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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF6
Z-value: 1.11
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Transcription factors associated with KLF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF6 | hg19_v2_chr10_-_3827371_3827386 | 0.32 | 1.2e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.3 | 77.3 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.6 | 61.1 | GO:0045921 | positive regulation of exocytosis(GO:0045921) |
| 2.7 | 54.8 | GO:0031167 | rRNA methylation(GO:0031167) |
| 1.6 | 45.6 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 2.6 | 40.8 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 9.4 | 28.3 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 2.2 | 28.0 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 1.8 | 28.0 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.4 | 28.0 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 5.3 | 26.6 | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 86.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.1 | 77.3 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.2 | 48.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 3.0 | 45.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.8 | 33.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.5 | 32.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 32.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 3.7 | 29.9 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.4 | 28.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 2.7 | 26.6 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.3 | 77.3 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 1.7 | 71.4 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 11.0 | 54.8 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.7 | 47.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.3 | 35.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.9 | 30.8 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.4 | 27.5 | GO:0019003 | GDP binding(GO:0019003) |
| 2.7 | 27.4 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.6 | 26.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 1.3 | 24.7 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 76.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.6 | 43.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 38.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.1 | 33.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 29.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 22.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.4 | 21.8 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.5 | 21.7 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 1.9 | 21.4 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.3 | 17.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 72.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 37.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.4 | 28.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 27.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 1.2 | 25.2 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.3 | 18.3 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 17.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.6 | 17.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.5 | 15.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.6 | 14.5 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |