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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for IRX6_IRX4
Z-value: 0.06
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Transcription factors associated with IRX6_IRX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX4 | hg19_v2_chr5_-_1882858_1883003 | 0.08 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX6_IRX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.8 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.7 | 6.4 | GO:2001015 | negative regulation of skeletal muscle cell differentiation(GO:2001015) |
| 0.3 | 4.5 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.1 | 3.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 1.7 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.3 | 1.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.2 | 1.3 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.1 | 1.3 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.3 | 1.2 | GO:0038155 | interleukin-23-mediated signaling pathway(GO:0038155) |
| 0.0 | 1.2 | GO:0046847 | filopodium assembly(GO:0046847) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | GO:0001726 | ruffle(GO:0001726) |
| 0.3 | 6.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.3 | 4.5 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.6 | 3.1 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.0 | 1.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 1.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.3 | 1.2 | GO:0072536 | interleukin-23 receptor complex(GO:0072536) |
| 0.0 | 1.1 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 1.0 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.9 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.3 | 6.4 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 4.5 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.3 | 3.1 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 1.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 1.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 1.3 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 1.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.3 | 1.2 | GO:0042020 | interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020) |
| 0.0 | 1.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.4 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 3.1 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 1.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.0 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.8 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |