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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MAFA
Z-value: 0.94
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Transcription factors associated with MAFA
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_33182823 Show fit | 19.72 |
ENST00000397061.3
|
nudix (nucleoside diphosphate linked moiety X)-type motif 19 |
|
| chr12_+_79258444 Show fit | 19.04 |
ENST00000261205.4
|
synaptotagmin I |
|
| chr12_+_79258547 Show fit | 17.15 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr16_+_56225248 Show fit | 15.08 |
ENST00000262493.6
|
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O |
|
| chr21_+_41239243 Show fit | 14.39 |
ENST00000328619.5
|
Purkinje cell protein 4 |
|
| chr11_-_777467 Show fit | 13.54 |
ENST00000397472.2
ENST00000524550.1 ENST00000319863.8 ENST00000526325.1 ENST00000442059.2 |
Parkinson disease 7 domain containing 1 |
|
| chr12_-_105478339 Show fit | 13.45 |
ENST00000424857.2
ENST00000258494.9 |
aldehyde dehydrogenase 1 family, member L2 |
|
| chr10_+_124221036 Show fit | 13.06 |
ENST00000368984.3
|
HtrA serine peptidase 1 |
|
| chr15_+_80696666 Show fit | 12.96 |
ENST00000303329.4
|
aryl-hydrocarbon receptor nuclear translocator 2 |
|
| chr1_+_163039143 Show fit | 12.90 |
ENST00000531057.1
ENST00000527809.1 ENST00000367908.4 |
regulator of G-protein signaling 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 36.2 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.2 | 19.7 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.3 | 15.1 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.1 | 14.1 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 4.5 | 13.5 | GO:0009258 | 10-formyltetrahydrofolate catabolic process(GO:0009258) |
| 2.6 | 13.1 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.1 | 13.0 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.3 | 12.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 1.1 | 12.1 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.1 | 11.2 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 36.2 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 21.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 19.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 15.6 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.3 | 15.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 14.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 13.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 11.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 10.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 10.1 | GO:0000776 | kinetochore(GO:0000776) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 36.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.2 | 19.7 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 1.4 | 15.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 4.5 | 13.5 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.4 | 13.1 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.9 | 13.0 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.4 | 12.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 1.7 | 12.1 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.5 | 11.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 11.1 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 36.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.7 | 15.1 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 13.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.4 | 6.6 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 3.4 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.2 | 2.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 2.2 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 43.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 15.1 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.4 | 12.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.4 | 9.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 8.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 6.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 6.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 5.3 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 5.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 4.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |