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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ISL2

Z-value: 0.82

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL LIM homeobox 2

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_95242044 13.50 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr10_-_95241951 13.06 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr3_+_172468505 12.61 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr2_-_10587897 12.36 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr3_+_172468472 11.58 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr4_+_113568207 11.48 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr11_-_107729887 9.78 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr8_-_121457608 8.52 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr3_-_141747950 8.48 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_99127225 7.59 ENST00000370189.5
ENST00000529992.1
SNX7
sorting nexin 7
chr12_+_64798095 7.34 ENST00000332707.5
XPOT
exportin, tRNA
chr7_-_16844611 7.30 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr11_+_101983176 7.25 ENST00000524575.1
YAP1
Yes-associated protein 1
chr12_+_104337515 7.20 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr3_+_139063372 6.09 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr2_-_136633940 5.88 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr2_+_86669118 5.69 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr11_-_62609281 5.62 ENST00000525239.1
ENST00000538098.2
WDR74
WD repeat domain 74
chr2_+_231921574 5.18 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr11_-_28129656 4.84 ENST00000263181.6
KIF18A
kinesin family member 18A
chr3_+_136649311 4.53 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr17_+_7155819 4.26 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chr4_+_169418195 4.19 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr17_-_64225508 4.04 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_169013666 4.04 ENST00000359299.3
ANXA10
annexin A10
chr2_+_234668894 3.97 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr5_-_130500922 3.96 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr11_-_327537 3.86 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr21_-_30445886 3.76 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr3_+_138327417 3.58 ENST00000338446.4
FAIM
Fas apoptotic inhibitory molecule
chr14_-_23058063 3.55 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1
defender against cell death 1
chr1_-_95391315 3.21 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr11_+_73498898 3.17 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr15_+_64680003 3.16 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr22_-_29107919 3.10 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chr17_-_48785216 3.03 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr15_+_79166065 3.02 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr3_+_138327542 3.02 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr14_-_67878917 3.00 ENST00000216446.4
PLEK2
pleckstrin 2
chr11_-_63376013 2.77 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr10_-_5046042 2.48 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr6_+_151561085 2.42 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_111804905 2.39 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chrX_-_100872911 2.31 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr14_-_51027838 2.22 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr20_-_33735070 2.21 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr9_+_12693336 2.09 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr10_+_35484793 2.03 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chrX_-_77225135 1.87 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr7_-_45151272 1.80 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
TBRG4
transforming growth factor beta regulator 4
chrX_+_102840408 1.77 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr4_+_128702969 1.64 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr5_+_32788945 1.53 ENST00000326958.1
AC026703.1
AC026703.1
chrX_+_108779004 1.37 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr12_+_26164645 1.37 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr17_-_10372875 1.35 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr10_-_29923893 1.28 ENST00000355867.4
SVIL
supervillin
chr1_-_21377383 1.26 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr8_+_70404996 1.17 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr18_-_64271363 1.17 ENST00000262150.2
CDH19
cadherin 19, type 2
chr2_+_234580525 1.11 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr17_-_7307358 1.07 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr5_-_139726181 1.01 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr4_+_169418255 0.99 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr1_-_93257951 0.94 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr1_+_149871171 0.90 ENST00000369150.1
BOLA1
bolA family member 1
chr11_-_13517565 0.90 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr4_+_88532028 0.89 ENST00000282478.7
DSPP
dentin sialophosphoprotein
chr17_-_3496171 0.89 ENST00000399756.4
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chrX_-_84634737 0.88 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr1_-_174992544 0.81 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chr2_+_234580499 0.81 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr12_+_75784850 0.77 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr2_-_163008903 0.77 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr12_-_54689532 0.72 ENST00000540264.2
ENST00000312156.4
NFE2
nuclear factor, erythroid 2
chr6_-_155776966 0.61 ENST00000159060.2
NOX3
NADPH oxidase 3
chr1_-_202897724 0.60 ENST00000435533.3
ENST00000367258.1
KLHL12
kelch-like family member 12
chr1_-_190446759 0.57 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr6_+_64345698 0.49 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr3_-_183145873 0.28 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF2L2
MCF.2 cell line derived transforming sequence-like 2
chr4_-_122085469 0.22 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr14_+_102276132 0.22 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr2_-_217560248 0.22 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr17_-_10325261 0.20 ENST00000403437.2
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr1_+_13421176 0.15 ENST00000376152.1
PRAMEF9
PRAME family member 9
chr9_+_111624577 0.14 ENST00000333999.3
ACTL7A
actin-like 7A
chr19_+_4402659 0.12 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr11_+_113779704 0.12 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr2_+_234826016 0.11 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr9_-_95166841 0.10 ENST00000262551.4
OGN
osteoglycin
chr7_+_141811539 0.09 ENST00000550469.2
ENST00000477922.3
RP11-1220K2.2
Putative inactive maltase-glucoamylase-like protein LOC93432
chr1_+_171227069 0.09 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr12_-_51422017 0.07 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr14_+_38677123 0.03 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr1_+_149871135 0.02 ENST00000369152.5
BOLA1
bolA family member 1
chr19_-_46234119 0.01 ENST00000317683.3
FBXO46
F-box protein 46

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
2.2 26.6 GO:0001778 plasma membrane repair(GO:0001778)
1.9 5.7 GO:0007290 spermatid nucleus elongation(GO:0007290)
1.6 24.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.5 4.5 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.2 7.3 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
1.0 3.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.0 5.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.8 7.3 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.7 2.2 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.6 5.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 1.9 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456) positive regulation of sperm motility(GO:1902093)
0.5 7.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.4 2.8 GO:0046485 ether lipid metabolic process(GO:0046485)
0.4 2.5 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.3 4.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.3 4.0 GO:0034392 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.3 0.9 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.3 0.9 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.3 3.8 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.3 1.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.3 0.8 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.3 1.0 GO:0051541 elastin metabolic process(GO:0051541)
0.3 18.6 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 5.2 GO:0003334 keratinocyte development(GO:0003334)
0.2 2.0 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.2 8.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 0.8 GO:0051552 flavone metabolic process(GO:0051552)
0.2 2.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 7.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 3.9 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 3.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 1.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) negative regulation of prostatic bud formation(GO:0060686)
0.1 3.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 2.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.6 GO:0048840 otolith development(GO:0048840)
0.1 3.2 GO:1901998 toxin transport(GO:1901998)
0.1 4.0 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.1 5.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 3.6 GO:0001824 blastocyst development(GO:0001824)
0.1 5.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.6 GO:0014029 neural crest formation(GO:0014029)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.4 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.9 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 5.8 GO:0016050 vesicle organization(GO:0016050)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 1.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 24.2 GO:0097149 centralspindlin complex(GO:0097149)
1.5 7.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.6 12.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 4.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.5 5.9 GO:0042555 MCM complex(GO:0042555)
0.4 4.8 GO:1990023 kinetochore microtubule(GO:0005828) mitotic spindle midzone(GO:1990023)
0.3 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.3 3.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 11.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 3.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.3 6.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 5.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.3 4.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 26.6 GO:0005901 caveola(GO:0005901)
0.2 4.0 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 5.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 2.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 3.0 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.9 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 3.6 GO:0002102 podosome(GO:0002102)
0.1 2.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.1 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 7.3 GO:0005643 nuclear pore(GO:0005643)
0.1 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.5 GO:0032982 myosin filament(GO:0032982)
0.0 0.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 3.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.0 2.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.8 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 4.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 4.3 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 2.4 GO:0005938 cell cortex(GO:0005938)
0.0 0.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 1.1 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.8 4.0 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.7 7.2 GO:0046790 virion binding(GO:0046790)
0.6 2.8 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.5 1.9 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.4 2.5 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.4 3.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 7.2 GO:0002162 dystroglycan binding(GO:0002162)
0.3 5.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 24.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 4.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 7.3 GO:0070064 proline-rich region binding(GO:0070064)
0.2 5.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 0.9 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.2 12.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 5.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 7.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 2.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 5.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 3.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 3.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 3.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 3.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 4.0 GO:0005080 protein kinase C binding(GO:0005080)
0.1 4.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 15.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 25.3 GO:0005543 phospholipid binding(GO:0005543)
0.1 1.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 2.5 GO:0050699 WW domain binding(GO:0050699)
0.1 1.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.9 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 3.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)
0.0 8.0 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.9 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.2 PID PLK1 PATHWAY PLK1 signaling events
0.2 31.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 8.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 7.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 12.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.1 PID ATM PATHWAY ATM pathway
0.1 8.5 PID E2F PATHWAY E2F transcription factor network
0.0 2.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.2 PID TNF PATHWAY TNF receptor signaling pathway
0.0 2.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.5 12.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.4 24.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.4 5.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 7.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 5.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 4.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 4.8 REACTOME KINESINS Genes involved in Kinesins
0.2 2.8 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 3.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 5.2 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 0.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 3.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.4 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes