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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for INSM1
Z-value: 0.31
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Transcription factors associated with INSM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| INSM1 | hg19_v2_chr20_+_20348740_20348765 | 0.11 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of INSM1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 31.7 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 1.4 | 20.5 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 1.0 | 18.5 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.2 | 17.5 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 5.3 | 15.8 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.8 | 10.8 | GO:0010731 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 1.1 | 10.2 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 0.7 | 10.2 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 2.3 | 9.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.6 | 9.0 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 31.7 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.2 | 19.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 17.1 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 16.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 15.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 12.1 | GO:0005874 | microtubule(GO:0005874) |
| 0.5 | 11.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 11.0 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.5 | 10.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.4 | 5.7 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.0 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 4.1 | 20.5 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 5.3 | 15.8 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 15.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 11.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 10.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 2.6 | 10.2 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.9 | 9.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 5.9 | GO:0043531 | ADP binding(GO:0043531) |
| 0.2 | 5.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 3.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 2.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.2 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 1.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.1 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.0 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 22.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 17.0 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.2 | 16.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 8.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 5.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 4.9 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 4.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 4.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 3.6 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |