ISMARA results: ISL1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ISL1

Z-value: 0.18

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Transcription factors associated with ISL1

Gene Symbol	Gene ID	Gene Info
ISL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000016082.10	ISL LIM homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ISL1	hg19_v2_chr5_+_50678921_50678921	-0.08	2.5e-01	Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_175711133 Show fit	36.26	ENST00000409597.1 ENST00000413882.1	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr4_-_176923483 Show fit	18.37	ENST00000280187.7 ENST00000512509.1	GPM6A Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6A
chr12_-_50290839 Show fit	15.57	ENST00000552863.1	FAIM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Fas apoptotic inhibitory molecule 2
chr4_-_186877806 Show fit	13.06	ENST00000355634.5	SORBS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorbin and SH3 domain containing 2
chr14_-_60337684 Show fit	12.33	ENST00000267484.5	RTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 1
chr8_+_26371763 Show fit	12.28	ENST00000521913.1	DPYSL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dihydropyrimidinase-like 2
chr1_-_95391315 Show fit	11.81	ENST00000545882.1 ENST00000415017.1	CNN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	calponin 3, acidic
chr2_-_224467093 Show fit	11.22	ENST00000305409.2	SCG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	secretogranin II
chrX_-_92928557 Show fit	11.14	ENST00000373079.3 ENST00000475430.2	NAP1L3 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleosome assembly protein 1-like 3
chr5_+_140772381 Show fit	10.45	ENST00000398604.2	PCDHGA8 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin gamma subfamily A, 8

Showing 1 to 10 of 168 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	36.3	GO:0008045	motor neuron axon guidance(GO:0008045)
0.7	23.3	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2	21.0	GO:0006334	nucleosome assembly(GO:0006334)
0.1	18.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5	18.4	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
1.0	15.6	GO:0021702	cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.2	15.1	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.1	15.0	GO:0043401	steroid hormone mediated signaling pathway(GO:0043401)
0.1	14.1	GO:0030516	regulation of axon extension(GO:0030516)
0.1	11.9	GO:0065004	protein-DNA complex assembly(GO:0065004)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.7	GO:0030018	Z disc(GO:0030018)
0.1	18.7	GO:0045211	postsynaptic membrane(GO:0045211)
0.8	18.4	GO:0044295	axonal growth cone(GO:0044295)
0.7	12.2	GO:0033270	paranode region of axon(GO:0033270)
0.1	11.6	GO:0043197	dendritic spine(GO:0043197)
0.6	11.2	GO:0031045	dense core granule(GO:0031045)
0.0	11.0	GO:0005815	microtubule organizing center(GO:0005815)
0.5	9.9	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	9.7	GO:0005925	focal adhesion(GO:0005925)
0.0	9.7	GO:0043005	neuron projection(GO:0043005)

Showing 1 to 10 of 52 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	36.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.9	23.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	18.4	GO:0005262	calcium channel activity(GO:0005262)
0.2	17.5	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.1	17.3	GO:0044325	ion channel binding(GO:0044325)
0.3	14.5	GO:0030507	spectrin binding(GO:0030507)
0.3	13.6	GO:0051393	alpha-actinin binding(GO:0051393)
0.0	13.1	GO:0005509	calcium ion binding(GO:0005509)
0.3	13.0	GO:0042056	chemoattractant activity(GO:0042056)
4.1	12.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)

Showing 1 to 10 of 63 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	35.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	24.9	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	9.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	7.6	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	4.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	4.0	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.1	3.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	2.9	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	2.5	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.9	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	35.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	12.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.5	10.3	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2	9.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	9.7	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.3	8.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	8.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.3	5.5	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1	3.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	3.7	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Showing 1 to 10 of 27 entries

Results for ISL1

Z-value: 0.18

Motif logo

Transcription factors associated with ISL1

Activity-expression correlation:

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: