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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for LHX6

Z-value: 0.78

Motif logo

Transcription factors associated with LHX6

Gene Symbol Gene ID Gene Info
ENSG00000106852.11 LIM homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX6hg19_v2_chr9_-_124989804_124989865,
hg19_v2_chr9_-_124991124_124991246
0.505.6e-15Click!

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_204380919 21.56 ENST00000367188.4
protein phosphatase 1, regulatory subunit 15B
chr12_-_45269430 12.92 ENST00000395487.2
NEL-like 2 (chicken)
chr11_-_76155618 12.81 ENST00000530759.1
RP11-111M22.3
chr6_-_167040731 12.29 ENST00000265678.4
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr12_-_45270151 12.28 ENST00000429094.2
NEL-like 2 (chicken)
chr12_-_45270077 12.13 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NEL-like 2 (chicken)
chr11_-_76155700 12.12 ENST00000572035.1
RP11-111M22.3
chr17_+_74733744 12.01 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
major facilitator superfamily domain containing 11
chr12_-_91546926 11.99 ENST00000550758.1
decorin
chr6_-_32095968 11.32 ENST00000375203.3
ENST00000375201.4
activating transcription factor 6 beta
chr17_-_1532106 10.77 ENST00000301335.5
ENST00000382147.4
solute carrier family 43 (amino acid system L transporter), member 2
chrX_-_47509887 10.51 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1, member of ETS oncogene family
chr19_-_19302931 10.47 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr10_-_28571015 9.79 ENST00000375719.3
ENST00000375732.1
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr1_-_13390765 9.59 ENST00000357367.2
PRAME family member 8
chr17_+_73452695 9.52 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
chr17_-_41466555 8.66 ENST00000586231.1
long intergenic non-protein coding RNA 910
chr1_+_44115814 8.24 ENST00000372396.3
lysine (K)-specific demethylase 4A
chr5_+_66300446 8.22 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr1_+_28261533 8.19 ENST00000411604.1
ENST00000373888.4
sphingomyelin phosphodiesterase, acid-like 3B
chr10_-_104001231 8.09 ENST00000370002.3
paired-like homeodomain 3
chr6_-_62996066 7.99 ENST00000281156.4
KH domain containing, RNA binding, signal transduction associated 2
chr14_-_52535712 7.57 ENST00000216286.5
ENST00000541773.1
nidogen 2 (osteonidogen)
chr16_-_55866997 7.55 ENST00000360526.3
ENST00000361503.4
carboxylesterase 1
chr3_+_115342349 7.51 ENST00000393780.3
growth associated protein 43
chr11_+_76156045 7.38 ENST00000533988.1
ENST00000524490.1
ENST00000334736.3
ENST00000343878.3
ENST00000533972.1
chromosome 11 open reading frame 30
chr22_+_41777927 7.28 ENST00000266304.4
thyrotrophic embryonic factor
chr6_-_31125850 7.18 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
coiled-coil alpha-helical rod protein 1
chr2_-_201936302 6.86 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
family with sequence similarity 126, member B
chr4_-_121843985 6.84 ENST00000264808.3
ENST00000428209.2
ENST00000515109.1
ENST00000394435.2
PR domain containing 5
chr11_+_5710919 6.79 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr13_+_37006421 6.63 ENST00000255465.4
cyclin A1
chr14_+_100842735 6.59 ENST00000554998.1
ENST00000402312.3
ENST00000335290.6
ENST00000554175.1
WD repeat domain 25
chr4_+_89513574 6.58 ENST00000402738.1
ENST00000431413.1
ENST00000422770.1
ENST00000407637.1
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr14_+_76127529 6.56 ENST00000556977.1
ENST00000557636.1
ENST00000286650.5
ENST00000298832.9
tubulin tyrosine ligase-like family, member 5
chr16_+_6533380 6.55 ENST00000552089.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr14_-_53258314 6.46 ENST00000216410.3
ENST00000557604.1
glucosamine-phosphate N-acetyltransferase 1
chr13_+_37006398 6.45 ENST00000418263.1
cyclin A1
chr17_-_44657017 6.37 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ADP-ribosylation factor-like 17A
chr2_+_113763031 5.94 ENST00000259211.6
interleukin 36, alpha
chr2_-_152118352 5.86 ENST00000331426.5
RNA binding motif protein 43
chr19_-_12833361 5.81 ENST00000592287.1
transportin 2
chr16_+_6533729 5.80 ENST00000551752.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_3521518 5.75 ENST00000382093.5
acireductone dioxygenase 1
chr12_+_7014064 5.66 ENST00000443597.2
leucine rich repeat containing 23
chr17_-_44439084 5.66 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ADP-ribosylation factor-like 17B
chr6_-_33285505 5.42 ENST00000431845.2
zinc finger and BTB domain containing 22
chr14_-_104181771 5.42 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
X-ray repair complementing defective repair in Chinese hamster cells 3
chr18_-_65184217 5.28 ENST00000310045.7
dermatan sulfate epimerase-like
chr5_-_54830871 5.27 ENST00000307259.8
phosphatidic acid phosphatase type 2A
chr16_+_55512742 5.22 ENST00000568715.1
ENST00000219070.4
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_+_7013897 5.16 ENST00000007969.8
ENST00000323702.5
leucine rich repeat containing 23
chr8_+_9413410 5.06 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr19_-_10121144 5.02 ENST00000264828.3
collagen, type V, alpha 3
chr3_+_67705121 5.00 ENST00000464420.1
ENST00000482677.1
RP11-81N13.1
chr17_+_80416482 4.87 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
nuclear prelamin A recognition factor
chr14_+_99947715 4.80 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
cyclin K
chr11_-_35287243 4.75 ENST00000464522.2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_+_104182061 4.75 ENST00000216602.6
zinc finger, FYVE domain containing 21
chr14_+_104182105 4.75 ENST00000311141.2
zinc finger, FYVE domain containing 21
chr11_-_133826852 4.73 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr1_+_145438469 4.67 ENST00000369317.4
thioredoxin interacting protein
chr18_+_5238549 4.61 ENST00000580684.1
long intergenic non-protein coding RNA 667
chr18_+_5238055 4.60 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
long intergenic non-protein coding RNA 667
chr11_-_236326 4.59 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
sirtuin 3
chr12_-_56753858 4.58 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
signal transducer and activator of transcription 2, 113kDa
chr12_+_7014126 4.57 ENST00000415834.1
ENST00000436789.1
leucine rich repeat containing 23
chr16_-_66584059 4.55 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
thymidine kinase 2, mitochondrial
chr3_-_105587879 4.53 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_-_9760482 4.53 ENST00000229402.3
killer cell lectin-like receptor subfamily B, member 1
chr10_-_123274693 4.50 ENST00000429361.1
fibroblast growth factor receptor 2
chr5_-_54830784 4.39 ENST00000264775.5
phosphatidic acid phosphatase type 2A
chr17_+_72772621 4.35 ENST00000335464.5
ENST00000417024.2
ENST00000578764.1
ENST00000582773.1
ENST00000582330.1
transmembrane protein 104
chr6_-_49681235 4.33 ENST00000339139.4
cysteine-rich secretory protein 2
chr7_+_100209725 4.20 ENST00000223054.4
motile sperm domain containing 3
chrX_+_77166172 4.19 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr11_-_128894053 4.18 ENST00000392657.3
Rho GTPase activating protein 32
chr5_-_112630598 4.15 ENST00000302475.4
mutated in colorectal cancers
chr7_+_149571045 4.14 ENST00000479613.1
ENST00000606024.1
ENST00000464662.1
ENST00000425642.2
ATPase, H+ transporting V0 subunit e2
chr9_+_71944241 3.97 ENST00000257515.8
family with sequence similarity 189, member A2
chr18_-_21017817 3.92 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
transmembrane protein 241
chr13_-_46626847 3.92 ENST00000242848.4
ENST00000282007.3
zinc finger CCCH-type containing 13
chr1_-_236228403 3.86 ENST00000366595.3
nidogen 1
chr15_-_77712477 3.85 ENST00000560626.2
pseudopodium-enriched atypical kinase 1
chrX_-_6453159 3.83 ENST00000381089.3
ENST00000398729.1
variable charge, X-linked 3A
chr13_+_37005967 3.82 ENST00000440264.1
ENST00000449823.1
cyclin A1
chr16_-_55867146 3.73 ENST00000422046.2
carboxylesterase 1
chr1_-_236228417 3.72 ENST00000264187.6
nidogen 1
chr10_-_72142345 3.71 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
leucine rich repeat containing 20
chr19_-_53400813 3.66 ENST00000595635.1
ENST00000594741.1
ENST00000597111.1
ENST00000593618.1
ENST00000597909.1
zinc finger protein 320
chr7_-_121784285 3.64 ENST00000417368.2
aminoadipate-semialdehyde synthase
chr10_+_13142225 3.61 ENST00000378747.3
optineurin
chr10_-_99447024 3.60 ENST00000370626.3
arginine vasopressin-induced 1
chr1_+_62439037 3.59 ENST00000545929.1
InaD-like (Drosophila)
chr2_-_242089677 3.57 ENST00000405260.1
PAS domain containing serine/threonine kinase
chr20_+_54967409 3.55 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr11_+_7110165 3.53 ENST00000306904.5
RNA binding motif protein, X-linked-like 2
chr4_+_74275057 3.52 ENST00000511370.1
albumin
chr2_+_220143989 3.48 ENST00000336576.5
DnaJ (Hsp40) homolog, subfamily B, member 2
chr6_+_160542870 3.43 ENST00000324965.4
ENST00000457470.2
solute carrier family 22 (organic cation transporter), member 1
chr14_+_22293618 3.36 ENST00000390432.2
T cell receptor alpha variable 10
chr7_+_100210133 3.27 ENST00000393950.2
ENST00000424091.2
motile sperm domain containing 3
chr17_+_80416050 3.27 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
nuclear prelamin A recognition factor
chr16_-_66583701 3.25 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
thymidine kinase 2, mitochondrial
chr2_+_166095898 3.20 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chr16_+_72088376 3.18 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
haptoglobin
haptoglobin-related protein
chr7_+_100209979 3.13 ENST00000493970.1
ENST00000379527.2
motile sperm domain containing 3
chr9_+_104161123 3.05 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
zinc finger protein 189
chr1_-_48866517 3.04 ENST00000371841.1
spermatogenesis associated 6
chr3_-_160823158 3.00 ENST00000392779.2
ENST00000392780.1
ENST00000494173.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr19_-_41870026 2.89 ENST00000243578.3
B9 protein domain 2
chr7_-_36764142 2.89 ENST00000258749.5
ENST00000535891.1
acyloxyacyl hydrolase (neutrophil)
chr2_+_90077680 2.89 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr1_+_241695670 2.88 ENST00000366557.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_+_71296204 2.80 ENST00000413702.1
mucin 7, secreted
chr6_+_26402517 2.78 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr6_+_160542821 2.72 ENST00000366963.4
solute carrier family 22 (organic cation transporter), member 1
chr12_-_95611149 2.71 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
FYVE, RhoGEF and PH domain containing 6
chrX_+_100353153 2.71 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
centromere protein I
chr1_-_13673511 2.62 ENST00000344998.3
ENST00000334600.6
PRAME family member 14
chr7_-_99277610 2.61 ENST00000343703.5
ENST00000222982.4
ENST00000439761.1
ENST00000339843.2
cytochrome P450, family 3, subfamily A, polypeptide 5
chr6_+_29624758 2.59 ENST00000376917.3
ENST00000376902.3
ENST00000533330.2
ENST00000376888.2
myelin oligodendrocyte glycoprotein
chr8_+_42010464 2.52 ENST00000518421.1
ENST00000174653.3
ENST00000396926.3
ENST00000521280.1
ENST00000522288.1
adaptor-related protein complex 3, mu 2 subunit
chr19_+_12902289 2.50 ENST00000302754.4
jun B proto-oncogene
chr3_-_160823040 2.47 ENST00000484127.1
ENST00000492353.1
ENST00000473142.1
ENST00000468268.1
ENST00000460353.1
ENST00000320474.4
ENST00000392781.2
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chrX_+_15525426 2.44 ENST00000342014.6
BMX non-receptor tyrosine kinase
chr17_+_73452545 2.41 ENST00000314256.7
KIAA0195
chr10_+_13141441 2.39 ENST00000263036.5
optineurin
chr4_+_165675269 2.38 ENST00000507311.1
RP11-294O2.2
chr21_+_35014706 2.35 ENST00000399353.1
ENST00000444491.1
ENST00000381318.3
intersectin 1 (SH3 domain protein)
chr6_-_27880174 2.35 ENST00000303324.2
olfactory receptor, family 2, subfamily B, member 2
chr7_-_87342564 2.28 ENST00000265724.3
ENST00000416177.1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_-_30585009 2.23 ENST00000376511.2
protein phosphatase 1, regulatory subunit 10
chr1_+_241695424 2.22 ENST00000366558.3
ENST00000366559.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_+_27677085 2.20 ENST00000545334.1
ENST00000540114.1
ENST00000537927.1
ENST00000318304.8
ENST00000535047.1
ENST00000542629.1
ENST00000228425.6
PTPRF interacting protein, binding protein 1 (liprin beta 1)
chr1_-_228613026 2.20 ENST00000366696.1
histone cluster 3, H3
chr5_-_20575959 2.18 ENST00000507958.1
cadherin 18, type 2
chr16_+_2479390 2.11 ENST00000397066.4
cyclin F
chr3_+_108541545 2.08 ENST00000295756.6
T cell receptor associated transmembrane adaptor 1
chr7_-_14029515 2.04 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ets variant 1
chr18_-_67624160 2.02 ENST00000581982.1
ENST00000280200.4
CD226 molecule
chr19_-_7694417 2.01 ENST00000358368.4
ENST00000534844.1
XPA binding protein 2
chr19_+_17858547 2.00 ENST00000600676.1
ENST00000600209.1
ENST00000596309.1
ENST00000598539.1
ENST00000597474.1
ENST00000593385.1
ENST00000598067.1
ENST00000593833.1
FCH domain only 1
chr10_+_13141585 2.00 ENST00000378764.2
optineurin
chr10_+_71562180 1.98 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
collagen, type XIII, alpha 1
chr3_-_99569821 1.97 ENST00000487087.1
filamin A interacting protein 1-like
chr16_+_31885079 1.95 ENST00000300870.10
ENST00000394846.3
zinc finger protein 267
chr11_+_117947782 1.90 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
transmembrane protease, serine 4
chr1_-_173886491 1.88 ENST00000367698.3
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr13_-_19755975 1.88 ENST00000400113.3
tubulin, alpha 3c
chr14_+_32798547 1.87 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr6_+_39760129 1.86 ENST00000274867.4
dishevelled associated activator of morphogenesis 2
chr9_-_95640218 1.80 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
zinc finger protein 484
chr12_+_106751436 1.78 ENST00000228347.4
polymerase (RNA) III (DNA directed) polypeptide B
chr6_+_26402465 1.75 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr19_+_17858509 1.74 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCH domain only 1
chr17_+_41476327 1.69 ENST00000320033.4
ADP-ribosylation factor-like 4D
chr3_+_108541608 1.68 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr14_-_76127519 1.68 ENST00000256319.6
chromosome 14 open reading frame 1
chr11_+_59856130 1.66 ENST00000278888.3
membrane-spanning 4-domains, subfamily A, member 2
chr17_-_40828969 1.64 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_+_151735431 1.58 ENST00000321531.5
ENST00000315067.8
ornithine decarboxylase antizyme 3
chr11_+_117947724 1.58 ENST00000534111.1
transmembrane protease, serine 4
chr12_-_22063787 1.56 ENST00000544039.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr2_+_220144052 1.54 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DnaJ (Hsp40) homolog, subfamily B, member 2
chr14_+_32798462 1.51 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr3_-_101039402 1.47 ENST00000193391.7
interphotoreceptor matrix proteoglycan 2
chr12_-_49418407 1.45 ENST00000526209.1
lysine (K)-specific methyltransferase 2D
chr17_-_40337470 1.42 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr17_-_40829026 1.41 ENST00000412503.1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr1_+_15986364 1.34 ENST00000345034.1
regulatory solute carrier protein, family 1, member 1
chr17_-_77770830 1.32 ENST00000269385.4
chromobox homolog 8
chr6_+_52051171 1.32 ENST00000340057.1
interleukin 17A
chr17_-_79623597 1.31 ENST00000574024.1
ENST00000331056.5
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr6_-_29395509 1.27 ENST00000377147.2
olfactory receptor, family 11, subfamily A, member 1
chr17_+_41323204 1.26 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
neighbor of BRCA1 gene 1
chrX_+_113818545 1.22 ENST00000371951.1
ENST00000276198.1
ENST00000371950.3
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
chr11_-_102668879 1.19 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chrX_+_37639302 1.18 ENST00000545017.1
ENST00000536160.1
cytochrome b-245, beta polypeptide
chr1_-_152386732 1.17 ENST00000271835.3
cornulin
chr6_+_148663729 1.15 ENST00000367467.3
SAM and SH3 domain containing 1
chr11_+_77532155 1.15 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
adipogenesis associated, Mth938 domain containing
chr20_-_50722183 1.14 ENST00000371523.4
ZFP64 zinc finger protein
chr5_+_142149932 1.14 ENST00000274498.4
Rho GTPase activating protein 26
chr11_+_33061543 1.11 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr19_-_14606900 1.10 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC PDZ domain containing family, member 1
chr9_+_117904097 1.08 ENST00000374016.1
deleted in esophageal cancer 1
chr1_+_28261621 0.99 ENST00000549094.1
sphingomyelin phosphodiesterase, acid-like 3B
chr19_+_56459198 0.98 ENST00000291971.3
ENST00000590542.1
NLR family, pyrin domain containing 8
chr6_-_29396243 0.94 ENST00000377148.1
olfactory receptor, family 11, subfamily A, member 1
chr10_+_71561704 0.94 ENST00000520267.1
collagen, type XIII, alpha 1
chr9_+_130565147 0.93 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
folylpolyglutamate synthase
chr7_+_142458507 0.92 ENST00000492062.1
protease, serine, 1 (trypsin 1)
chrY_+_14813160 0.92 ENST00000338981.3
ubiquitin specific peptidase 9, Y-linked
chr13_+_73632897 0.90 ENST00000377687.4
Kruppel-like factor 5 (intestinal)
chr15_+_40697988 0.86 ENST00000487418.2
ENST00000479013.2
isovaleryl-CoA dehydrogenase
chr9_+_136501478 0.86 ENST00000393056.2
ENST00000263611.2
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr12_+_118573663 0.84 ENST00000261313.2
phosphatidylethanolamine binding protein 1
chr3_+_156009623 0.82 ENST00000389634.5
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_+_77532233 0.81 ENST00000525409.1
adipogenesis associated, Mth938 domain containing

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
2.7 37.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
2.4 21.8 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898)
1.9 7.8 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.8 5.4 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
1.7 5.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.6 4.8 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
1.5 4.5 GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
1.5 11.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.4 9.8 GO:0071896 protein localization to adherens junction(GO:0071896)
1.4 4.2 GO:0071284 cellular response to lead ion(GO:0071284)
1.3 3.9 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
1.3 6.5 GO:0006041 glucosamine metabolic process(GO:0006041)
1.3 5.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
1.3 5.0 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
1.2 3.6 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
1.2 3.5 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
1.1 11.3 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
1.1 6.6 GO:0018095 protein polyglutamylation(GO:0018095)
1.1 3.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
1.0 5.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
1.0 8.2 GO:1900113 histone H3-K36 demethylation(GO:0070544) negative regulation of histone H3-K9 trimethylation(GO:1900113)
1.0 4.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
1.0 12.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.0 10.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.0 10.5 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.9 6.1 GO:0048241 epinephrine transport(GO:0048241)
0.9 11.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.8 3.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.8 7.5 GO:0016198 axon choice point recognition(GO:0016198)
0.7 16.9 GO:0007141 male meiosis I(GO:0007141)
0.7 2.0 GO:0060369 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.7 2.6 GO:0009822 alkaloid catabolic process(GO:0009822)
0.6 5.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.6 4.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 4.6 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.5 7.6 GO:0032836 glomerular basement membrane development(GO:0032836)
0.4 2.5 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.4 5.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.4 5.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 10.8 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.3 1.7 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.3 2.0 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.3 2.3 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.3 1.6 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.3 0.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.3 1.2 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.3 1.5 GO:0001555 oocyte growth(GO:0001555)
0.3 1.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 4.7 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.3 1.3 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 4.7 GO:0002347 response to tumor cell(GO:0002347)
0.3 7.6 GO:0071711 basement membrane organization(GO:0071711)
0.2 5.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 3.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2 1.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 2.4 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 1.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 6.8 GO:0051567 histone H3-K9 methylation(GO:0051567)
0.2 1.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.2 4.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 4.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.2 2.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 9.5 GO:0006458 'de novo' protein folding(GO:0006458)
0.2 0.9 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.2 2.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.2 6.8 GO:0070206 protein trimerization(GO:0070206)
0.2 4.6 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 16.5 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.2 11.2 GO:0030574 collagen catabolic process(GO:0030574)
0.1 2.7 GO:0007548 sex differentiation(GO:0007548)
0.1 4.1 GO:0007035 vacuolar acidification(GO:0007035)
0.1 3.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.7 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.8 GO:0060539 diaphragm development(GO:0060539)
0.1 3.0 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.9 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.9 GO:0006552 leucine catabolic process(GO:0006552)
0.1 4.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 7.2 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.9 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 3.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 2.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 5.9 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.1 0.5 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 2.2 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.1 1.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 2.8 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.1 0.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 2.9 GO:0006954 inflammatory response(GO:0006954)
0.0 2.2 GO:0016233 telomere capping(GO:0016233)
0.0 1.1 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 1.3 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 2.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.3 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 3.9 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 2.6 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 1.6 GO:0010107 potassium ion import(GO:0010107)
0.0 3.5 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 2.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 1.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 1.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.2 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.2 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.0 10.5 GO:0007517 muscle organ development(GO:0007517)
0.0 1.7 GO:0009306 protein secretion(GO:0009306)
0.0 2.6 GO:0046718 viral entry into host cell(GO:0046718)
0.0 2.9 GO:0030449 regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.0 0.5 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.5 GO:0014047 glutamate secretion(GO:0014047)
0.0 5.7 GO:0048511 rhythmic process(GO:0048511)
0.0 0.4 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.5 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.6 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 0.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.9 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 1.7 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 16.9 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
1.7 5.0 GO:0005588 collagen type V trimer(GO:0005588)
1.6 4.8 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
1.3 21.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.1 7.5 GO:0032584 growth cone membrane(GO:0032584)
1.0 3.9 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.9 2.8 GO:0097679 other organism cytoplasm(GO:0097679)
0.9 8.1 GO:0005638 lamin filament(GO:0005638)
0.9 5.4 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.9 12.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.8 9.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.8 3.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.8 3.0 GO:0097224 sperm connecting piece(GO:0097224)
0.5 1.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.5 3.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.4 2.0 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.4 4.7 GO:0060077 inhibitory synapse(GO:0060077)
0.4 2.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.3 2.5 GO:0035976 AP1 complex(GO:0035976)
0.3 8.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.3 4.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 5.1 GO:0000242 pericentriolar material(GO:0000242)
0.2 7.6 GO:0005605 basal lamina(GO:0005605)
0.2 2.9 GO:0036038 MKS complex(GO:0036038)
0.2 3.2 GO:0033270 voltage-gated sodium channel complex(GO:0001518) paranode region of axon(GO:0033270)
0.2 2.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 4.8 GO:0030673 axolemma(GO:0030673)
0.1 2.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 4.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.3 GO:0035102 PRC1 complex(GO:0035102)
0.1 7.6 GO:0005604 basement membrane(GO:0005604)
0.1 6.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.9 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 10.5 GO:0043679 axon terminus(GO:0043679)
0.1 6.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 10.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 17.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 6.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 5.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 5.3 GO:0043197 dendritic spine(GO:0043197)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.0 36.9 GO:0005794 Golgi apparatus(GO:0005794)
0.0 5.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.1 GO:0030133 transport vesicle(GO:0030133)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.2 GO:0030017 sarcomere(GO:0030017)
0.0 6.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.5 GO:0072562 blood microparticle(GO:0072562)
0.0 2.1 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.8 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
2.3 11.3 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
1.8 5.5 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
1.8 5.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
1.6 9.5 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
1.5 6.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
1.4 4.2 GO:0032767 copper-dependent protein binding(GO:0032767)
1.3 6.6 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
1.3 3.9 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
1.3 7.6 GO:0043237 laminin-1 binding(GO:0043237)
1.0 8.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.0 10.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.0 2.9 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.8 7.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.7 4.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.7 5.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 11.3 GO:0035497 cAMP response element binding(GO:0035497)
0.5 3.2 GO:0030492 hemoglobin binding(GO:0030492)
0.5 2.3 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.5 4.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 8.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 5.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 8.9 GO:0005521 lamin binding(GO:0005521)
0.3 1.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.3 10.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 8.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 9.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 5.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 3.0 GO:0032027 myosin light chain binding(GO:0032027)
0.3 24.6 GO:0005518 collagen binding(GO:0005518)
0.2 3.7 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 3.4 GO:0043495 protein anchor(GO:0043495)
0.2 5.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 3.5 GO:0015643 toxic substance binding(GO:0015643)
0.2 1.7 GO:0019863 IgE binding(GO:0019863)
0.2 4.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 3.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 19.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 5.0 GO:0001671 ATPase activator activity(GO:0001671)
0.2 2.6 GO:0070330 aromatase activity(GO:0070330)
0.2 5.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.9 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 3.6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 3.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 14.1 GO:0032947 protein complex scaffold(GO:0032947)
0.1 1.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 1.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 6.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.4 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.1 2.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 4.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 38.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 4.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 21.0 GO:0000287 magnesium ion binding(GO:0000287)
0.1 6.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 6.5 GO:0048029 monosaccharide binding(GO:0048029)
0.1 7.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.8 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 3.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.9 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.9 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 7.2 GO:0008201 heparin binding(GO:0008201)
0.0 33.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.8 GO:0070402 NADPH binding(GO:0070402)
0.0 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.0 8.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.3 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 6.3 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.6 GO:0001618 virus receptor activity(GO:0001618)
0.0 6.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 7.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 4.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.2 GO:0042393 histone binding(GO:0042393)
0.0 1.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 PID BARD1 PATHWAY BARD1 signaling events
0.7 16.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 10.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.5 11.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 5.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.3 20.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 15.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.3 8.9 NABA COLLAGENS Genes encoding collagen proteins
0.3 12.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 15.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 32.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 4.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 5.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 1.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 1.3 PID IL27 PATHWAY IL27-mediated signaling events
0.1 3.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 4.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.4 PID FGF PATHWAY FGF signaling pathway
0.0 1.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 2.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.8 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway
0.0 5.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 24.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 8.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.6 22.8 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.4 12.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.4 6.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.4 5.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 9.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 4.5 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.3 10.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 10.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 6.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 4.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 5.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 3.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 4.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 3.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 5.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 2.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 8.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 4.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 4.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 1.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.0 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1 2.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 10.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.4 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors