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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXB6_PRRX2

Z-value: 0.72

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol Gene ID Gene Info
ENSG00000108511.8 homeobox B6
ENSG00000167157.9 paired related homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRRX2hg19_v2_chr9_+_132427883_1324279510.492.0e-14Click!
HOXB6hg19_v2_chr17_-_46682321_46682362-0.063.6e-01Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_16761007 140.21 ENST00000354662.1
ENST00000441439.2
LIM domain only 3 (rhombotin-like 2)
chr4_-_176733897 133.83 ENST00000393658.2
glycoprotein M6A
chr2_-_175711133 74.69 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr12_-_16759711 64.75 ENST00000447609.1
LIM domain only 3 (rhombotin-like 2)
chr16_+_7382745 62.91 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_50201327 58.09 ENST00000412315.1
neurexin 1
chr18_-_53089723 56.11 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr1_+_50569575 52.82 ENST00000371827.1
ELAV like neuron-specific RNA binding protein 4
chr5_-_88179302 52.26 ENST00000504921.2
myocyte enhancer factor 2C
chr13_-_67802549 47.29 ENST00000328454.5
ENST00000377865.2
protocadherin 9
chr1_+_50574585 46.23 ENST00000371824.1
ENST00000371823.4
ELAV like neuron-specific RNA binding protein 4
chr18_-_52989217 46.01 ENST00000570287.2
transcription factor 4
chr3_+_111717600 42.93 ENST00000273368.4
transgelin 3
chr8_-_18744528 41.55 ENST00000523619.1
pleckstrin and Sec7 domain containing 3
chr8_+_80523321 40.64 ENST00000518111.1
stathmin-like 2
chr13_-_36429763 40.48 ENST00000379893.1
doublecortin-like kinase 1
chr4_+_41258786 39.77 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_224467093 38.80 ENST00000305409.2
secretogranin II
chr3_+_111717511 37.27 ENST00000478951.1
ENST00000393917.2
transgelin 3
chr7_-_31380502 37.04 ENST00000297142.3
neuronal differentiation 6
chr12_-_16758304 36.21 ENST00000320122.6
LIM domain only 3 (rhombotin-like 2)
chr12_-_91576561 35.81 ENST00000547568.2
ENST00000552962.1
decorin
chrX_-_13835147 35.69 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr3_+_111718036 35.35 ENST00000455401.2
transgelin 3
chr3_+_158787041 35.18 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1 readthrough
chr5_-_24645078 33.67 ENST00000264463.4
cadherin 10, type 2 (T2-cadherin)
chr12_-_16758059 32.75 ENST00000261169.6
LIM domain only 3 (rhombotin-like 2)
chr12_+_79258444 32.61 ENST00000261205.4
synaptotagmin I
chr3_+_111718173 32.11 ENST00000494932.1
transgelin 3
chr8_+_85618155 31.34 ENST00000523850.1
ENST00000521376.1
RALY RNA binding protein-like
chr3_+_159557637 30.85 ENST00000445224.2
schwannomin interacting protein 1
chr12_-_91576429 30.80 ENST00000552145.1
ENST00000546745.1
decorin
chr12_+_79258547 30.51 ENST00000457153.2
synaptotagmin I
chr12_-_91576750 30.20 ENST00000228329.5
ENST00000303320.3
ENST00000052754.5
decorin
chr18_-_52989525 29.70 ENST00000457482.3
transcription factor 4
chr6_-_46293378 29.58 ENST00000330430.6
regulator of calcineurin 2
chr3_+_115342349 28.54 ENST00000393780.3
growth associated protein 43
chr5_+_66300446 26.94 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr3_-_114477787 26.70 ENST00000464560.1
zinc finger and BTB domain containing 20
chr3_+_35721106 26.58 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
cAMP-regulated phosphoprotein, 21kDa
chr10_-_21786179 25.93 ENST00000377113.5
cancer susceptibility candidate 10
chrX_-_13835461 25.92 ENST00000316715.4
ENST00000356942.5
glycoprotein M6B
chr13_-_45010939 25.41 ENST00000261489.2
TSC22 domain family, member 1
chr3_-_114477962 25.04 ENST00000471418.1
zinc finger and BTB domain containing 20
chr11_+_131240373 24.56 ENST00000374791.3
ENST00000436745.1
neurotrimin
chr14_+_22977587 22.37 ENST00000390504.1
T cell receptor alpha joining 33
chr4_-_41884620 21.95 ENST00000504870.1
long intergenic non-protein coding RNA 682
chr2_-_2334888 21.32 ENST00000428368.2
ENST00000399161.2
myelin transcription factor 1-like
chr16_-_29910853 21.27 ENST00000308713.5
seizure related 6 homolog (mouse)-like 2
chr8_-_102803163 21.10 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
neurocalcin delta
chr12_-_91539918 20.99 ENST00000548218.1
decorin
chr11_-_129062093 20.90 ENST00000310343.9
Rho GTPase activating protein 32
chr1_-_156399184 20.42 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
chromosome 1 open reading frame 61
chr1_+_65730385 20.39 ENST00000263441.7
ENST00000395325.3
DnaJ (Hsp40) homolog, subfamily C, member 6
chr9_+_87284622 20.32 ENST00000395882.1
neurotrophic tyrosine kinase, receptor, type 2
chr11_-_111794446 20.24 ENST00000527950.1
crystallin, alpha B
chr12_-_91574142 20.24 ENST00000547937.1
decorin
chr2_+_183943464 20.14 ENST00000354221.4
dual specificity phosphatase 19
chrX_+_135278908 19.70 ENST00000539015.1
ENST00000370683.1
four and a half LIM domains 1
chr8_-_120651020 19.58 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr1_-_57045228 19.44 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr12_+_79439405 19.37 ENST00000552744.1
synaptotagmin I
chr17_-_78450398 19.26 ENST00000306773.4
neuronal pentraxin I
chrX_+_135251783 19.13 ENST00000394153.2
four and a half LIM domains 1
chr11_-_111782696 19.11 ENST00000227251.3
ENST00000526180.1
crystallin, alpha B
chr3_-_58613323 19.05 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chrX_+_135279179 18.82 ENST00000370676.3
four and a half LIM domains 1
chr3_+_35722487 18.80 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chr4_-_186877806 18.60 ENST00000355634.5
sorbin and SH3 domain containing 2
chr4_-_87028478 18.55 ENST00000515400.1
ENST00000395157.3
mitogen-activated protein kinase 10
chr1_+_84630053 18.53 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_170736243 18.37 ENST00000296921.5
T-cell leukemia homeobox 3
chr6_+_45296048 18.24 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
runt-related transcription factor 2
chr15_+_93443419 18.22 ENST00000557381.1
ENST00000420239.2
chromodomain helicase DNA binding protein 2
chr16_+_8806800 18.01 ENST00000561870.1
ENST00000396600.2
4-aminobutyrate aminotransferase
chr8_+_104831472 17.95 ENST00000262231.10
ENST00000507740.1
regulating synaptic membrane exocytosis 2
chr18_-_21891460 17.59 ENST00000357041.4
oxysterol binding protein-like 1A
chr18_-_53070913 17.39 ENST00000568186.1
ENST00000564228.1
transcription factor 4
chr4_-_153274078 17.37 ENST00000263981.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_158141843 17.35 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr11_-_125366089 17.17 ENST00000366139.3
ENST00000278919.3
fasciculation and elongation protein zeta 1 (zygin I)
chr4_+_158141899 16.53 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr2_+_166428839 16.52 ENST00000342316.4
cysteine-serine-rich nuclear protein 3
chr18_-_53177984 16.40 ENST00000543082.1
transcription factor 4
chr4_+_72204755 16.36 ENST00000512686.1
ENST00000340595.3
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr7_-_27183263 16.27 ENST00000222726.3
homeobox A5
chrX_+_135252050 16.11 ENST00000449474.1
ENST00000345434.3
four and a half LIM domains 1
chr2_+_54785485 15.83 ENST00000333896.5
spectrin, beta, non-erythrocytic 1
chr4_+_113970772 15.60 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr14_-_98444386 15.13 ENST00000556462.1
ENST00000556138.1
chromosome 14 open reading frame 64
chr11_-_111782484 15.06 ENST00000533971.1
crystallin, alpha B
chr8_-_18541603 15.01 ENST00000428502.2
pleckstrin and Sec7 domain containing 3
chr16_+_6533380 14.95 ENST00000552089.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr5_+_156712372 14.87 ENST00000541131.1
cytoplasmic FMR1 interacting protein 2
chr18_-_53069419 14.81 ENST00000570177.2
transcription factor 4
chr2_-_60780536 14.77 ENST00000538214.1
B-cell CLL/lymphoma 11A (zinc finger protein)
chrX_-_72434628 14.66 ENST00000536638.1
ENST00000373517.3
nucleosome assembly protein 1-like 2
chr15_+_34261089 14.56 ENST00000383263.5
cholinergic receptor, muscarinic 5
chr18_-_53257027 14.49 ENST00000568740.1
ENST00000564403.2
ENST00000537578.1
transcription factor 4
chr1_+_50571949 14.39 ENST00000357083.4
ELAV like neuron-specific RNA binding protein 4
chr2_+_102508955 14.34 ENST00000414004.2
FLJ20373
chr11_+_123396528 14.32 ENST00000322282.7
ENST00000529750.1
GRAM domain containing 1B
chr6_+_45296391 14.28 ENST00000371436.6
ENST00000576263.1
runt-related transcription factor 2
chr8_+_104892639 14.20 ENST00000436393.2
regulating synaptic membrane exocytosis 2
chr4_+_158141806 14.16 ENST00000393815.2
glutamate receptor, ionotropic, AMPA 2
chr5_+_161494521 14.08 ENST00000356592.3
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_+_103204553 13.94 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr5_+_140810132 13.91 ENST00000252085.3
protocadherin gamma subfamily A, 12
chr14_-_101036119 13.81 ENST00000355173.2
brain-enriched guanylate kinase-associated
chr4_+_113739244 13.77 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ankyrin 2, neuronal
chr4_+_88754069 13.62 ENST00000395102.4
ENST00000497649.2
matrix extracellular phosphoglycoprotein
chr22_-_36236623 13.61 ENST00000405409.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_114343039 13.52 ENST00000481632.1
zinc finger and BTB domain containing 20
chr7_-_37026108 13.36 ENST00000396045.3
engulfment and cell motility 1
chr1_+_162602244 13.30 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr11_+_92085707 13.19 ENST00000525166.1
FAT atypical cadherin 3
chr17_+_76311791 13.17 ENST00000586321.1
AC061992.2
chr18_+_32290218 13.12 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
dystrobrevin, alpha
chr17_+_41363854 13.11 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
transmembrane protein 106A
chr12_-_50290839 13.10 ENST00000552863.1
Fas apoptotic inhibitory molecule 2
chr2_+_166152283 13.08 ENST00000375427.2
sodium channel, voltage-gated, type II, alpha subunit
chr5_+_67586465 12.95 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_88896819 12.94 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
secreted phosphoprotein 1
chr11_-_84634217 12.83 ENST00000524982.1
discs, large homolog 2 (Drosophila)
chr2_+_166150541 12.69 ENST00000283256.6
sodium channel, voltage-gated, type II, alpha subunit
chr2_+_66662690 12.67 ENST00000488550.1
Meis homeobox 1
chr12_+_54447637 12.45 ENST00000609810.1
ENST00000430889.2
homeobox C4
Homeobox protein Hox-C4
chr1_+_155829286 12.31 ENST00000368324.4
synaptotagmin XI
chr4_+_158142750 12.28 ENST00000505888.1
ENST00000449365.1
glutamate receptor, ionotropic, AMPA 2
chr4_+_41614909 12.24 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIM and calponin homology domains 1
chr12_+_81110684 11.99 ENST00000228644.3
myogenic factor 5
chr2_+_210444748 11.94 ENST00000392194.1
microtubule-associated protein 2
chr6_-_6007200 11.91 ENST00000244766.2
neuritin 1
chr1_+_92632542 11.85 ENST00000409154.4
ENST00000370378.4
KIAA1107
chr2_+_210444142 11.85 ENST00000360351.4
ENST00000361559.4
microtubule-associated protein 2
chr2_+_162272605 11.84 ENST00000389554.3
T-box, brain, 1
chr9_-_124989804 11.78 ENST00000373755.2
ENST00000373754.2
LIM homeobox 6
chr5_+_59783941 11.77 ENST00000506884.1
ENST00000504876.2
prostate androgen-regulated transcript 1 (non-protein coding)
chr5_+_161274940 11.53 ENST00000393943.4
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_88754113 11.49 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr5_+_66254698 11.44 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
microtubule associated serine/threonine kinase family member 4
chr12_-_9268707 11.26 ENST00000318602.7
alpha-2-macroglobulin
chr3_-_127541194 11.24 ENST00000453507.2
monoglyceride lipase
chr16_+_89334512 11.23 ENST00000602042.1
AC137932.1
chr8_-_27115931 11.18 ENST00000523048.1
stathmin-like 4
chr10_-_62149433 11.17 ENST00000280772.2
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_186877502 11.07 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
sorbin and SH3 domain containing 2
chr3_+_129247479 11.04 ENST00000296271.3
rhodopsin
chr16_-_21289627 10.99 ENST00000396023.2
ENST00000415987.2
crystallin, mu
chr2_-_177502659 10.96 ENST00000295549.4
long intergenic non-protein coding RNA 1116
chr5_+_161274685 10.94 ENST00000428797.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_-_169654139 10.87 ENST00000366787.3
thrombospondin 2
chr5_+_156696362 10.78 ENST00000377576.3
cytoplasmic FMR1 interacting protein 2
chr5_+_161494770 10.62 ENST00000414552.2
ENST00000361925.4
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_-_124990680 10.61 ENST00000541397.2
ENST00000560485.1
LIM homeobox 6
chr2_-_183291741 10.56 ENST00000351439.5
ENST00000409365.1
phosphodiesterase 1A, calmodulin-dependent
chr5_-_11588907 10.44 ENST00000513598.1
ENST00000503622.1
catenin (cadherin-associated protein), delta 2
chr10_-_49813090 10.39 ENST00000249601.4
Rho GTPase activating protein 22
chr9_+_2158443 10.23 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_171034646 10.21 ENST00000409044.3
ENST00000408978.4
myosin IIIB
chr18_-_53303123 10.19 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
transcription factor 4
chr5_-_1882858 10.14 ENST00000511126.1
ENST00000231357.2
iroquois homeobox 4
chr8_-_87755878 10.12 ENST00000320005.5
cyclic nucleotide gated channel beta 3
chr2_+_66662510 10.09 ENST00000272369.9
ENST00000407092.2
Meis homeobox 1
chr6_+_69942298 10.06 ENST00000238918.8
brain-specific angiogenesis inhibitor 3
chr17_-_26220366 10.02 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYR motif containing 9
Uncharacterized protein
chr13_+_96085847 10.01 ENST00000376873.3
claudin 10
chr2_-_213403565 10.00 ENST00000342788.4
ENST00000436443.1
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr5_+_140762268 9.98 ENST00000518325.1
protocadherin gamma subfamily A, 7
chr5_+_161112563 9.96 ENST00000274545.5
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr8_-_120685608 9.96 ENST00000427067.2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr11_-_123525289 9.86 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
sodium channel, voltage-gated, type III, beta subunit
chr3_+_69985792 9.80 ENST00000531774.1
microphthalmia-associated transcription factor
chr15_+_62853562 9.80 ENST00000561311.1
talin 2
chr15_+_74422585 9.79 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
immunoglobulin superfamily containing leucine-rich repeat 2
chr5_+_161275320 9.75 ENST00000437025.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr14_-_69261310 9.67 ENST00000336440.3
ZFP36 ring finger protein-like 1
chr5_-_11589131 9.64 ENST00000511377.1
catenin (cadherin-associated protein), delta 2
chr10_+_95517660 9.60 ENST00000371413.3
leucine-rich, glioma inactivated 1
chr5_-_115910091 9.60 ENST00000257414.8
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_99578776 9.58 ENST00000515287.1
tetraspanin 5
chr5_-_138210977 9.57 ENST00000274711.6
ENST00000521094.2
leucine rich repeat transmembrane neuronal 2
chr9_+_2158485 9.56 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_-_27115903 9.48 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
stathmin-like 4
chr18_-_53253112 9.42 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
transcription factor 4
chr17_-_29624343 9.32 ENST00000247271.4
oligodendrocyte myelin glycoprotein
chr5_+_174151536 9.25 ENST00000239243.6
ENST00000507785.1
msh homeobox 2
chr2_-_60780702 9.19 ENST00000359629.5
B-cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_166060552 9.16 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chr15_+_43985084 9.04 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chrX_+_135251835 8.85 ENST00000456445.1
four and a half LIM domains 1
chr9_-_14308004 8.80 ENST00000493697.1
nuclear factor I/B
chr4_-_99578789 8.69 ENST00000511651.1
ENST00000505184.1
tetraspanin 5
chr1_+_84630645 8.62 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr9_-_13165457 8.62 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr4_+_114214125 8.62 ENST00000509550.1
ankyrin 2, neuronal
chr1_+_50575292 8.53 ENST00000371821.1
ENST00000371819.1
ELAV like neuron-specific RNA binding protein 4
chr5_+_161112754 8.51 ENST00000523217.1
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr11_-_111175739 8.48 ENST00000532918.1
colorectal cancer associated 1
chr2_-_152589670 8.48 ENST00000604864.1
ENST00000603639.1
nebulin

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
45.7 273.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
27.5 82.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
16.2 64.7 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
13.0 38.9 GO:0007412 axon target recognition(GO:0007412)
12.7 38.0 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
12.2 146.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
10.2 40.6 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
9.6 28.7 GO:1904800 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
8.2 65.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
7.6 7.6 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
6.2 61.7 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
5.4 27.1 GO:0097338 response to clozapine(GO:0097338)
5.4 16.3 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
5.3 21.3 GO:0072658 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
4.9 9.8 GO:0045773 positive regulation of axon extension(GO:0045773)
4.7 23.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
4.7 23.3 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
4.6 23.1 GO:0003322 pancreatic A cell development(GO:0003322)
4.5 18.0 GO:1904450 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
4.3 12.9 GO:0035938 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
4.3 86.1 GO:0071420 cellular response to histamine(GO:0071420)
4.3 34.2 GO:0002051 osteoblast fate commitment(GO:0002051)
4.1 12.3 GO:1905154 negative regulation of membrane invagination(GO:1905154)
3.8 15.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
3.7 7.5 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
3.7 37.0 GO:0016198 axon choice point recognition(GO:0016198)
3.6 3.6 GO:0021781 glial cell fate commitment(GO:0021781)
3.4 20.1 GO:0021764 amygdala development(GO:0021764)
3.3 10.0 GO:2000366 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
3.3 13.2 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
3.2 9.7 GO:0048382 mesendoderm development(GO:0048382)
3.2 25.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
3.1 12.4 GO:0018032 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
3.1 9.3 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
3.1 39.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
3.0 121.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
3.0 54.4 GO:0007021 tubulin complex assembly(GO:0007021)
3.0 3.0 GO:1902285 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285)
2.9 14.7 GO:2000035 regulation of stem cell division(GO:2000035)
2.9 29.1 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
2.9 40.4 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
2.9 17.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
2.8 56.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
2.8 2.8 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
2.7 13.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
2.6 7.8 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
2.5 15.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
2.4 31.6 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
2.4 24.2 GO:0060385 axonogenesis involved in innervation(GO:0060385)
2.4 16.8 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.3 4.7 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
2.3 18.5 GO:0007258 JUN phosphorylation(GO:0007258)
2.3 25.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
2.3 20.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
2.2 6.7 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
2.2 59.4 GO:0008045 motor neuron axon guidance(GO:0008045)
2.1 4.3 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
2.1 8.5 GO:0007525 somatic muscle development(GO:0007525)
2.1 6.2 GO:0060018 astrocyte fate commitment(GO:0060018)
2.0 30.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
2.0 4.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
2.0 23.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
1.9 7.7 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.9 7.5 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
1.9 5.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.8 40.3 GO:0021542 dentate gyrus development(GO:0021542)
1.8 5.4 GO:0009214 cAMP catabolic process(GO:0006198) cyclic nucleotide catabolic process(GO:0009214)
1.8 3.6 GO:0051866 general adaptation syndrome(GO:0051866)
1.8 5.4 GO:0048867 stem cell fate determination(GO:0048867)
1.8 101.0 GO:0003254 regulation of membrane depolarization(GO:0003254)
1.8 5.3 GO:0014043 negative regulation of neuron maturation(GO:0014043)
1.7 7.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
1.7 7.0 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
1.7 12.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
1.7 8.5 GO:0019805 quinolinate biosynthetic process(GO:0019805)
1.7 18.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.6 8.2 GO:0006543 glutamine catabolic process(GO:0006543)
1.6 11.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.6 12.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
1.6 11.0 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
1.5 25.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
1.5 25.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
1.5 13.1 GO:0021681 cerebellar granular layer development(GO:0021681)
1.4 4.3 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.4 11.4 GO:0008090 retrograde axonal transport(GO:0008090)
1.4 5.5 GO:0036343 psychomotor behavior(GO:0036343) motor behavior(GO:0061744)
1.4 4.1 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
1.4 53.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.4 2.7 GO:2000382 positive regulation of mesoderm development(GO:2000382)
1.4 39.4 GO:0008038 neuron recognition(GO:0008038)
1.3 2.7 GO:0034505 tooth mineralization(GO:0034505)
1.3 13.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
1.3 14.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
1.3 2.6 GO:0061113 pancreas morphogenesis(GO:0061113)
1.3 11.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
1.3 3.9 GO:0030035 microspike assembly(GO:0030035)
1.3 7.7 GO:0018095 protein polyglutamylation(GO:0018095)
1.3 6.4 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.3 68.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.3 7.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
1.2 186.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2 66.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.2 21.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
1.2 4.7 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
1.2 2.3 GO:1990637 response to prolactin(GO:1990637)
1.2 13.9 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
1.1 3.4 GO:0060325 face morphogenesis(GO:0060325)
1.1 6.7 GO:0015811 L-cystine transport(GO:0015811)
1.1 11.2 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
1.1 12.2 GO:0006554 lysine catabolic process(GO:0006554)
1.1 4.4 GO:0036269 swimming behavior(GO:0036269)
1.1 4.4 GO:0060023 soft palate development(GO:0060023)
1.1 14.2 GO:0007638 mechanosensory behavior(GO:0007638)
1.1 5.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.1 4.3 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.1 3.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.1 1.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.1 3.2 GO:0003099 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
1.1 7.4 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.1 4.2 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
1.0 32.2 GO:0097120 receptor localization to synapse(GO:0097120)
1.0 32.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
1.0 29.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.0 3.0 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
1.0 4.9 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.0 6.8 GO:0070166 enamel mineralization(GO:0070166)
1.0 9.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.0 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.9 1.9 GO:0021612 facial nerve structural organization(GO:0021612)
0.9 4.6 GO:0015824 proline transport(GO:0015824)
0.9 2.7 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.9 5.4 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.9 4.5 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.9 15.2 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.9 11.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.9 1.7 GO:0050955 thermoception(GO:0050955)
0.8 15.8 GO:0035640 exploration behavior(GO:0035640)
0.8 3.3 GO:0048807 ectoderm and mesoderm interaction(GO:0007499) female genitalia morphogenesis(GO:0048807) positive regulation of somatic stem cell population maintenance(GO:1904674)
0.8 0.8 GO:0050787 detoxification of mercury ion(GO:0050787)
0.8 3.3 GO:0061743 motor learning(GO:0061743)
0.8 4.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8 6.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.8 5.3 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.8 3.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.8 3.0 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.8 3.0 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
0.7 6.0 GO:0070995 NADPH oxidation(GO:0070995)
0.7 5.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.7 5.9 GO:0016926 protein desumoylation(GO:0016926)
0.7 24.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.7 5.1 GO:0061325 cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.7 7.3 GO:0060539 diaphragm development(GO:0060539)
0.7 3.6 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.7 4.4 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.7 3.6 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.7 2.1 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.7 11.0 GO:0018298 protein-chromophore linkage(GO:0018298)
0.7 188.7 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.7 11.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 3.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.7 4.7 GO:0036438 maintenance of lens transparency(GO:0036438)
0.7 2.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.6 20.7 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 3.2 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025)
0.6 3.2 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.6 9.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.6 2.4 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.6 17.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.6 1.8 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.6 0.6 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.6 5.9 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.6 4.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.6 3.5 GO:0071105 response to interleukin-11(GO:0071105)
0.6 1.7 GO:0010710 regulation of collagen catabolic process(GO:0010710) negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.6 5.7 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.6 1.7 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.6 4.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.6 3.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.6 1.7 GO:0048664 neuron fate determination(GO:0048664)
0.5 18.5 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.5 10.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.5 3.8 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.5 2.2 GO:0002331 pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.5 3.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.5 6.4 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.5 1.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.5 0.5 GO:0035711 T-helper 1 cell activation(GO:0035711)
0.5 5.8 GO:0006527 arginine catabolic process(GO:0006527)
0.5 28.3 GO:0051899 membrane depolarization(GO:0051899)
0.5 1.0 GO:0021798 neuroblast differentiation(GO:0014016) forebrain dorsal/ventral pattern formation(GO:0021798)
0.5 25.4 GO:0015701 bicarbonate transport(GO:0015701)
0.5 4.1 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.5 15.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.5 3.0 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.5 5.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.5 5.4 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.5 2.0 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.5 4.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.5 1.5 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.5 2.9 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
0.5 1.0 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.5 10.6 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.5 1.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 2.8 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.5 3.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.5 27.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.5 3.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.5 3.6 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 1.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.4 2.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.4 4.4 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.4 3.0 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.4 8.3 GO:0048665 neuron fate specification(GO:0048665)
0.4 0.4 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.4 1.7 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.4 15.6 GO:0014047 glutamate secretion(GO:0014047)
0.4 4.6 GO:0006600 creatine metabolic process(GO:0006600)
0.4 4.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 7.3 GO:0015874 norepinephrine transport(GO:0015874)
0.4 1.5 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.4 1.5 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.4 0.8 GO:0044245 polysaccharide digestion(GO:0044245)
0.4 3.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of heart rate by epinephrine(GO:0003065)
0.4 3.0 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.4 2.2 GO:0035865 cellular response to potassium ion(GO:0035865)
0.4 12.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.4 0.7 GO:0061386 closure of optic fissure(GO:0061386)
0.4 9.0 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.4 5.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 6.0 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.4 4.2 GO:0035878 nail development(GO:0035878)
0.3 2.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.3 20.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 1.7 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 2.0 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.3 1.0 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.3 2.3 GO:0006591 ornithine metabolic process(GO:0006591)
0.3 24.8 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.3 4.5 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.3 6.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.3 3.8 GO:1903671 negative regulation of sprouting angiogenesis(GO:1903671)
0.3 13.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.3 1.5 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.3 3.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 13.7 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.3 5.0 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.3 2.3 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.3 4.0 GO:0006020 inositol metabolic process(GO:0006020)
0.3 2.8 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.3 14.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3 2.8 GO:0015889 cobalamin transport(GO:0015889)
0.3 7.6 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.3 2.0 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.3 1.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3 5.3 GO:0050954 sensory perception of sound(GO:0007605) sensory perception of mechanical stimulus(GO:0050954)
0.3 3.1 GO:0071285 cellular response to lithium ion(GO:0071285)
0.3 0.8 GO:0043416 positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416)
0.2 2.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 2.0 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.2 6.1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.2 0.7 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.2 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 1.3 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.2 1.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.2 26.9 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 4.4 GO:0010107 potassium ion import(GO:0010107)
0.2 0.8 GO:0021997 response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.2 9.4 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.2 2.9 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 1.9 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.2 0.8 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2 0.7 GO:0042730 fibrinolysis(GO:0042730)
0.2 3.7 GO:0003334 keratinocyte development(GO:0003334)
0.2 1.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 2.0 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 2.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 0.5 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.2 1.1 GO:0048840 otolith development(GO:0048840)
0.2 0.3 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.2 0.3 GO:0086053 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2 4.2 GO:0015695 organic cation transport(GO:0015695)
0.2 0.5 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.2 2.3 GO:0005513 detection of calcium ion(GO:0005513)
0.2 4.4 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.2 1.6 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 9.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 2.5 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.2 0.8 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 0.9 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.2 0.9 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.2 1.5 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 4.4 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 1.6 GO:0021670 lateral ventricle development(GO:0021670)
0.1 0.9 GO:0060612 adipose tissue development(GO:0060612)
0.1 1.6 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 0.4 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 1.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.4 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1 5.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 3.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 6.3 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 0.3 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.8 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 3.5 GO:0048536 spleen development(GO:0048536)
0.1 0.6 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.1 11.7 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 15.0 GO:0006813 potassium ion transport(GO:0006813)
0.1 2.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.4 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 1.8 GO:0061053 somite development(GO:0061053)
0.1 6.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 2.9 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1 1.4 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.1 0.9 GO:0009642 response to light intensity(GO:0009642)
0.1 1.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 1.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 13.2 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.0 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.1 1.7 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 0.7 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.1 4.4 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 2.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.4 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 2.9 GO:1901998 toxin transport(GO:1901998)
0.1 2.6 GO:0009408 response to heat(GO:0009408)
0.1 0.5 GO:0008218 bioluminescence(GO:0008218)
0.1 1.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.3 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 1.8 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 2.1 GO:0006986 response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966)
0.1 2.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.7 GO:0032232 negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.1 0.6 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 7.4 GO:0008360 regulation of cell shape(GO:0008360)
0.1 1.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 1.4 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 1.0 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.0 1.9 GO:0061512 protein localization to cilium(GO:0061512)
0.0 1.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 1.8 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 3.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:0048469 cell maturation(GO:0048469)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.5 GO:0042073 intraciliary transport(GO:0042073)
0.0 1.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.2 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.0 2.6 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 2.3 GO:0007286 spermatid development(GO:0007286)
0.0 0.8 GO:0051693 actin filament capping(GO:0051693)
0.0 0.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 2.0 GO:0015698 inorganic anion transport(GO:0015698)
0.0 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.5 GO:0050906 detection of stimulus involved in sensory perception(GO:0050906)
0.0 0.1 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.5 82.5 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
12.1 60.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
10.3 144.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
6.1 133.7 GO:0044295 axonal growth cone(GO:0044295)
5.7 28.5 GO:0032584 growth cone membrane(GO:0032584)
4.6 27.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
4.5 18.0 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
3.9 11.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
3.9 11.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
3.8 15.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
3.7 62.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
3.4 54.4 GO:0097512 cardiac myofibril(GO:0097512)
3.3 23.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
3.3 115.6 GO:1902711 GABA-A receptor complex(GO:1902711)
2.9 11.4 GO:0031673 H zone(GO:0031673)
2.5 12.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
2.4 38.8 GO:0031045 dense core granule(GO:0031045)
2.2 15.1 GO:0032437 cuticular plate(GO:0032437)
2.1 6.4 GO:0072534 perineuronal net(GO:0072534)
2.0 17.6 GO:0016013 syntrophin complex(GO:0016013)
1.9 26.2 GO:0043194 axon initial segment(GO:0043194)
1.9 16.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.7 51.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.5 21.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.4 27.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.2 12.1 GO:0045180 basal cortex(GO:0045180)
1.2 49.1 GO:0048786 presynaptic active zone(GO:0048786)
1.1 13.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.1 4.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.1 5.4 GO:0044308 axonal spine(GO:0044308)
1.0 10.5 GO:0071953 elastic fiber(GO:0071953)
1.0 88.5 GO:0044291 cell-cell contact zone(GO:0044291)
1.0 68.6 GO:0042734 presynaptic membrane(GO:0042734)
0.9 0.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.8 218.9 GO:0060076 excitatory synapse(GO:0060076)
0.8 186.9 GO:0043209 myelin sheath(GO:0043209)
0.8 8.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.7 4.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 11.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.7 157.0 GO:0032993 protein-DNA complex(GO:0032993)
0.7 5.5 GO:0030478 actin cap(GO:0030478)
0.7 6.1 GO:0005579 membrane attack complex(GO:0005579)
0.7 3.4 GO:0070852 cell body fiber(GO:0070852)
0.7 4.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.6 3.2 GO:0060198 clathrin-sculpted vesicle(GO:0060198) clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.6 9.9 GO:0031012 extracellular matrix(GO:0031012)
0.6 19.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 1.7 GO:0030314 junctional membrane complex(GO:0030314)
0.6 5.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 6.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.5 4.3 GO:0014802 terminal cisterna(GO:0014802)
0.5 2.5 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.5 4.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.5 2.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.5 5.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.5 5.0 GO:0005922 connexon complex(GO:0005922)
0.5 3.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.5 5.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 54.2 GO:0030426 growth cone(GO:0030426)
0.4 43.8 GO:0043204 perikaryon(GO:0043204)
0.4 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 50.9 GO:0030018 Z disc(GO:0030018)
0.4 58.8 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.7 GO:0071438 invadopodium membrane(GO:0071438)
0.3 2.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 4.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 4.9 GO:0031430 M band(GO:0031430)
0.3 56.0 GO:0098794 postsynapse(GO:0098794)
0.3 1.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.3 6.2 GO:0035371 microtubule plus-end(GO:0035371)
0.3 1.8 GO:0036019 endolysosome(GO:0036019)
0.3 7.1 GO:0005581 collagen trimer(GO:0005581)
0.2 8.6 GO:0034707 chloride channel complex(GO:0034707)
0.2 3.6 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128)
0.2 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 12.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 5.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 44.7 GO:0005802 trans-Golgi network(GO:0005802)
0.2 4.4 GO:0031594 neuromuscular junction(GO:0031594)
0.2 3.0 GO:0032059 bleb(GO:0032059)
0.2 12.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 1.1 GO:0030056 hemidesmosome(GO:0030056)
0.2 5.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.8 GO:0000124 SAGA complex(GO:0000124)
0.2 10.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 13.3 GO:0042383 sarcolemma(GO:0042383)
0.2 9.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.5 GO:0005921 gap junction(GO:0005921)
0.2 3.0 GO:0097225 sperm midpiece(GO:0097225)
0.2 7.8 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 4.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 3.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 6.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.5 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 5.7 GO:0005902 microvillus(GO:0005902)
0.1 39.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 17.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 7.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 20.4 GO:0030424 axon(GO:0030424)
0.1 8.9 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 1.1 GO:0031674 I band(GO:0031674)
0.1 7.0 GO:0030133 transport vesicle(GO:0030133)
0.1 1.0 GO:0032994 protein-lipid complex(GO:0032994) plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 3.0 GO:0005657 replication fork(GO:0005657)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 1.6 GO:0071141 SMAD protein complex(GO:0071141)
0.1 0.3 GO:0097060 synaptic membrane(GO:0097060)
0.1 18.2 GO:0045202 synapse(GO:0045202)
0.1 1.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 11.6 GO:0005770 late endosome(GO:0005770)
0.1 3.1 GO:0005811 lipid particle(GO:0005811)
0.1 3.2 GO:0031904 endosome lumen(GO:0031904)
0.1 4.7 GO:0036064 ciliary basal body(GO:0036064)
0.1 9.3 GO:0030027 lamellipodium(GO:0030027)
0.1 11.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 1.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 189.5 GO:0016021 integral component of membrane(GO:0016021)
0.1 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.5 GO:0016235 aggresome(GO:0016235)
0.0 8.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.5 GO:0098798 mitochondrial protein complex(GO:0098798)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.2 GO:0030496 midbody(GO:0030496)
0.0 0.4 GO:0098791 Golgi subcompartment(GO:0098791)
0.0 0.4 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.9 GO:0005929 cilium(GO:0005929)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
17.0 220.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
16.5 82.5 GO:0030348 syntaxin-3 binding(GO:0030348)
9.9 39.8 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
7.4 29.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
6.4 32.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
6.0 71.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
5.4 32.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
5.0 25.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
4.7 23.3 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
4.5 18.0 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
4.4 57.4 GO:0008503 benzodiazepine receptor activity(GO:0008503)
4.1 65.3 GO:0097109 neuroligin family protein binding(GO:0097109)
3.8 11.3 GO:0019959 interleukin-8 binding(GO:0019959)
3.2 107.8 GO:0017091 AU-rich element binding(GO:0017091)
3.1 68.3 GO:0035198 miRNA binding(GO:0035198)
3.1 12.4 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
3.1 18.5 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.9 22.8 GO:0050816 phosphothreonine binding(GO:0050816)
2.7 8.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
2.7 11.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
2.7 13.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
2.7 27.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
2.7 13.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.6 62.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
2.6 7.8 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
2.6 7.7 GO:0001596 angiotensin type I receptor activity(GO:0001596)
2.4 7.3 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
2.4 49.8 GO:0002162 dystroglycan binding(GO:0002162)
2.2 6.6 GO:0005148 prolactin receptor binding(GO:0005148)
2.2 159.2 GO:0050840 extracellular matrix binding(GO:0050840)
2.2 56.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.0 13.7 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
1.9 15.2 GO:0043559 insulin binding(GO:0043559)
1.8 3.6 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
1.8 7.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.7 5.2 GO:0005549 odorant binding(GO:0005549)
1.7 27.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
1.7 51.7 GO:0005212 structural constituent of eye lens(GO:0005212)
1.6 8.2 GO:0004359 glutaminase activity(GO:0004359)
1.6 11.4 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.5 10.5 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
1.5 7.4 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.5 34.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.4 10.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
1.4 5.5 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.3 4.0 GO:0017129 triglyceride binding(GO:0017129)
1.2 155.0 GO:0005262 calcium channel activity(GO:0005262)
1.2 2.4 GO:0005137 interleukin-5 receptor binding(GO:0005137)
1.2 52.4 GO:0030507 spectrin binding(GO:0030507)
1.2 5.8 GO:0016403 dimethylargininase activity(GO:0016403)
1.1 9.0 GO:0004111 creatine kinase activity(GO:0004111)
1.1 6.7 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
1.1 4.5 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
1.1 53.1 GO:0046875 ephrin receptor binding(GO:0046875)
1.1 33.9 GO:0004385 guanylate kinase activity(GO:0004385)
1.1 15.3 GO:0042043 neurexin family protein binding(GO:0042043)
1.1 7.6 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.1 5.4 GO:0008046 axon guidance receptor activity(GO:0008046)
1.1 3.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
1.1 3.2 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
1.0 18.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.0 11.0 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
1.0 7.0 GO:0003680 AT DNA binding(GO:0003680)
1.0 20.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
1.0 4.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.9 3.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.9 20.4 GO:0030506 ankyrin binding(GO:0030506)
0.9 2.7 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.9 7.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.9 6.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.9 11.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.9 136.7 GO:0044325 ion channel binding(GO:0044325)
0.8 3.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.8 7.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.8 3.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.8 1.6 GO:0005174 CD40 receptor binding(GO:0005174)
0.8 14.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.8 2.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8 3.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.7 5.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.7 10.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.7 5.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.7 19.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.7 4.2 GO:0016015 morphogen activity(GO:0016015)
0.7 2.1 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.7 27.6 GO:0042056 chemoattractant activity(GO:0042056)
0.7 11.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.7 17.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.7 2.6 GO:0030305 heparanase activity(GO:0030305)
0.7 10.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.6 4.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.6 5.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.6 9.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.6 4.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.6 7.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6 4.4 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.6 6.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.6 4.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.6 3.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.6 5.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.6 123.9 GO:0051015 actin filament binding(GO:0051015)
0.6 17.4 GO:0015248 sterol transporter activity(GO:0015248)
0.6 10.4 GO:0051400 BH domain binding(GO:0051400)
0.6 11.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 8.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.5 43.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 21.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.5 3.6 GO:0001515 opioid peptide activity(GO:0001515)
0.5 2.6 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.5 3.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.5 5.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.5 6.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 3.9 GO:0038132 neuregulin binding(GO:0038132)
0.5 1.4 GO:0032093 SAM domain binding(GO:0032093)
0.5 9.7 GO:0005523 tropomyosin binding(GO:0005523)
0.5 3.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.5 3.6 GO:0022821 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.5 1.4 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.4 7.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.4 2.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 5.9 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.4 4.9 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.4 14.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 3.2 GO:0005534 galactose binding(GO:0005534)
0.4 8.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.4 2.7 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.4 1.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.4 64.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 5.4 GO:0005243 gap junction channel activity(GO:0005243)
0.4 5.6 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.4 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.4 5.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 48.1 GO:0005057 receptor signaling protein activity(GO:0005057)
0.3 1.0 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.3 4.0 GO:0008199 ferric iron binding(GO:0008199)
0.3 7.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 5.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 3.1 GO:0019534 toxin transporter activity(GO:0019534)
0.3 2.8 GO:0031432 titin binding(GO:0031432)
0.3 1.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.3 50.9 GO:0005516 calmodulin binding(GO:0005516)
0.3 34.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 2.6 GO:0070410 co-SMAD binding(GO:0070410)
0.3 3.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 2.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 2.8 GO:0031419 cobalamin binding(GO:0031419)
0.3 0.8 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.2 8.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 2.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 3.2 GO:0005522 profilin binding(GO:0005522)
0.2 3.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 4.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 1.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 10.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 12.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 18.5 GO:0001618 virus receptor activity(GO:0001618)
0.2 137.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 1.9 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 26.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 1.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.2 2.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 2.0 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 5.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 3.3 GO:0070330 aromatase activity(GO:0070330)
0.2 0.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2 4.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 8.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 9.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 6.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 1.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 2.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 1.0 GO:0042301 phosphate ion binding(GO:0042301)
0.2 0.8 GO:0097108 patched binding(GO:0005113) hedgehog family protein binding(GO:0097108)
0.2 4.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 3.6 GO:0070412 R-SMAD binding(GO:0070412)
0.2 3.9 GO:0003785 actin monomer binding(GO:0003785)
0.2 1.5 GO:0047035 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 36.2 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 4.4 GO:0005109 frizzled binding(GO:0005109)
0.1 1.9 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 0.8 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 5.9 GO:0008009 chemokine activity(GO:0008009)
0.1 1.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.8 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 5.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 7.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 2.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.8 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 4.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 3.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 2.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 8.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 2.4 GO:0008144 drug binding(GO:0008144)
0.1 2.0 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1 15.4 GO:0015631 tubulin binding(GO:0015631)
0.1 0.6 GO:0031433 telethonin binding(GO:0031433)
0.1 6.9 GO:0003774 motor activity(GO:0003774)
0.1 6.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.6 GO:0015026 coreceptor activity(GO:0015026)
0.1 6.1 GO:0002020 protease binding(GO:0002020)
0.1 3.2 GO:0005254 chloride channel activity(GO:0005254)
0.1 1.7 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 3.2 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 4.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.2 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.9 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.8 GO:0022843 voltage-gated cation channel activity(GO:0022843)
0.0 0.5 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 134.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
2.0 116.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
1.9 1.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
1.8 93.0 PID NCADHERIN PATHWAY N-cadherin signaling events
1.4 166.2 PID AR PATHWAY Coregulation of Androgen receptor activity
1.3 88.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
1.2 63.5 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.0 71.1 PID FGF PATHWAY FGF signaling pathway
0.7 27.1 PID IL3 PATHWAY IL3-mediated signaling events
0.7 41.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.7 20.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.6 13.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6 8.4 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.6 11.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 3.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 31.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.5 40.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.5 5.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 2.4 PID IL5 PATHWAY IL5-mediated signaling events
0.5 25.6 PID CDC42 PATHWAY CDC42 signaling events
0.4 5.4 PID SHP2 PATHWAY SHP2 signaling
0.4 7.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.4 15.9 SIG CHEMOTAXIS Genes related to chemotaxis
0.4 21.6 PID LKB1 PATHWAY LKB1 signaling events
0.3 10.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 2.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.3 13.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.3 0.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3 12.7 PID MYC PATHWAY C-MYC pathway
0.3 15.2 PID BMP PATHWAY BMP receptor signaling
0.3 10.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 15.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 3.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 5.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 51.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 16.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 9.3 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.2 10.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 3.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 2.8 PID CD40 PATHWAY CD40/CD40L signaling
0.1 1.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 4.7 PID IL23 PATHWAY IL23-mediated signaling events
0.1 0.5 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 21.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 5.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.8 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.7 PID RHOA PATHWAY RhoA signaling pathway
0.1 2.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 3.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 3.2 PID TNF PATHWAY TNF receptor signaling pathway
0.1 1.8 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 3.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 14.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 98.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
5.5 295.0 REACTOME MYOGENESIS Genes involved in Myogenesis
5.0 136.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
4.5 13.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
3.6 110.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
2.6 71.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.5 83.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.4 61.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
1.4 41.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.3 15.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.2 18.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.2 22.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.1 4.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.1 9.7 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
1.0 11.0 REACTOME OPSINS Genes involved in Opsins
1.0 24.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.0 24.3 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.9 18.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.9 20.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.8 12.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.8 11.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.7 10.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.7 26.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.6 19.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.6 20.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6 12.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.6 8.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.6 9.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.6 20.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.6 11.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.5 5.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 16.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.5 6.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.4 27.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.4 6.1 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.4 7.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 3.8 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.4 4.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 14.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 2.7 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.3 5.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 55.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 6.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 6.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 6.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 11.4 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.3 5.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 9.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 8.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.3 15.6 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.3 14.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.3 12.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 6.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 4.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.3 6.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 6.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 7.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 17.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 13.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 10.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.2 7.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 3.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 3.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 1.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 8.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 2.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 7.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 14.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 23.4 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 3.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.3 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.1 1.6 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 7.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 8.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.1 5.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 2.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 10.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 2.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 0.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 2.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 5.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.1 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo