ISMARA results: IRF2_STAT2_IRF8

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 0.23

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol	Gene ID	Gene Info
IRF2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000168310.6	interferon regulatory factor 2
STAT2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000170581.9	signal transducer and activator of transcription 2
IRF8 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140968.6	interferon regulatory factor 8
IRF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000125347.9	interferon regulatory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF1	hg19_v2_chr5_-_131826457_131826514	0.77	3.1e-44	Click!
IRF2	hg19_v2_chr4_-_185395672_185395734	0.72	1.2e-36	Click!
IRF8	hg19_v2_chr16_+_85942594_85942635	0.56	1.6e-19	Click!
STAT2	hg19_v2_chr12_-_56753858_56753930	0.02	8.1e-01	Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_32821924 Show fit	199.84	ENST00000374859.2 ENST00000453265.2	PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr1_+_948803 Show fit	165.30	ENST00000379389.4	ISG15 Ensembl NCBI GeneCards UniProt NextProt Show fit	ISG15 ubiquitin-like modifier
chr16_-_67970990 Show fit	147.63	ENST00000358514.4	PSMB10 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 10
chr11_-_615942 Show fit	126.93	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon regulatory factor 7
chr6_-_33282163 Show fit	109.81	ENST00000434618.2 ENST00000456592.2	TAPBP Ensembl NCBI GeneCards UniProt NextProt Show fit	TAP binding protein (tapasin)
chr21_+_42733870 Show fit	106.90	ENST00000330714.3 ENST00000436410.1 ENST00000435611.1	MX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	myxovirus (influenza virus) resistance 2 (mouse)
chr6_+_32811885 Show fit	105.61	ENST00000458296.1 ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1	TAPSAR1 Ensembl NCBI GeneCards UniProt NextProt Show fit PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32811771 Show fit	104.75	ENST00000395339.3 ENST00000374882.3	PSMB8 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 8
chr19_-_17516449 Show fit	98.27	ENST00000252593.6	BST2 Ensembl NCBI GeneCards UniProt NextProt Show fit	bone marrow stromal cell antigen 2
chr1_+_158979792 Show fit	95.71	ENST00000359709.3 ENST00000430894.2	IFI16 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon, gamma-inducible protein 16

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.4	1007.3	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
5.9	293.4	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
21.6	280.9	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
34.3	274.3	GO:0032020	ISG15-protein conjugation(GO:0032020)
44.8	223.8	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
19.9	219.3	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
15.2	152.2	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.3	140.8	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
42.8	128.5	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
15.2	121.9	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)

Showing 1 to 10 of 345 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
69.7	557.8	GO:1990111	spermatoproteasome complex(GO:1990111)
0.8	338.1	GO:0016607	nuclear speck(GO:0016607)
0.5	232.7	GO:0010008	endosome membrane(GO:0010008)
2.8	205.2	GO:0035577	azurophil granule membrane(GO:0035577)
2.9	202.5	GO:0015030	Cajal body(GO:0015030)
30.6	183.7	GO:0042825	TAP complex(GO:0042825)
0.6	179.4	GO:0031965	nuclear membrane(GO:0031965)
9.6	173.1	GO:0097342	ripoptosome(GO:0097342)
0.4	172.4	GO:0005759	mitochondrial matrix(GO:0005759)
1.3	162.6	GO:0005643	nuclear pore(GO:0005643)

Showing 1 to 10 of 171 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
23.4	703.1	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
9.9	308.3	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
1.8	296.0	GO:0001047	core promoter binding(GO:0001047)
2.4	266.0	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
38.2	228.9	GO:0046979	TAP2 binding(GO:0046979)
0.6	190.8	GO:0003924	GTPase activity(GO:0003924)
13.8	165.3	GO:0031386	protein tag(GO:0031386)
20.9	146.4	GO:0061133	endopeptidase activator activity(GO:0061133)
42.8	128.5	GO:0008859	exoribonuclease II activity(GO:0008859)
11.1	121.9	GO:0017128	phospholipid scramblase activity(GO:0017128)

Showing 1 to 10 of 235 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	270.5	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
2.5	193.5	PID RAC1 PATHWAY	RAC1 signaling pathway
6.0	179.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
2.8	116.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.6	103.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
6.7	94.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
3.4	92.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.2	79.1	PID PLK1 PATHWAY	PLK1 signaling events
1.4	76.9	PID AURORA B PATHWAY	Aurora B signaling
0.9	68.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells

Showing 1 to 10 of 58 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.6	855.2	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
10.1	808.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
5.2	244.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
6.6	235.9	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
17.8	231.9	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
7.0	203.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
17.0	170.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
7.6	143.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.6	114.5	REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	Genes involved in Class I MHC mediated antigen processing & presentation
0.8	83.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 99 entries

Results for IRF2_STAT2_IRF8_IRF1

Z-value: 0.23

Motif logo

Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Activity-expression correlation:

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: