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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HSF2

Z-value: 0.61

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Transcription factors associated with HSF2

Gene Symbol Gene ID Gene Info
HSF2
ENSG00000025156.8 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF2hg19_v2_chr6_+_122720681_122720713-0.152.5e-02Click!

Activity profile of HSF2 motif

Sorted Z-values of HSF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_75931861 28.81 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr12_+_69979210 19.59 ENST00000544368.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr12_+_69979113 16.05 ENST00000299300.6
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr12_+_69979446 15.13 ENST00000543146.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr18_+_3449695 14.54 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr9_+_33025209 13.96 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr2_+_198365122 13.54 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr18_-_812231 13.19 ENST00000314574.4
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr18_+_3449821 12.92 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr11_+_65770227 12.20 ENST00000527348.1
BANF1
barrier to autointegration factor 1
chr14_-_102553371 12.02 ENST00000553585.1
ENST00000216281.8
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr12_+_2904102 11.93 ENST00000001008.4
FKBP4
FK506 binding protein 4, 59kDa
chr2_+_198365095 11.46 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr18_+_3451584 11.43 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr9_+_91926103 11.29 ENST00000314355.6
CKS2
CDC28 protein kinase regulatory subunit 2
chr21_-_30445886 10.92 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr12_-_53012343 10.74 ENST00000305748.3
KRT73
keratin 73
chr2_-_10978103 10.58 ENST00000404824.2
PDIA6
protein disulfide isomerase family A, member 6
chr11_+_75273101 10.34 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chrX_-_102942961 10.08 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr18_+_3451646 10.03 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1
TGFB-induced factor homeobox 1
chrX_-_102943022 9.71 ENST00000433176.2
MORF4L2
mortality factor 4 like 2
chrX_-_102941596 9.59 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2
mortality factor 4 like 2
chr11_-_82997013 9.28 ENST00000529073.1
ENST00000529611.1
CCDC90B
coiled-coil domain containing 90B
chr11_-_82997371 9.25 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chr11_+_75273246 9.20 ENST00000526397.1
ENST00000529643.1
ENST00000525492.1
ENST00000530284.1
ENST00000532356.1
ENST00000524558.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chrX_-_152989531 8.80 ENST00000458587.2
ENST00000416815.1
BCAP31
B-cell receptor-associated protein 31
chr11_+_65769550 8.77 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
BANF1
barrier to autointegration factor 1
chr11_+_65769946 8.55 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr7_+_130126165 8.39 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr7_-_26240357 8.03 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr7_+_26240776 7.85 ENST00000337620.4
CBX3
chromobox homolog 3
chr6_+_151646800 7.77 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr8_-_141931287 7.74 ENST00000517887.1
PTK2
protein tyrosine kinase 2
chr11_-_82997420 7.70 ENST00000455220.2
ENST00000529689.1
CCDC90B
coiled-coil domain containing 90B
chr7_+_130126012 7.59 ENST00000341441.5
MEST
mesoderm specific transcript
chr8_-_81083341 7.36 ENST00000519303.2
TPD52
tumor protein D52
chr15_+_96869165 6.87 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr19_-_14628645 6.86 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr6_-_53213780 6.83 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr19_-_14629224 6.43 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_-_188419200 6.30 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_178128250 6.15 ENST00000448782.1
ENST00000446151.2
NFE2L2
nuclear factor, erythroid 2-like 2
chr8_-_81083890 5.98 ENST00000518937.1
TPD52
tumor protein D52
chrX_-_153775426 5.73 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr11_-_122933043 5.68 ENST00000534624.1
ENST00000453788.2
ENST00000527387.1
HSPA8
heat shock 70kDa protein 8
chr19_+_17416609 5.45 ENST00000602206.1
MRPL34
mitochondrial ribosomal protein L34
chr1_-_6453426 5.36 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr4_-_74088800 5.17 ENST00000509867.2
ANKRD17
ankyrin repeat domain 17
chr11_-_122932730 5.07 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr14_+_89060749 5.01 ENST00000555900.1
ENST00000406216.3
ENST00000557737.1
ZC3H14
zinc finger CCCH-type containing 14
chr1_+_206516200 5.01 ENST00000295713.5
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr3_+_158787041 5.00 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr11_-_89956461 5.00 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr11_-_89956227 4.85 ENST00000457199.2
ENST00000530765.1
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr16_+_765092 4.66 ENST00000568223.2
METRN
meteorin, glial cell differentiation regulator
chr14_+_89060739 4.56 ENST00000318308.6
ZC3H14
zinc finger CCCH-type containing 14
chr4_-_22517620 4.48 ENST00000502482.1
ENST00000334304.5
GPR125
G protein-coupled receptor 125
chr2_-_219151487 4.42 ENST00000444881.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr5_-_146833222 4.37 ENST00000534907.1
DPYSL3
dihydropyrimidinase-like 3
chr3_-_123411191 4.37 ENST00000354792.5
ENST00000508240.1
MYLK
myosin light chain kinase
chr13_-_31736027 4.35 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr6_+_44215603 4.30 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr5_-_146833485 4.29 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr15_+_42651691 4.13 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
CAPN3
calpain 3, (p94)
chr6_+_149539767 3.98 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr14_-_67859422 3.79 ENST00000556532.1
PLEK2
pleckstrin 2
chr4_-_159644507 3.78 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr2_-_188419078 3.62 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_-_6453399 3.47 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr1_+_27248203 3.24 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr2_+_11674213 3.20 ENST00000381486.2
GREB1
growth regulation by estrogen in breast cancer 1
chrX_+_135230712 3.18 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr11_+_86013253 3.14 ENST00000533986.1
ENST00000278483.3
C11orf73
chromosome 11 open reading frame 73
chr17_+_73663402 3.04 ENST00000355423.3
SAP30BP
SAP30 binding protein
chrX_+_135279179 2.99 ENST00000370676.3
FHL1
four and a half LIM domains 1
chrX_+_135278908 2.92 ENST00000539015.1
ENST00000370683.1
FHL1
four and a half LIM domains 1
chr3_-_185655795 2.88 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr12_+_119616447 2.58 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr11_+_27062860 2.55 ENST00000528583.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_-_56494713 2.31 ENST00000407977.2
RNF43
ring finger protein 43
chr7_-_150652924 2.22 ENST00000330883.4
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_-_85581701 2.19 ENST00000295802.4
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr20_+_4666882 2.14 ENST00000379440.4
ENST00000430350.2
PRNP
prion protein
chr8_-_81083731 2.14 ENST00000379096.5
TPD52
tumor protein D52
chr13_+_49684445 2.09 ENST00000398316.3
FNDC3A
fibronectin type III domain containing 3A
chr15_-_43785303 2.04 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
TP53BP1
tumor protein p53 binding protein 1
chr6_+_31783291 1.81 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A
heat shock 70kDa protein 1A
chr11_+_27062502 1.78 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_-_56494882 1.73 ENST00000584437.1
RNF43
ring finger protein 43
chr12_-_123011536 1.72 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr14_-_25479811 1.72 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr6_+_31795506 1.64 ENST00000375650.3
HSPA1B
heat shock 70kDa protein 1B
chr14_-_65409502 1.61 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr17_-_56494908 1.60 ENST00000577716.1
RNF43
ring finger protein 43
chr18_-_19284724 1.53 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr10_+_104535994 1.52 ENST00000369889.4
WBP1L
WW domain binding protein 1-like
chr16_-_30457048 1.46 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chr2_-_85581623 1.42 ENST00000449375.1
ENST00000409984.2
ENST00000457495.2
ENST00000263854.6
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr13_-_31736478 1.34 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr3_-_48632593 1.02 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr6_+_32121789 0.99 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr6_+_152126790 0.94 ENST00000456483.2
ESR1
estrogen receptor 1
chr4_+_184427235 0.89 ENST00000412117.1
ENST00000434682.2
ING2
inhibitor of growth family, member 2
chr17_-_39661849 0.85 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr20_+_57427765 0.80 ENST00000371100.4
GNAS
GNAS complex locus
chr6_-_155635583 0.75 ENST00000367166.4
TFB1M
transcription factor B1, mitochondrial
chr17_-_7297833 0.73 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr4_-_151936416 0.70 ENST00000510413.1
ENST00000507224.1
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr14_-_65409438 0.65 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_97405775 0.56 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L
lectin, mannose-binding 2-like
chr7_+_120629653 0.56 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr6_+_32121908 0.55 ENST00000375143.2
ENST00000424499.1
PPT2
palmitoyl-protein thioesterase 2
chrX_-_110655391 0.42 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr6_-_22297730 0.41 ENST00000306482.1
PRL
prolactin
chr16_+_71392616 0.36 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr2_+_11682790 0.23 ENST00000389825.3
ENST00000381483.2
GREB1
growth regulation by estrogen in breast cancer 1
chr11_-_414948 0.19 ENST00000530494.1
ENST00000528209.1
ENST00000431843.2
ENST00000528058.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr3_-_129407535 0.13 ENST00000432054.2
TMCC1
transmembrane and coiled-coil domain family 1
chr20_+_61867235 0.13 ENST00000342412.6
ENST00000217169.3
BIRC7
baculoviral IAP repeat containing 7
chr11_-_130298888 0.13 ENST00000257359.6
ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr1_-_216596738 0.06 ENST00000307340.3
ENST00000366943.2
ENST00000366942.3
USH2A
Usher syndrome 2A (autosomal recessive, mild)
chr5_-_135701164 0.05 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr1_-_168698433 0.05 ENST00000367817.3
DPT
dermatopontin
chr11_+_66276550 0.04 ENST00000419755.3
CTD-3074O7.11
Bardet-Biedl syndrome 1 protein
chr1_+_168195229 0.01 ENST00000271375.4
ENST00000367825.3
SFT2D2
SFT2 domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.9 50.8 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
7.2 28.8 GO:0099640 axo-dendritic protein transport(GO:0099640)
3.3 9.8 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
3.0 12.0 GO:0043335 protein unfolding(GO:0043335)
2.5 29.5 GO:0015074 DNA integration(GO:0015074)
2.4 19.5 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
2.4 19.1 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
2.2 8.8 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
2.2 10.8 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
2.1 24.7 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
1.9 5.7 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.8 8.8 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.7 6.9 GO:0009956 radial pattern formation(GO:0009956)
1.6 8.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
1.5 6.1 GO:1903786 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
1.4 5.6 GO:0038018 Wnt receptor catabolic process(GO:0038018)
1.3 5.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.2 9.9 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
1.1 4.4 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
1.1 10.9 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
1.1 4.3 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
1.0 29.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.9 3.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.9 3.5 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.9 5.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.9 7.7 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.7 2.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.7 2.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 2.1 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.7 4.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.6 9.6 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.5 4.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 11.9 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.5 7.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.5 5.0 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.5 1.5 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.4 4.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 13.2 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.4 8.7 GO:0051764 actin crosslink formation(GO:0051764)
0.3 11.3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.3 2.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 1.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.9 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 9.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 10.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.9 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 0.8 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 11.6 GO:0070268 cornification(GO:0070268)
0.1 0.9 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 11.7 GO:0030183 B cell differentiation(GO:0030183)
0.1 16.0 GO:0007498 mesoderm development(GO:0007498)
0.1 4.0 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 5.4 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 35.2 GO:0042493 response to drug(GO:0042493)
0.0 2.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 4.7 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.8 GO:0031167 rRNA methylation(GO:0031167)
0.0 1.5 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.2 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 4.2 GO:0006338 chromatin remodeling(GO:0006338)
0.0 3.2 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 1.0 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 2.1 GO:0009566 fertilization(GO:0009566)
0.0 0.4 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 58.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
2.0 14.0 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.7 5.2 GO:0097447 dendritic tree(GO:0097447)
1.5 10.8 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.5 8.8 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
1.1 4.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.9 29.4 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.6 28.8 GO:1904115 axon cytoplasm(GO:1904115)
0.6 7.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.6 10.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 11.9 GO:0044295 axonal growth cone(GO:0044295)
0.4 2.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.4 5.0 GO:0044327 dendritic spine head(GO:0044327)
0.3 11.6 GO:0045095 keratin filament(GO:0045095)
0.3 2.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 11.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 4.5 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.2 8.7 GO:0031941 filamentous actin(GO:0031941)
0.1 12.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 20.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 5.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 31.6 GO:0000793 condensed chromosome(GO:0000793)
0.1 13.2 GO:0005884 actin filament(GO:0005884)
0.1 8.0 GO:0015030 Cajal body(GO:0015030)
0.1 3.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 3.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.7 GO:0000145 exocyst(GO:0000145)
0.1 0.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 3.5 GO:0016235 aggresome(GO:0016235)
0.1 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.1 4.1 GO:0030315 T-tubule(GO:0030315)
0.0 2.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.4 GO:0035579 specific granule membrane(GO:0035579)
0.0 37.1 GO:0044429 mitochondrial part(GO:0044429)
0.0 3.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 23.5 GO:0005730 nucleolus(GO:0005730)
0.0 9.6 GO:0005925 focal adhesion(GO:0005925)
0.0 4.2 GO:0031975 organelle envelope(GO:0031967) envelope(GO:0031975)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 38.9 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 28.8 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
4.0 11.9 GO:0032767 copper-dependent protein binding(GO:0032767)
2.8 30.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
1.9 5.7 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
1.9 61.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
1.7 48.9 GO:0070410 co-SMAD binding(GO:0070410)
1.6 16.3 GO:0030911 TPR domain binding(GO:0030911)
1.6 11.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.1 7.8 GO:1990226 histone methyltransferase binding(GO:1990226)
1.1 4.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
1.1 8.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.9 8.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.9 8.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.9 4.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.9 5.2 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.5 2.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.5 10.6 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.5 7.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 1.5 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.5 7.7 GO:0008432 JUN kinase binding(GO:0008432)
0.4 5.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 13.3 GO:0001671 ATPase activator activity(GO:0001671)
0.4 2.1 GO:1903135 cupric ion binding(GO:1903135)
0.3 12.4 GO:0070717 poly-purine tract binding(GO:0070717)
0.3 4.1 GO:0031432 titin binding(GO:0031432)
0.3 1.5 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.3 30.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 3.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.3 8.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 13.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 9.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 6.9 GO:0001972 retinoic acid binding(GO:0001972)
0.2 29.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 3.8 GO:0080025 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 5.6 GO:0005109 frizzled binding(GO:0005109)
0.2 0.8 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 4.4 GO:0005123 death receptor binding(GO:0005123)
0.1 0.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 6.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.9 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.9 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 7.3 GO:0051087 chaperone binding(GO:0051087)
0.1 2.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 5.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.8 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 3.6 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 6.9 GO:0044325 ion channel binding(GO:0044325)
0.0 0.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.6 GO:0005537 mannose binding(GO:0005537)
0.0 4.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 28.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 53.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 12.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 17.2 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.3 17.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 14.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 14.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 7.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 19.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.2 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.6 PID P73PATHWAY p73 transcription factor network
0.1 2.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 2.0 PID ATM PATHWAY ATM pathway
0.0 4.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 29.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
2.0 61.7 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
1.0 48.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.7 13.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.7 4.0 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.6 8.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.6 16.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.5 41.2 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4 7.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 20.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 9.9 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.3 5.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 15.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 10.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 8.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 5.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 7.8 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.1 6.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 8.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 4.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4