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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for IRF7
Z-value: 0.49
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Transcription factors associated with IRF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF7 | hg19_v2_chr11_-_615570_615728 | -0.29 | 1.2e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 48.2 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 2.3 | 38.4 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.6 | 35.0 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.2 | 33.2 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 1.6 | 32.4 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.1 | 32.3 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.3 | 29.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 1.1 | 25.4 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.9 | 22.8 | GO:0030220 | platelet formation(GO:0030220) |
| 2.2 | 22.0 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 39.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.9 | 38.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.4 | 35.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 2.1 | 25.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.7 | 25.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 24.4 | GO:0005770 | late endosome(GO:0005770) |
| 1.5 | 22.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 1.5 | 16.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.8 | 16.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.2 | 16.4 | GO:0072686 | mitotic spindle(GO:0072686) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 74.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 3.4 | 40.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.7 | 32.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 2.3 | 32.7 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.7 | 32.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 2.7 | 27.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 25.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.8 | 19.2 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 18.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.8 | 18.6 | GO:0000339 | RNA cap binding(GO:0000339) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 104.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.9 | 59.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 27.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.4 | 20.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 20.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.8 | 18.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 14.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.3 | 12.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 12.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 11.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 65.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.5 | 43.5 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.8 | 43.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.1 | 36.5 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.4 | 27.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 24.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.8 | 22.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 20.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.8 | 18.9 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.6 | 18.1 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |