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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for IRF9
Z-value: 0.27
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Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 0.45 | 5.0e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 72.8 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 4.4 | 48.1 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 2.2 | 17.5 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 3.3 | 16.6 | GO:2000110 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.2 | 14.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 3.5 | 13.9 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 13.1 | GO:0009615 | response to virus(GO:0009615) |
| 1.6 | 12.8 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.2 | 11.9 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.9 | 8.4 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 39.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 39.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 34.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 31.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 23.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 22.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 16.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.1 | 12.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.1 | 7.9 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.1 | 7.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 50.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 48.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.2 | 43.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.2 | 23.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 18.9 | GO:0005525 | GTP binding(GO:0005525) |
| 1.6 | 17.5 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.8 | 14.0 | GO:0019864 | IgG binding(GO:0019864) |
| 1.4 | 8.6 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.1 | 8.4 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.3 | 8.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 11.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.7 | 9.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 8.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 7.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 5.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.0 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 4.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 2.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 129.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.7 | 33.1 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 2.4 | 9.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 8.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 6.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 6.4 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 5.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 4.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 2.2 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |