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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ISL1

Z-value: 0.18

Motif logo

Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ENSG00000016082.10 ISL LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_50678921-0.082.5e-01Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_175711133 36.26 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr4_-_176923483 18.37 ENST00000280187.7
ENST00000512509.1
glycoprotein M6A
chr12_-_50290839 15.57 ENST00000552863.1
Fas apoptotic inhibitory molecule 2
chr4_-_186877806 13.06 ENST00000355634.5
sorbin and SH3 domain containing 2
chr14_-_60337684 12.33 ENST00000267484.5
reticulon 1
chr8_+_26371763 12.28 ENST00000521913.1
dihydropyrimidinase-like 2
chr1_-_95391315 11.81 ENST00000545882.1
ENST00000415017.1
calponin 3, acidic
chr2_-_224467093 11.22 ENST00000305409.2
secretogranin II
chrX_-_92928557 11.14 ENST00000373079.3
ENST00000475430.2
nucleosome assembly protein 1-like 3
chr5_+_140772381 10.45 ENST00000398604.2
protocadherin gamma subfamily A, 8
chr3_+_158787041 10.38 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1 readthrough
chr4_-_186877502 10.26 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
sorbin and SH3 domain containing 2
chr18_-_21977748 10.01 ENST00000399441.4
ENST00000319481.3
oxysterol binding protein-like 1A
chr6_-_116575226 9.89 ENST00000420283.1
TSPY-like 4
chrX_+_55478538 9.79 ENST00000342972.1
melanoma antigen family H, 1
chr1_-_156217875 9.03 ENST00000292291.5
progestin and adipoQ receptor family member VI
chr3_+_35721106 8.82 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
cAMP-regulated phosphoprotein, 21kDa
chr1_-_156217822 8.22 ENST00000368270.1
progestin and adipoQ receptor family member VI
chr18_-_5544241 7.75 ENST00000341928.2
ENST00000540638.2
erythrocyte membrane protein band 4.1-like 3
chr8_-_101571964 6.93 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ankyrin repeat domain 46
chr8_+_21911054 6.92 ENST00000519850.1
ENST00000381470.3
dematin actin binding protein
chr9_-_113761720 6.39 ENST00000541779.1
ENST00000374430.2
lysophosphatidic acid receptor 1
chrX_+_135252050 5.98 ENST00000449474.1
ENST00000345434.3
four and a half LIM domains 1
chrX_+_135251783 5.89 ENST00000394153.2
four and a half LIM domains 1
chrX_-_102941596 5.81 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
mortality factor 4 like 2
chr9_+_103947311 5.76 ENST00000395056.2
Lipid phosphate phosphatase-related protein type 1
chr11_-_134281812 5.52 ENST00000392580.1
ENST00000312527.4
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr8_-_101571933 5.41 ENST00000520311.1
ankyrin repeat domain 46
chr4_-_87281196 5.39 ENST00000359221.3
mitogen-activated protein kinase 10
chr12_-_30887948 5.01 ENST00000433722.2
caprin family member 2
chr5_+_140248518 4.97 ENST00000398640.2
protocadherin alpha 11
chr4_-_87281224 4.96 ENST00000395169.3
ENST00000395161.2
mitogen-activated protein kinase 10
chr4_+_169418195 4.95 ENST00000261509.6
ENST00000335742.7
palladin, cytoskeletal associated protein
chr5_-_138210977 4.74 ENST00000274711.6
ENST00000521094.2
leucine rich repeat transmembrane neuronal 2
chr4_+_113970772 4.61 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr2_+_166152283 4.49 ENST00000375427.2
sodium channel, voltage-gated, type II, alpha subunit
chr2_+_172543919 4.47 ENST00000452242.1
ENST00000340296.4
dynein, cytoplasmic 1, intermediate chain 2
chrX_-_23926004 4.37 ENST00000379226.4
ENST00000379220.3
apolipoprotein O
chr3_-_33686743 4.24 ENST00000333778.6
ENST00000539981.1
cytoplasmic linker associated protein 2
chr8_-_19540266 4.24 ENST00000311540.4
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr8_-_19540086 4.21 ENST00000332246.6
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr7_+_16793160 3.98 ENST00000262067.4
tetraspanin 13
chr5_-_142782862 3.71 ENST00000415690.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr18_+_72167096 3.67 ENST00000324301.8
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr18_-_53177984 3.62 ENST00000543082.1
transcription factor 4
chr18_-_52989217 3.49 ENST00000570287.2
transcription factor 4
chr7_-_31380502 3.43 ENST00000297142.3
neuronal differentiation 6
chr5_+_137203465 3.21 ENST00000239926.4
myotilin
chrX_+_135251835 3.21 ENST00000456445.1
four and a half LIM domains 1
chr14_+_20811766 3.12 ENST00000250416.5
ENST00000527915.1
poly (ADP-ribose) polymerase 2
chr5_+_140593509 3.03 ENST00000341948.4
protocadherin beta 13
chr10_+_123923205 3.00 ENST00000369004.3
ENST00000260733.3
transforming, acidic coiled-coil containing protein 2
chr10_-_62332357 3.00 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr5_-_94417339 2.88 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
multiple C2 domains, transmembrane 1
chr18_-_52989525 2.86 ENST00000457482.3
transcription factor 4
chr5_+_137203557 2.69 ENST00000515645.1
myotilin
chr5_+_32788945 2.66 ENST00000326958.1
AC026703.1
chr18_+_46065393 2.65 ENST00000256413.3
CBP80/20-dependent translation initiation factor
chr7_+_90338712 2.48 ENST00000265741.3
ENST00000406263.1
cyclin-dependent kinase 14
chr4_+_4861385 2.48 ENST00000382723.4
msh homeobox 1
chr7_+_129932974 2.45 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
carboxypeptidase A4
chr3_-_149095652 2.43 ENST00000305366.3
transmembrane 4 L six family member 1
chr20_+_61448376 2.36 ENST00000343916.3
collagen, type IX, alpha 3
chr3_-_192445289 2.24 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
fibroblast growth factor 12
chr11_-_102668879 2.21 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr6_+_167704798 2.02 ENST00000230256.3
unc-93 homolog A (C. elegans)
chr16_+_2198604 2.00 ENST00000210187.6
RAB26, member RAS oncogene family
chr15_+_65822756 1.99 ENST00000562901.1
ENST00000261875.5
ENST00000442729.2
ENST00000565299.1
ENST00000568793.1
protein tyrosine phosphatase-like A domain containing 1
chr1_-_160254913 1.97 ENST00000440949.3
ENST00000368072.5
ENST00000608310.1
ENST00000556710.1
peroxisomal biogenesis factor 19
DDB1 and CUL4 associated factor 8
DDB1- and CUL4-associated factor 8
chr5_+_137203541 1.93 ENST00000421631.2
myotilin
chr12_+_14572070 1.89 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
activating transcription factor 7 interacting protein
chr19_-_50143452 1.88 ENST00000246792.3
related RAS viral (r-ras) oncogene homolog
chr22_+_40390930 1.84 ENST00000333407.6
family with sequence similarity 83, member F
chr11_-_18258342 1.81 ENST00000278222.4
serum amyloid A4, constitutive
chr6_+_167704838 1.77 ENST00000366829.2
unc-93 homolog A (C. elegans)
chr10_+_135340859 1.76 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr12_-_57037284 1.72 ENST00000551570.1
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_+_179322481 1.71 ENST00000259037.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr1_+_82266053 1.64 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr15_+_59279851 1.59 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
ring finger protein 111
chr17_-_15501932 1.57 ENST00000583965.1
CMT1A duplicated region transcript 1
chr10_-_95241951 1.54 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
myoferlin
chr12_-_53012343 1.48 ENST00000305748.3
keratin 73
chr19_-_17488143 1.48 ENST00000599426.1
ENST00000252590.4
plasmalemma vesicle associated protein
chr11_+_22688150 1.46 ENST00000454584.2
growth arrest-specific 2
chr2_+_28618532 1.46 ENST00000545753.1
FOS-like antigen 2
chr17_-_64225508 1.44 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr6_+_36853607 1.40 ENST00000480824.2
ENST00000355190.3
ENST00000373685.1
chromosome 6 open reading frame 89
chr10_-_95242044 1.40 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
myoferlin
chr20_+_60174827 1.35 ENST00000543233.1
cadherin 4, type 1, R-cadherin (retinal)
chr1_+_100598691 1.32 ENST00000370143.1
ENST00000370141.2
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr6_-_11779014 1.31 ENST00000229583.5
androgen-dependent TFPI-regulating protein
chr1_+_206972215 1.29 ENST00000340758.2
interleukin 19
chr17_+_66521936 1.29 ENST00000592800.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr3_+_157154578 1.27 ENST00000295927.3
pentraxin 3, long
chr11_-_62783276 1.25 ENST00000535878.1
ENST00000545207.1
solute carrier family 22 (organic anion transporter), member 8
chr11_-_62783303 1.23 ENST00000336232.2
ENST00000430500.2
solute carrier family 22 (organic anion transporter), member 8
chr1_+_35734562 1.19 ENST00000314607.6
ENST00000373297.2
zinc finger, MYM-type 4
chr16_+_3493611 1.15 ENST00000407558.4
ENST00000572169.1
ENST00000572757.1
ENST00000573593.1
ENST00000570372.1
ENST00000424546.2
ENST00000575733.1
ENST00000573201.1
ENST00000574950.1
ENST00000573580.1
ENST00000608722.1
N(alpha)-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60
chrY_-_6740649 1.11 ENST00000383036.1
ENST00000383037.4
amelogenin, Y-linked
chr2_+_171034646 1.09 ENST00000409044.3
ENST00000408978.4
myosin IIIB
chr12_-_10251603 1.03 ENST00000457018.2
C-type lectin domain family 1, member A
chr3_-_119276575 1.02 ENST00000383669.3
ENST00000383668.3
CD80 molecule
chr7_-_107880508 0.95 ENST00000425651.2
neuronal cell adhesion molecule
chr1_-_8000872 0.91 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr21_-_47575481 0.89 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
formimidoyltransferase cyclodeaminase
chr2_-_214016314 0.85 ENST00000434687.1
ENST00000374319.4
IKAROS family zinc finger 2 (Helios)
chr6_-_111136513 0.85 ENST00000368911.3
cyclin-dependent kinase 19
chr4_+_169418255 0.85 ENST00000505667.1
ENST00000511948.1
palladin, cytoskeletal associated protein
chr12_-_10251576 0.83 ENST00000315330.4
C-type lectin domain family 1, member A
chr22_-_43355858 0.83 ENST00000402229.1
ENST00000407585.1
ENST00000453079.1
protein kinase C and casein kinase substrate in neurons 2
chr1_-_79472365 0.82 ENST00000370742.3
EGF, latrophilin and seven transmembrane domain containing 1
chr3_-_138312971 0.81 ENST00000485115.1
ENST00000484888.1
ENST00000468900.1
ENST00000542237.1
ENST00000481834.1
centrosomal protein 70kDa
chr16_+_47496023 0.79 ENST00000567200.1
phosphorylase kinase, beta
chr6_+_31515337 0.75 ENST00000376148.4
ENST00000376145.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr10_-_17659357 0.74 ENST00000326961.6
ENST00000361271.3
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr9_+_2029019 0.73 ENST00000382194.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_211421262 0.72 ENST00000233072.5
carbamoyl-phosphate synthase 1, mitochondrial
chr3_+_148508845 0.71 ENST00000491148.1
carboxypeptidase B1 (tissue)
chr9_+_27109133 0.70 ENST00000519097.1
ENST00000380036.4
TEK tyrosine kinase, endothelial
chr12_-_10251539 0.69 ENST00000420265.2
C-type lectin domain family 1, member A
chr10_-_115613828 0.66 ENST00000361384.2
DNA cross-link repair 1A
chr2_-_217560248 0.66 ENST00000233813.4
insulin-like growth factor binding protein 5
chr17_-_47045949 0.61 ENST00000357424.2
gastric inhibitory polypeptide
chr5_+_32710736 0.61 ENST00000415685.2
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_+_234216454 0.61 ENST00000447536.1
ENST00000409110.1
S-antigen; retina and pineal gland (arrestin)
chr8_+_119294456 0.60 ENST00000366457.2
Uncharacterized protein
chr21_-_34185989 0.56 ENST00000487113.1
ENST00000382373.4
chromosome 21 open reading frame 62
chr10_-_116444371 0.55 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr12_-_121454148 0.50 ENST00000535367.1
ENST00000538296.1
ENST00000445832.3
ENST00000536407.2
ENST00000366211.2
ENST00000539736.1
ENST00000288757.3
ENST00000537817.1
chromosome 12 open reading frame 43
chr5_+_34757309 0.49 ENST00000397449.1
retinoic acid induced 14
chr8_+_70404996 0.47 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr21_-_34186006 0.45 ENST00000490358.1
chromosome 21 open reading frame 62
chr18_+_55018044 0.45 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_+_79086088 0.44 ENST00000370751.5
ENST00000342282.3
interferon-induced protein 44-like
chr14_-_92198403 0.43 ENST00000553329.1
ENST00000256343.3
catsper channel auxiliary subunit beta
chr21_-_42219065 0.42 ENST00000400454.1
Down syndrome cell adhesion molecule
chrX_+_65382433 0.38 ENST00000374727.3
hephaestin
chr7_-_44580861 0.36 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1-like 1
chr1_+_221054584 0.36 ENST00000549319.1
H2.0-like homeobox
chr18_-_13915530 0.36 ENST00000327606.3
melanocortin 2 receptor (adrenocorticotropic hormone)
chr11_-_66496430 0.35 ENST00000533211.1
spectrin, beta, non-erythrocytic 2
chr1_+_197170592 0.30 ENST00000535699.1
crumbs homolog 1 (Drosophila)
chr9_+_131084815 0.28 ENST00000300452.3
ENST00000609948.1
coenzyme Q4
chr2_-_55920952 0.27 ENST00000447944.2
polyribonucleotide nucleotidyltransferase 1
chrX_-_100129128 0.27 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NADPH oxidase 1
chr16_-_23464459 0.26 ENST00000307149.5
component of oligomeric golgi complex 7
chr17_-_2996290 0.26 ENST00000331459.1
olfactory receptor, family 1, subfamily D, member 2
chr12_-_102591604 0.26 ENST00000329406.4
pro-melanin-concentrating hormone
chr1_-_93257951 0.25 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
ecotropic viral integration site 5
chr12_-_28124903 0.23 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
parathyroid hormone-like hormone
chr8_-_25281747 0.23 ENST00000421054.2
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr1_+_197382957 0.21 ENST00000367397.1
crumbs homolog 1 (Drosophila)
chr3_+_38307293 0.21 ENST00000311856.4
solute carrier family 22 (organic anion/urate transporter), member 13
chr22_-_31885727 0.18 ENST00000330125.5
ENST00000344710.5
ENST00000397518.1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr11_+_30252549 0.16 ENST00000254122.3
ENST00000417547.1
follicle stimulating hormone, beta polypeptide
chr18_+_46065483 0.14 ENST00000382998.4
CBP80/20-dependent translation initiation factor
chr11_+_60995849 0.14 ENST00000537932.1
pepsinogen 4, group I (pepsinogen A)
chr3_+_119501557 0.13 ENST00000337940.4
nuclear receptor subfamily 1, group I, member 2
chr6_+_168418553 0.12 ENST00000354419.2
ENST00000351261.3
kinesin family member 25
chr13_-_108870623 0.12 ENST00000405925.1
ligase IV, DNA, ATP-dependent
chr12_-_52761262 0.11 ENST00000257901.3
keratin 85
chr3_-_167191814 0.09 ENST00000466903.1
ENST00000264677.4
serpin peptidase inhibitor, clade I (pancpin), member 2
chrX_-_30327495 0.06 ENST00000453287.1
nuclear receptor subfamily 0, group B, member 1
chr22_-_32651326 0.06 ENST00000266086.4
solute carrier family 5 (glucose activated ion channel), member 4
chr2_+_170366203 0.03 ENST00000284669.1
kelch-like family member 41
chr8_-_59412717 0.03 ENST00000301645.3
cytochrome P450, family 7, subfamily A, polypeptide 1
chrX_-_100129320 0.02 ENST00000372966.3
NADPH oxidase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
1.6 6.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.5 4.6 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.3 10.3 GO:0007258 JUN phosphorylation(GO:0007258)
1.2 6.9 GO:0070560 protein secretion by platelet(GO:0070560)
1.1 7.8 GO:0002175 protein localization to paranode region of axon(GO:0002175)
1.1 36.3 GO:0008045 motor neuron axon guidance(GO:0008045)
1.0 3.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
1.0 15.6 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.8 2.5 GO:0090427 activation of meiosis(GO:0090427)
0.7 3.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.7 11.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.7 23.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 4.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 11.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.5 3.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.5 18.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.4 4.5 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 4.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.4 1.8 GO:0010193 response to ozone(GO:0010193)
0.3 4.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.3 0.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.3 0.9 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.3 6.1 GO:0003334 keratinocyte development(GO:0003334)
0.3 2.2 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.3 2.9 GO:0001778 plasma membrane repair(GO:0001778)
0.3 1.3 GO:0044793 negative regulation by host of viral process(GO:0044793) negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.2 1.4 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.2 15.1 GO:1901016 regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.2 0.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 10.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.2 1.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 5.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 1.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 1.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 2.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.2 1.4 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.2 0.3 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.2 3.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 5.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 21.0 GO:0006334 nucleosome assembly(GO:0006334)
0.2 5.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 0.9 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.1 1.0 GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1 0.7 GO:0034201 response to oleic acid(GO:0034201)
0.1 14.1 GO:0030516 regulation of axon extension(GO:0030516)
0.1 0.8 GO:0070836 caveola assembly(GO:0070836)
0.1 4.4 GO:0042407 cristae formation(GO:0042407)
0.1 18.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.6 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 2.5 GO:0021542 dentate gyrus development(GO:0021542)
0.1 0.3 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965) rRNA import into mitochondrion(GO:0035928)
0.1 1.3 GO:2000480 negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.3 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.1 11.9 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.1 1.5 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.1 0.2 GO:1990637 response to prolactin(GO:1990637)
0.1 0.3 GO:0045726 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.5 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.1 2.2 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 2.0 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 1.7 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.1 GO:0034505 tooth mineralization(GO:0034505)
0.1 15.0 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.1 0.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 8.8 GO:0034605 cellular response to heat(GO:0034605)
0.1 2.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.0 1.8 GO:0050918 positive chemotaxis(GO:0050918)
0.0 4.0 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.0 2.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 3.0 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 2.9 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 2.4 GO:0016573 histone acetylation(GO:0016573)
0.0 0.4 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 3.3 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.7 GO:0007286 spermatid development(GO:0007286)
0.0 1.5 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.1 GO:0046606 negative regulation of centrosome cycle(GO:0046606)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.4 GO:0044295 axonal growth cone(GO:0044295)
0.8 2.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.7 12.2 GO:0033270 paranode region of axon(GO:0033270)
0.6 4.4 GO:0061617 MICOS complex(GO:0061617)
0.6 11.2 GO:0031045 dense core granule(GO:0031045)
0.5 9.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 2.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.4 4.2 GO:0045180 basal cortex(GO:0045180)
0.2 1.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.2 8.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 38.7 GO:0030018 Z disc(GO:0030018)
0.2 5.8 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 4.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.9 GO:0043194 axon initial segment(GO:0043194)
0.1 6.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.9 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.4 GO:0036128 CatSper complex(GO:0036128)
0.1 1.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 11.6 GO:0043197 dendritic spine(GO:0043197)
0.1 18.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 8.8 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 5.2 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 1.0 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 6.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 5.7 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.4 GO:0030496 midbody(GO:0030496)
0.0 8.4 GO:0005874 microtubule(GO:0005874)
0.0 11.0 GO:0005815 microtubule organizing center(GO:0005815)
0.0 9.7 GO:0005925 focal adhesion(GO:0005925)
0.0 0.5 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 9.7 GO:0043005 neuron projection(GO:0043005)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 1.1 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
2.8 8.4 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
1.8 5.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.7 10.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.2 3.7 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
1.0 3.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.9 23.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.8 36.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.8 10.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 3.7 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.7 6.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 1.6 GO:0032184 SUMO polymer binding(GO:0032184)
0.5 11.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 4.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 2.4 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.3 14.5 GO:0030507 spectrin binding(GO:0030507)
0.3 13.6 GO:0051393 alpha-actinin binding(GO:0051393)
0.3 1.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 1.7 GO:0043532 angiostatin binding(GO:0043532)
0.3 10.0 GO:0015248 sterol transporter activity(GO:0015248)
0.3 13.0 GO:0042056 chemoattractant activity(GO:0042056)
0.3 2.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.2 4.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.7 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 0.9 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 4.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 4.2 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.4 GO:0031489 myosin V binding(GO:0031489)
0.2 17.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 1.3 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 18.4 GO:0005262 calcium channel activity(GO:0005262)
0.1 0.6 GO:0002046 opsin binding(GO:0002046)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 17.3 GO:0044325 ion channel binding(GO:0044325)
0.1 1.8 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 4.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 2.5 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.1 1.3 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 3.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.4 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.3 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 13.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 1.9 GO:0016887 ATPase activity(GO:0016887)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 35.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.3 24.9 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 9.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 4.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 3.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 7.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 4.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.7 ST GAQ PATHWAY G alpha q Pathway
0.0 1.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.3 ST ADRENERGIC Adrenergic Pathway
0.0 1.3 PID IL23 PATHWAY IL23-mediated signaling events
0.0 2.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.6 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.4 12.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 1.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 8.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 5.5 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 8.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 35.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 9.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 3.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 9.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 1.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation