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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXB4_LHX9

Z-value: 0.63

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Transcription factors associated with HOXB4_LHX9

Gene Symbol Gene ID Gene Info
ENSG00000182742.5 homeobox B4
ENSG00000143355.11 LIM homeobox 9

Activity profile of HOXB4_LHX9 motif

Sorted Z-values of HOXB4_LHX9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_169418195 25.35 ENST00000261509.6
ENST00000335742.7
palladin, cytoskeletal associated protein
chr15_-_72523924 19.05 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
pyruvate kinase, muscle
chr3_-_149095652 18.56 ENST00000305366.3
transmembrane 4 L six family member 1
chr7_-_87856280 17.53 ENST00000490437.1
ENST00000431660.1
sorcin
chr7_-_87856303 17.32 ENST00000394641.3
sorcin
chr6_-_38670897 15.09 ENST00000373365.4
glyoxalase I
chr7_+_141438118 13.84 ENST00000265304.6
ENST00000498107.1
ENST00000467681.1
ENST00000465582.1
ENST00000463093.1
single-stranded DNA binding protein 1, mitochondrial
chr4_-_103749179 13.38 ENST00000502690.1
ubiquitin-conjugating enzyme E2D 3
chrX_-_77225135 13.12 ENST00000458128.1
phosphoglycerate mutase family member 4
chr11_-_107729887 13.03 ENST00000525815.1
solute carrier family 35, member F2
chr3_+_138340049 11.96 ENST00000464668.1
Fas apoptotic inhibitory molecule
chr4_-_103749205 11.15 ENST00000508249.1
ubiquitin-conjugating enzyme E2D 3
chr17_+_66511540 10.65 ENST00000588188.2
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr1_-_197115818 10.31 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr2_+_187454749 10.14 ENST00000261023.3
ENST00000374907.3
integrin, alpha V
chr3_-_185538849 9.44 ENST00000421047.2
insulin-like growth factor 2 mRNA binding protein 2
chr3_+_138340067 8.87 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr6_+_114178512 8.59 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr1_-_212965104 8.26 ENST00000422588.2
ENST00000366975.6
ENST00000366977.3
ENST00000366976.1
NSL1, MIS12 kinetochore complex component
chr4_+_113568207 8.11 ENST00000511529.1
La ribonucleoprotein domain family, member 7
chr3_+_139063372 7.98 ENST00000478464.1
mitochondrial ribosomal protein S22
chr2_+_102456277 7.62 ENST00000421882.1
mitogen-activated protein kinase kinase kinase kinase 4
chr3_+_23851928 7.56 ENST00000467766.1
ENST00000424381.1
ubiquitin-conjugating enzyme E2E 1
chr16_+_15489603 7.42 ENST00000568766.1
ENST00000287594.7
Uncharacterized protein
MPV17 mitochondrial membrane protein-like
chr7_-_107642348 7.33 ENST00000393561.1
laminin, beta 1
chr12_+_64798095 7.29 ENST00000332707.5
exportin, tRNA
chr17_+_48823975 7.25 ENST00000513969.1
ENST00000503728.1
LUC7-like 3 (S. cerevisiae)
chr17_+_48823896 7.19 ENST00000511974.1
LUC7-like 3 (S. cerevisiae)
chr5_-_176889381 7.18 ENST00000393563.4
ENST00000512501.1
drebrin 1
chrX_+_100663243 7.17 ENST00000316594.5
heterogeneous nuclear ribonucleoprotein H2 (H')
chr19_-_14945933 6.98 ENST00000322301.3
olfactory receptor, family 7, subfamily A, member 5
chrX_-_100662881 6.98 ENST00000218516.3
galactosidase, alpha
chr11_-_63376013 6.83 ENST00000540943.1
phospholipase A2, group XVI
chr6_+_34204642 6.72 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr14_-_67878917 6.58 ENST00000216446.4
pleckstrin 2
chr12_-_8803128 6.58 ENST00000543467.1
microfibrillar associated protein 5
chr2_-_176046391 6.53 ENST00000392541.3
ENST00000409194.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr10_-_58120996 6.50 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZW10 interacting kinetochore protein
chr20_-_1447467 6.41 ENST00000353088.2
ENST00000350991.4
NSFL1 (p97) cofactor (p47)
chr12_+_49621658 6.35 ENST00000541364.1
tubulin, alpha 1c
chr11_-_104827425 6.32 ENST00000393150.3
caspase 4, apoptosis-related cysteine peptidase
chr8_-_90996837 6.27 ENST00000519426.1
ENST00000265433.3
nibrin
chr3_-_141719195 6.18 ENST00000397991.4
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_+_234637754 6.06 ENST00000482026.1
ENST00000609767.1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr15_+_64680003 6.03 ENST00000261884.3
thyroid hormone receptor interactor 4
chr20_+_19867150 5.95 ENST00000255006.6
Ras and Rab interactor 2
chr20_-_1447547 5.95 ENST00000476071.1
NSFL1 (p97) cofactor (p47)
chr2_+_27886330 5.91 ENST00000326019.6
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr2_+_172778952 5.88 ENST00000392584.1
ENST00000264108.4
histone acetyltransferase 1
chr13_-_24007815 5.60 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr4_-_103749313 5.38 ENST00000394803.5
ubiquitin-conjugating enzyme E2D 3
chr10_+_5135981 5.23 ENST00000380554.3
aldo-keto reductase family 1, member C3
chr3_-_141747950 5.05 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_+_237994519 5.03 ENST00000392008.2
ENST00000409334.1
ENST00000409629.1
COP9 signalosome subunit 8
chr1_+_155278539 4.97 ENST00000447866.1
farnesyl diphosphate synthase
chr7_+_115862858 4.95 ENST00000393481.2
testis derived transcript (3 LIM domains)
chr6_+_30687978 4.93 ENST00000327892.8
ENST00000435534.1
tubulin, beta class I
chr20_-_43133491 4.85 ENST00000411544.1
serine incorporator 3
chr6_-_82957433 4.64 ENST00000306270.7
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr18_-_51751132 4.63 ENST00000256429.3
methyl-CpG binding domain protein 2
chr8_-_90996459 4.62 ENST00000517337.1
ENST00000409330.1
nibrin
chr7_+_107224364 4.57 ENST00000491150.1
B-cell receptor-associated protein 29
chr2_-_74619152 4.55 ENST00000440727.1
ENST00000409240.1
dynactin 1
chr18_-_47018869 4.47 ENST00000583036.1
ENST00000580261.1
ribosomal protein L17
chr1_+_155278625 4.41 ENST00000368356.4
ENST00000356657.6
farnesyl diphosphate synthase
chr4_-_103749105 4.38 ENST00000394801.4
ENST00000394804.2
ubiquitin-conjugating enzyme E2D 3
chr8_+_104310661 4.38 ENST00000522566.1
frizzled family receptor 6
chrX_-_16887963 4.28 ENST00000380084.4
retinoblastoma binding protein 7
chr15_-_55489097 4.22 ENST00000260443.4
ribosomal L24 domain containing 1
chr10_-_105845674 4.16 ENST00000353479.5
ENST00000369733.3
collagen, type XVII, alpha 1
chr2_-_70520539 4.10 ENST00000482975.2
ENST00000438261.1
small nuclear ribonucleoprotein polypeptide G
chr12_-_10978957 4.08 ENST00000240619.2
taste receptor, type 2, member 10
chr17_-_39743139 3.99 ENST00000167586.6
keratin 14
chr18_-_47018897 3.97 ENST00000418495.1
ribosomal protein L17
chr11_+_35201826 3.96 ENST00000531873.1
CD44 molecule (Indian blood group)
chr2_-_136678123 3.96 ENST00000422708.1
aspartyl-tRNA synthetase
chr14_+_55595762 3.87 ENST00000254301.9
lectin, galactoside-binding, soluble, 3
chr3_+_148709128 3.82 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
glycogenin 1
chr2_+_219110149 3.80 ENST00000456575.1
actin related protein 2/3 complex, subunit 2, 34kDa
chr2_-_74618964 3.72 ENST00000417090.1
ENST00000409868.1
dynactin 1
chr1_-_89357179 3.71 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
general transcription factor IIB
chr7_-_144435985 3.70 ENST00000549981.1
thiamin pyrophosphokinase 1
chr3_+_136649311 3.69 ENST00000469404.1
ENST00000467911.1
NCK adaptor protein 1
chr13_-_31038370 3.65 ENST00000399489.1
ENST00000339872.4
high mobility group box 1
chr4_-_103748880 3.59 ENST00000453744.2
ENST00000349311.8
ubiquitin-conjugating enzyme E2D 3
chr3_+_157154578 3.42 ENST00000295927.3
pentraxin 3, long
chr17_+_33914460 3.40 ENST00000537622.2
adaptor-related protein complex 2, beta 1 subunit
chr3_-_149293990 3.38 ENST00000472417.1
WW domain containing transcription regulator 1
chr18_-_47018769 3.38 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
ribosomal protein L17
chr8_-_49834299 3.32 ENST00000396822.1
snail family zinc finger 2
chr20_-_33735070 3.30 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
ER degradation enhancer, mannosidase alpha-like 2
chr7_+_73868120 3.28 ENST00000265755.3
GTF2I repeat domain containing 1
chr14_-_104387888 3.27 ENST00000286953.3
chromosome 14 open reading frame 2
chr4_+_169418255 3.26 ENST00000505667.1
ENST00000511948.1
palladin, cytoskeletal associated protein
chr15_+_66679155 3.21 ENST00000307102.5
mitogen-activated protein kinase kinase 1
chr7_+_116654935 3.17 ENST00000432298.1
ENST00000422922.1
suppression of tumorigenicity 7
chr9_+_125132803 3.17 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_-_18548426 3.08 ENST00000357193.3
ENST00000536719.1
tumor susceptibility 101
chr10_+_122610687 3.06 ENST00000263461.6
WD repeat domain 11
chr1_+_81771806 3.04 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
latrophilin 2
chr14_-_104387831 3.03 ENST00000557040.1
ENST00000414262.2
ENST00000555030.1
ENST00000554713.1
ENST00000553430.1
chromosome 14 open reading frame 2
chr14_+_35591928 3.03 ENST00000605870.1
ENST00000557404.3
KIAA0391
chr11_+_57480046 3.01 ENST00000378312.4
ENST00000278422.4
thioredoxin-related transmembrane protein 2
chr7_+_73868220 2.99 ENST00000455841.2
GTF2I repeat domain containing 1
chr7_+_23145884 2.95 ENST00000409689.1
ENST00000410047.1
kelch-like family member 7
chr12_+_112279782 2.91 ENST00000550735.2
mitogen-activated protein kinase-activated protein kinase 5
chr6_+_36562132 2.90 ENST00000373715.6
ENST00000339436.7
serine/arginine-rich splicing factor 3
chr1_-_67266939 2.88 ENST00000304526.2
insulin-like 5
chr12_+_20963632 2.85 ENST00000540853.1
ENST00000261196.2
solute carrier organic anion transporter family, member 1B3
chr15_+_80351910 2.85 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr2_-_191115229 2.76 ENST00000409820.2
ENST00000410045.1
3-hydroxyisobutyryl-CoA hydrolase
chr16_-_66764119 2.70 ENST00000569320.1
dynein, cytoplasmic 1, light intermediate chain 2
chr13_+_48611665 2.67 ENST00000258662.2
nudix (nucleoside diphosphate linked moiety X)-type motif 15
chr8_-_49833978 2.59 ENST00000020945.1
snail family zinc finger 2
chr6_+_30585486 2.55 ENST00000259873.4
ENST00000506373.2
mitochondrial ribosomal protein S18B
chr5_+_36152091 2.49 ENST00000274254.5
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr22_+_22730353 2.48 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr3_+_44840679 2.44 ENST00000425755.1
kinesin family member 15
chr6_-_109702885 2.42 ENST00000504373.1
CD164 molecule, sialomucin
chr18_+_21452804 2.32 ENST00000269217.6
laminin, alpha 3
chr1_-_77685084 2.31 ENST00000370812.3
ENST00000359130.1
ENST00000445065.1
ENST00000370813.5
phosphatidylinositol glycan anchor biosynthesis, class K
chr15_+_67418047 2.27 ENST00000540846.2
SMAD family member 3
chr7_+_73868439 2.25 ENST00000424337.2
GTF2I repeat domain containing 1
chr1_-_153518270 2.25 ENST00000354332.4
ENST00000368716.4
S100 calcium binding protein A4
chr12_+_20963647 2.24 ENST00000381545.3
solute carrier organic anion transporter family, member 1B3
chr7_-_22862406 2.21 ENST00000372879.4
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr2_-_27886460 2.21 ENST00000404798.2
ENST00000405491.1
ENST00000464789.2
ENST00000406540.1
suppressor of Ty 7 (S. cerevisiae)-like
chr2_-_88285309 2.18 ENST00000420840.2
RANBP2-like and GRIP domain containing 2
chr6_+_42584847 2.18 ENST00000372883.3
ubiquitin protein ligase E3 component n-recognin 2
chr5_+_36152163 2.16 ENST00000274255.6
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr17_+_33914276 2.14 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
adaptor-related protein complex 2, beta 1 subunit
chr19_+_23945768 2.11 ENST00000486528.1
ENST00000496398.1
ribosomal protein SA pseudogene 58
chr14_+_35591735 2.09 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
KIAA0391
chrX_+_108779004 2.05 ENST00000218004.1
nuclear transport factor 2-like export factor 2
chr15_+_89631381 2.03 ENST00000352732.5
abhydrolase domain containing 2
chr7_-_86849883 2.00 ENST00000433078.1
transmembrane protein 243, mitochondrial
chr1_-_39339777 1.97 ENST00000397572.2
MYC binding protein
chr4_-_39979576 1.94 ENST00000303538.8
ENST00000503396.1
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr4_+_169552748 1.92 ENST00000504519.1
ENST00000512127.1
palladin, cytoskeletal associated protein
chr3_-_151034734 1.92 ENST00000260843.4
G protein-coupled receptor 87
chrX_-_100872911 1.92 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
armadillo repeat containing, X-linked 6
chr14_-_35591433 1.80 ENST00000261475.5
ENST00000555644.1
protein phosphatase 2, regulatory subunit B'', gamma
chr14_+_50234309 1.71 ENST00000298307.5
kelch domain containing 2
chr9_-_128246769 1.71 ENST00000444226.1
mitogen-activated protein kinase associated protein 1
chr1_-_190446759 1.71 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr8_-_30670384 1.59 ENST00000221138.4
ENST00000518243.1
protein phosphatase 2, catalytic subunit, beta isozyme
chr18_+_21452964 1.55 ENST00000587184.1
laminin, alpha 3
chr5_-_16916624 1.52 ENST00000513882.1
myosin X
chr16_+_24549014 1.52 ENST00000564314.1
ENST00000567686.1
retinoblastoma binding protein 6
chr22_-_32651326 1.52 ENST00000266086.4
solute carrier family 5 (glucose activated ion channel), member 4
chr5_-_125930929 1.50 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
aldehyde dehydrogenase 7 family, member A1
chr8_+_9953214 1.47 ENST00000382490.5
methionine sulfoxide reductase A
chrX_+_70503433 1.39 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
non-POU domain containing, octamer-binding
chr8_+_9953061 1.38 ENST00000522907.1
ENST00000528246.1
methionine sulfoxide reductase A
chr18_-_3219847 1.33 ENST00000261606.7
myomesin 1
chr14_+_35591858 1.31 ENST00000603544.1
KIAA0391
chr22_-_39268308 1.26 ENST00000407418.3
chromobox homolog 6
chr10_+_101491968 1.22 ENST00000370476.5
ENST00000370472.4
cutC copper transporter
chr14_+_23938891 1.12 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
neuroguidin, EIF4E binding protein
chr2_+_87135076 1.11 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr20_+_30697298 1.11 ENST00000398022.2
transmembrane 9 superfamily protein member 4
chr5_+_89770664 1.05 ENST00000503973.1
ENST00000399107.1
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr5_+_179159813 1.05 ENST00000292599.3
mastermind-like 1 (Drosophila)
chr5_+_89770696 1.05 ENST00000504930.1
ENST00000514483.1
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr15_-_60771280 0.95 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NMDA receptor regulated 2
chr6_+_29079668 0.93 ENST00000377169.1
olfactory receptor, family 2, subfamily J, member 3
chr1_+_201979645 0.93 ENST00000367284.5
ENST00000367283.3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr1_-_109584608 0.92 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WD repeat domain 47
chr11_-_327537 0.87 ENST00000602735.1
interferon induced transmembrane protein 3
chrX_-_18690210 0.86 ENST00000379984.3
retinoschisin 1
chr17_+_40118759 0.85 ENST00000393892.3
2',3'-cyclic nucleotide 3' phosphodiesterase
chr3_-_122233723 0.85 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
karyopherin alpha 1 (importin alpha 5)
chr1_+_62439037 0.79 ENST00000545929.1
InaD-like (Drosophila)
chr4_-_70518941 0.77 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr5_+_140593509 0.74 ENST00000341948.4
protocadherin beta 13
chr6_+_26365443 0.68 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
butyrophilin, subfamily 3, member A2
chrX_+_19362011 0.67 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
pyruvate dehydrogenase (lipoamide) alpha 1
chrX_+_84258832 0.66 ENST00000373173.2
apolipoprotein O-like
chr17_-_37607497 0.65 ENST00000394287.3
ENST00000300651.6
mediator complex subunit 1
chrX_+_100075368 0.64 ENST00000415585.2
ENST00000372972.2
ENST00000413437.1
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
chr4_+_69962185 0.62 ENST00000305231.7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr11_+_22696314 0.62 ENST00000532398.1
ENST00000433790.1
growth arrest-specific 2
chr5_+_112849373 0.62 ENST00000161863.4
ENST00000515883.1
YTH domain containing 2
chr14_+_104182105 0.60 ENST00000311141.2
zinc finger, FYVE domain containing 21
chr4_+_69962212 0.60 ENST00000508661.1
UDP glucuronosyltransferase 2 family, polypeptide B7
chr14_+_104182061 0.59 ENST00000216602.6
zinc finger, FYVE domain containing 21
chr3_+_186353756 0.57 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
fetuin B
chr3_-_164796269 0.57 ENST00000264382.3
sucrase-isomaltase (alpha-glucosidase)
chr17_+_67498538 0.54 ENST00000589647.1
mitogen-activated protein kinase kinase 6
chr2_-_225811747 0.52 ENST00000409592.3
dedicator of cytokinesis 10
chr18_-_24443151 0.51 ENST00000440832.3
aquaporin 4
chr5_-_149829314 0.51 ENST00000407193.1
ribosomal protein S14
chr8_+_105235572 0.51 ENST00000523362.1
regulating synaptic membrane exocytosis 2
chr2_+_102953608 0.47 ENST00000311734.2
ENST00000409584.1
interleukin 1 receptor-like 1
chr20_-_21494654 0.46 ENST00000377142.4
NK2 homeobox 2
chr12_-_68619586 0.46 ENST00000229134.4
interleukin 26
chr2_+_27255806 0.45 ENST00000238788.9
ENST00000404032.3
transmembrane protein 214
chr12_-_10605929 0.45 ENST00000347831.5
ENST00000359151.3
killer cell lectin-like receptor subfamily C, member 1
chr14_-_80697396 0.44 ENST00000557010.1
deiodinase, iodothyronine, type II
chr4_-_90757364 0.43 ENST00000508895.1
synuclein, alpha (non A4 component of amyloid precursor)

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB4_LHX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 34.8 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
3.3 13.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
3.2 19.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
2.7 10.9 GO:0031860 telomeric 3' overhang formation(GO:0031860)
2.5 10.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
2.2 15.1 GO:0009438 methylglyoxal metabolic process(GO:0009438)
2.0 5.9 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.9 9.4 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
1.9 7.4 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
1.8 7.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.7 5.2 GO:0016095 polyprenol catabolic process(GO:0016095)
1.7 10.3 GO:0051661 maintenance of centrosome location(GO:0051661)
1.7 8.5 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.7 6.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
1.4 4.3 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
1.4 13.8 GO:0051096 positive regulation of helicase activity(GO:0051096)
1.3 30.5 GO:0003334 keratinocyte development(GO:0003334)
1.3 4.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
1.3 3.9 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
1.2 3.7 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.2 6.1 GO:0070980 biphenyl catabolic process(GO:0070980)
1.2 7.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
1.1 5.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
1.1 3.3 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
1.1 4.4 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
1.1 6.4 GO:0090646 mitochondrial tRNA processing(GO:0090646)
1.1 4.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
1.0 8.3 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
1.0 3.1 GO:2000397 ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
1.0 6.8 GO:0046485 ether lipid metabolic process(GO:0046485)
0.9 7.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.9 3.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.9 3.6 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.9 7.0 GO:0016139 glycoside catabolic process(GO:0016139)
0.8 4.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.8 36.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.8 10.7 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.7 5.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.7 6.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.7 4.9 GO:0009597 detection of virus(GO:0009597)
0.7 3.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.7 2.7 GO:0006203 dGTP catabolic process(GO:0006203)
0.7 4.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 3.7 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.6 2.9 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.6 4.0 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.5 3.2 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.5 4.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.5 2.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.4 2.2 GO:0071233 cellular response to leucine(GO:0071233)
0.4 3.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.4 8.6 GO:0051764 actin crosslink formation(GO:0051764)
0.4 5.6 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.4 12.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.4 14.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.4 1.1 GO:0060920 atrioventricular node development(GO:0003162) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.3 1.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.3 2.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.3 2.8 GO:0030091 protein repair(GO:0030091)
0.3 5.0 GO:0000338 protein deneddylation(GO:0000338)
0.3 6.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 8.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 1.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.3 2.9 GO:0090400 stress-induced premature senescence(GO:0090400)
0.2 1.8 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.2 0.6 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 1.5 GO:0042426 choline catabolic process(GO:0042426)
0.2 11.2 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 6.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.2 2.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.2 3.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.2 0.5 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 1.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 4.6 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 6.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 0.5 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 4.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 7.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 10.5 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 3.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 4.1 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 3.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 6.0 GO:1901998 toxin transport(GO:1901998)
0.1 5.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 3.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.6 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.4 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 1.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 11.1 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 1.7 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 12.5 GO:0051028 mRNA transport(GO:0051028)
0.1 0.9 GO:0009642 response to light intensity(GO:0009642)
0.1 0.4 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.1 0.9 GO:0060056 mammary gland involution(GO:0060056)
0.1 12.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 12.8 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 0.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.7 GO:0042407 cristae formation(GO:0042407)
0.1 0.3 GO:2001023 regulation of response to drug(GO:2001023)
0.1 2.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.6 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.1 2.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.5 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.3 GO:0048539 bone marrow development(GO:0048539)
0.1 1.5 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 1.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.4 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 1.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.8 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.3 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.9 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.4 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 2.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 4.0 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 1.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.8 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902)
0.0 0.2 GO:0015816 glycine transport(GO:0015816)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.5 GO:0006833 water transport(GO:0006833)
0.0 2.1 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 6.7 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.5 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.3 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 1.5 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 0.0 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.2 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.3 GO:0006706 steroid catabolic process(GO:0006706)
0.0 10.1 GO:0043066 negative regulation of apoptotic process(GO:0043066)
0.0 0.5 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 34.8 GO:0044326 dendritic spine neck(GO:0044326)
3.4 10.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
3.1 12.4 GO:1990730 VCP-NSFL1C complex(GO:1990730)
2.4 7.3 GO:0005607 laminin-2 complex(GO:0005607)
1.7 8.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
1.6 10.9 GO:0030870 Mre11 complex(GO:0030870)
1.5 10.3 GO:0036449 microtubule minus-end(GO:0036449)
1.3 6.4 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
1.3 3.8 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.1 6.3 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.8 2.4 GO:0005873 plus-end kinesin complex(GO:0005873)
0.8 18.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.8 2.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.6 6.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.6 30.5 GO:0002102 podosome(GO:0002102)
0.6 4.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.6 8.3 GO:0005869 dynactin complex(GO:0005869)
0.5 10.7 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.5 13.1 GO:0097228 sperm principal piece(GO:0097228)
0.5 3.9 GO:0005610 laminin-5 complex(GO:0005610)
0.4 3.1 GO:0000813 ESCRT I complex(GO:0000813)
0.4 10.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4 6.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 3.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 1.3 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.3 4.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 6.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 2.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.3 6.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 5.6 GO:0036020 endolysosome membrane(GO:0036020)
0.3 2.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 1.9 GO:0070852 cell body fiber(GO:0070852)
0.3 4.1 GO:0043073 germ cell nucleus(GO:0043073)
0.3 13.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 7.2 GO:0005921 gap junction(GO:0005921)
0.2 3.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 6.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 4.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 4.2 GO:0030056 hemidesmosome(GO:0030056)
0.2 1.4 GO:0042382 paraspeckles(GO:0042382)
0.2 14.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 4.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 16.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 26.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 1.7 GO:0031932 TORC2 complex(GO:0031932)
0.1 2.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 5.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 4.0 GO:0045095 keratin filament(GO:0045095)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.1 2.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.8 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 2.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 7.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 3.9 GO:0001772 immunological synapse(GO:0001772)
0.1 1.5 GO:0031527 filopodium membrane(GO:0031527)
0.1 6.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 4.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 9.4 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 6.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 0.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 26.6 GO:0010008 endosome membrane(GO:0010008)
0.1 0.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 1.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 7.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 8.3 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.1 GO:0032040 small-subunit processome(GO:0032040)
0.0 3.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 5.9 GO:0005874 microtubule(GO:0005874)
0.0 3.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.0 0.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.8 GO:0005819 spindle(GO:0005819)
0.0 7.1 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 19.1 GO:0004743 pyruvate kinase activity(GO:0004743)
3.3 13.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
2.0 10.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.9 15.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.9 9.4 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.7 7.0 GO:0016936 galactoside binding(GO:0016936)
1.4 6.8 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
1.3 5.2 GO:0047718 enone reductase activity(GO:0035671) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
1.3 29.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
1.3 7.6 GO:0042296 ISG15 transferase activity(GO:0042296)
1.2 4.6 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
1.0 3.8 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.0 7.6 GO:0004111 creatine kinase activity(GO:0004111)
0.9 34.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.9 2.7 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) NADH pyrophosphatase activity(GO:0035529) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.9 37.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 3.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.8 4.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.8 2.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.7 3.7 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.7 4.0 GO:1990254 keratin filament binding(GO:1990254)
0.6 3.6 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.6 6.5 GO:0046790 virion binding(GO:0046790)
0.6 2.8 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.5 10.7 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.5 7.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.5 3.9 GO:0019863 IgE binding(GO:0019863)
0.5 3.7 GO:0016778 diphosphotransferase activity(GO:0016778)
0.5 2.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.5 6.3 GO:0050700 CARD domain binding(GO:0050700)
0.4 2.0 GO:0070728 leucine binding(GO:0070728)
0.4 4.8 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.4 6.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 7.2 GO:0005522 profilin binding(GO:0005522)
0.4 1.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.4 4.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 9.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 4.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 10.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 5.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 8.7 GO:0070840 dynein complex binding(GO:0070840)
0.3 5.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.2 2.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 6.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 7.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 2.2 GO:0015266 protein channel activity(GO:0015266)
0.2 1.2 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.2 0.6 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.2 7.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 3.7 GO:0070628 proteasome binding(GO:0070628)
0.2 1.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 1.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.2 8.6 GO:0005080 protein kinase C binding(GO:0005080)
0.2 0.7 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 7.3 GO:0000049 tRNA binding(GO:0000049)
0.2 4.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 0.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 2.8 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 3.1 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 3.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 14.9 GO:0043130 ubiquitin binding(GO:0043130)
0.1 2.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 26.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 6.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 9.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 4.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 0.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 10.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 18.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 0.4 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 10.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 1.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 2.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 2.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 6.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 2.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 7.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.3 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 10.1 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 4.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.8 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 48.8 PID BARD1 PATHWAY BARD1 signaling events
0.4 8.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 10.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.2 14.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 8.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 10.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 13.7 PID NOTCH PATHWAY Notch signaling pathway
0.2 4.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 11.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 3.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 7.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 6.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 4.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 5.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 2.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 8.3 PID E2F PATHWAY E2F transcription factor network
0.1 3.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 4.8 PID BCR 5PATHWAY BCR signaling pathway
0.1 1.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 2.9 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 5.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 37.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.8 8.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.7 6.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.5 10.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.5 3.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.4 10.9 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 6.8 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.3 10.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 3.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.3 8.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 9.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 4.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 5.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 7.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 6.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.2 3.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 6.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 5.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 4.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 7.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 1.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 3.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 12.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 7.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 12.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 3.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.4 REACTOME KINESINS Genes involved in Kinesins
0.1 3.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 4.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.5 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.1 4.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 12.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 4.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.3 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 7.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 6.5 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 2.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.7 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 3.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 8.9 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 2.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 2.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.8 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 2.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation