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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 0.23

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
IRF2
ENSG00000168310.6 interferon regulatory factor 2
STAT2
ENSG00000170581.9 signal transducer and activator of transcription 2
IRF8
ENSG00000140968.6 interferon regulatory factor 8
IRF1
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF1hg19_v2_chr5_-_131826457_1318265140.773.1e-44Click!
IRF2hg19_v2_chr4_-_185395672_1853957340.721.2e-36Click!
IRF8hg19_v2_chr16_+_85942594_859426350.561.6e-19Click!
STAT2hg19_v2_chr12_-_56753858_567539300.028.1e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32821924 199.84 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr1_+_948803 165.30 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr16_-_67970990 147.63 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr11_-_615942 126.93 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr6_-_33282163 109.81 ENST00000434618.2
ENST00000456592.2
TAPBP
TAP binding protein (tapasin)
chr21_+_42733870 106.90 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr6_+_32811885 105.61 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1
PSMB9
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32811771 104.75 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr19_-_17516449 98.27 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr1_+_158979792 95.71 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979680 92.83 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979686 92.43 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr11_-_615570 89.81 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr19_+_1077393 89.17 ENST00000590577.1
HMHA1
histocompatibility (minor) HA-1
chr1_+_174843548 87.50 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr2_-_231084820 87.29 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr7_+_74188309 85.50 ENST00000289473.4
ENST00000433458.1
NCF1
neutrophil cytosolic factor 1
chr6_-_32821599 82.69 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr21_+_42792442 77.84 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_-_91174215 76.32 ENST00000371837.1
LIPA
lipase A, lysosomal acid, cholesterol esterase
chr1_+_79086088 74.45 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr1_+_79115503 68.63 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr14_+_58711539 67.56 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr11_+_5710919 65.61 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr6_+_26365443 65.00 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr6_+_6588902 61.35 ENST00000230568.4
LY86
lymphocyte antigen 86
chr6_+_26440700 59.85 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr2_+_201981527 59.52 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_-_231084659 59.29 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr12_+_25205446 58.58 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr2_-_231084617 58.00 ENST00000409815.2
SP110
SP110 nuclear body protein
chr16_-_88851618 56.96 ENST00000301015.9
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr12_-_49319265 56.70 ENST00000552878.1
ENST00000453172.2
FKBP11
FK506 binding protein 11, 19 kDa
chr12_-_49318715 55.78 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa
chr3_-_49851313 55.60 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr13_+_50070077 55.38 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr15_+_45003675 54.91 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr4_+_147096837 54.82 ENST00000296581.5
ENST00000502781.1
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr14_+_24605361 54.82 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_+_113416191 54.61 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr14_+_24605389 54.55 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_-_100841930 53.66 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr11_-_57335280 53.58 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr13_+_50070491 53.48 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr2_-_152146385 52.52 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr14_-_100841670 51.94 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr15_+_89182178 51.77 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_-_154580616 49.69 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr11_-_104905840 49.21 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr6_-_31324943 49.20 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr12_+_113344755 48.62 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_191878874 48.34 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr20_+_388935 48.27 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_104972158 47.92 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr19_+_18284477 47.48 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr15_+_89181974 46.67 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr4_-_185395672 46.43 ENST00000393593.3
IRF2
interferon regulatory factor 2
chr8_+_144640477 46.15 ENST00000262580.4
GSDMD
gasdermin D
chr1_+_12227035 46.04 ENST00000376259.3
ENST00000536782.1
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr16_-_31214051 45.49 ENST00000350605.4
PYCARD
PYD and CARD domain containing
chr1_-_151319710 43.22 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr3_-_49142178 43.20 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
QARS
glutaminyl-tRNA synthetase
chrX_+_123095546 42.53 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr3_-_49142504 41.70 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr11_+_63304273 40.67 ENST00000439013.2
ENST00000255688.3
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr19_+_10196781 38.71 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr5_-_95158375 38.59 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr17_+_46908350 38.00 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
CALCOCO2
calcium binding and coiled-coil domain 2
chrX_+_37639264 37.66 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr1_+_179050512 34.86 ENST00000367627.3
TOR3A
torsin family 3, member A
chr20_+_388679 34.67 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_158801095 34.59 ENST00000368141.4
MNDA
myeloid cell nuclear differentiation antigen
chr21_+_42798094 34.58 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_-_89531041 34.47 ENST00000370473.4
GBP1
guanylate binding protein 1, interferon-inducible
chr2_-_191878681 34.37 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr16_+_12058961 34.10 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr2_+_231280908 33.74 ENST00000427101.2
ENST00000432979.1
SP100
SP100 nuclear antigen
chr2_+_120687335 33.70 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr18_+_3262954 32.51 ENST00000584539.1
MYL12B
myosin, light chain 12B, regulatory
chr4_+_37892682 31.49 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr5_-_95158644 31.48 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr17_+_25958174 31.12 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr16_+_12059050 30.85 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr15_+_89182156 30.09 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_+_25205666 29.97 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr6_-_41909191 29.60 ENST00000512426.1
ENST00000372987.4
CCND3
cyclin D3
chr12_-_10022735 28.50 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr20_-_5100591 28.47 ENST00000379143.5
PCNA
proliferating cell nuclear antigen
chr15_+_78832747 28.41 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr2_+_201981119 28.27 ENST00000395148.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr12_+_6561190 28.10 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr16_+_12059091 27.90 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_-_159239257 27.88 ENST00000337147.7
ENST00000392177.4
EZR
ezrin
chr12_+_94542459 27.80 ENST00000258526.4
PLXNC1
plexin C1
chr5_+_49962495 27.73 ENST00000515175.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr5_+_96212185 27.52 ENST00000379904.4
ERAP2
endoplasmic reticulum aminopeptidase 2
chr3_+_63898275 26.98 ENST00000538065.1
ATXN7
ataxin 7
chr3_-_146262488 26.32 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr12_+_25205568 26.11 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr12_+_113344811 26.10 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr5_+_96211643 26.01 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr9_-_100881466 25.97 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr5_-_142783694 25.74 ENST00000394466.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr14_+_35452104 25.73 ENST00000216774.6
ENST00000546080.1
SRP54
signal recognition particle 54kDa
chr11_-_4414880 25.57 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr10_+_91087651 25.53 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_111746966 25.32 ENST00000369752.5
DENND2D
DENN/MADD domain containing 2D
chr2_+_201994569 25.27 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr14_-_24615805 25.18 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_-_67169253 25.12 ENST00000527663.1
ENST00000312989.7
PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr6_+_37400974 24.53 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr3_-_172241250 24.39 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr3_-_30936153 24.11 ENST00000454381.3
ENST00000282538.5
GADL1
glutamate decarboxylase-like 1
chr14_+_24630465 23.98 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr3_-_146262365 23.86 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr14_+_35452169 23.75 ENST00000555557.1
SRP54
signal recognition particle 54kDa
chr16_+_29831715 23.67 ENST00000563915.1
ENST00000357402.5
MVP
major vault protein
chr11_-_60719213 23.57 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr6_+_25963020 23.31 ENST00000357085.3
TRIM38
tripartite motif containing 38
chr18_+_48405463 23.16 ENST00000382927.3
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr11_+_1874200 22.96 ENST00000311604.3
LSP1
lymphocyte-specific protein 1
chr12_-_53594227 22.83 ENST00000550743.2
ITGB7
integrin, beta 7
chr3_-_121379739 22.76 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr14_+_73563735 22.76 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr16_-_75681522 22.75 ENST00000568378.1
ENST00000568682.1
ENST00000570215.1
ENST00000319410.5
ENST00000302445.3
KARS
lysyl-tRNA synthetase
chr16_+_29831757 22.71 ENST00000452209.2
ENST00000395353.1
ENST00000566066.1
ENST00000563558.1
MVP
major vault protein
chrX_+_37639302 22.61 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr17_+_6659153 22.57 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr7_-_138794081 22.47 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr2_+_201994208 22.23 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr15_-_80263506 21.81 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr12_-_31479045 21.74 ENST00000539409.1
ENST00000395766.1
FAM60A
family with sequence similarity 60, member A
chr5_-_149792295 21.60 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr12_+_113344582 21.60 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr18_+_48405419 21.49 ENST00000321341.5
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr1_-_25291475 21.43 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr3_-_146262428 21.30 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr6_-_32920794 21.18 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr2_+_201994042 21.15 ENST00000417748.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr22_+_39436862 21.08 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr3_+_151986709 21.08 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
MBNL1
muscleblind-like splicing regulator 1
chr1_-_27998689 21.00 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr4_-_103748271 20.85 ENST00000343106.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_+_202122703 20.82 ENST00000447616.1
ENST00000358485.4
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr6_+_29691198 20.77 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr5_-_96143602 20.55 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr1_+_165864800 20.47 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr10_+_91152303 20.46 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_86669118 20.30 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr6_+_26402465 20.29 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_+_29691056 20.16 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr17_-_40264692 20.14 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_+_231191875 20.11 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
SP140L
SP140 nuclear body protein-like
chr19_+_49838653 19.98 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr11_-_14358620 19.92 ENST00000531421.1
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr11_+_5646213 19.83 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr5_+_118690466 19.51 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_35099315 19.50 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
SNX6
sorting nexin 6
chr2_+_85811525 19.36 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chr2_+_86668464 19.31 ENST00000409064.1
KDM3A
lysine (K)-specific demethylase 3A
chr3_+_152017181 19.04 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr14_+_91580777 18.79 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
C14orf159
chromosome 14 open reading frame 159
chr4_-_83765613 18.75 ENST00000503937.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr17_+_18380051 18.38 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr1_+_165864821 18.36 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr6_-_170862322 18.32 ENST00000262193.6
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr14_+_91581011 18.30 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
C14orf159
chromosome 14 open reading frame 159
chr13_+_53216565 18.21 ENST00000357495.2
HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr17_-_5342380 18.01 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr6_-_26056695 17.79 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr3_-_146262352 17.36 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262637 17.35 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr6_-_31239846 17.25 ENST00000415537.1
ENST00000376228.5
ENST00000383329.3
HLA-C
major histocompatibility complex, class I, C
chr4_-_103747011 17.19 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_-_73687997 17.19 ENST00000545212.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr4_-_103746683 16.88 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_+_60223225 16.76 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr14_+_91580732 16.75 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
C14orf159
chromosome 14 open reading frame 159
chr1_+_64058939 16.73 ENST00000371084.3
PGM1
phosphoglucomutase 1
chr1_-_153919128 16.68 ENST00000361217.4
DENND4B
DENN/MADD domain containing 4B
chr11_-_65381643 16.61 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr3_-_167452262 16.53 ENST00000487947.2
PDCD10
programmed cell death 10
chr1_-_19426149 16.45 ENST00000429347.2
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr12_+_75874460 16.36 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr11_+_313503 16.35 ENST00000528780.1
ENST00000328221.5
IFITM1
interferon induced transmembrane protein 1
chr11_+_60223312 16.14 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr1_+_158149737 16.00 ENST00000368171.3
CD1D
CD1d molecule
chr22_-_36556821 15.91 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr3_-_146262293 15.71 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr2_-_225434538 15.71 ENST00000409096.1
CUL3
cullin 3
chr17_+_41158742 15.65 ENST00000415816.2
ENST00000438323.2
IFI35
interferon-induced protein 35
chr11_-_67169265 15.24 ENST00000358239.4
ENST00000376745.4
PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chrX_+_80457442 15.18 ENST00000373212.5
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr3_+_38179969 15.11 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
MYD88
myeloid differentiation primary response 88
chr5_+_133861790 15.03 ENST00000395003.1
PHF15
jade family PHD finger 2
chr16_+_50776021 14.98 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chrX_-_20236970 14.97 ENST00000379548.4
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chrX_+_70503037 14.97 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr10_+_51572408 14.95 ENST00000374082.1
NCOA4
nuclear receptor coactivator 4
chr9_-_32526184 14.92 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
44.8 223.8 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
42.8 128.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
34.3 274.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
32.8 98.3 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
28.3 84.9 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
28.1 28.1 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
25.4 101.6 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
21.6 280.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
21.1 105.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
20.7 82.7 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
19.9 219.3 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
19.0 57.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
17.5 52.5 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
16.6 49.7 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
16.5 49.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
15.4 46.2 GO:0035915 pore formation in membrane of other organism(GO:0035915)
15.2 121.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
15.2 152.2 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
15.2 45.5 GO:0002585 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
13.8 69.0 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
13.2 39.6 GO:0007290 spermatid nucleus elongation(GO:0007290)
12.1 60.3 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
11.8 11.8 GO:0034165 regulation of toll-like receptor 9 signaling pathway(GO:0034163) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
11.6 46.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
11.5 46.1 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
11.5 103.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
11.2 67.1 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
11.1 89.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
10.4 1007.3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
10.1 40.4 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
9.7 38.8 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
9.5 47.3 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
9.0 27.0 GO:0039516 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
8.8 70.3 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
7.8 54.6 GO:0018377 protein myristoylation(GO:0018377)
7.8 31.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
7.6 22.8 GO:0002276 basophil activation involved in immune response(GO:0002276)
7.3 22.0 GO:1990108 protein linear deubiquitination(GO:1990108)
7.1 28.5 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
6.9 27.6 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
6.8 20.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
6.7 6.7 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
6.6 39.7 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
6.6 32.9 GO:0072642 positive regulation of interferon-beta secretion(GO:0035549) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
6.4 44.6 GO:1902031 regulation of NADP metabolic process(GO:1902031)
5.9 293.4 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
5.7 22.8 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
5.3 21.2 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
4.9 24.5 GO:0080009 mRNA methylation(GO:0080009)
4.9 24.5 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
4.6 36.5 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
4.5 49.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
4.4 35.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
4.4 35.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
4.3 17.4 GO:1903121 regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
4.3 13.0 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
4.1 12.3 GO:0045062 extrathymic T cell selection(GO:0045062)
4.0 16.0 GO:0019883 antigen processing and presentation of endogenous antigen(GO:0019883)
4.0 23.8 GO:0070383 DNA cytosine deamination(GO:0070383)
3.9 15.7 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.9 19.5 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
3.9 70.1 GO:0045838 positive regulation of membrane potential(GO:0045838)
3.8 46.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
3.8 15.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
3.7 43.9 GO:0035455 response to interferon-alpha(GO:0035455)
3.6 10.9 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
3.6 10.9 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
3.6 82.8 GO:0072643 interferon-gamma secretion(GO:0072643)
3.6 14.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
3.3 23.3 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
3.3 23.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
3.2 12.8 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
3.1 12.4 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
2.9 8.8 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
2.9 11.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.9 8.7 GO:1903028 positive regulation of opsonization(GO:1903028)
2.9 20.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
2.8 2.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
2.8 25.1 GO:0016584 nucleosome positioning(GO:0016584)
2.8 16.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
2.7 8.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
2.7 10.8 GO:0090527 actin filament reorganization(GO:0090527)
2.6 15.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
2.6 7.9 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
2.6 10.4 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
2.6 46.4 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
2.5 7.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.5 7.4 GO:0032621 central nervous system myelin formation(GO:0032289) interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661) toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
2.5 17.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.5 12.3 GO:0006741 NADP biosynthetic process(GO:0006741)
2.4 116.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
2.4 16.6 GO:0007256 activation of JNKK activity(GO:0007256)
2.4 9.4 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
2.3 106.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
2.2 29.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
2.2 10.9 GO:0033625 positive regulation of integrin activation(GO:0033625)
2.2 8.7 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
2.2 6.5 GO:0007518 myoblast fate determination(GO:0007518)
2.1 10.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.1 4.1 GO:0042256 mature ribosome assembly(GO:0042256)
2.0 13.9 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
2.0 4.0 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
1.9 5.8 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.9 7.8 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
1.9 15.5 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
1.9 5.8 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
1.9 3.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.9 5.6 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
1.8 3.6 GO:0006059 hexitol metabolic process(GO:0006059)
1.8 5.4 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.8 34.2 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
1.8 5.4 GO:0071283 cellular response to iron(III) ion(GO:0071283)
1.8 32.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
1.8 3.6 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
1.8 10.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
1.7 6.9 GO:0016554 cytidine to uridine editing(GO:0016554)
1.7 39.1 GO:0016578 histone deubiquitination(GO:0016578)
1.7 76.3 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
1.7 5.0 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.7 9.9 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.7 5.0 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) negative regulation of mitotic cell cycle DNA replication(GO:1903464) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.6 95.2 GO:0002260 lymphocyte homeostasis(GO:0002260)
1.6 8.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
1.6 19.6 GO:0010623 programmed cell death involved in cell development(GO:0010623)
1.6 14.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.6 19.4 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
1.6 9.4 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.6 14.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.5 7.7 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
1.5 63.1 GO:0006536 glutamate metabolic process(GO:0006536)
1.5 5.9 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.5 7.3 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
1.5 2.9 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.5 2.9 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
1.5 2.9 GO:0072300 positive regulation of metanephric glomerulus development(GO:0072300)
1.4 5.8 GO:0005986 sucrose biosynthetic process(GO:0005986)
1.4 53.4 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
1.4 114.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.4 18.5 GO:0019388 galactose catabolic process(GO:0019388)
1.4 15.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
1.4 6.8 GO:0070836 caveola assembly(GO:0070836)
1.4 13.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
1.3 4.0 GO:0002384 hepatic immune response(GO:0002384)
1.3 4.0 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
1.3 6.7 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
1.3 140.8 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
1.3 3.8 GO:0021569 rhombomere 3 development(GO:0021569)
1.2 13.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
1.2 26.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
1.2 100.3 GO:0006906 vesicle fusion(GO:0006906)
1.2 4.8 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
1.2 3.6 GO:0071492 cellular response to UV-A(GO:0071492)
1.2 4.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
1.2 6.9 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
1.1 21.8 GO:0008053 mitochondrial fusion(GO:0008053)
1.1 6.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.1 3.3 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391) positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
1.0 1.0 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)
1.0 3.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
1.0 5.1 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
1.0 1.0 GO:0048087 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of developmental pigmentation(GO:0048087) positive regulation of pigment cell differentiation(GO:0050942) positive regulation of neuroepithelial cell differentiation(GO:1902913)
1.0 2.9 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
1.0 4.8 GO:0097338 response to clozapine(GO:0097338)
1.0 7.6 GO:0090344 negative regulation of cell aging(GO:0090344)
0.9 18.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.9 0.9 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.9 8.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.9 10.6 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.9 3.5 GO:0043335 protein unfolding(GO:0043335)
0.9 10.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.9 4.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.9 11.1 GO:0016180 snRNA processing(GO:0016180)
0.9 5.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.8 7.5 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.8 5.8 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.8 4.9 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.8 14.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.8 4.0 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.8 5.6 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.8 28.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.8 11.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.8 6.2 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.8 12.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.8 7.7 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.8 7.6 GO:0015886 heme transport(GO:0015886)
0.8 3.8 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.8 6.0 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.8 3.0 GO:0043248 proteasome assembly(GO:0043248)
0.7 14.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.7 5.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.7 2.2 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.7 2.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.7 37.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.7 15.1 GO:0006828 manganese ion transport(GO:0006828)
0.7 7.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.7 3.6 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.7 15.0 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.7 2.8 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.7 3.4 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.7 11.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.7 5.4 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.6 5.2 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.6 3.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.6 16.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.6 3.0 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.6 1.7 GO:0070842 aggresome assembly(GO:0070842)
0.6 1.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.6 14.9 GO:0003094 glomerular filtration(GO:0003094)
0.6 10.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 11.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 27.7 GO:0006298 mismatch repair(GO:0006298)
0.6 29.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.6 3.3 GO:1990441 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990441)
0.6 3.9 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.6 4.4 GO:0015867 ADP transport(GO:0015866) ATP transport(GO:0015867) adenine nucleotide transport(GO:0051503)
0.5 4.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.5 10.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.5 7.3 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.5 9.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.5 0.5 GO:1990791 dorsal root ganglion development(GO:1990791)
0.5 2.0 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.5 10.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 6.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 6.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.5 10.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.5 1.9 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.5 30.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.4 1.3 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.4 4.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 4.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.4 6.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.4 12.0 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.4 2.4 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.4 1.2 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.4 1.2 GO:0070541 response to platinum ion(GO:0070541)
0.4 1.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 2.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 2.6 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.4 4.1 GO:0033227 dsRNA transport(GO:0033227)
0.4 3.3 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.4 1.8 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 10.1 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.3 35.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.3 13.0 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.3 2.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 9.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.3 1.0 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.3 6.1 GO:0032418 lysosome localization(GO:0032418)
0.3 5.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 0.6 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.3 1.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.3 3.3 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.3 5.7 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.3 45.1 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 1.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.3 2.6 GO:0001783 B cell apoptotic process(GO:0001783)
0.3 0.6 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.3 1.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.3 3.7 GO:0043583 ear development(GO:0043583) inner ear development(GO:0048839)
0.3 5.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.3 0.8 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.3 6.1 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.3 1.9 GO:0006105 succinate metabolic process(GO:0006105)
0.3 6.6 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.4 GO:0036258 multivesicular body organization(GO:0036257) multivesicular body assembly(GO:0036258)
0.3 6.3 GO:0014904 myotube cell development(GO:0014904)
0.3 0.8 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.3 1.0 GO:0090309 regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.3 2.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.3 4.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 8.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 1.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 13.9 GO:0043966 histone H3 acetylation(GO:0043966)
0.2 3.5 GO:0051639 actin filament network formation(GO:0051639)
0.2 6.3 GO:0006491 N-glycan processing(GO:0006491)
0.2 10.5 GO:0051972 regulation of telomerase activity(GO:0051972)
0.2 7.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 6.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 15.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.2 11.2 GO:0045576 mast cell activation(GO:0045576)
0.2 3.0 GO:0003014 renal system process(GO:0003014)
0.2 29.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 6.5 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 8.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 5.5 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.2 2.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 5.2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.2 2.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 12.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 5.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 3.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.2 4.9 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.2 3.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2 8.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 0.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 0.5 GO:0001897 cytolysis by symbiont of host cells(GO:0001897) hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.1 3.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 9.9 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.3 GO:0071698 olfactory placode formation(GO:0030910) ureteric bud formation(GO:0060676) cranial ganglion development(GO:0061550) trigeminal ganglion development(GO:0061551) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) mesonephric tubule formation(GO:0072172) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 7.1 GO:0006968 cellular defense response(GO:0006968)
0.1 1.6 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.6 GO:0006574 valine catabolic process(GO:0006574)
0.1 11.5 GO:0008652 cellular amino acid biosynthetic process(GO:0008652)
0.1 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 1.2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.1 8.3 GO:0006413 translational initiation(GO:0006413)
0.1 0.7 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.1 5.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 53.9 GO:0016032 viral process(GO:0016032)
0.1 1.6 GO:0008356 asymmetric cell division(GO:0008356)
0.1 0.7 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 3.1 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 2.6 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 1.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 2.2 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 0.5 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 1.1 GO:0033151 V(D)J recombination(GO:0033151)
0.1 2.5 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 1.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 4.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.2 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.1 0.5 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 9.7 GO:0008360 regulation of cell shape(GO:0008360)
0.1 4.1 GO:0030641 regulation of cellular pH(GO:0030641)
0.1 2.7 GO:0048477 oogenesis(GO:0048477)
0.1 3.2 GO:0006400 tRNA modification(GO:0006400)
0.1 3.6 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.7 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.7 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 2.0 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 3.2 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 3.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.2 GO:0043473 pigmentation(GO:0043473)
0.0 0.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 1.2 GO:0015992 proton transport(GO:0015992)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.4 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
69.7 557.8 GO:1990111 spermatoproteasome complex(GO:1990111)
30.6 183.7 GO:0042825 TAP complex(GO:0042825)
24.4 146.4 GO:0008537 proteasome activator complex(GO:0008537)
23.8 142.6 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
17.8 89.1 GO:0071797 LUBAC complex(GO:0071797)
11.8 129.6 GO:0042612 MHC class I protein complex(GO:0042612)
11.5 34.5 GO:0044393 microspike(GO:0044393)
10.7 85.5 GO:0032010 phagolysosome(GO:0032010)
9.9 49.7 GO:0044530 supraspliceosomal complex(GO:0044530)
9.7 116.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
9.6 173.1 GO:0097342 ripoptosome(GO:0097342)
9.5 28.5 GO:0070557 PCNA-p21 complex(GO:0070557)
7.0 21.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
6.7 53.9 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
6.2 130.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
6.2 49.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
5.7 22.8 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
5.7 34.0 GO:0030905 retromer, tubulation complex(GO:0030905)
5.6 39.0 GO:0030870 Mre11 complex(GO:0030870)
5.0 54.8 GO:0005688 U6 snRNP(GO:0005688)
5.0 14.9 GO:0071751 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
4.6 59.8 GO:0043020 NADPH oxidase complex(GO:0043020)
4.3 34.1 GO:0043196 varicosity(GO:0043196)
4.0 40.5 GO:0042587 glycogen granule(GO:0042587)
4.0 32.1 GO:0070552 BRISC complex(GO:0070552)
3.7 11.2 GO:0036398 TCR signalosome(GO:0036398)
3.2 29.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
3.1 21.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
3.0 14.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
2.9 202.5 GO:0015030 Cajal body(GO:0015030)
2.9 14.4 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
2.8 205.2 GO:0035577 azurophil granule membrane(GO:0035577)
2.8 8.4 GO:1990622 CHOP-ATF3 complex(GO:1990622)
2.6 7.7 GO:0005674 transcription factor TFIIF complex(GO:0005674)
2.5 7.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
2.5 27.0 GO:0035631 CD40 receptor complex(GO:0035631)
2.4 7.3 GO:0031213 RSF complex(GO:0031213)
2.4 28.9 GO:0044754 autolysosome(GO:0044754)
2.4 7.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.2 4.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
2.0 8.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.9 15.0 GO:0042382 paraspeckles(GO:0042382)
1.8 60.5 GO:0031258 lamellipodium membrane(GO:0031258)
1.8 3.6 GO:0097454 Schwann cell microvillus(GO:0097454)
1.8 8.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.7 15.7 GO:0005827 polar microtubule(GO:0005827)
1.7 11.6 GO:0072487 MSL complex(GO:0072487)
1.5 10.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
1.4 13.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
1.3 162.6 GO:0005643 nuclear pore(GO:0005643)
1.3 12.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
1.3 5.0 GO:0070985 TFIIK complex(GO:0070985)
1.2 11.1 GO:0032039 integrator complex(GO:0032039)
1.2 3.5 GO:0020003 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
1.1 10.3 GO:0072546 ER membrane protein complex(GO:0072546)
1.1 7.9 GO:0070765 gamma-secretase complex(GO:0070765)
1.1 30.2 GO:0070822 Sin3-type complex(GO:0070822)
1.1 7.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.1 38.0 GO:0000421 autophagosome membrane(GO:0000421)
1.1 21.2 GO:0042611 MHC protein complex(GO:0042611)
1.0 8.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.0 4.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.0 5.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.9 4.7 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.9 26.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.9 59.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.8 7.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.8 18.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.8 8.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.8 9.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.8 338.1 GO:0016607 nuclear speck(GO:0016607)
0.7 8.9 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.7 15.5 GO:0030686 90S preribosome(GO:0030686)
0.7 13.2 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.7 21.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.7 32.5 GO:0099738 cell cortex region(GO:0099738)
0.7 4.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.7 2.0 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.6 1.9 GO:0005588 collagen type V trimer(GO:0005588)
0.6 17.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.6 5.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.6 3.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.6 10.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.6 57.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.6 14.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 13.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.6 100.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.6 8.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.6 4.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.6 10.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.6 11.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.6 179.4 GO:0031965 nuclear membrane(GO:0031965)
0.5 2.2 GO:0031085 BLOC-3 complex(GO:0031085)
0.5 10.9 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.5 232.7 GO:0010008 endosome membrane(GO:0010008)
0.5 27.3 GO:0001772 immunological synapse(GO:0001772)
0.5 1.9 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.5 64.6 GO:0001650 fibrillar center(GO:0001650)
0.5 19.3 GO:0097542 ciliary tip(GO:0097542)
0.5 1.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.4 1.8 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.4 4.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 11.9 GO:0005776 autophagosome(GO:0005776)
0.4 76.6 GO:0005769 early endosome(GO:0005769)
0.4 3.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 5.4 GO:0005577 fibrinogen complex(GO:0005577)
0.4 3.3 GO:0044327 dendritic spine head(GO:0044327)
0.4 4.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 6.3 GO:0000786 nucleosome(GO:0000786)
0.4 5.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.4 28.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.4 24.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 17.7 GO:0005801 cis-Golgi network(GO:0005801)
0.4 10.5 GO:0005876 spindle microtubule(GO:0005876)
0.4 30.1 GO:0016363 nuclear matrix(GO:0016363)
0.4 172.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 14.0 GO:0016235 aggresome(GO:0016235)
0.3 2.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 8.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 7.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 4.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 83.6 GO:0000790 nuclear chromatin(GO:0000790)
0.3 4.5 GO:0032059 bleb(GO:0032059)
0.3 0.3 GO:0061702 inflammasome complex(GO:0061702)
0.3 6.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 3.4 GO:0043083 synaptic cleft(GO:0043083)
0.3 31.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 6.2 GO:0005840 ribosome(GO:0005840)
0.2 2.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 3.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.2 1.6 GO:0033269 internode region of axon(GO:0033269)
0.2 1.1 GO:0097149 centralspindlin complex(GO:0097149)
0.2 23.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 3.1 GO:0031105 septin complex(GO:0031105)
0.2 3.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 2.3 GO:0032993 protein-DNA complex(GO:0032993)
0.2 7.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 7.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 23.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.5 GO:0031143 pseudopodium(GO:0031143)
0.2 4.2 GO:0035580 specific granule lumen(GO:0035580)
0.2 1.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.2 20.9 GO:0005802 trans-Golgi network(GO:0005802)
0.2 16.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 5.9 GO:0031201 SNARE complex(GO:0031201)
0.2 42.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 6.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 10.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.2 2.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.6 GO:0043296 apical junction complex(GO:0043296)
0.2 11.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 16.0 GO:0005635 nuclear envelope(GO:0005635)
0.2 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.1 11.7 GO:0005814 centriole(GO:0005814)
0.1 1.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 8.2 GO:0016605 PML body(GO:0016605)
0.1 1.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 51.5 GO:0000139 Golgi membrane(GO:0000139)
0.1 15.2 GO:0031968 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.1 7.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 13.0 GO:0001726 ruffle(GO:0001726)
0.1 99.5 GO:0005739 mitochondrion(GO:0005739)
0.1 0.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 5.3 GO:0005604 basement membrane(GO:0005604)
0.1 10.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 3.7 GO:0000922 spindle pole(GO:0000922)
0.0 99.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 8.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0031082 BLOC complex(GO:0031082)
0.0 1.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
42.8 128.5 GO:0008859 exoribonuclease II activity(GO:0008859)
38.2 228.9 GO:0046979 TAP2 binding(GO:0046979)
28.3 84.9 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
23.4 703.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
21.1 105.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
20.9 146.4 GO:0061133 endopeptidase activator activity(GO:0061133)
15.3 76.3 GO:0004771 sterol esterase activity(GO:0004771)
15.2 45.5 GO:0032090 Pyrin domain binding(GO:0032090)
13.8 165.3 GO:0031386 protein tag(GO:0031386)
13.4 40.1 GO:0001069 regulatory region RNA binding(GO:0001069)
12.6 63.1 GO:0047820 D-glutamate cyclase activity(GO:0047820)
11.1 121.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
10.4 31.1 GO:0048030 disaccharide binding(GO:0048030)
9.9 308.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
9.9 49.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
9.5 57.0 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
9.3 55.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
8.9 53.4 GO:0042296 ISG15 transferase activity(GO:0042296)
8.5 85.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
8.3 82.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
7.9 23.6 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
7.4 44.6 GO:0008948 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
7.4 29.6 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
7.1 28.5 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
7.0 35.2 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
7.0 70.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
6.4 25.7 GO:0004000 adenosine deaminase activity(GO:0004000)
6.0 24.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
6.0 18.0 GO:0030984 kininogen binding(GO:0030984)
5.9 29.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
5.8 46.1 GO:0070087 chromo shadow domain binding(GO:0070087)
5.5 38.8 GO:0004849 uridine kinase activity(GO:0004849)
5.4 21.5 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
5.1 46.2 GO:1901612 cardiolipin binding(GO:1901612)
4.9 24.5 GO:0008174 mRNA methyltransferase activity(GO:0008174)
4.2 16.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
4.1 103.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
4.0 16.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
3.9 15.7 GO:0031208 POZ domain binding(GO:0031208)
3.9 113.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
3.9 19.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
3.8 22.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
3.5 42.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
3.3 20.0 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
3.3 59.8 GO:0019864 IgG binding(GO:0019864)
3.3 16.4 GO:0042289 MHC class II protein binding(GO:0042289)
3.1 9.3 GO:0098770 FBXO family protein binding(GO:0098770)
3.1 18.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
3.0 8.9 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
2.9 14.5 GO:1990460 leptin receptor binding(GO:1990460)
2.9 49.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
2.9 17.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
2.7 8.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
2.6 7.9 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
2.5 7.5 GO:0032184 SUMO polymer binding(GO:0032184)
2.4 266.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
2.4 33.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
2.4 7.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
2.3 6.8 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
2.2 91.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
2.2 8.8 GO:0097001 ceramide binding(GO:0097001)
2.2 22.0 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
2.2 65.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
2.1 39.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.9 5.8 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
1.9 40.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
1.8 7.3 GO:0004074 biliverdin reductase activity(GO:0004074)
1.8 29.1 GO:0032036 myosin heavy chain binding(GO:0032036)
1.8 296.0 GO:0001047 core promoter binding(GO:0001047)
1.8 16.3 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.8 19.5 GO:0034452 dynactin binding(GO:0034452)
1.7 34.9 GO:0044548 S100 protein binding(GO:0044548)
1.7 8.7 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
1.7 5.1 GO:0004531 deoxyribonuclease II activity(GO:0004531)
1.7 40.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.7 9.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.6 13.1 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
1.6 27.3 GO:0017154 semaphorin receptor activity(GO:0017154)
1.6 16.0 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
1.6 15.5 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.4 5.8 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
1.4 7.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.4 8.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.4 20.3 GO:0031996 thioesterase binding(GO:0031996)
1.3 4.0 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
1.3 5.4 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
1.3 40.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
1.2 15.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
1.1 22.8 GO:0070566 adenylyltransferase activity(GO:0070566)
1.1 14.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
1.1 4.5 GO:0055077 gap junction hemi-channel activity(GO:0055077)
1.1 8.9 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
1.1 6.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.1 21.8 GO:0051400 BH domain binding(GO:0051400)
1.1 36.9 GO:0051879 Hsp90 protein binding(GO:0051879)
1.1 7.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
1.0 7.3 GO:0001849 complement component C1q binding(GO:0001849)
1.0 13.6 GO:0005123 death receptor binding(GO:0005123)
1.0 10.4 GO:0048019 receptor antagonist activity(GO:0048019)
1.0 8.1 GO:0089720 caspase binding(GO:0089720)
1.0 3.0 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
1.0 3.0 GO:0033149 FFAT motif binding(GO:0033149)
0.9 14.1 GO:0048156 tau protein binding(GO:0048156)
0.9 34.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.9 47.0 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.8 42.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.8 6.7 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.8 11.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.8 3.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.8 22.6 GO:0042605 peptide antigen binding(GO:0042605)
0.8 12.0 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.8 5.5 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.8 5.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.8 13.7 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.8 7.6 GO:0015232 heme transporter activity(GO:0015232)
0.8 12.8 GO:0005522 profilin binding(GO:0005522)
0.7 7.9 GO:0033592 RNA strand annealing activity(GO:0033592)
0.7 5.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.7 10.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.7 7.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.7 2.1 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.7 4.1 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.7 7.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.7 1.3 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.7 4.0 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.7 4.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.6 1.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.6 6.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 11.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.6 17.4 GO:0008143 poly(A) binding(GO:0008143)
0.6 18.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.6 0.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.6 96.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 4.7 GO:0016778 diphosphotransferase activity(GO:0016778)
0.6 44.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.6 22.2 GO:0004623 phospholipase A2 activity(GO:0004623)
0.6 4.0 GO:0019863 IgE binding(GO:0019863)
0.6 190.8 GO:0003924 GTPase activity(GO:0003924)
0.6 3.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.6 3.9 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.6 4.4 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.5 23.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.5 7.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.5 27.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.5 7.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.5 11.9 GO:0001968 fibronectin binding(GO:0001968)
0.5 10.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 7.2 GO:0031491 nucleosome binding(GO:0031491)
0.4 17.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.4 25.9 GO:0035064 methylated histone binding(GO:0035064)
0.4 8.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 21.9 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.4 20.2 GO:0050681 androgen receptor binding(GO:0050681)
0.4 1.6 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.4 10.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 4.7 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.4 2.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 6.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.4 8.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.4 10.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 12.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.4 2.8 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.4 18.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 1.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 34.6 GO:0043130 ubiquitin binding(GO:0043130)
0.3 2.9 GO:0035325 Toll-like receptor binding(GO:0035325)
0.3 17.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.3 6.0 GO:0050811 GABA receptor binding(GO:0050811)
0.3 4.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 63.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 13.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 3.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.3 10.6 GO:0005319 lipid transporter activity(GO:0005319)
0.3 1.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 36.9 GO:0019903 protein phosphatase binding(GO:0019903)
0.3 3.2 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3 0.8 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 10.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.3 38.6 GO:0003823 antigen binding(GO:0003823)
0.3 3.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 15.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 4.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 8.2 GO:0043531 ADP binding(GO:0043531)
0.2 2.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 8.7 GO:0019894 kinesin binding(GO:0019894)
0.2 10.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 5.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.1 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 5.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 10.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 40.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 1.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.2 2.5 GO:0008252 nucleotidase activity(GO:0008252)
0.2 2.1 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.2 4.9 GO:0001671 ATPase activator activity(GO:0001671)
0.2 22.5 GO:0017124 SH3 domain binding(GO:0017124)
0.2 3.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 5.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 6.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 6.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 6.6 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.6 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.1 1.7 GO:0070628 proteasome binding(GO:0070628)
0.1 2.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 2.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 7.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 2.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 49.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 24.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 5.7 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 1.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 23.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 0.7 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 5.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 6.1 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.3 GO:0044390 ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 1.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 7.4 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.6 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0019902 phosphatase binding(GO:0019902)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0031402 sodium ion binding(GO:0031402)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 94.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
6.0 179.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
3.4 92.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
2.8 116.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
2.5 193.5 PID RAC1 PATHWAY RAC1 signaling pathway
1.7 270.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
1.6 44.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
1.5 35.6 PID TRAIL PATHWAY TRAIL signaling pathway
1.5 53.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
1.5 26.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.5 31.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.4 76.9 PID AURORA B PATHWAY Aurora B signaling
1.2 79.1 PID PLK1 PATHWAY PLK1 signaling events
1.2 68.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
1.0 30.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
1.0 37.7 PID ALK1 PATHWAY ALK1 signaling events
0.9 22.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.9 68.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.9 39.9 PID RHOA PATHWAY RhoA signaling pathway
0.8 37.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.8 7.3 ST STAT3 PATHWAY STAT3 Pathway
0.8 28.5 PID BARD1 PATHWAY BARD1 signaling events
0.7 15.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.7 19.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.6 103.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.6 5.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 20.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 20.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.5 12.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.5 21.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 1.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.4 10.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.4 10.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.3 13.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 2.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3 47.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 19.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 12.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 24.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 11.9 PID E2F PATHWAY E2F transcription factor network
0.2 5.2 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.2 17.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 9.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.4 PID AURORA A PATHWAY Aurora A signaling
0.1 4.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 3.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 2.4 PID P73PATHWAY p73 transcription factor network
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
17.8 231.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
17.0 170.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
11.6 855.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
10.1 808.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
7.6 143.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
7.0 203.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
6.6 235.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
5.2 244.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
4.9 82.8 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
4.5 66.9 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
3.6 53.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
2.4 28.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
2.3 21.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
2.2 70.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
2.1 40.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.0 36.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
1.4 17.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
1.3 36.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.2 35.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.1 27.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
1.1 16.8 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.1 38.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
1.1 9.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
1.0 21.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
1.0 20.5 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.9 17.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.9 18.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.9 41.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.9 20.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.8 83.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 43.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.8 60.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7 25.3 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.7 10.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.7 31.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.7 14.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.7 34.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.7 6.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.6 11.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.6 114.5 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.6 16.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.6 14.0 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.6 46.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.6 5.0 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.5 66.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 21.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.5 5.6 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.5 4.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.5 36.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5 7.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.5 29.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.5 35.6 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.4 6.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 27.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 6.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.4 47.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 62.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 8.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.4 19.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 11.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 3.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 36.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.3 7.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.3 9.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.3 9.3 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.3 7.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 15.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 5.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 4.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 22.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 4.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 5.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 1.4 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 3.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 8.6 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.2 5.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 3.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 6.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 7.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 6.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 3.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.2 10.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 5.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 13.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 2.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 2.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism