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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXB4_LHX9
Z-value: 0.63
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Transcription factors associated with HOXB4_LHX9
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB4_LHX9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 36.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 5.0 | 34.8 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 1.3 | 30.5 | GO:0003334 | keratinocyte development(GO:0003334) |
| 3.2 | 19.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 2.2 | 15.1 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 0.4 | 14.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 1.4 | 13.8 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 3.3 | 13.1 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 12.8 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 0.1 | 12.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 34.8 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.6 | 30.5 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 26.6 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 26.5 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.8 | 18.5 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.1 | 16.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 14.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.3 | 13.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.5 | 13.1 | GO:0097228 | sperm principal piece(GO:0097228) |
| 3.1 | 12.4 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 37.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.9 | 34.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.3 | 29.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 26.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 4.8 | 19.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 18.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.9 | 15.1 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 14.9 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 3.3 | 13.1 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 10.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 48.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 14.5 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.2 | 13.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 11.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 10.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 10.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.4 | 8.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 8.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 8.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 7.1 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 37.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 12.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 12.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 12.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 10.9 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.3 | 10.7 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.5 | 10.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 9.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 8.9 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.8 | 8.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |