.3 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.6 | 36.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 35.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 79.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.4 | 41.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 34.7 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.6 | 33.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.7 | 32.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.5 | 30.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.4 | 24.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.4 | 24.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.6 | 23.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 21.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 65.7 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.6 | 56.8 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 1.9 | 50.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 44.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.1 | 39.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 39.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 32.8 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.3 | 31.3 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.7 | 30.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.9 | 26.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |