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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF1
Z-value: 0.39
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Transcription factors associated with KLF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg19_v2_chr19_-_12997995_12998021 | -0.36 | 3.2e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 91.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 12.4 | 74.4 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 3.6 | 64.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 13.6 | 54.3 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 15.4 | 46.3 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 3.4 | 37.8 | GO:0002934 | desmosome organization(GO:0002934) |
| 2.6 | 34.3 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 2.3 | 32.9 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.6 | 27.5 | GO:0035329 | hippo signaling(GO:0035329) |
| 2.4 | 26.1 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 169.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.7 | 117.6 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 80.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.3 | 65.4 | GO:0031430 | M band(GO:0031430) |
| 9.3 | 46.3 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 1.2 | 42.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.4 | 38.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.4 | 34.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 2.8 | 33.8 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 11.0 | 32.9 | GO:0034676 | integrin alpha6-beta4 complex(GO:0034676) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 111.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.3 | 107.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 89.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 5.9 | 64.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 18.1 | 54.3 | GO:0048030 | disaccharide binding(GO:0048030) |
| 7.7 | 46.3 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 3.3 | 43.2 | GO:0038132 | neuregulin binding(GO:0038132) |
| 2.0 | 37.7 | GO:0044548 | S100 protein binding(GO:0044548) |
| 1.2 | 34.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.6 | 34.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 134.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.9 | 69.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.5 | 57.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 57.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.1 | 51.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.5 | 42.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.8 | 41.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 35.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 27.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.1 | 22.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 91.6 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 1.9 | 87.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 1.6 | 81.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 49.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.7 | 46.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 1.2 | 31.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.3 | 27.6 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.6 | 25.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 23.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.9 | 23.2 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |