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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXC11

Z-value: 1.33

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Transcription factors associated with HOXC11

Gene Symbol Gene ID Gene Info
HOXC11
ENSG00000123388.4 homeobox C11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC11hg19_v2_chr12_+_54366894_54366922-0.427.1e-11Click!

Activity profile of HOXC11 motif

Sorted Z-values of HOXC11 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_190044480 32.16 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr18_+_3252265 21.69 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr12_-_54071181 19.48 ENST00000338662.5
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr2_-_136678123 18.79 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr8_+_26150628 14.36 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_-_93519471 11.37 ENST00000451238.1
TFPI2
tissue factor pathway inhibitor 2
chr5_-_111091948 11.33 ENST00000447165.2
NREP
neuronal regeneration related protein
chr6_+_12290586 11.03 ENST00000379375.5
EDN1
endothelin 1
chr2_-_176046391 10.87 ENST00000392541.3
ENST00000409194.1
ATP5G3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr2_+_109204909 10.66 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_134464376 10.43 ENST00000454108.1
ENST00000361675.2
CALD1
caldesmon 1
chr14_+_56127989 10.34 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr2_-_207023918 10.07 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr7_-_47579188 9.89 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr8_+_104831554 9.76 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr19_+_36036477 9.66 ENST00000222284.5
ENST00000392204.2
TMEM147
transmembrane protein 147
chr7_+_134464414 9.58 ENST00000361901.2
CALD1
caldesmon 1
chr6_+_32812568 9.37 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr19_+_36036583 9.30 ENST00000392205.1
TMEM147
transmembrane protein 147
chr7_-_151217166 8.65 ENST00000496004.1
RHEB
Ras homolog enriched in brain
chr19_-_39924349 8.39 ENST00000602153.1
RPS16
ribosomal protein S16
chr2_+_27440229 8.30 ENST00000264705.4
ENST00000403525.1
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr18_+_3252206 8.14 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr16_-_2314222 7.61 ENST00000566397.1
RNPS1
RNA binding protein S1, serine-rich domain
chr1_+_167298281 7.42 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr17_-_39684550 7.40 ENST00000455635.1
ENST00000361566.3
KRT19
keratin 19
chr4_-_74088800 6.95 ENST00000509867.2
ANKRD17
ankyrin repeat domain 17
chr10_+_114709999 6.80 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr19_+_19626531 6.69 ENST00000507754.4
NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr17_-_77924627 6.29 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr1_-_9129895 6.20 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_-_10851762 6.12 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_37216055 6.02 ENST00000336686.4
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr1_+_23345930 5.92 ENST00000356634.3
KDM1A
lysine (K)-specific demethylase 1A
chr12_+_1800179 5.91 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr19_+_49468558 5.77 ENST00000331825.6
FTL
ferritin, light polypeptide
chr14_-_25479811 5.55 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr11_+_64001962 5.38 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chr1_+_23345943 5.21 ENST00000400181.4
ENST00000542151.1
KDM1A
lysine (K)-specific demethylase 1A
chr19_-_45927622 5.14 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr16_-_67978016 5.04 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr22_-_30642782 4.93 ENST00000249075.3
LIF
leukemia inhibitory factor
chr10_+_47894023 4.90 ENST00000358474.5
FAM21B
family with sequence similarity 21, member B
chr7_-_41742697 4.67 ENST00000242208.4
INHBA
inhibin, beta A
chr11_-_27723158 4.67 ENST00000395980.2
BDNF
brain-derived neurotrophic factor
chr4_+_169013666 4.63 ENST00000359299.3
ANXA10
annexin A10
chr2_-_145278475 4.36 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr5_+_43121698 4.08 ENST00000505606.2
ENST00000509634.1
ENST00000509341.1
ZNF131
zinc finger protein 131
chr4_-_25865159 4.03 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr3_-_79816965 3.96 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_-_82969405 3.59 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr16_+_67906919 3.53 ENST00000358933.5
EDC4
enhancer of mRNA decapping 4
chr9_+_12693336 3.47 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr1_-_94147385 3.40 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr6_+_31683117 3.31 ENST00000375825.3
ENST00000375824.1
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr19_-_36233332 3.28 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGFLR1
IGF-like family receptor 1
chr15_+_67418047 3.16 ENST00000540846.2
SMAD3
SMAD family member 3
chr6_+_46761118 3.14 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr1_+_12524965 3.03 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr4_+_144354644 2.91 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr17_-_79876010 2.83 ENST00000328666.6
SIRT7
sirtuin 7
chr7_-_27205136 2.78 ENST00000396345.1
ENST00000343483.6
HOXA9
homeobox A9
chrX_-_133792480 2.76 ENST00000359237.4
PLAC1
placenta-specific 1
chr6_+_15246501 2.72 ENST00000341776.2
JARID2
jumonji, AT rich interactive domain 2
chr10_+_17271266 2.71 ENST00000224237.5
VIM
vimentin
chr10_+_115614370 2.61 ENST00000369301.3
NHLRC2
NHL repeat containing 2
chr1_-_9129631 2.51 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr7_+_22766766 2.47 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr2_+_211421262 2.43 ENST00000233072.5
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr8_+_134203273 2.43 ENST00000250160.6
WISP1
WNT1 inducible signaling pathway protein 1
chrX_-_107682702 2.42 ENST00000372216.4
COL4A6
collagen, type IV, alpha 6
chr17_+_58018269 2.32 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr10_-_96829246 2.28 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr12_+_64173583 2.23 ENST00000261234.6
TMEM5
transmembrane protein 5
chr2_+_208423891 2.19 ENST00000448277.1
ENST00000457101.1
CREB1
cAMP responsive element binding protein 1
chr5_+_148521381 2.07 ENST00000504238.1
ABLIM3
actin binding LIM protein family, member 3
chr4_+_160188889 1.96 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr2_+_228678550 1.95 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr5_-_88119580 1.67 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chrX_+_65382433 1.65 ENST00000374727.3
HEPH
hephaestin
chr3_+_173116225 1.62 ENST00000457714.1
NLGN1
neuroligin 1
chr16_+_15031300 1.59 ENST00000328085.6
NPIPA1
nuclear pore complex interacting protein family, member A1
chr13_-_46679185 1.47 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr15_+_49715293 1.46 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr6_+_6588902 1.44 ENST00000230568.4
LY86
lymphocyte antigen 86
chr1_-_204135450 1.42 ENST00000272190.8
ENST00000367195.2
REN
renin
chr8_+_76452097 1.35 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr1_+_87794150 1.30 ENST00000370544.5
LMO4
LIM domain only 4
chr3_+_190105909 1.26 ENST00000456423.1
CLDN16
claudin 16
chrX_-_105282712 1.26 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_+_25205568 1.23 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr7_-_122840015 1.22 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr13_-_46679144 1.22 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr12_-_28124903 1.20 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr6_-_41703952 1.16 ENST00000358871.2
ENST00000403298.4
TFEB
transcription factor EB
chr10_-_115614127 1.06 ENST00000369305.1
DCLRE1A
DNA cross-link repair 1A
chr19_+_1440838 1.01 ENST00000594262.1
AC027307.3
Uncharacterized protein
chr5_+_145718587 0.95 ENST00000230732.4
POU4F3
POU class 4 homeobox 3
chr7_-_81399355 0.95 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_-_64029879 0.92 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr12_+_25205666 0.88 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr15_-_68497657 0.86 ENST00000448060.2
ENST00000467889.1
CALML4
calmodulin-like 4
chr17_-_46806540 0.83 ENST00000290295.7
HOXB13
homeobox B13
chr2_+_176987088 0.71 ENST00000249499.6
HOXD9
homeobox D9
chr16_-_21663950 0.69 ENST00000268389.4
IGSF6
immunoglobulin superfamily, member 6
chr3_+_15045419 0.65 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr17_+_7461613 0.61 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chrX_+_99899180 0.58 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr1_-_9129598 0.56 ENST00000535586.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_-_40739501 0.54 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr13_-_103719196 0.45 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr16_-_21663919 0.44 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr1_+_62439037 0.40 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr22_+_40573921 0.38 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr6_-_31745085 0.36 ENST00000375686.3
ENST00000447450.1
VWA7
von Willebrand factor A domain containing 7
chr7_-_151217001 0.35 ENST00000262187.5
RHEB
Ras homolog enriched in brain
chr12_-_24102576 0.35 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
SOX5
SRY (sex determining region Y)-box 5
chr11_-_102576537 0.35 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr8_+_104831472 0.34 ENST00000262231.10
ENST00000507740.1
RIMS2
regulating synaptic membrane exocytosis 2
chr2_-_166930131 0.20 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr8_-_57123815 0.18 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chrX_+_107683096 0.16 ENST00000328300.6
ENST00000361603.2
COL4A5
collagen, type IV, alpha 5
chr3_+_89156674 0.12 ENST00000336596.2
EPHA3
EPH receptor A3
chr9_-_73736511 0.12 ENST00000377110.3
ENST00000377111.2
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_-_47219733 0.12 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4
solute carrier family 38, member 4
chr12_-_52779433 0.05 ENST00000257951.3
KRT84
keratin 84
chr8_-_59412717 0.03 ENST00000301645.3
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr7_-_81399438 0.02 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 32.2 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
6.3 18.8 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
3.7 11.1 GO:0046098 guanine metabolic process(GO:0046098)
3.7 11.0 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
2.8 8.3 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
1.7 7.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.6 4.7 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.6 4.7 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
1.3 4.0 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
1.3 5.0 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
1.2 4.9 GO:0060708 histone H3-K27 acetylation(GO:0043974) leukemia inhibitory factor signaling pathway(GO:0048861) spongiotrophoblast differentiation(GO:0060708) regulation of histone H3-K27 acetylation(GO:1901674)
1.2 8.4 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
1.1 10.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
1.1 4.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
1.0 9.0 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.9 30.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.9 2.8 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.9 5.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
0.8 5.8 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.8 2.5 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.8 14.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.7 6.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.7 5.9 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.7 3.5 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.7 2.7 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.7 2.0 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.7 2.0 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.6 3.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.6 3.7 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.6 5.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.6 2.4 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) response to oleic acid(GO:0034201)
0.6 5.4 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.5 1.6 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.5 1.5 GO:0060437 lung growth(GO:0060437)
0.5 6.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 3.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.4 1.7 GO:0060025 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) regulation of synaptic activity(GO:0060025)
0.4 2.2 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.4 19.0 GO:0031648 protein destabilization(GO:0031648)
0.4 11.4 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.3 2.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.3 29.8 GO:0070527 platelet aggregation(GO:0070527)
0.3 10.7 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.3 1.4 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.3 0.8 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.3 2.8 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.2 9.9 GO:0048286 lung alveolus development(GO:0048286)
0.2 2.7 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.2 2.8 GO:0042118 endothelial cell activation(GO:0042118)
0.2 0.9 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 7.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 7.4 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.2 8.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 2.7 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614) positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 2.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 1.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 6.3 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 1.3 GO:0042659 regulation of cell fate specification(GO:0042659)
0.1 3.3 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 1.2 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.1 10.1 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.1 1.0 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.1 0.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 1.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 1.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 9.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 7.4 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 0.5 GO:0071313 cellular response to caffeine(GO:0071313)
0.1 1.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.7 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 10.3 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.9 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 2.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 0.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 11.2 GO:0006936 muscle contraction(GO:0006936)
0.0 0.2 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 2.1 GO:0006903 vesicle targeting(GO:0006903)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 32.2 GO:0005588 collagen type V trimer(GO:0005588)
2.8 11.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
2.0 10.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.7 30.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.6 4.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.4 5.8 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
1.3 20.0 GO:0030478 actin cap(GO:0030478)
1.2 7.4 GO:1990357 terminal web(GO:1990357)
1.2 9.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.9 18.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.8 7.6 GO:0061574 ASAP complex(GO:0061574)
0.7 5.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.6 3.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.6 2.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 14.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 3.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 2.6 GO:0005587 collagen type IV trimer(GO:0005587)
0.3 28.6 GO:0016459 myosin complex(GO:0016459)
0.3 5.5 GO:0000145 exocyst(GO:0000145)
0.2 11.1 GO:1990391 DNA repair complex(GO:1990391)
0.2 10.1 GO:0048786 presynaptic active zone(GO:0048786)
0.2 3.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.6 GO:0032433 filopodium tip(GO:0032433)
0.1 5.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 8.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 8.3 GO:0043195 terminal bouton(GO:0043195)
0.1 6.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.4 GO:0035579 specific granule membrane(GO:0035579)
0.1 0.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 2.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 5.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.3 GO:0030175 filopodium(GO:0030175)
0.0 2.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.2 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 23.3 GO:0005925 focal adhesion(GO:0005925)
0.0 9.0 GO:0005681 spliceosomal complex(GO:0005681)
0.0 15.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 4.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.9 GO:0044452 nucleolar part(GO:0044452)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 1.6 GO:0005643 nuclear pore(GO:0005643)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 12.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.4 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 18.8 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
3.7 11.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
3.6 10.7 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
2.2 11.0 GO:0031708 endothelin B receptor binding(GO:0031708)
1.6 4.7 GO:0070699 type II activin receptor binding(GO:0070699)
1.6 4.7 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.3 5.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.2 8.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
1.1 30.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 2.8 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.9 5.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.8 14.4 GO:0048156 tau protein binding(GO:0048156)
0.7 5.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.7 20.0 GO:0005523 tropomyosin binding(GO:0005523)
0.7 4.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.7 2.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.6 3.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.6 3.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.5 2.0 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.5 49.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 5.8 GO:0008199 ferric iron binding(GO:0008199)
0.5 10.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.5 2.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.5 2.7 GO:1990254 keratin filament binding(GO:1990254)
0.4 4.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 9.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 5.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.3 2.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 5.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 2.2 GO:1990763 arrestin family protein binding(GO:1990763)
0.2 9.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 0.9 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 10.3 GO:0019894 kinesin binding(GO:0019894)
0.2 3.7 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.2 0.5 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 1.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 9.0 GO:0019003 GDP binding(GO:0019003)
0.1 0.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 4.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 4.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 14.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.7 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.4 GO:0030275 LRR domain binding(GO:0030275)
0.1 6.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.4 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 6.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 5.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 8.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.5 GO:0004497 monooxygenase activity(GO:0004497)
0.0 1.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.2 GO:0008017 microtubule binding(GO:0008017)
0.0 9.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 34.7 NABA COLLAGENS Genes encoding collagen proteins
0.3 5.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 4.7 PID ALK1 PATHWAY ALK1 signaling events
0.2 11.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 2.5 ST STAT3 PATHWAY STAT3 Pathway
0.2 7.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 9.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 12.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 11.0 PID ENDOTHELIN PATHWAY Endothelins
0.1 14.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 9.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 5.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID AP1 PATHWAY AP-1 transcription factor network
0.1 2.9 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 2.7 PID AURORA B PATHWAY Aurora B signaling
0.0 2.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 6.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 4.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 34.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.5 18.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 9.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 8.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 10.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 4.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 20.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 5.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 8.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 3.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 5.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 5.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.2 14.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 7.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 16.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 2.9 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.2 7.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 4.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 9.4 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 2.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 5.4 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 8.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.1 11.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 10.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells