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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ISX
Z-value: 1.45
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Transcription factors associated with ISX
Network of associatons between targets according to the STRING database.
First level regulatory network of ISX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 96.5 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 7.7 | 61.5 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536) |
| 0.3 | 47.9 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 3.7 | 37.0 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 8.5 | 34.2 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 3.6 | 32.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 4.0 | 32.2 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 9.9 | 29.8 | GO:1904481 | response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482) |
| 5.8 | 29.1 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 2.9 | 23.5 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 93.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.1 | 63.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 45.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 36.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 5.7 | 34.4 | GO:0090661 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 3.1 | 34.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 11.4 | 34.1 | GO:0033597 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 4.6 | 32.2 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.2 | 29.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 23.6 | GO:0001726 | ruffle(GO:0001726) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 68.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 1.3 | 61.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.3 | 40.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 9.3 | 37.0 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 5.7 | 34.4 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 2.0 | 34.2 | GO:0003906 | AT DNA binding(GO:0003680) DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 10.8 | 32.3 | GO:0098626 | methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626) |
| 6.0 | 29.8 | GO:0070905 | serine binding(GO:0070905) |
| 0.1 | 26.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.5 | 22.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 64.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 26.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.3 | 26.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 11.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 11.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 11.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.4 | 8.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 5.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 97.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.9 | 68.9 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 2.5 | 37.0 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 3.8 | 34.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 1.0 | 32.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 29.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.8 | 29.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.9 | 28.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.4 | 22.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 1.1 | 21.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |