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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF13
Z-value: 0.95
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Transcription factors associated with KLF13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF13 | hg19_v2_chr15_+_31619013_31619095 | 0.33 | 5.6e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 35.8 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 7.1 | 28.3 | GO:0019859 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 1.3 | 22.5 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.4 | 21.5 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.3 | 20.4 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 1.4 | 19.4 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 2.7 | 18.8 | GO:0045007 | depurination(GO:0045007) |
| 1.0 | 12.5 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
| 0.7 | 12.3 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.4 | 11.2 | GO:0031643 | positive regulation of myelination(GO:0031643) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 23.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 23.7 | GO:0005615 | extracellular space(GO:0005615) |
| 3.8 | 22.5 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.2 | 20.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 19.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 18.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 2.2 | 17.9 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 16.3 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.2 | 12.5 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 28.3 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.1 | 20.0 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 1.4 | 19.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 1.1 | 19.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 4.7 | 18.8 | GO:0032408 | MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408) |
| 0.2 | 12.5 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.0 | 12.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 12.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.3 | 10.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.6 | 10.4 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 11.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 11.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 10.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 10.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 8.5 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 7.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 6.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 28.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 22.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.3 | 19.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 1.0 | 18.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.5 | 14.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 12.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.4 | 12.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.8 | 11.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.5 | 10.1 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 8.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |