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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXC9
Z-value: 0.17
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Transcription factors associated with HOXC9
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_81083890 Show fit | 10.44 |
ENST00000518937.1
|
tumor protein D52 |
|
| chrX_-_13835147 Show fit | 9.58 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr6_-_52859046 Show fit | 8.25 |
ENST00000457564.1
ENST00000541324.1 ENST00000370960.1 |
glutathione S-transferase alpha 4 |
|
| chr9_+_137979506 Show fit | 6.85 |
ENST00000539529.1
ENST00000392991.4 ENST00000371793.3 |
olfactomedin 1 |
|
| chr1_+_149230680 Show fit | 6.54 |
ENST00000443018.1
|
RP11-403I13.5 |
|
| chr18_+_32558208 Show fit | 6.30 |
ENST00000436190.2
|
microtubule-associated protein, RP/EB family, member 2 |
|
| chr8_+_132916318 Show fit | 6.22 |
ENST00000254624.5
ENST00000522709.1 |
EFR3 homolog A (S. cerevisiae) |
|
| chr2_+_187371440 Show fit | 6.09 |
ENST00000445547.1
|
zinc finger CCCH-type containing 15 |
|
| chr1_+_163039143 Show fit | 6.08 |
ENST00000531057.1
ENST00000527809.1 ENST00000367908.4 |
regulator of G-protein signaling 4 |
|
| chr13_-_24007815 Show fit | 5.71 |
ENST00000382298.3
|
spastic ataxia of Charlevoix-Saguenay (sacsin) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.0 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.4 | 12.1 | GO:1901687 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 1.0 | 9.6 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 9.6 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 3.0 | 9.0 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 1.5 | 7.6 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.8 | 6.8 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 0.2 | 6.4 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.2 | 6.2 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 6.2 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.5 | 10.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.8 | 9.6 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 8.6 | GO:0045121 | membrane raft(GO:0045121) |
| 0.3 | 7.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.3 | 6.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 6.7 | GO:0043197 | dendritic spine(GO:0043197) |
| 1.3 | 6.4 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.2 | 6.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.8 | 5.7 | GO:0070852 | cell body fiber(GO:0070852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.0 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 14.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 12.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.9 | 9.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 3.0 | 9.0 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.0 | 7.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 7.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 6.9 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.0 | 6.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 6.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 7.0 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 5.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 3.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 3.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 3.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 2.7 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 2.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.3 | 12.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.3 | 10.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 9.8 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 9.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 8.9 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.0 | 7.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 6.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 5.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 5.1 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |