ISMARA results: JUND

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for JUND

Z-value: 0.40

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Transcription factors associated with JUND

Gene Symbol	Gene ID	Gene Info
JUND Ensembl NCBI GeneCards UniProt NextProt	ENSG00000130522.4	JunD proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
JUND	hg19_v2_chr19_-_18391708_18391739	0.60	8.5e-23	Click!

Activity profile of JUND motif

Sorted Z-values of JUND motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_84035905 Show fit	21.77	ENST00000311507.4	PLAC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	placenta-specific 8
chr4_-_84035868 Show fit	21.00	ENST00000426923.2 ENST00000509973.1	PLAC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	placenta-specific 8
chr3_-_18466026 Show fit	17.64	ENST00000417717.2	SATB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SATB homeobox 1
chr5_-_140013275 Show fit	13.87	ENST00000512545.1 ENST00000302014.6 ENST00000401743.2	CD14 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD14 molecule
chr22_-_37545972 Show fit	13.70	ENST00000216223.5	IL2RB Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 2 receptor, beta
chr15_+_89182178 Show fit	12.32	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr16_+_23847339 Show fit	12.15	ENST00000303531.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr15_+_89181974 Show fit	11.99	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr12_+_54891495 Show fit	10.44	ENST00000293373.6	NCKAP1L Ensembl NCBI GeneCards UniProt NextProt Show fit	NCK-associated protein 1-like
chr1_-_153348067 Show fit	9.83	ENST00000368737.3	S100A12 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A12

Showing 1 to 10 of 114 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	42.8	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
10.8	32.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
1.4	16.2	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1	16.2	GO:0051225	spindle assembly(GO:0051225)
3.5	13.9	GO:0071727	toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
2.0	13.7	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.2	13.2	GO:0034113	heterotypic cell-cell adhesion(GO:0034113)
4.0	12.1	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
1.7	11.7	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
2.6	10.4	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)

Showing 1 to 10 of 68 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	42.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.5	32.3	GO:0015030	Cajal body(GO:0015030)
0.4	17.6	GO:0005720	nuclear heterochromatin(GO:0005720)
0.1	17.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	16.5	GO:0001772	immunological synapse(GO:0001772)
1.8	16.2	GO:0070652	HAUS complex(GO:0070652)
2.8	13.9	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.3	13.2	GO:0008305	integrin complex(GO:0008305)
0.7	10.4	GO:0031209	SCAR complex(GO:0031209)
0.0	9.3	GO:0034774	secretory granule lumen(GO:0034774)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	52.5	GO:0003682	chromatin binding(GO:0003682)
10.8	32.4	GO:0008859	exoribonuclease II activity(GO:0008859)
0.1	15.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	14.4	GO:0004872	receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
4.6	13.9	GO:0016019	peptidoglycan receptor activity(GO:0016019)
3.4	13.7	GO:0004911	interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1	13.1	GO:0030295	protein kinase activator activity(GO:0030295)
4.0	12.1	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
1.7	9.9	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.5	9.7	GO:0050786	RAGE receptor binding(GO:0050786)

Showing 1 to 10 of 52 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	16.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	14.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.4	13.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.3	13.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	12.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.4	11.7	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	8.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	6.7	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	5.3	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	4.5	PID CD40 PATHWAY	CD40/CD40L signaling

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	39.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	21.9	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.2	14.5	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
1.2	13.9	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.3	12.9	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.4	12.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	12.1	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.4	9.7	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	8.7	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.1	7.6	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Showing 1 to 10 of 29 entries

Results for JUND

Z-value: 0.40

Motif logo

Transcription factors associated with JUND

Activity-expression correlation:

Activity profile of JUND motif

Sorted Z-values of JUND motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: