ISMARA results: HSF2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HSF2

Z-value: 0.61

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Transcription factors associated with HSF2

Gene Symbol	Gene ID	Gene Info
HSF2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000025156.8	heat shock transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HSF2	hg19_v2_chr6_+_122720681_122720713	-0.15	2.5e-02	Click!

Activity profile of HSF2 motif

Sorted Z-values of HSF2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_75931861 Show fit	28.81	ENST00000248553.6	HSPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 27kDa protein 1
chr12_+_69979210 Show fit	19.59	ENST00000544368.2	CCT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chaperonin containing TCP1, subunit 2 (beta)
chr12_+_69979113 Show fit	16.05	ENST00000299300.6	CCT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chaperonin containing TCP1, subunit 2 (beta)
chr12_+_69979446 Show fit	15.13	ENST00000543146.2	CCT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chaperonin containing TCP1, subunit 2 (beta)
chr18_+_3449695 Show fit	14.54	ENST00000343820.5	TGIF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TGFB-induced factor homeobox 1
chr9_+_33025209 Show fit	13.96	ENST00000330899.4 ENST00000544625.1	DNAJA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily A, member 1
chr2_+_198365122 Show fit	13.54	ENST00000604458.1	HSPE1-MOB4 Ensembl NCBI GeneCards UniProt NextProt Show fit	HSPE1-MOB4 readthrough
chr18_-_812231 Show fit	13.19	ENST00000314574.4	YES1 Ensembl NCBI GeneCards UniProt NextProt Show fit	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr18_+_3449821 Show fit	12.92	ENST00000407501.2 ENST00000405385.3 ENST00000546979.1	TGIF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TGFB-induced factor homeobox 1
chr11_+_65770227 Show fit	12.20	ENST00000527348.1	BANF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	barrier to autointegration factor 1

Showing 1 to 10 of 126 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
16.9	50.8	GO:0051086	chaperone mediated protein folding independent of cofactor(GO:0051086)
0.1	35.2	GO:0042493	response to drug(GO:0042493)
2.5	29.5	GO:0015074	DNA integration(GO:0015074)
1.0	29.4	GO:0043968	histone H2A acetylation(GO:0043968)
7.2	28.8	GO:0099640	axo-dendritic protein transport(GO:0099640)
2.1	24.7	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
2.4	19.5	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
2.4	19.1	GO:1903748	negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.1	16.0	GO:0007498	mesoderm development(GO:0007498)
0.4	13.2	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)

Showing 1 to 10 of 65 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	58.3	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.0	38.9	GO:0005654	nucleoplasm(GO:0005654)
0.0	37.1	GO:0044429	mitochondrial part(GO:0044429)
0.1	31.6	GO:0000793	condensed chromosome(GO:0000793)
0.9	29.4	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.6	28.8	GO:1904115	axon cytoplasm(GO:1904115)
0.0	23.5	GO:0005730	nucleolus(GO:0005730)
0.1	20.6	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
2.0	14.0	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1	13.2	GO:0005884	actin filament(GO:0005884)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	61.7	GO:0044183	protein binding involved in protein folding(GO:0044183)
1.7	48.9	GO:0070410	co-SMAD binding(GO:0070410)
0.3	30.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.8	30.4	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.2	29.5	GO:0047485	protein N-terminus binding(GO:0047485)
9.6	28.8	GO:0008426	protein kinase C inhibitor activity(GO:0008426)
1.6	16.3	GO:0030911	TPR domain binding(GO:0030911)
0.4	13.3	GO:0001671	ATPase activator activity(GO:0001671)
0.2	13.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.3	12.4	GO:0070717	poly-purine tract binding(GO:0070717)

Showing 1 to 10 of 52 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	53.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.6	28.8	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	19.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	17.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	17.2	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.1	14.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	14.0	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.4	12.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	7.8	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	5.6	PID P73PATHWAY	p73 transcription factor network

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	61.7	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
1.0	48.9	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.5	41.2	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
3.3	29.5	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.3	20.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	16.3	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.2	15.5	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.7	13.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	10.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3	9.9	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)

Showing 1 to 10 of 26 entries

Results for HSF2

Z-value: 0.61

Motif logo

Transcription factors associated with HSF2

Activity-expression correlation:

Activity profile of HSF2 motif

Sorted Z-values of HSF2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: