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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for IRF3

Z-value: 0.10

Motif logo

Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50168861_501688730.393.8e-09Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32821924 20.03 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr2_+_127413677 13.73 ENST00000356887.7
glycophorin C (Gerbich blood group)
chr2_+_127413481 13.61 ENST00000259254.4
glycophorin C (Gerbich blood group)
chr2_+_127413704 13.28 ENST00000409836.3
glycophorin C (Gerbich blood group)
chr14_+_24605361 11.80 ENST00000206451.6
ENST00000559123.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_-_10022735 11.78 ENST00000228438.2
C-type lectin domain family 2, member B
chr19_-_17516449 11.61 ENST00000252593.6
bone marrow stromal cell antigen 2
chr2_-_231084820 11.21 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr14_+_24605389 11.11 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr2_-_231084617 10.21 ENST00000409815.2
SP110 nuclear body protein
chr6_-_32821599 10.01 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_615570 9.97 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr6_+_26440700 9.88 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
butyrophilin, subfamily 3, member A3
chr21_+_42792442 9.79 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615942 9.69 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr19_+_10196781 9.62 ENST00000253110.11
chromosome 19 open reading frame 66
chr11_-_57335280 9.17 ENST00000287156.4
ubiquitin-conjugating enzyme E2L 6
chr19_+_18284477 9.12 ENST00000407280.3
interferon, gamma-inducible protein 30
chr1_+_948803 8.83 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr2_-_231084659 8.80 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr16_-_67970990 8.53 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr15_-_62352570 8.52 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr8_-_67525473 8.31 ENST00000522677.3
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr1_+_79115503 7.67 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr4_-_74847800 7.59 ENST00000296029.3
platelet factor 4
chr7_-_138794081 6.99 ENST00000464606.1
zinc finger CCCH-type, antiviral 1
chr3_-_172241250 6.43 ENST00000420541.2
ENST00000241261.2
tumor necrosis factor (ligand) superfamily, member 10
chr6_+_26365443 6.35 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
butyrophilin, subfamily 3, member A2
chr7_-_92747269 6.08 ENST00000446617.1
ENST00000379958.2
sterile alpha motif domain containing 9
chr12_+_113416191 5.90 ENST00000342315.4
ENST00000392583.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr22_+_31892261 5.78 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
Sfi1 homolog, spindle assembly associated (yeast)
chr5_-_95158644 5.72 ENST00000237858.6
glutaredoxin (thioltransferase)
chr19_+_49977466 5.67 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
fms-related tyrosine kinase 3 ligand
chr6_+_26402465 5.60 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr12_+_6561190 5.54 ENST00000544021.1
ENST00000266556.7
TAP binding protein-like
chr3_+_63898275 5.19 ENST00000538065.1
ataxin 7
chr4_-_169239921 4.91 ENST00000514995.1
ENST00000393743.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_138794394 4.64 ENST00000242351.5
ENST00000471652.1
zinc finger CCCH-type, antiviral 1
chr10_+_91087651 4.54 ENST00000371818.4
interferon-induced protein with tetratricopeptide repeats 3
chr2_+_201981527 4.48 ENST00000441224.1
CASP8 and FADD-like apoptosis regulator
chr9_-_95087838 4.33 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
nucleolar protein 8
chr22_-_36556821 4.30 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
apolipoprotein L, 3
chr15_+_45003675 4.21 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
beta-2-microglobulin
chr9_-_95087604 4.16 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
nucleolar protein 8
chr19_+_49977818 4.13 ENST00000594009.1
ENST00000595510.1
fms-related tyrosine kinase 3 ligand
chr15_-_55611306 4.00 ENST00000563262.1
RAB27A, member RAS oncogene family
chr17_+_36861735 3.94 ENST00000378137.5
ENST00000325718.7
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr22_+_31892373 3.94 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
Sfi1 homolog, spindle assembly associated (yeast)
chr14_+_73525144 3.93 ENST00000261973.7
ENST00000540173.1
RNA binding motif protein 25
chr3_+_63897605 3.90 ENST00000487717.1
ataxin 7
chr4_-_87855851 3.84 ENST00000473559.1
chromosome 4 open reading frame 36
chr5_-_96143602 3.84 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
endoplasmic reticulum aminopeptidase 1
chr17_+_25958174 3.78 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr14_+_73525229 3.70 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RNA binding motif protein 25
chr19_+_10196981 3.60 ENST00000591813.1
chromosome 19 open reading frame 66
chr2_+_201980827 3.50 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CASP8 and FADD-like apoptosis regulator
chr5_-_77656175 3.49 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
chr22_+_36649056 3.37 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
apolipoprotein L, 1
chr11_-_4414880 3.27 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr9_-_32526184 3.23 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_-_24615805 3.15 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr5_-_95158375 3.07 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
glutaredoxin (thioltransferase)
chr6_+_26402517 3.01 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr4_+_87928140 2.83 ENST00000307808.6
AF4/FMR2 family, member 1
chr4_+_118955500 2.79 ENST00000296499.5
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr2_-_157198860 2.77 ENST00000409572.1
nuclear receptor subfamily 4, group A, member 2
chr4_+_87856129 2.63 ENST00000395146.4
ENST00000507468.1
AF4/FMR2 family, member 1
chr17_+_6659153 2.61 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr5_-_135701164 2.60 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
transient receptor potential cation channel, subfamily C, member 7
chr6_-_41039567 2.55 ENST00000468811.1
O-acyl-ADP-ribose deacylase 1
chr2_-_163175133 2.50 ENST00000421365.2
ENST00000263642.2
interferon induced with helicase C domain 1
chr4_-_156875003 2.47 ENST00000433477.3
cathepsin O
chr12_-_99288536 2.41 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ankyrin repeat and sterile alpha motif domain containing 1B
chr12_+_133614119 2.39 ENST00000327668.7
zinc finger protein 84
chr1_+_145292806 2.33 ENST00000448873.2
neuroblastoma breakpoint family, member 10
chr17_-_63052929 2.32 ENST00000439174.2
guanine nucleotide binding protein (G protein), alpha 13
chrX_-_109561294 2.31 ENST00000372059.2
ENST00000262844.5
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr11_+_5646213 2.30 ENST00000429814.2
tripartite motif containing 34
chr6_-_32806506 2.29 ENST00000374897.2
ENST00000452392.2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr10_-_14996017 2.28 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DNA cross-link repair 1C
chr9_-_140082983 2.23 ENST00000323927.2
anaphase promoting complex subunit 2
chr1_-_25747283 2.22 ENST00000346452.4
ENST00000340849.4
ENST00000349438.4
ENST00000294413.7
ENST00000413854.1
ENST00000455194.1
ENST00000243186.6
ENST00000425135.1
Rh blood group, CcEe antigens
chr22_+_39436862 2.19 ENST00000381565.2
ENST00000452957.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr17_-_40264692 2.14 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr7_-_32931387 2.03 ENST00000304056.4
kelch repeat and BTB (POZ) domain containing 2
chr9_-_32526299 1.87 ENST00000379882.1
ENST00000379883.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_-_28223166 1.83 ENST00000304658.5
exportin 6
chr12_+_133613878 1.76 ENST00000392319.2
ENST00000543758.1
zinc finger protein 84
chr12_+_133613937 1.71 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
zinc finger protein 84
chr3_+_42190714 1.70 ENST00000449246.1
trafficking protein, kinesin binding 1
chr2_+_201981119 1.63 ENST00000395148.2
CASP8 and FADD-like apoptosis regulator
chr10_-_14996070 1.61 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DNA cross-link repair 1C
chr3_-_53079281 1.57 ENST00000394750.1
Scm-like with four mbt domains 1
chr20_+_388935 1.53 ENST00000382181.2
ENST00000400247.3
RanBP-type and C3HC4-type zinc finger containing 1
chr19_+_50887585 1.48 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
polymerase (DNA directed), delta 1, catalytic subunit
chr14_-_91976794 1.46 ENST00000555462.1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr15_+_55611128 1.37 ENST00000164305.5
ENST00000539642.1
phosphatidylinositol glycan anchor biosynthesis, class B
chr14_+_73525265 1.36 ENST00000525161.1
RNA binding motif protein 25
chr2_-_73869508 1.31 ENST00000272425.3
N-acetyltransferase 8 (GCN5-related, putative)
chrX_-_48937531 1.29 ENST00000473974.1
ENST00000475880.1
ENST00000396681.4
ENST00000553851.1
ENST00000471338.1
ENST00000476728.1
ENST00000376368.2
ENST00000485908.1
ENST00000376372.3
ENST00000376358.3
WD repeat domain 45
WD repeat domain phosphoinositide-interacting protein 4
chr2_+_99771418 1.23 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr12_-_8218997 1.23 ENST00000307637.4
complement component 3a receptor 1
chr4_+_89378261 1.12 ENST00000264350.3
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr6_+_3068606 1.08 ENST00000259808.4
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr20_+_388679 1.02 ENST00000356286.5
ENST00000475269.1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_159046617 1.02 ENST00000368130.4
absent in melanoma 2
chr16_-_11350036 0.99 ENST00000332029.2
suppressor of cytokine signaling 1
chr3_-_160283348 0.99 ENST00000334256.4
karyopherin alpha 4 (importin alpha 3)
chr8_+_145438870 0.93 ENST00000527931.1
family with sequence similarity 203, member B
chr17_+_79373540 0.92 ENST00000307745.7
BAH and coiled-coil domain-containing protein 1
chr1_+_221054584 0.92 ENST00000549319.1
H2.0-like homeobox
chr16_+_58283814 0.91 ENST00000443128.2
ENST00000219299.4
coiled-coil domain containing 113
chr14_-_24615523 0.91 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_+_100495864 0.86 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr6_-_90529418 0.85 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1, midasin homolog (yeast)
chr6_+_31540056 0.81 ENST00000418386.2
lymphotoxin alpha
chr20_+_61436146 0.76 ENST00000290291.6
opioid growth factor receptor
chr5_-_96143796 0.74 ENST00000296754.3
endoplasmic reticulum aminopeptidase 1
chr16_-_29875057 0.73 ENST00000219789.6
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr19_-_47735918 0.72 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BCL2 binding component 3
chr17_-_61517572 0.70 ENST00000582997.1
cytochrome b561
chr1_-_89664595 0.69 ENST00000355754.6
guanylate binding protein 4
chr22_+_36044411 0.69 ENST00000409652.4
apolipoprotein L, 6
chr9_-_100954910 0.68 ENST00000375077.4
coronin, actin binding protein, 2A
chr2_+_113672770 0.66 ENST00000311328.2
interleukin 37
chr1_+_25598989 0.65 ENST00000454452.2
Rh blood group, D antigen
chr1_+_25598872 0.59 ENST00000328664.4
Rh blood group, D antigen
chr15_-_88799948 0.57 ENST00000394480.2
neurotrophic tyrosine kinase, receptor, type 3
chr16_-_29874462 0.56 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr19_+_50432400 0.46 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
activating transcription factor 5
chr12_-_48963829 0.45 ENST00000301046.2
ENST00000549817.1
lactalbumin, alpha-
chr9_+_140083099 0.45 ENST00000322310.5
Sjogren syndrome nuclear autoantigen 1
chr11_+_124735282 0.44 ENST00000397801.1
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr6_-_30181133 0.41 ENST00000454678.2
ENST00000434785.1
tripartite motif containing 26
chr2_+_69240302 0.40 ENST00000303714.4
anthrax toxin receptor 1
chr2_+_69240415 0.40 ENST00000409829.3
anthrax toxin receptor 1
chr11_+_66008698 0.39 ENST00000531597.1
phosphofurin acidic cluster sorting protein 1
chr6_-_30181156 0.31 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
tripartite motif containing 26
chr8_+_22446763 0.28 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
Uncharacterized protein
chr1_-_154580616 0.23 ENST00000368474.4
adenosine deaminase, RNA-specific
chr3_+_187086120 0.22 ENST00000259030.2
receptor (chemosensory) transporter protein 4
chr1_+_76190357 0.22 ENST00000370834.5
ENST00000541113.1
ENST00000543667.1
ENST00000420607.2
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr14_-_20881579 0.20 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
telomerase-associated protein 1
chr7_+_134832808 0.18 ENST00000275767.3
transmembrane protein 140
chr12_-_322821 0.16 ENST00000359674.4
solute carrier family 6 (neurotransmitter transporter), member 12
chrX_+_119384607 0.16 ENST00000326624.2
ENST00000557385.1
zinc finger and BTB domain containing 33
chr1_+_25599018 0.12 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
Rh blood group, D antigen
chr6_-_27840099 0.10 ENST00000328488.2
histone cluster 1, H3i
chrX_+_154610428 0.02 ENST00000354514.4
H2A histone family, member B2

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 19.7 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
3.9 11.6 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
3.3 9.8 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
2.8 8.5 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
2.7 10.9 GO:0046967 cytosol to ER transport(GO:0046967)
2.4 19.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
2.1 4.2 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.9 7.6 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.8 7.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.5 7.6 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.3 3.8 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.1 8.5 GO:1902570 protein localization to nucleolus(GO:1902570)
0.9 2.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.9 9.8 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.9 8.8 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.8 5.9 GO:0018377 protein myristoylation(GO:0018377)
0.8 5.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.8 9.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.8 3.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.8 2.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.8 4.6 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.7 40.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.7 4.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.6 15.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.6 5.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.6 55.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.5 1.6 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.5 8.8 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.4 2.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.4 1.1 GO:0032242 regulation of nucleoside transport(GO:0032242)
0.3 6.4 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.3 2.8 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.3 0.8 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3 2.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 0.8 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.3 2.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.3 2.8 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 1.5 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 2.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 0.6 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2 1.7 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.2 0.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.4 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 1.0 GO:0070269 pyroptosis(GO:0070269)
0.1 0.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 2.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 5.0 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 1.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 2.6 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.2 GO:0009249 protein lipoylation(GO:0009249)
0.1 9.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 3.6 GO:0015695 organic cation transport(GO:0015695)
0.1 7.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.2 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.1 0.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 7.9 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 1.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 2.6 GO:0035456 response to interferon-beta(GO:0035456)
0.1 0.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 1.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 2.7 GO:0019835 cytolysis(GO:0019835)
0.1 0.7 GO:0022900 electron transport chain(GO:0022900)
0.1 0.4 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 1.0 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.8 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.3 GO:0070206 protein trimerization(GO:0070206)
0.0 1.0 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 1.8 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.6 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 1.3 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 3.2 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.4 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 27.0 GO:0008537 proteasome activator complex(GO:0008537)
3.6 28.6 GO:1990111 spermatoproteasome complex(GO:1990111)
2.5 7.6 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
1.8 10.9 GO:0042825 TAP complex(GO:0042825)
0.8 4.2 GO:0031905 early endosome lumen(GO:0031905)
0.7 2.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.5 9.9 GO:0097342 ripoptosome(GO:0097342)
0.4 2.2 GO:0071797 LUBAC complex(GO:0071797)
0.4 9.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.4 1.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 4.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 40.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 3.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 1.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 11.6 GO:0005771 multivesicular body(GO:0005771)
0.1 1.0 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 5.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 9.7 GO:0005814 centriole(GO:0005814)
0.1 9.1 GO:0043202 lysosomal lumen(GO:0043202)
0.1 2.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 7.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 8.9 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 5.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 5.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0031527 lamellipodium membrane(GO:0031258) filopodium membrane(GO:0031527)
0.0 1.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 9.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.4 GO:0031968 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 0.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 1.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.0 1.8 GO:0005769 early endosome(GO:0005769)
0.0 9.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.9 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 27.0 GO:0061133 endopeptidase activator activity(GO:0061133)
1.7 10.3 GO:0042296 ISG15 transferase activity(GO:0042296)
1.7 10.0 GO:0046979 TAP2 binding(GO:0046979)
1.5 7.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.3 3.8 GO:0048030 disaccharide binding(GO:0048030)
1.1 4.6 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
1.0 28.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 8.8 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.7 8.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.7 8.8 GO:0031386 protein tag(GO:0031386)
0.5 3.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.5 2.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 11.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 2.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 0.9 GO:0046977 TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.3 1.0 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.3 1.4 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.3 9.9 GO:0005123 death receptor binding(GO:0005123)
0.3 1.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.3 1.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 5.0 GO:0070403 NAD+ binding(GO:0070403)
0.2 22.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 2.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 7.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 9.1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.2 0.7 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.2 4.0 GO:0031489 myosin V binding(GO:0031489)
0.1 1.5 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 2.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 9.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.4 GO:0004461 lactose synthase activity(GO:0004461)
0.1 3.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 13.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 1.2 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.1 6.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 2.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.8 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 32.7 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 11.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 5.2 GO:0005319 lipid transporter activity(GO:0005319)
0.0 9.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 9.8 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.0 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 5.2 GO:0019902 phosphatase binding(GO:0019902)
0.0 2.7 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 1.5 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 25.7 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 4.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 7.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 19.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 10.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 15.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 5.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 8.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 19.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.8 7.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.8 55.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.6 16.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.5 11.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.5 7.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 19.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 8.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.2 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 4.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 2.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 4.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 10.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.2 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 1.5 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 2.3 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 2.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 1.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling