ISMARA results: HOXC11

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXC11

Z-value: 1.33

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Transcription factors associated with HOXC11

Gene Symbol	Gene ID	Gene Info
HOXC11 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000123388.4	homeobox C11

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC11	hg19_v2_chr12_+_54366894_54366922	-0.42	7.1e-11	Click!

Activity profile of HOXC11 motif

Sorted Z-values of HOXC11 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_190044480 Show fit	32.16	ENST00000374866.3	COL5A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type V, alpha 2
chr18_+_3252265 Show fit	21.69	ENST00000580887.1 ENST00000536605.1	MYL12A Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin, light chain 12A, regulatory, non-sarcomeric
chr12_-_54071181 Show fit	19.48	ENST00000338662.5	ATP5G2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr2_-_136678123 Show fit	18.79	ENST00000422708.1	DARS Ensembl NCBI GeneCards UniProt NextProt Show fit	aspartyl-tRNA synthetase
chr8_+_26150628 Show fit	14.36	ENST00000523925.1 ENST00000315985.7	PPP2R2A Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 2, regulatory subunit B, alpha
chr7_-_93519471 Show fit	11.37	ENST00000451238.1	TFPI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tissue factor pathway inhibitor 2
chr5_-_111091948 Show fit	11.33	ENST00000447165.2	NREP Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal regeneration related protein
chr6_+_12290586 Show fit	11.03	ENST00000379375.5	EDN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	endothelin 1
chr2_-_176046391 Show fit	10.87	ENST00000392541.3 ENST00000409194.1	ATP5G3 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr2_+_109204909 Show fit	10.66	ENST00000393310.1	LIMS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM and senescent cell antigen-like domains 1

Showing 1 to 10 of 128 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC11

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.0	32.2	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.9	30.3	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.3	29.8	GO:0070527	platelet aggregation(GO:0070527)
0.4	19.0	GO:0031648	protein destabilization(GO:0031648)
6.3	18.8	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.8	14.4	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.4	11.4	GO:0071498	cellular response to fluid shear stress(GO:0071498)
0.0	11.2	GO:0006936	muscle contraction(GO:0006936)
3.7	11.1	GO:0046098	guanine metabolic process(GO:0046098)
3.7	11.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)

Showing 1 to 10 of 84 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	32.2	GO:0005588	collagen type V trimer(GO:0005588)
1.7	30.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3	28.6	GO:0016459	myosin complex(GO:0016459)
0.0	23.3	GO:0005925	focal adhesion(GO:0005925)
1.3	20.0	GO:0030478	actin cap(GO:0030478)
0.9	18.8	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	15.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.4	14.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	12.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	11.1	GO:1990391	DNA repair complex(GO:1990391)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	49.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
1.1	30.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.7	20.0	GO:0005523	tropomyosin binding(GO:0005523)
3.8	18.8	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.1	14.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.8	14.4	GO:0048156	tau protein binding(GO:0048156)
3.7	11.1	GO:0061752	telomeric repeat-containing RNA binding(GO:0061752)
2.2	11.0	GO:0031708	endothelin B receptor binding(GO:0031708)
3.6	10.7	GO:0004087	carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2	10.3	GO:0019894	kinesin binding(GO:0019894)

Showing 1 to 10 of 62 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	34.7	NABA COLLAGENS	Genes encoding collagen proteins
0.1	14.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	12.8	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	11.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	11.0	PID ENDOTHELIN PATHWAY	Endothelins
0.2	9.0	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	9.0	PID MTOR 4PATHWAY	mTOR signaling pathway
0.1	8.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	7.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	6.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	34.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	20.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	18.8	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.2	16.8	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	14.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	11.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	10.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	10.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	9.4	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.4	9.0	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK

Showing 1 to 10 of 36 entries

Results for HOXC11

Z-value: 1.33

Motif logo

Transcription factors associated with HOXC11

Activity-expression correlation:

Activity profile of HOXC11 motif

Sorted Z-values of HOXC11 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC11

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: