ISMARA results: LHX2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for LHX2

Z-value: 0.26

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Transcription factors associated with LHX2

Gene Symbol	Gene ID	Gene Info
LHX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106689.6	LIM homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LHX2	hg19_v2_chr9_+_126777676_126777700, hg19_v2_chr9_+_126773880_126773895	-0.04	5.9e-01	Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_6309517 Show fit	12.86	ENST00000382519.4 ENST00000009180.4	CD9 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD9 molecule
chr7_-_5998714 Show fit	4.98	ENST00000539903.1	RSPH10B Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 10 homolog B (Chlamydomonas)
chr6_+_125524785 Show fit	4.24	ENST00000392482.2	TPD52L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor protein D52-like 1
chr21_-_43735628 Show fit	4.08	ENST00000291525.10 ENST00000518498.1	TFF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	trefoil factor 3 (intestinal)
chr4_+_70894130 Show fit	3.57	ENST00000526767.1 ENST00000530128.1 ENST00000381057.3	HTN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	histatin 3
chr21_-_43735446 Show fit	3.54	ENST00000398431.2	TFF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	trefoil factor 3 (intestinal)
chr14_+_56078695 Show fit	3.52	ENST00000416613.1	KTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	kinectin 1 (kinesin receptor)
chr10_-_116286656 Show fit	3.44	ENST00000428430.1 ENST00000369266.3 ENST00000392952.3	ABLIM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actin binding LIM protein 1
chr1_-_28527152 Show fit	3.31	ENST00000321830.5	AL353354.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr14_-_69864993 Show fit	3.22	ENST00000555373.1	ERH Ensembl NCBI GeneCards UniProt NextProt Show fit	enhancer of rudimentary homolog (Drosophila)

Showing 1 to 10 of 128 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	12.9	GO:0009414	response to water deprivation(GO:0009414)
0.0	6.8	GO:0007586	digestion(GO:0007586)
0.2	6.7	GO:0050832	defense response to fungus(GO:0050832)
0.0	4.3	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	4.1	GO:0046330	positive regulation of JNK cascade(GO:0046330)
0.4	3.5	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	3.5	GO:0007018	microtubule-based movement(GO:0007018)
0.0	3.3	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	3.3	GO:0071806	protein transmembrane transport(GO:0071806)
0.4	3.2	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.6	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.3	10.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	6.0	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	3.5	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	3.4	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	3.3	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	3.3	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.3	3.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.2	3.2	GO:0034709	methylosome(GO:0034709)
0.1	3.1	GO:0042101	T cell receptor complex(GO:0042101)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.9	GO:0005178	integrin binding(GO:0005178)
0.0	9.2	GO:0045296	cadherin binding(GO:0045296)
0.3	3.3	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1	3.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.8	3.2	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1	3.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.2	3.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.4	3.0	GO:0034235	GPI anchor binding(GO:0034235)
0.0	3.0	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.6	2.9	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.9	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	7.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	4.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	2.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.8	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	1.8	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	1.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	4.2	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	3.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	3.3	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.2	3.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	3.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	2.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	2.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.9	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	1.8	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK

Showing 1 to 10 of 27 entries

Results for LHX2

Z-value: 0.26

Motif logo

Transcription factors associated with LHX2

Activity-expression correlation:

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: