ISMARA results: KLF12

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for KLF12

Z-value: 0.43

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Transcription factors associated with KLF12

Gene Symbol	Gene ID	Gene Info
KLF12 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000118922.12	Kruppel like factor 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF12	hg19_v2_chr13_-_74708372_74708409	-0.34	2.5e-07	Click!

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_89402148 Show fit	23.04	ENST00000560601.1	ACAN Ensembl NCBI GeneCards UniProt NextProt Show fit	aggrecan
chrX_+_23682379 Show fit	16.47	ENST00000379349.1	PRDX4 Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxiredoxin 4
chrX_+_49028265 Show fit	11.17	ENST00000376322.3 ENST00000376327.5	PLP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteolipid protein 2 (colonic epithelium-enriched)
chr12_-_56120838 Show fit	10.75	ENST00000548160.1	CD63 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD63 molecule
chr1_+_155178481 Show fit	10.68	ENST00000368376.3	MTX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	metaxin 1
chr12_-_53012343 Show fit	10.19	ENST00000305748.3	KRT73 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 73
chr11_-_64013288 Show fit	9.88	ENST00000542235.1	PPP1R14B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_+_13051206 Show fit	9.51	ENST00000586760.1	CALR Ensembl NCBI GeneCards UniProt NextProt Show fit	calreticulin
chr15_+_64428529 Show fit	9.39	ENST00000560861.1	SNX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorting nexin 1
chr12_+_53848549 Show fit	9.10	ENST00000439930.3 ENST00000548933.1 ENST00000562264.1	PCBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	poly(rC) binding protein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	33.1	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.2	29.7	GO:0030449	regulation of complement activation(GO:0030449)
0.2	23.4	GO:0031424	keratinization(GO:0031424)
1.2	23.0	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.2	19.4	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
2.3	18.8	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
1.0	17.6	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.2	17.1	GO:0048207	vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
3.3	16.5	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
2.2	15.5	GO:0090649	response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)

Showing 1 to 10 of 166 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	33.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.2	29.3	GO:0043202	lysosomal lumen(GO:0043202)
0.1	24.6	GO:0031968	mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.1	22.8	GO:0072562	blood microparticle(GO:0072562)
0.4	16.5	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	16.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.3	15.7	GO:0045095	keratin filament(GO:0045095)
1.7	15.1	GO:0072546	ER membrane protein complex(GO:0072546)
1.1	12.7	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
1.0	12.5	GO:0005642	annulate lamellae(GO:0005642)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	43.5	GO:0003823	antigen binding(GO:0003823)
0.2	23.2	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.8	23.0	GO:0005540	hyaluronic acid binding(GO:0005540)
0.3	22.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.7	20.1	GO:0003746	translation elongation factor activity(GO:0003746)
2.1	16.5	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.3	15.7	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.1	15.1	GO:0030246	carbohydrate binding(GO:0030246)
2.3	13.7	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
1.3	12.7	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)

Showing 1 to 10 of 121 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	21.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	15.4	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.2	14.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	11.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.3	10.9	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	10.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	9.0	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	8.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	6.7	PID EPO PATHWAY	EPO signaling pathway
0.2	6.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	41.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	23.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
1.3	23.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	21.5	REACTOME TRANSLATION	Genes involved in Translation
0.3	19.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2	16.2	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.3	14.4	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.2	14.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	12.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3	12.0	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

Showing 1 to 10 of 56 entries

Results for KLF12

Z-value: 0.43

Motif logo

Transcription factors associated with KLF12

Activity-expression correlation:

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: