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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF16_SP2
Z-value: 0.66
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP2 | hg19_v2_chr17_+_45973516_45973618 | 0.21 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 249.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 2.6 | 220.7 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.5 | 184.9 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 1.8 | 138.4 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 9.5 | 114.4 | GO:0009113 | purine nucleobase biosynthetic process(GO:0009113) |
| 4.1 | 111.5 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 2.3 | 107.9 | GO:0006363 | transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363) |
| 2.3 | 101.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.9 | 100.8 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) |
| 3.5 | 94.8 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 798.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 1.9 | 206.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.6 | 188.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 3.7 | 140.8 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 2.4 | 137.9 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.2 | 130.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.4 | 115.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 3.6 | 97.8 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 7.3 | 95.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 3.0 | 93.9 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 530.5 | GO:0003723 | RNA binding(GO:0003723) |
| 1.7 | 362.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.7 | 236.4 | GO:0042393 | histone binding(GO:0042393) |
| 4.7 | 226.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 3.1 | 133.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.6 | 123.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 29.4 | 117.5 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 1.3 | 109.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 4.8 | 95.6 | GO:0070628 | proteasome binding(GO:0070628) |
| 10.3 | 93.1 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 268.0 | PID E2F PATHWAY | E2F transcription factor network |
| 2.1 | 249.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.7 | 167.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 3.2 | 166.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 2.6 | 146.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.3 | 132.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 2.4 | 100.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.8 | 78.4 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 1.2 | 71.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 4.9 | 68.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 337.2 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 2.2 | 307.0 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 1.3 | 215.5 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 3.7 | 179.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 6.1 | 177.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 2.8 | 165.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 4.0 | 162.7 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 4.5 | 158.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.9 | 155.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 9.1 | 154.1 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |