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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF14_SP8
Z-value: 0.62
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Transcription factors associated with KLF14_SP8
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF14_SP8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 48.6 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.7 | 47.4 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 2.1 | 35.7 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 7.6 | 30.4 | GO:0019859 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 1.7 | 30.0 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 1.3 | 29.5 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 1.8 | 25.3 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 2.5 | 25.1 | GO:1904415 | regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417) |
| 1.9 | 22.6 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.3 | 20.6 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 29.3 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 28.1 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 2.2 | 26.8 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 25.9 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 4.2 | 25.5 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.4 | 22.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 21.6 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.3 | 20.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.7 | 20.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 1.6 | 20.6 | GO:0016461 | unconventional myosin complex(GO:0016461) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 88.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 40.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 9.5 | 38.0 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.4 | 33.0 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 1.2 | 29.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 2.4 | 29.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.1 | 27.6 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 1.8 | 25.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.4 | 23.0 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 1.0 | 21.2 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 39.0 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.3 | 27.1 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 24.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.4 | 15.9 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 15.6 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.6 | 13.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 11.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 11.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.5 | 10.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.5 | 10.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.0 | 28.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 25.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 22.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 22.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.5 | 13.3 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.3 | 12.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.8 | 12.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.6 | 12.6 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 12.6 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |