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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ISL2
Z-value: 0.82
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Transcription factors associated with ISL2
Network of associatons between targets according to the STRING database.
First level regulatory network of ISL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 26.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 1.6 | 24.2 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.3 | 18.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 3.1 | 12.4 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.2 | 8.5 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 1.2 | 7.3 | GO:1903899 | positive regulation of PERK-mediated unfolded protein response(GO:1903899) |
| 0.8 | 7.3 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.1 | 7.3 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.5 | 7.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.6 | 5.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.6 | GO:0005901 | caveola(GO:0005901) |
| 4.8 | 24.2 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.6 | 12.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 11.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.5 | 7.3 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.1 | 7.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.3 | 6.9 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.5 | 5.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 5.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 5.2 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.3 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.2 | 24.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 15.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 12.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 8.0 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.2 | 7.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 7.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.7 | 7.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.3 | 7.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 5.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.4 | 24.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 12.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 8.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.3 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 7.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 2.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.5 | 12.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 7.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.5 | 7.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.4 | 5.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 5.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 5.2 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.2 | 4.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 4.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 3.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |