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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for IKZF2
Z-value: 0.36
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Transcription factors associated with IKZF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF2 | hg19_v2_chr2_-_214014959_214015058 | 0.11 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_189839046 Show fit | 9.08 |
ENST00000304636.3
ENST00000317840.5 |
collagen, type III, alpha 1 |
|
| chr5_-_42811986 Show fit | 8.26 |
ENST00000511224.1
ENST00000507920.1 ENST00000510965.1 |
selenoprotein P, plasma, 1 |
|
| chr5_-_42812143 Show fit | 7.86 |
ENST00000514985.1
|
selenoprotein P, plasma, 1 |
|
| chr1_-_57045228 Show fit | 7.24 |
ENST00000371250.3
|
phosphatidic acid phosphatase type 2B |
|
| chr12_-_91573316 Show fit | 6.87 |
ENST00000393155.1
|
decorin |
|
| chr12_-_91573249 Show fit | 6.86 |
ENST00000550099.1
ENST00000546391.1 ENST00000551354.1 |
decorin |
|
| chr12_-_91573132 Show fit | 6.82 |
ENST00000550563.1
ENST00000546370.1 |
decorin |
|
| chrX_+_73164149 Show fit | 5.77 |
ENST00000602938.1
ENST00000602294.1 ENST00000602920.1 ENST00000602737.1 ENST00000602772.1 |
JPX transcript, XIST activator (non-protein coding) |
|
| chrX_+_133733457 Show fit | 5.57 |
ENST00000440614.1
|
RP11-308B5.2 |
|
| chr18_-_53070913 Show fit | 5.48 |
ENST00000568186.1
ENST00000564228.1 |
transcription factor 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 20.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.3 | 15.7 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.6 | 9.6 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 1.1 | 9.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 2.1 | 8.5 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.0 | 7.7 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 7.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.4 | 7.1 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.4 | 6.8 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.1 | 6.6 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 20.6 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 3.1 | 15.7 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 1.0 | 9.1 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 8.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 8.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 7.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.0 | 7.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 5.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.9 | 4.7 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.4 | 4.6 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.3 | 15.7 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 11.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 11.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.7 | 9.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.6 | 8.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 7.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 7.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.9 | 7.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.2 | 6.9 | GO:0005521 | lamin binding(GO:0005521) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 17.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 12.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 8.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 8.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 7.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 4.4 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 4.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 3.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 25.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.7 | 15.7 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 12.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 10.8 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 7.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 7.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 5.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.2 | 5.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 4.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.4 | 4.7 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |