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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MAFA

Z-value: 0.94

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Transcription factors associated with MAFA

Gene Symbol Gene ID Gene Info
MAFA
ENSG00000182759.3 MAF bZIP transcription factor A

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_33182823 19.72 ENST00000397061.3
NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr12_+_79258444 19.04 ENST00000261205.4
SYT1
synaptotagmin I
chr12_+_79258547 17.15 ENST00000457153.2
SYT1
synaptotagmin I
chr16_+_56225248 15.08 ENST00000262493.6
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr21_+_41239243 14.39 ENST00000328619.5
PCP4
Purkinje cell protein 4
chr11_-_777467 13.54 ENST00000397472.2
ENST00000524550.1
ENST00000319863.8
ENST00000526325.1
ENST00000442059.2
PDDC1
Parkinson disease 7 domain containing 1
chr12_-_105478339 13.45 ENST00000424857.2
ENST00000258494.9
ALDH1L2
aldehyde dehydrogenase 1 family, member L2
chr10_+_124221036 13.06 ENST00000368984.3
HTRA1
HtrA serine peptidase 1
chr15_+_80696666 12.96 ENST00000303329.4
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr1_+_163039143 12.90 ENST00000531057.1
ENST00000527809.1
ENST00000367908.4
RGS4
regulator of G-protein signaling 4
chr9_-_100000957 11.93 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
RP11-498P14.5
chr10_-_79397391 11.50 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_+_141121164 11.49 ENST00000510338.1
ENST00000504673.1
ZBTB38
zinc finger and BTB domain containing 38
chrX_-_92928557 11.15 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr12_-_123215306 10.76 ENST00000356987.2
ENST00000436083.2
HCAR1
hydroxycarboxylic acid receptor 1
chr13_+_53226963 10.12 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
SUGT1
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr6_-_74161977 10.10 ENST00000370318.1
ENST00000370315.3
MB21D1
Mab-21 domain containing 1
chr16_-_46865047 9.81 ENST00000394806.2
C16orf87
chromosome 16 open reading frame 87
chr3_+_196439170 9.40 ENST00000392391.3
ENST00000314118.4
PIGX
phosphatidylinositol glycan anchor biosynthesis, class X
chr5_-_118324200 8.40 ENST00000515439.3
ENST00000510708.1
DTWD2
DTW domain containing 2
chr3_-_196439065 7.94 ENST00000399942.4
ENST00000409690.3
CEP19
centrosomal protein 19kDa
chr8_+_85095769 7.19 ENST00000518566.1
RALYL
RALY RNA binding protein-like
chr7_-_73133959 7.01 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr1_-_57045228 6.72 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr22_-_28197486 6.67 ENST00000302326.4
MN1
meningioma (disrupted in balanced translocation) 1
chrX_-_47509887 6.62 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1
ELK1, member of ETS oncogene family
chr2_+_191745535 6.47 ENST00000320717.3
GLS
glutaminase
chr5_-_114505624 6.46 ENST00000513154.1
TRIM36
tripartite motif containing 36
chr10_+_120967072 6.43 ENST00000392870.2
GRK5
G protein-coupled receptor kinase 5
chr8_+_85095497 6.21 ENST00000522455.1
ENST00000521695.1
RALYL
RALY RNA binding protein-like
chr17_+_41363854 6.10 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr15_-_66858298 6.07 ENST00000537670.1
LCTL
lactase-like
chr7_-_135412925 5.85 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr11_+_107461948 5.81 ENST00000265840.7
ENST00000443271.2
ELMOD1
ELMO/CED-12 domain containing 1
chr16_+_70258261 5.48 ENST00000594734.1
FKSG63
FKSG63
chrX_-_107975917 5.46 ENST00000563887.1
RP6-24A23.6
Uncharacterized protein
chr2_+_118846008 5.39 ENST00000245787.4
INSIG2
insulin induced gene 2
chr1_-_216978709 5.39 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr5_-_179285785 5.30 ENST00000520698.1
ENST00000518235.1
ENST00000376931.2
ENST00000518219.1
ENST00000521333.1
ENST00000523084.1
C5orf45
chromosome 5 open reading frame 45
chrX_-_43741594 5.28 ENST00000536181.1
ENST00000378069.4
MAOB
monoamine oxidase B
chr8_+_85095553 5.12 ENST00000521268.1
RALYL
RALY RNA binding protein-like
chr1_+_156124162 4.90 ENST00000368282.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr5_-_179285848 4.82 ENST00000403396.2
ENST00000292586.6
C5orf45
chromosome 5 open reading frame 45
chr1_+_66458072 4.75 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_45956822 4.69 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr16_-_21436459 4.62 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr4_+_6784401 4.35 ENST00000425103.1
ENST00000307659.5
KIAA0232
KIAA0232
chr9_-_130712995 4.35 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr16_-_29517141 4.34 ENST00000550665.1
RP11-231C14.4
Uncharacterized protein
chr19_+_54641444 4.30 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr1_+_110754094 4.16 ENST00000369787.3
ENST00000413138.3
ENST00000438661.2
KCNC4
potassium voltage-gated channel, Shaw-related subfamily, member 4
chr4_+_72052964 4.10 ENST00000264485.5
ENST00000425175.1
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr11_-_2182388 4.10 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
INS
INS-IGF2
insulin
INS-IGF2 readthrough
chr7_-_30029367 3.93 ENST00000242059.5
SCRN1
secernin 1
chr19_+_12949251 3.88 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chrX_-_65858865 3.86 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
EDA2R
ectodysplasin A2 receptor
chr7_-_30029574 3.79 ENST00000426154.1
ENST00000421434.1
ENST00000434476.2
SCRN1
secernin 1
chr4_+_72053017 3.71 ENST00000351898.6
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr1_-_54872059 3.62 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr5_+_176853702 3.40 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
GRK6
G protein-coupled receptor kinase 6
chr2_-_30143525 3.37 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr16_-_29415350 3.22 ENST00000524087.1
NPIPB11
nuclear pore complex interacting protein family, member B11
chr2_+_26915584 2.99 ENST00000302909.3
KCNK3
potassium channel, subfamily K, member 3
chrX_-_65859096 2.96 ENST00000456230.2
EDA2R
ectodysplasin A2 receptor
chr12_+_53817633 2.91 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
AMHR2
anti-Mullerian hormone receptor, type II
chr16_+_22524844 2.81 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr8_-_63998590 2.55 ENST00000260116.4
TTPA
tocopherol (alpha) transfer protein
chrX_-_106959631 2.46 ENST00000486554.1
ENST00000372390.4
TSC22D3
TSC22 domain family, member 3
chr11_-_62783303 2.44 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr11_-_62783276 2.21 ENST00000535878.1
ENST00000545207.1
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr1_+_200842083 2.20 ENST00000304244.2
GPR25
G protein-coupled receptor 25
chr16_-_21868739 2.05 ENST00000415645.2
NPIPB4
nuclear pore complex interacting protein family, member B4
chr11_+_72929402 1.81 ENST00000393596.2
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr10_-_49701686 1.81 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr22_-_27014043 1.80 ENST00000215939.2
CRYBB1
crystallin, beta B1
chr6_+_42896865 1.73 ENST00000372836.4
ENST00000394142.3
CNPY3
canopy FGF signaling regulator 3
chr1_+_174769006 1.69 ENST00000489615.1
RABGAP1L
RAB GTPase activating protein 1-like
chr5_-_22853429 1.65 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr17_+_25936862 1.64 ENST00000582410.1
KSR1
kinase suppressor of ras 1
chr11_-_66103932 1.60 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr5_-_39270725 1.58 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr9_+_131549610 1.50 ENST00000223865.8
TBC1D13
TBC1 domain family, member 13
chr11_+_118826999 1.49 ENST00000264031.2
UPK2
uroplakin 2
chr6_+_7727030 1.43 ENST00000283147.6
BMP6
bone morphogenetic protein 6
chr19_-_48547294 1.39 ENST00000293255.2
CABP5
calcium binding protein 5
chr14_+_81421355 1.38 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr11_+_72929319 1.37 ENST00000393597.2
ENST00000311131.2
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr7_-_22234381 1.30 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_+_36103631 1.28 ENST00000203166.5
ENST00000379045.2
HAUS5
HAUS augmin-like complex, subunit 5
chr1_+_202091980 1.22 ENST00000367282.5
GPR37L1
G protein-coupled receptor 37 like 1
chr16_-_67514982 1.21 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr10_-_29811456 1.08 ENST00000535393.1
SVIL
supervillin
chr10_-_70231639 1.03 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
DNA2
DNA replication helicase/nuclease 2
chr7_-_100860851 0.89 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr10_-_81708854 0.72 ENST00000372292.3
SFTPD
surfactant protein D
chr12_-_22487618 0.72 ENST00000404299.3
ENST00000396037.4
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr2_+_85811525 0.71 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chr10_-_79397479 0.64 ENST00000404771.3
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr12_+_54943134 0.59 ENST00000243052.3
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr1_-_45956800 0.57 ENST00000538496.1
TESK2
testis-specific kinase 2
chr9_-_127905736 0.54 ENST00000336505.6
ENST00000373549.4
SCAI
suppressor of cancer cell invasion
chr15_-_41047421 0.44 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr14_+_81421710 0.37 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr6_+_89791507 0.31 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr2_+_103236004 0.31 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr14_+_81421861 0.31 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chrX_+_68725084 0.30 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr7_-_151433342 0.22 ENST00000433631.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr10_-_102289611 0.18 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NDUFB8
SEC31B
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr2_+_102624977 0.17 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chrX_-_153141302 0.11 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr14_+_81421921 0.11 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr14_+_50779071 0.09 ENST00000426751.2
ATP5S
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr7_-_150754935 0.06 ENST00000297518.4
CDK5
cyclin-dependent kinase 5
chr22_+_22599189 0.02 ENST00000302273.2
VPREB1
pre-B lymphocyte 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 36.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
4.5 13.5 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258)
2.6 13.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.8 7.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
1.7 10.1 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
1.4 4.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
1.3 6.7 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
1.1 12.1 GO:0034465 response to carbon monoxide(GO:0034465)
0.8 3.4 GO:0036269 swimming behavior(GO:0036269)
0.8 5.3 GO:0010269 response to selenium ion(GO:0010269)
0.7 2.9 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.7 6.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.6 2.5 GO:0090212 vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
0.6 6.6 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.5 2.2 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.5 3.6 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.5 5.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.5 5.8 GO:0008272 sulfate transport(GO:0008272)
0.5 6.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.5 10.1 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.5 9.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.4 4.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.4 2.5 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 1.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 12.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.3 15.1 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.3 3.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.3 0.9 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.3 3.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 4.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 0.7 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.2 6.5 GO:0007340 acrosome reaction(GO:0007340)
0.2 19.7 GO:0009062 fatty acid catabolic process(GO:0009062)
0.2 7.8 GO:0015701 bicarbonate transport(GO:0015701)
0.2 1.2 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.1 4.9 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 14.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 4.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.6 GO:0042428 serotonin metabolic process(GO:0042428)
0.1 11.2 GO:0006334 nucleosome assembly(GO:0006334)
0.1 5.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 13.0 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 1.7 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.1 1.2 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 4.2 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 10.0 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 1.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 3.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 5.3 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.5 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 1.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 1.7 GO:0034332 adherens junction organization(GO:0034332)
0.0 0.7 GO:0097503 sialylation(GO:0097503)
0.0 0.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 3.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 1.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.3 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.2 GO:0046320 regulation of fatty acid oxidation(GO:0046320)
0.0 0.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:1902803 regulation of synaptic vesicle transport(GO:1902803)
0.0 7.2 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 8.6 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 3.9 GO:0007010 cytoskeleton organization(GO:0007010)
0.0 1.3 GO:0007098 centrosome cycle(GO:0007098)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 36.2 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
1.8 7.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.3 5.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 4.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 19.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 15.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 4.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 1.1 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.3 GO:0070652 HAUS complex(GO:0070652)
0.1 15.6 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 2.5 GO:0005770 late endosome(GO:0005770)
0.1 7.9 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 1.0 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 6.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.1 GO:0031904 endosome lumen(GO:0031904)
0.1 10.1 GO:0000776 kinetochore(GO:0000776)
0.1 6.0 GO:0005903 brush border(GO:0005903)
0.0 11.5 GO:0072562 blood microparticle(GO:0072562)
0.0 6.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.7 GO:0042599 lamellar body(GO:0042599)
0.0 14.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 13.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 8.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 10.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 8.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 1.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 21.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 36.2 GO:0030348 syntaxin-3 binding(GO:0030348)
4.5 13.5 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
3.3 9.8 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
1.7 12.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
1.5 6.1 GO:0008422 beta-glucosidase activity(GO:0008422)
1.4 15.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.2 19.7 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.9 13.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.8 5.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.7 5.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.7 2.9 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.7 5.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.6 7.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.6 2.5 GO:0008431 vitamin E binding(GO:0008431)
0.5 3.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.5 11.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.4 7.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 12.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 13.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 1.0 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.3 4.7 GO:0015301 inorganic anion exchanger activity(GO:0005452) anion:anion antiporter activity(GO:0015301)
0.3 2.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.3 3.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 7.7 GO:0016805 dipeptidase activity(GO:0016805)
0.3 0.9 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.3 4.9 GO:0038191 neuropilin binding(GO:0038191)
0.3 2.5 GO:0043426 MRF binding(GO:0043426)
0.2 6.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 3.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 4.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 4.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.4 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 1.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 3.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 6.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.3 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 3.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 11.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 7.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 10.1 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 5.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.7 GO:0005516 calmodulin binding(GO:0005516)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 15.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.7 36.2 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.4 6.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 2.9 PID ALK2 PATHWAY ALK2 signaling events
0.2 11.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 4.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 13.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID ARF6 PATHWAY Arf6 signaling events
0.0 5.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 3.4 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 43.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5 15.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4 3.0 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 9.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.4 12.9 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.2 4.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 4.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 4.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 6.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 6.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.2 3.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 2.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 4.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 4.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.0 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 3.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 8.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 5.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.2 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 3.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases