ISMARA results: LHX6

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for LHX6

Z-value: 0.78

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Transcription factors associated with LHX6

Gene Symbol	Gene ID	Gene Info
LHX6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106852.11	LIM homeobox 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LHX6	hg19_v2_chr9_-_124989804_124989865, hg19_v2_chr9_-_124991124_124991246	0.50	5.6e-15	Click!

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_204380919 Show fit	21.56	ENST00000367188.4	PPP1R15B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 15B
chr12_-_45269430 Show fit	12.92	ENST00000395487.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr11_-_76155618 Show fit	12.81	ENST00000530759.1	RP11-111M22.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-111M22.3
chr6_-_167040731 Show fit	12.29	ENST00000265678.4	RPS6KA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr12_-_45270151 Show fit	12.28	ENST00000429094.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr12_-_45270077 Show fit	12.13	ENST00000551601.1 ENST00000549027.1 ENST00000452445.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr11_-_76155700 Show fit	12.12	ENST00000572035.1	RP11-111M22.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-111M22.3
chr17_+_74733744 Show fit	12.01	ENST00000586689.1 ENST00000587661.1 ENST00000593181.1 ENST00000336509.4 ENST00000355954.3	MFSD11 Ensembl NCBI GeneCards UniProt NextProt Show fit	major facilitator superfamily domain containing 11
chr12_-_91546926 Show fit	11.99	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr6_-_32095968 Show fit	11.32	ENST00000375203.3 ENST00000375201.4	ATF6B Ensembl NCBI GeneCards UniProt NextProt Show fit	activating transcription factor 6 beta

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	37.3	GO:0070050	neuron cellular homeostasis(GO:0070050)
2.4	21.8	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.7	16.9	GO:0007141	male meiosis I(GO:0007141)
0.2	16.5	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
1.0	12.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.5	11.8	GO:0001920	negative regulation of receptor recycling(GO:0001920)
1.1	11.3	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.9	11.3	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.2	11.2	GO:0030574	collagen catabolic process(GO:0030574)
0.3	10.8	GO:1902475	L-alpha-amino acid transmembrane transport(GO:1902475)

Showing 1 to 10 of 120 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	36.9	GO:0005794	Golgi apparatus(GO:0005794)
1.3	21.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	17.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
3.4	16.9	GO:0097123	cyclin A1-CDK2 complex(GO:0097123)
0.9	12.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	10.5	GO:0043679	axon terminus(GO:0043679)
0.1	10.0	GO:0031225	anchored component of membrane(GO:0031225)
0.8	9.8	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.3	8.2	GO:0005721	pericentric heterochromatin(GO:0005721)
0.9	8.1	GO:0005638	lamin filament(GO:0005638)

Showing 1 to 10 of 63 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	38.5	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	33.8	GO:0005509	calcium ion binding(GO:0005509)
0.3	24.6	GO:0005518	collagen binding(GO:0005518)
0.1	21.0	GO:0000287	magnesium ion binding(GO:0000287)
0.2	19.2	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.1	14.1	GO:0032947	protein complex scaffold(GO:0032947)
2.3	11.3	GO:0004771	sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.5	11.3	GO:0035497	cAMP response element binding(GO:0035497)
0.3	10.8	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
1.0	10.0	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)

Showing 1 to 10 of 87 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	32.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	20.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.7	16.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	15.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.3	15.2	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	12.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.5	11.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5	10.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	8.9	NABA COLLAGENS	Genes encoding collagen proteins
0.1	5.9	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	24.7	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.6	22.8	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.4	12.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	10.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	10.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	10.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.3	9.7	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	8.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	8.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.4	6.5	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis

Showing 1 to 10 of 47 entries

Results for LHX6

Z-value: 0.78

Motif logo

Transcription factors associated with LHX6

Activity-expression correlation:

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: