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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HSF4
Z-value: 1.19
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Transcription factors associated with HSF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF4 | hg19_v2_chr16_+_67197288_67197362 | -0.68 | 1.2e-30 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.3 | 263.6 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 17.8 | 142.8 | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion(GO:1903748) |
| 3.8 | 108.9 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 20.7 | 103.6 | GO:1904764 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 1.8 | 90.5 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 7.2 | 85.9 | GO:0015074 | DNA integration(GO:0015074) |
| 15.7 | 62.8 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 7.8 | 62.1 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
| 2.8 | 60.7 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 11.3 | 56.4 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.9 | 263.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 5.8 | 163.7 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 149.2 | GO:0005730 | nucleolus(GO:0005730) |
| 3.3 | 108.9 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 14.8 | 103.6 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.6 | 90.9 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 1.4 | 87.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.4 | 85.9 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.1 | 70.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 68.7 | GO:0031966 | mitochondrial membrane(GO:0031966) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 247.2 | GO:0003723 | RNA binding(GO:0003723) |
| 5.5 | 175.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 14.7 | 162.1 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.8 | 135.2 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 2.5 | 130.3 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 22.0 | 88.0 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 7.0 | 84.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 10.5 | 73.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 6.3 | 62.8 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 1.7 | 56.4 | GO:0042288 | MHC class I protein binding(GO:0042288) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 132.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.9 | 105.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 67.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.0 | 66.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.0 | 65.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.8 | 58.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 1.4 | 47.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.5 | 44.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.5 | 32.1 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.5 | 31.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 263.6 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.8 | 103.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 3.0 | 103.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 3.0 | 91.9 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 1.3 | 90.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.6 | 87.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 9.5 | 85.9 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 1.3 | 83.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.8 | 65.8 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.7 | 65.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |