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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF1
Z-value: 0.39
Motif logo
Transcription factors associated with KLF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
KLF1
|
ENSG00000105610.4 | Kruppel like factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg19_v2_chr19_-_12997995_12998021 | -0.36 | 3.2e-08 | Click! |
Activity profile of KLF1 motif
Sorted Z-values of KLF1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 46.3 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 13.6 | 54.3 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 12.4 | 74.4 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 6.1 | 91.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 5.1 | 15.3 | GO:1902463 | protein localization to cell leading edge(GO:1902463) |
| 4.5 | 22.5 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 4.4 | 13.1 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 4.3 | 12.8 | GO:0021678 | fourth ventricle development(GO:0021592) third ventricle development(GO:0021678) |
| 3.8 | 15.1 | GO:0097010 | eukaryotic translation initiation factor 4F complex assembly(GO:0097010) |
| 3.7 | 11.2 | GO:2000017 | positive regulation of determination of dorsal identity(GO:2000017) |
| 3.6 | 64.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 3.6 | 17.9 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 3.4 | 37.8 | GO:0002934 | desmosome organization(GO:0002934) |
| 3.2 | 25.4 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 3.1 | 15.6 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 2.9 | 8.8 | GO:0048597 | B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 2.9 | 11.5 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 2.8 | 14.1 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 2.8 | 13.9 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
| 2.6 | 34.3 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 2.5 | 12.4 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 2.5 | 7.4 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
| 2.4 | 19.1 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 2.4 | 26.1 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 2.3 | 32.9 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 2.3 | 13.8 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 2.3 | 20.5 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 2.2 | 18.0 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 2.1 | 6.3 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366) |
| 2.0 | 6.1 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 2.0 | 6.1 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 2.0 | 11.7 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 1.9 | 24.1 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 1.8 | 23.2 | GO:1904896 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 1.8 | 8.8 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 1.7 | 8.7 | GO:0033490 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 1.7 | 12.0 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 1.7 | 5.1 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 1.7 | 23.6 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 1.6 | 4.8 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 1.6 | 6.3 | GO:2000542 | regulation of endodermal cell differentiation(GO:1903224) negative regulation of gastrulation(GO:2000542) |
| 1.5 | 15.5 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 1.5 | 13.9 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 1.5 | 10.7 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 1.5 | 15.3 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 1.5 | 13.7 | GO:0030091 | protein repair(GO:0030091) |
| 1.5 | 4.5 | GO:0051097 | negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252) |
| 1.5 | 1.5 | GO:1903179 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
| 1.5 | 7.4 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 1.5 | 10.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.5 | 7.3 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
| 1.4 | 4.3 | GO:0050917 | sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917) |
| 1.4 | 8.4 | GO:0016479 | negative regulation of transcription from RNA polymerase I promoter(GO:0016479) |
| 1.3 | 8.0 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 1.2 | 6.0 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 1.2 | 3.5 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 1.2 | 3.5 | GO:0093001 | glycolytic process through glucose-1-phosphate(GO:0061622) glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 1.1 | 8.0 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 1.1 | 8.9 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 1.1 | 6.7 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 1.1 | 6.5 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.1 | 6.5 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 1.1 | 3.2 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563) |
| 1.0 | 3.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.0 | 7.0 | GO:0032808 | lacrimal gland development(GO:0032808) |
| 1.0 | 3.0 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
| 1.0 | 10.8 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 1.0 | 11.7 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 1.0 | 4.9 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.9 | 12.2 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.9 | 17.7 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.9 | 10.1 | GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086) |
| 0.9 | 15.0 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.9 | 10.4 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.9 | 12.0 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.8 | 3.4 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.8 | 3.4 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
| 0.8 | 5.8 | GO:0003415 | chondrocyte hypertrophy(GO:0003415) |
| 0.8 | 3.3 | GO:0042247 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 0.8 | 3.2 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.8 | 8.6 | GO:1902669 | positive regulation of axon guidance(GO:1902669) |
| 0.8 | 3.1 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.8 | 8.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.7 | 2.9 | GO:0090678 | metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936) |
| 0.7 | 2.1 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 0.7 | 4.2 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.7 | 22.3 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.7 | 3.3 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.6 | 7.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.6 | 10.4 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.6 | 7.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.6 | 27.5 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.6 | 16.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.6 | 3.8 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.6 | 17.9 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.6 | 2.5 | GO:0021897 | forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) |
| 0.6 | 12.2 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.6 | 3.0 | GO:2000784 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.6 | 4.7 | GO:0097033 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.6 | 10.9 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.6 | 3.9 | GO:0042492 | auditory receptor cell fate commitment(GO:0009912) gamma-delta T cell differentiation(GO:0042492) inner ear receptor cell fate commitment(GO:0060120) |
| 0.6 | 16.0 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.5 | 6.6 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.5 | 17.3 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.5 | 2.7 | GO:0035524 | proline transmembrane transport(GO:0035524) |
| 0.5 | 4.8 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.5 | 8.2 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.5 | 9.8 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.5 | 20.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.5 | 2.5 | GO:0006041 | glucosamine metabolic process(GO:0006041) glucose 1-phosphate metabolic process(GO:0019255) |
| 0.5 | 7.3 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.5 | 3.9 | GO:0000278 | mitotic cell cycle(GO:0000278) |
| 0.5 | 3.8 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.4 | 10.5 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.4 | 1.3 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.4 | 13.7 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.4 | 1.2 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713) |
| 0.4 | 10.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.4 | 9.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 3.8 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.3 | 8.0 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.3 | 2.6 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.3 | 8.6 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.3 | 7.3 | GO:0043086 | negative regulation of catalytic activity(GO:0043086) |
| 0.3 | 2.1 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.3 | 6.7 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.3 | 0.5 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.2 | 2.2 | GO:0046600 | negative regulation of centriole replication(GO:0046600) circadian regulation of translation(GO:0097167) |
| 0.2 | 1.4 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.2 | 2.4 | GO:1900016 | negative regulation of cytokine production involved in inflammatory response(GO:1900016) |
| 0.2 | 1.6 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.2 | 8.6 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.2 | 4.8 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.2 | 10.1 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.2 | 1.3 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.2 | 9.9 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.2 | 5.4 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.2 | 16.1 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.2 | 13.3 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.2 | 1.6 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.2 | 11.0 | GO:0048146 | positive regulation of fibroblast proliferation(GO:0048146) |
| 0.2 | 7.9 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.2 | 11.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 10.4 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.2 | 2.9 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 0.7 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.2 | 0.5 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.2 | 2.0 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.2 | 7.3 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.2 | 1.1 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.2 | 5.9 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.1 | 5.5 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.1 | 0.4 | GO:0036484 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) |
| 0.1 | 10.1 | GO:0048675 | axon extension(GO:0048675) |
| 0.1 | 13.6 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.1 | 3.8 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
| 0.1 | 7.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.1 | 1.9 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.1 | 6.1 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 3.6 | GO:1900046 | regulation of blood coagulation(GO:0030193) regulation of coagulation(GO:0050818) regulation of hemostasis(GO:1900046) |
| 0.1 | 6.8 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.1 | 10.6 | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway(GO:2001243) |
| 0.1 | 1.0 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.1 | 1.4 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.1 | 3.0 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.1 | 1.4 | GO:0033182 | regulation of histone ubiquitination(GO:0033182) |
| 0.1 | 10.7 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.1 | 0.4 | GO:0010628 | positive regulation of gene expression(GO:0010628) |
| 0.1 | 0.6 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.1 | 0.9 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.1 | 23.0 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.1 | 4.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 2.9 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.1 | 0.4 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.1 | 0.6 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
| 0.1 | 6.7 | GO:0035383 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 0.1 | 5.5 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.1 | 0.8 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.1 | 0.7 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 5.7 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 2.5 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 1.4 | GO:0050954 | sensory perception of sound(GO:0007605) sensory perception of mechanical stimulus(GO:0050954) |
| 0.0 | 3.2 | GO:0006415 | translational termination(GO:0006415) |
| 0.0 | 3.5 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.0 | 1.0 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 0.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 1.1 | GO:0009712 | catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712) |
| 0.0 | 0.1 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.0 | 0.4 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.0 | 0.8 | GO:0008593 | regulation of Notch signaling pathway(GO:0008593) |
| 0.0 | 0.8 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.4 | GO:0016311 | dephosphorylation(GO:0016311) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.0 | 32.9 | GO:0034676 | integrin alpha6-beta4 complex(GO:0034676) |
| 9.3 | 46.3 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 3.7 | 22.5 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 3.3 | 13.1 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 3.0 | 12.0 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 2.8 | 33.8 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 2.8 | 8.4 | GO:0031523 | Myb complex(GO:0031523) |
| 2.8 | 22.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 2.6 | 12.8 | GO:0097513 | myosin II filament(GO:0097513) |
| 2.4 | 9.7 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 2.2 | 6.6 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 2.1 | 6.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 2.1 | 12.4 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 2.0 | 17.9 | GO:0005638 | lamin filament(GO:0005638) |
| 1.9 | 15.3 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 1.8 | 21.2 | GO:0090543 | Flemming body(GO:0090543) |
| 1.6 | 6.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 1.5 | 18.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.5 | 27.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) endolysosome membrane(GO:0036020) |
| 1.3 | 26.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 1.3 | 10.2 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 1.3 | 10.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 1.3 | 65.4 | GO:0031430 | M band(GO:0031430) |
| 1.2 | 18.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 1.2 | 42.5 | GO:0032420 | stereocilium(GO:0032420) |
| 1.1 | 8.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 1.1 | 8.8 | GO:0042382 | paraspeckles(GO:0042382) |
| 1.1 | 6.3 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 1.0 | 22.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 1.0 | 17.0 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.9 | 12.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.9 | 22.5 | GO:0046930 | pore complex(GO:0046930) |
| 0.9 | 6.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.9 | 6.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.8 | 17.9 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.8 | 25.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.8 | 3.8 | GO:0005726 | perichromatin fibrils(GO:0005726) interchromatin granule(GO:0035061) |
| 0.7 | 1.5 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.7 | 117.6 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.7 | 7.1 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.7 | 3.5 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.7 | 8.3 | GO:0008091 | spectrin(GO:0008091) |
| 0.7 | 15.1 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.7 | 3.3 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.6 | 3.8 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.6 | 3.6 | GO:0070938 | contractile ring(GO:0070938) |
| 0.5 | 7.3 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.5 | 5.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.5 | 18.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.5 | 1.4 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.5 | 8.0 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.4 | 7.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.4 | 12.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 4.7 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.4 | 34.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.4 | 3.2 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.4 | 38.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.4 | 3.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.4 | 8.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.4 | 20.0 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.3 | 10.8 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.3 | 6.0 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.3 | 26.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.3 | 7.8 | GO:0043034 | costamere(GO:0043034) |
| 0.3 | 1.4 | GO:0032021 | NELF complex(GO:0032021) |
| 0.3 | 8.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.3 | 5.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 18.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 80.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 5.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 0.8 | GO:0031417 | NatC complex(GO:0031417) |
| 0.2 | 6.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 2.2 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.2 | 1.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.2 | 25.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 11.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 4.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.2 | 9.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 7.8 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 3.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 2.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 13.7 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 10.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 4.1 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 14.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 1.5 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 0.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 12.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 7.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.6 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 8.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.1 | 2.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 7.8 | GO:1902554 | serine/threonine protein kinase complex(GO:1902554) |
| 0.1 | 2.1 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 169.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 2.5 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 3.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 1.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 7.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.1 | 54.3 | GO:0048030 | disaccharide binding(GO:0048030) |
| 8.0 | 24.1 | GO:0003978 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 7.7 | 46.3 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 5.9 | 64.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 4.6 | 13.9 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 4.6 | 27.4 | GO:1990254 | keratin filament binding(GO:1990254) |
| 4.6 | 13.7 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 4.4 | 13.1 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 4.1 | 12.2 | GO:0045155 | electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155) |
| 3.9 | 23.6 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 3.8 | 23.0 | GO:0051021 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 3.8 | 15.1 | GO:0034057 | RNA strand-exchange activity(GO:0034057) |
| 3.3 | 43.2 | GO:0038132 | neuregulin binding(GO:0038132) |
| 3.0 | 20.8 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 2.8 | 14.1 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 2.8 | 13.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 2.5 | 7.6 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 2.5 | 2.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 2.4 | 9.7 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 2.4 | 19.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 2.4 | 9.5 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 2.3 | 13.8 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 2.1 | 19.1 | GO:0048495 | Roundabout binding(GO:0048495) |
| 2.1 | 18.9 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 2.1 | 10.4 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 2.0 | 37.7 | GO:0044548 | S100 protein binding(GO:0044548) |
| 1.7 | 8.6 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 1.7 | 8.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.5 | 13.7 | GO:0015288 | porin activity(GO:0015288) |
| 1.3 | 12.0 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 1.3 | 27.6 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 1.2 | 34.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 1.1 | 6.7 | GO:0008948 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948) |
| 1.1 | 16.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 1.1 | 4.3 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 1.0 | 7.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.0 | 4.9 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.9 | 18.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.8 | 12.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.8 | 3.8 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.7 | 2.2 | GO:0097158 | pre-mRNA intronic pyrimidine-rich binding(GO:0097158) |
| 0.7 | 7.3 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.7 | 2.1 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.7 | 6.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.7 | 5.4 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.7 | 10.7 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.7 | 9.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.6 | 6.3 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
| 0.6 | 10.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.6 | 29.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 3.1 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.6 | 6.8 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.6 | 8.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.6 | 111.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.6 | 19.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.6 | 3.5 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.6 | 34.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.5 | 2.7 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.5 | 7.0 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.5 | 4.5 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
| 0.5 | 8.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.5 | 10.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.5 | 14.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.4 | 1.8 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 0.4 | 3.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.4 | 1.3 | GO:0070026 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026) nitrite reductase activity(GO:0098809) |
| 0.4 | 10.2 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.4 | 2.5 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.4 | 4.8 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.4 | 8.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.4 | 13.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.4 | 1.1 | GO:0052593 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.4 | 7.1 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.4 | 12.4 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.4 | 11.5 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.4 | 3.9 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.4 | 19.3 | GO:0043531 | ADP binding(GO:0043531) |
| 0.3 | 7.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.3 | 3.3 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.3 | 1.2 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.3 | 9.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.3 | 1.7 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.3 | 8.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 2.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.3 | 4.8 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.3 | 11.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.3 | 12.3 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.3 | 89.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 107.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 8.5 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.2 | 12.8 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 3.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 4.7 | GO:0005112 | Notch binding(GO:0005112) |
| 0.2 | 0.6 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.2 | 1.0 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.2 | 15.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 8.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 3.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 1.5 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
| 0.1 | 6.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 1.6 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 3.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 3.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.1 | 3.0 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 10.3 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 6.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 1.4 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.1 | 7.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 7.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 1.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 3.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 1.5 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 0.1 | 4.1 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.1 | 2.9 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.1 | 0.7 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 6.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 6.9 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 3.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 3.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 6.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.8 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 2.6 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.3 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 3.2 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 4.1 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 2.1 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 1.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 3.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 13.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 7.3 | GO:0004857 | enzyme inhibitor activity(GO:0004857) |
| 0.0 | 5.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 4.2 | GO:0019904 | protein domain specific binding(GO:0019904) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 134.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.9 | 69.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 1.8 | 41.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 1.1 | 51.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 1.1 | 22.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.7 | 8.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.7 | 12.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.6 | 7.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.6 | 0.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.5 | 22.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.5 | 57.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 42.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.5 | 57.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.5 | 20.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.4 | 8.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.4 | 3.2 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.4 | 8.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 9.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.3 | 10.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 17.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 18.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 27.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 8.4 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.3 | 15.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.3 | 8.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 18.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.3 | 10.9 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.3 | 7.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 5.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.3 | 5.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 6.3 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.2 | 35.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 8.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 9.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 6.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 7.2 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 4.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 13.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 4.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 6.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 6.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 1.9 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 2.9 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 6.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 2.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 1.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 3.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 9.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 91.6 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 3.0 | 20.8 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 1.9 | 87.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 1.6 | 81.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.3 | 11.7 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 1.3 | 27.6 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 1.2 | 14.8 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 1.2 | 23.0 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 1.2 | 31.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.9 | 23.2 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.7 | 46.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.7 | 13.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.6 | 22.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.6 | 20.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.6 | 25.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.6 | 3.9 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.5 | 8.0 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.5 | 18.0 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.4 | 12.1 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.4 | 8.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.4 | 10.1 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.4 | 13.7 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.4 | 7.1 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.4 | 22.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.4 | 11.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.4 | 7.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.4 | 14.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.4 | 9.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 6.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.4 | 8.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.4 | 4.3 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.3 | 6.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.3 | 49.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 3.2 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.3 | 9.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 10.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 7.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 13.7 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.3 | 8.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 2.1 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.2 | 8.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 2.5 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.2 | 19.8 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 5.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 12.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 15.3 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.2 | 2.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 10.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 23.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 18.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 3.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 23.1 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.1 | 3.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 14.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 5.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.6 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 2.1 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 3.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.6 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 2.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |