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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOXD1

Z-value: 0.82

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.11 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_177053402-0.371.5e-08Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_187371440 13.12 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chrX_+_77154935 7.01 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr4_+_113568207 6.42 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr12_+_28410128 6.34 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr15_-_55563072 6.20 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_37393406 5.75 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr15_-_55562479 5.07 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr22_+_24951949 4.49 ENST00000402849.1
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr12_-_118797475 4.10 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr18_-_33709268 4.09 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr19_+_11071546 4.06 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr11_-_71823266 3.79 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chrX_+_114827818 3.49 ENST00000420625.2
PLS3
plastin 3
chr8_-_49834299 3.46 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr11_-_71823796 3.27 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr15_-_55562582 2.94 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr1_-_151431647 2.83 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr11_+_73498898 2.76 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chrX_+_107288197 2.63 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_107288239 2.52 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_71823715 2.50 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr8_-_49833978 2.38 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr11_-_95657231 2.37 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr12_+_29376592 2.34 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr12_+_29376673 2.27 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr17_-_27418537 1.73 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr7_-_99716952 1.69 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_151431909 1.61 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr4_+_144354644 1.23 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr2_+_11682790 1.01 ENST00000389825.3
ENST00000381483.2
GREB1
growth regulation by estrogen in breast cancer 1
chr7_-_99717463 0.98 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr12_+_15699286 0.95 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr4_-_74486217 0.89 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr8_-_42623747 0.86 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr5_+_176811431 0.79 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr2_+_54350316 0.74 ENST00000606865.1
ACYP2
acylphosphatase 2, muscle type
chr4_-_74486347 0.69 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_190446759 0.68 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr14_+_74034310 0.65 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr3_+_111718173 0.47 ENST00000494932.1
TAGLN3
transgelin 3
chr11_-_102651343 0.39 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr3_+_111717511 0.39 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr12_-_53171128 0.36 ENST00000332411.2
KRT76
keratin 76
chr11_-_102709441 0.35 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr3_-_164796269 0.35 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr3_+_111717600 0.33 ENST00000273368.4
TAGLN3
transgelin 3
chr5_+_148737562 0.24 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr10_+_18549645 0.17 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_+_117544366 0.11 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr3_-_151034734 0.08 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr4_-_25865159 0.06 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 14.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.9 5.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.5 4.6 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.8 4.1 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.6 2.4 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.5 6.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.5 9.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.4 4.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.3 4.4 GO:0051382 kinetochore assembly(GO:0051382)
0.3 7.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 0.9 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 0.8 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.3 5.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 3.5 GO:0051639 actin filament network formation(GO:0051639)
0.1 4.5 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 2.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 5.8 GO:0008542 visual learning(GO:0008542)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.4 GO:0048733 sebaceous gland development(GO:0048733)
0.0 2.8 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.4 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 2.7 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 1.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 14.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.6 4.5 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.4 7.0 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 9.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 4.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 4.1 GO:0071564 npBAF complex(GO:0071564)
0.1 2.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 4.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 3.5 GO:0032432 actin filament bundle(GO:0032432)
0.0 10.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.3 GO:0043197 dendritic spine(GO:0043197)
0.0 4.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 13.1 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
1.5 4.5 GO:0071209 U7 snRNA binding(GO:0071209)
0.5 14.2 GO:0031489 myosin V binding(GO:0031489)
0.3 4.1 GO:0030957 Tat protein binding(GO:0030957)
0.2 7.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 2.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.7 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.8 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 2.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 5.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 13.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 4.1 GO:0051015 actin filament binding(GO:0051015)
0.0 1.2 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 5.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 8.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 4.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 4.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 2.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 4.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 7.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 2.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix