ISMARA results: HOXC8

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXC8

Z-value: 0.55

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Transcription factors associated with HOXC8

Gene Symbol	Gene ID	Gene Info
HOXC8 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000037965.4	homeobox C8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC8	hg19_v2_chr12_+_54402790_54402832	-0.34	1.8e-07	Click!

Activity profile of HOXC8 motif

Sorted Z-values of HOXC8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_-_109590174 Show fit	24.44	ENST00000372054.1	GNG5P2 Ensembl NCBI GeneCards UniProt NextProt Show fit	guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chr8_-_27695552 Show fit	22.95	ENST00000522944.1 ENST00000301905.4	PBK Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZ binding kinase
chrX_+_119737806 Show fit	18.79	ENST00000371317.5	MCTS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	malignant T cell amplified sequence 1
chr3_-_64009658 Show fit	15.72	ENST00000394431.2	PSMD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr18_+_657578 Show fit	15.41	ENST00000323274.10	TYMS Ensembl NCBI GeneCards UniProt NextProt Show fit	thymidylate synthetase
chr16_-_46655538 Show fit	15.26	ENST00000303383.3	SHCBP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SHC SH2-domain binding protein 1
chr5_+_159848854 Show fit	14.55	ENST00000517480.1 ENST00000520452.1 ENST00000393964.1	PTTG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pituitary tumor-transforming 1
chr2_-_89292422 Show fit	13.81	ENST00000495489.1	IGKV1-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-8
chr2_+_89890533 Show fit	13.37	ENST00000429992.2	IGKV2D-40 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 2D-40
chr5_+_135385202 Show fit	13.28	ENST00000514554.1	TGFBI Ensembl NCBI GeneCards UniProt NextProt Show fit	transforming growth factor, beta-induced, 68kDa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	233.2	GO:0006958	complement activation, classical pathway(GO:0006958)
0.5	77.6	GO:0002377	immunoglobulin production(GO:0002377)
0.5	56.6	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.4	47.9	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.8	37.1	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.8	36.8	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.6	32.3	GO:0007077	mitotic nuclear envelope disassembly(GO:0007077)
3.5	24.6	GO:0009753	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
2.4	23.5	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
3.6	21.5	GO:0014038	regulation of Schwann cell differentiation(GO:0014038)

Showing 1 to 10 of 419 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	97.3	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.7	54.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.3	48.8	GO:0015934	large ribosomal subunit(GO:0015934)
0.0	48.6	GO:0005615	extracellular space(GO:0005615)
1.3	40.5	GO:0005838	proteasome regulatory particle(GO:0005838)
0.2	33.4	GO:0072562	blood microparticle(GO:0072562)
0.2	25.9	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
4.6	22.8	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
2.8	22.6	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.4	22.2	GO:0010494	cytoplasmic stress granule(GO:0010494)

Showing 1 to 10 of 226 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	208.4	GO:0003823	antigen binding(GO:0003823)
1.8	97.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.3	67.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.5	33.5	GO:0003743	translation initiation factor activity(GO:0003743)
0.3	28.8	GO:0003697	single-stranded DNA binding(GO:0003697)
1.1	25.8	GO:0008143	poly(A) binding(GO:0008143)
0.1	24.8	GO:0045296	cadherin binding(GO:0045296)
0.8	23.7	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3	23.6	GO:0032947	protein complex scaffold(GO:0032947)
2.3	23.4	GO:0019237	centromeric DNA binding(GO:0019237)

Showing 1 to 10 of 302 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	46.3	PID AURORA B PATHWAY	Aurora B signaling
0.3	39.0	PID E2F PATHWAY	E2F transcription factor network
1.6	22.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	21.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.6	21.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	17.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.5	17.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.3	16.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	15.2	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.2	14.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 60 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	82.2	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.6	44.5	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7	42.3	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.4	41.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.1	29.5	REACTOME KINESINS	Genes involved in Kinesins
0.7	24.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.9	23.9	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	23.6	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
1.6	22.8	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
1.2	22.4	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation

Showing 1 to 10 of 115 entries

Results for HOXC8

Z-value: 0.55

Motif logo

Transcription factors associated with HOXC8

Activity-expression correlation:

Activity profile of HOXC8 motif

Sorted Z-values of HOXC8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: