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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXC13
Z-value: 1.09
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Transcription factors associated with HOXC13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC13 | hg19_v2_chr12_+_54332535_54332636 | 0.53 | 6.3e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 46.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.5 | 24.0 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.2 | 22.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 6.6 | 19.8 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 19.5 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 6.4 | 19.1 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 1.5 | 18.1 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
| 0.2 | 17.3 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 15.2 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 1.8 | 14.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 46.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 45.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 29.0 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 28.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 6.7 | 20.2 | GO:0044609 | DBIRD complex(GO:0044609) |
| 4.8 | 19.1 | GO:1990745 | EARP complex(GO:1990745) |
| 0.0 | 18.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.9 | 18.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 16.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 16.2 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 46.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 22.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 20.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.4 | 19.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 19.1 | GO:0019905 | syntaxin binding(GO:0019905) |
| 1.3 | 18.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 2.3 | 16.2 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 2.9 | 14.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 2.4 | 14.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.2 | 12.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 55.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 26.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.8 | 14.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 11.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 9.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 8.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 8.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 7.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 6.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 46.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.8 | 19.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 14.2 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.2 | 13.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 11.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 11.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 11.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 10.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 10.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 9.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |