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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for IRF9

Z-value: 0.27

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.455.0e-12Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_42798094 24.23 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42733870 23.83 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_+_113344755 14.22 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_79115503 10.21 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr1_+_79086088 9.85 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr12_+_113344582 9.71 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr8_-_27941380 9.00 ENST00000413272.2
ENST00000341513.6
NUGGC
nuclear GTPase, germinal center associated
chr9_-_32526184 8.73 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_-_615570 8.63 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr6_+_6588902 8.41 ENST00000230568.4
LY86
lymphocyte antigen 86
chr3_-_121379739 8.35 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_-_17516449 7.98 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr11_-_615942 7.98 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr1_-_150738261 7.86 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr1_+_158979792 7.70 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr12_+_113344811 7.61 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_-_121477039 7.50 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr14_+_24630465 7.42 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr1_+_158979680 7.19 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr17_+_6659153 7.17 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr13_+_50070491 7.04 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr1_+_158979686 6.97 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr3_-_122283100 6.81 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr2_-_55920952 6.67 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr13_+_50070077 6.55 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr12_-_121476959 5.90 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr11_-_57335280 5.76 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr10_+_91092241 5.06 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_161600990 5.06 ENST00000531221.1
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr4_-_76944621 5.03 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_-_161600942 4.87 ENST00000421702.2
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr6_-_31324943 4.55 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr3_-_146262428 4.54 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr14_+_94577074 4.39 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr6_-_24936170 4.28 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr1_+_948803 4.21 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr5_-_95297534 4.20 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr1_-_161600822 4.11 ENST00000534776.1
ENST00000540048.1
FCGR3B
FCGR3A
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr2_-_152146385 4.11 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr9_-_32526299 3.91 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chrX_+_37639264 3.72 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr5_-_95297678 3.66 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr3_-_146262352 3.65 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr12_+_113376157 3.60 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_-_163175133 3.36 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr4_-_169239921 3.31 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chrX_+_37639302 3.01 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr4_+_89378261 2.82 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr13_-_46961580 2.80 ENST00000378787.3
ENST00000378797.2
ENST00000429979.1
ENST00000378781.3
KIAA0226L
KIAA0226-like
chr11_+_5646213 2.75 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr18_+_42260861 2.73 ENST00000282030.5
SETBP1
SET binding protein 1
chr16_-_15736881 2.71 ENST00000540441.2
KIAA0430
KIAA0430
chr3_-_146262637 2.56 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr3_-_146262365 2.54 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr3_+_151986709 2.53 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
MBNL1
muscleblind-like splicing regulator 1
chr11_-_4414880 2.32 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr3_-_146262488 2.27 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr15_+_91643442 2.22 ENST00000394232.1
SV2B
synaptic vesicle glycoprotein 2B
chr17_-_40264692 2.22 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr19_+_10196981 2.21 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr1_+_162602244 2.18 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chr6_+_106546808 2.07 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr10_+_91174314 2.03 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr3_-_146262293 1.94 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr15_+_45003675 1.86 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr2_+_7017796 1.85 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr12_-_56753858 1.85 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr1_+_154377669 1.79 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr16_+_28962128 1.45 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr5_-_142783694 1.44 ENST00000394466.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr16_+_28875126 1.30 ENST00000359285.5
ENST00000538342.1
SH2B1
SH2B adaptor protein 1
chr20_-_56195525 1.25 ENST00000371173.3
ENST00000395822.3
ENST00000340462.4
ENST00000343535.4
ZBP1
Z-DNA binding protein 1
chr10_-_91174215 1.25 ENST00000371837.1
LIPA
lipase A, lysosomal acid, cholesterol esterase
chr22_+_40297105 1.24 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr3_-_142166904 1.16 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr12_-_121476750 1.12 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr12_+_113376249 1.06 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr22_+_40297079 1.05 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr10_+_91061712 1.04 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_82462425 0.89 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr1_+_241695424 0.89 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_241695670 0.89 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_-_32806506 0.83 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr20_+_61436146 0.81 ENST00000290291.6
OGFR
opioid growth factor receptor
chr6_+_72922505 0.74 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_126240442 0.71 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr6_+_72922590 0.68 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_10222189 0.67 ENST00000321826.4
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr17_-_4167142 0.66 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr17_-_54991369 0.61 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr17_+_38296576 0.58 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr14_+_100531615 0.54 ENST00000392920.3
EVL
Enah/Vasp-like
chr2_-_152118352 0.44 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr19_+_17516494 0.39 ENST00000534306.1
CTD-2521M24.9
CTD-2521M24.9
chrX_-_48858667 0.34 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr7_+_134832808 0.33 ENST00000275767.3
TMEM140
transmembrane protein 140
chr9_+_102668915 0.31 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr9_+_70971815 0.28 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr18_-_67624160 0.28 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr15_-_26108355 0.27 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr11_-_67141090 0.20 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr5_-_142783175 0.20 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr1_-_207119738 0.11 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr3_-_28390581 0.07 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr17_+_41363854 0.07 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr9_-_33264676 0.07 ENST00000472232.3
ENST00000379704.2
BAG1
BCL2-associated athanogene
chrX_+_22056165 0.05 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr9_-_33264557 0.04 ENST00000473781.1
ENST00000488499.1
BAG1
BCL2-associated athanogene
chr5_-_59481406 0.03 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_17516531 0.02 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
CTD-2521M24.9

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 48.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
3.5 13.9 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
3.3 16.6 GO:2000110 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
2.7 8.0 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
2.2 6.7 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965) rRNA import into mitochondrion(GO:0035928)
2.2 17.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
1.6 12.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.4 5.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.4 4.1 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
1.3 6.7 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.1 6.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.0 5.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
1.0 72.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.9 8.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.6 6.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.6 1.8 GO:0002384 hepatic immune response(GO:0002384)
0.6 2.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.5 8.4 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.5 6.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.4 2.1 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.4 1.2 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.4 1.8 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 7.2 GO:0035456 response to interferon-beta(GO:0035456)
0.3 7.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 1.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 11.9 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 14.0 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 2.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 0.7 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.1 0.3 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 0.3 GO:0060369 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 7.9 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.4 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 0.1 GO:0032607 interferon-alpha production(GO:0032607)
0.1 0.3 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.3 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.8 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 2.8 GO:0070206 protein trimerization(GO:0070206)
0.1 0.7 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.6 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.5 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.3 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 13.1 GO:0009615 response to virus(GO:0009615)
0.0 1.3 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 2.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 2.5 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0002415 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 1.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.9 GO:0036021 endolysosome lumen(GO:0036021)
0.6 6.7 GO:0042788 polysomal ribosome(GO:0042788)
0.6 6.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 1.8 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 6.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 23.6 GO:0005643 nuclear pore(GO:0005643)
0.2 2.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 7.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 22.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.7 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 34.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 12.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 31.2 GO:0016607 nuclear speck(GO:0016607)
0.0 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 16.4 GO:0045121 membrane raft(GO:0045121)
0.0 0.3 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 3.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.9 GO:0005811 lipid particle(GO:0005811)
0.0 39.5 GO:0005739 mitochondrion(GO:0005739)
0.0 3.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.3 GO:0001650 fibrillar center(GO:0001650)
0.0 2.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 4.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 39.5 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 50.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.6 17.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.4 8.6 GO:0042296 ISG15 transferase activity(GO:0042296)
1.3 6.7 GO:0034046 poly(G) binding(GO:0034046)
1.0 5.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.8 2.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.8 14.0 GO:0019864 IgG binding(GO:0019864)
0.6 1.8 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.5 5.7 GO:0031386 protein tag(GO:0031386)
0.4 2.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 6.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.6 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 8.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 7.9 GO:0001968 fibronectin binding(GO:0001968)
0.3 1.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.3 1.3 GO:0004771 sterol esterase activity(GO:0004771)
0.2 6.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 23.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 1.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 48.1 GO:0008017 microtubule binding(GO:0008017)
0.2 43.7 GO:0001047 core promoter binding(GO:0001047)
0.2 0.6 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.2 4.4 GO:0005521 lamin binding(GO:0005521)
0.1 0.3 GO:0046977 peptide antigen-transporting ATPase activity(GO:0015433) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 2.9 GO:0042605 peptide antigen binding(GO:0042605)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.8 GO:0004985 opioid receptor activity(GO:0004985)
0.1 8.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 18.9 GO:0005525 GTP binding(GO:0005525)
0.0 1.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 5.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 11.5 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 18.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 6.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 5.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 4.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.9 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 7.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.7 33.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.5 129.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.3 1.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.2 8.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 1.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 6.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 5.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 4.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.2 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 6.4 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC