ISMARA results: HOXB7

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXB7

Z-value: 0.58

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Transcription factors associated with HOXB7

Gene Symbol	Gene ID	Gene Info
HOXB7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000260027.3	homeobox B7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXB7	hg19_v2_chr17_-_46688334_46688385	-0.10	1.4e-01	Click!

Activity profile of HOXB7 motif

Sorted Z-values of HOXB7 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_20646824 Show fit	13.87	ENST00000272233.4	RHOB Ensembl NCBI GeneCards UniProt NextProt Show fit	ras homolog family member B
chr10_-_21786179 Show fit	13.48	ENST00000377113.5	CASC10 Ensembl NCBI GeneCards UniProt NextProt Show fit	cancer susceptibility candidate 10
chr3_-_58613323 Show fit	12.46	ENST00000474531.1 ENST00000465970.1	FAM107A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 107, member A
chr12_-_91573132 Show fit	12.45	ENST00000550563.1 ENST00000546370.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr18_+_29171689 Show fit	12.00	ENST00000237014.3	TTR Ensembl NCBI GeneCards UniProt NextProt Show fit	transthyretin
chr12_-_91546926 Show fit	10.39	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr17_-_42992856 Show fit	10.15	ENST00000588316.1 ENST00000435360.2 ENST00000586793.1 ENST00000588735.1 ENST00000588037.1 ENST00000592320.1 ENST00000253408.5	GFAP Ensembl NCBI GeneCards UniProt NextProt Show fit	glial fibrillary acidic protein
chr9_-_93405352 Show fit	10.14	ENST00000375765.3	DIRAS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	DIRAS family, GTP-binding RAS-like 2
chr2_+_113033164 Show fit	9.89	ENST00000409871.1 ENST00000343936.4	ZC3H6 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger CCCH-type containing 6
chr10_+_13142225 Show fit	9.54	ENST00000378747.3	OPTN Ensembl NCBI GeneCards UniProt NextProt Show fit	optineurin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	36.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.6	26.2	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.0	24.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.4	17.1	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7	16.9	GO:0061154	endothelial tube morphogenesis(GO:0061154)
1.3	16.3	GO:0070327	thyroid hormone transport(GO:0070327)
2.5	12.4	GO:0070980	biphenyl catabolic process(GO:0070980)
2.9	11.5	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.2	10.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.1	10.6	GO:0052695	cellular glucuronidation(GO:0052695)

Showing 1 to 10 of 200 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	36.7	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	28.0	GO:0005615	extracellular space(GO:0005615)
0.3	22.4	GO:0055038	recycling endosome membrane(GO:0055038)
0.2	17.7	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	15.1	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	13.9	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7	12.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.7	11.6	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.3	11.4	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1	9.5	GO:0005796	Golgi lumen(GO:0005796)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	45.1	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.5	40.4	GO:0050840	extracellular matrix binding(GO:0050840)
1.2	24.1	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
1.6	17.7	GO:0008430	selenium binding(GO:0008430)
0.1	14.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	12.0	GO:0030507	spectrin binding(GO:0030507)
0.3	11.4	GO:0016917	GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
1.4	10.8	GO:0070324	thyroid hormone binding(GO:0070324)
0.2	10.8	GO:0005158	insulin receptor binding(GO:0005158)
0.1	9.6	GO:0019003	GDP binding(GO:0019003)

Showing 1 to 10 of 143 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	43.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	18.5	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	17.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	12.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	9.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	8.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	7.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	6.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	6.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	6.0	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	42.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
1.4	36.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	20.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	14.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	13.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3	13.4	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.1	11.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	10.9	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	8.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.7	8.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate

Showing 1 to 10 of 63 entries

Results for HOXB7

Z-value: 0.58

Motif logo

Transcription factors associated with HOXB7

Activity-expression correlation:

Activity profile of HOXB7 motif

Sorted Z-values of HOXB7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: