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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXB5

Z-value: 0.59

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.188.5e-03Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_48380205 14.28 ENST00000446158.1
ENST00000414061.1
EBP
emopamil binding protein (sterol isomerase)
chr19_-_50143452 10.12 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr15_-_72523454 7.90 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
PKM
pyruvate kinase, muscle
chr14_-_102704783 6.96 ENST00000522534.1
MOK
MOK protein kinase
chr15_+_74218787 6.82 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr2_-_47168850 5.83 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr12_+_66217911 5.67 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr19_-_16045220 5.38 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr3_-_127541194 4.96 ENST00000453507.2
MGLL
monoglyceride lipase
chr2_-_47168906 4.45 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr17_+_46970178 4.10 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr17_+_46970134 3.94 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chrX_+_47077632 3.87 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr17_+_46970127 3.81 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr1_+_154229547 3.67 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr17_-_29233769 3.52 ENST00000581216.1
TEFM
transcription elongation factor, mitochondrial
chr12_+_53693466 3.40 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr16_-_84651647 3.13 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr16_-_50402836 2.91 ENST00000394688.3
BRD7
bromodomain containing 7
chr1_+_155658849 2.91 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr6_-_31510181 2.74 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr17_-_29233221 2.74 ENST00000580840.1
TEFM
transcription elongation factor, mitochondrial
chr1_+_116915855 2.70 ENST00000295598.5
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr16_-_1821496 2.62 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr3_+_51422478 2.51 ENST00000528157.1
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr8_-_133097902 2.30 ENST00000262283.5
OC90
Otoconin-90
chr16_-_1821721 2.07 ENST00000219302.3
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr6_+_121756809 2.04 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_161193349 2.01 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr12_-_101801505 1.83 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr6_-_31509714 1.79 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr7_+_155090271 1.74 ENST00000476756.1
INSIG1
insulin induced gene 1
chr16_-_30381580 1.55 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr1_+_155579979 1.41 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr17_+_2496971 1.31 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr12_+_56915713 1.22 ENST00000262031.5
ENST00000552247.2
RBMS2
RNA binding motif, single stranded interacting protein 2
chrM_+_12331 1.22 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr17_-_42143963 1.19 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_154975110 1.18 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr15_-_75017711 1.18 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr1_+_235492300 1.14 ENST00000476121.1
ENST00000497327.1
GGPS1
geranylgeranyl diphosphate synthase 1
chr4_-_114900831 1.02 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr7_+_130020932 0.90 ENST00000484324.1
CPA1
carboxypeptidase A1 (pancreatic)
chr5_+_175298573 0.89 ENST00000512824.1
CPLX2
complexin 2
chr12_+_56915776 0.80 ENST00000550726.1
ENST00000542360.1
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_+_41157421 0.78 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr8_-_93107696 0.66 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_-_195538760 0.63 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr1_+_41157671 0.60 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr1_-_155658085 0.55 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1
chr12_-_7818474 0.52 ENST00000229304.4
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr20_-_48184638 0.42 ENST00000244043.4
PTGIS
prostaglandin I2 (prostacyclin) synthase
chr8_-_93107443 0.42 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_21945335 0.42 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr3_+_130613226 0.40 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr3_-_195538728 0.30 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr1_+_41157361 0.26 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr1_-_155658766 0.15 ENST00000295566.4
ENST00000368330.2
YY1AP1
YY1 associated protein 1
chr7_+_120969045 0.15 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr8_-_93107827 0.09 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_97285336 0.08 ENST00000229955.3
ENST00000417980.1
GPR63
G protein-coupled receptor 63
chr2_+_219283815 0.07 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr1_+_22307592 0.04 ENST00000400277.2
CELA3B
chymotrypsin-like elastase family, member 3B
chrX_+_135230712 0.04 ENST00000535737.1
FHL1
four and a half LIM domains 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.3 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
1.9 5.7 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
1.3 5.4 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
1.3 7.9 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.7 5.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.7 6.3 GO:0006390 mitochondrial DNA replication(GO:0006264) transcription from mitochondrial promoter(GO:0006390)
0.7 2.0 GO:2000909 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.6 3.7 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.6 1.7 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.5 2.0 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.5 4.5 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.4 1.2 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.4 4.7 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.4 2.7 GO:0031944 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032) response to glycoside(GO:1903416)
0.4 11.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.3 1.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.3 10.1 GO:0060325 face morphogenesis(GO:0060325)
0.2 1.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 3.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 10.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 1.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 3.9 GO:0030252 growth hormone secretion(GO:0030252)
0.1 6.8 GO:0035904 aorta development(GO:0035904)
0.1 0.5 GO:0016554 cytidine to uridine editing(GO:0016554) DNA cytosine deamination(GO:0070383)
0.1 2.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 1.4 GO:0048311 mitochondrion distribution(GO:0048311)
0.1 3.1 GO:0050832 defense response to fungus(GO:0050832)
0.1 2.3 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 2.9 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408) oxidative stress-induced premature senescence(GO:0090403)
0.0 0.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.9 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 2.9 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 1.6 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 1.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 1.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.5 5.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 1.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 4.5 GO:0005688 U6 snRNP(GO:0005688)
0.2 3.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 1.3 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.2 7.0 GO:0097546 ciliary base(GO:0097546)
0.1 1.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 2.0 GO:0005916 fascia adherens(GO:0005916)
0.1 2.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.9 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 10.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 2.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 6.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 2.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.9 GO:0090544 BAF-type complex(GO:0090544)
0.1 6.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 11.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 14.3 GO:0005635 nuclear envelope(GO:0005635)
0.0 3.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.9 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 10.2 GO:0005925 focal adhesion(GO:0005925)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
2.0 7.9 GO:0004743 pyruvate kinase activity(GO:0004743)
1.9 5.7 GO:0035501 MH1 domain binding(GO:0035501)
1.6 6.3 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.6 4.5 GO:0030621 U4 snRNA binding(GO:0030621)
0.5 2.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.4 11.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 6.8 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.4 5.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 2.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.2 1.2 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.2 0.9 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.2 4.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 2.7 GO:1990239 steroid hormone binding(GO:1990239)
0.2 10.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 10.1 GO:0019003 GDP binding(GO:0019003)
0.1 5.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.3 GO:0034452 dynactin binding(GO:0034452)
0.1 2.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 2.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 1.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.0 2.5 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 14.3 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 2.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 6.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 11.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.5 10.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.5 14.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 5.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 10.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 7.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes