ISMARA results: MAFB

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MAFB

Z-value: 0.04

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Transcription factors associated with MAFB

Gene Symbol	Gene ID	Gene Info
MAFB Ensembl NCBI GeneCards UniProt NextProt	ENSG00000204103.2	MAF bZIP transcription factor B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MAFB	hg19_v2_chr20_-_39317868_39317884	-0.13	5.1e-02	Click!

Activity profile of MAFB motif

Sorted Z-values of MAFB motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_60337684 Show fit	45.07	ENST00000267484.5	RTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 1
chr4_-_102268484 Show fit	21.06	ENST00000394853.4	PPP3CA Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_-_55277512 Show fit	20.72	ENST00000402434.2	RTN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 4
chr2_+_191745535 Show fit	20.30	ENST00000320717.3	GLS Ensembl NCBI GeneCards UniProt NextProt Show fit	glutaminase
chr2_-_55277436 Show fit	18.46	ENST00000354474.6	RTN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 4
chr6_+_150070831 Show fit	15.54	ENST00000367380.5	PCMT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr2_-_55277692 Show fit	14.58	ENST00000394611.2	RTN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 4
chr2_-_55277654 Show fit	14.21	ENST00000337526.6 ENST00000317610.7 ENST00000357732.4	RTN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 4
chr6_+_150070857 Show fit	13.15	ENST00000544496.1	PCMT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein-L-isoaspartate (D-aspartate) O-methyltransferase
chrX_-_47479246 Show fit	13.15	ENST00000295987.7 ENST00000340666.4	SYN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synapsin I

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.7	87.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
12.1	36.3	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
1.5	34.2	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
3.2	29.0	GO:0030091	protein repair(GO:0030091)
1.4	28.6	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.8	27.8	GO:0090383	phagosome acidification(GO:0090383)
2.2	24.0	GO:2000582	positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
2.3	23.2	GO:0051610	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.4	20.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
2.5	19.7	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)

Showing 1 to 10 of 506 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	72.7	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
1.0	53.2	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.2	51.3	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.5	43.2	GO:0043195	terminal bouton(GO:0043195)
4.7	42.2	GO:0005955	calcineurin complex(GO:0005955)
0.1	38.1	GO:0045202	synapse(GO:0045202)
0.2	37.0	GO:0030427	site of polarized growth(GO:0030427)
0.2	34.0	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.9	31.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	26.2	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Showing 1 to 10 of 210 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	70.3	GO:0045296	cadherin binding(GO:0045296)
4.3	42.6	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3	32.0	GO:0019888	protein phosphatase regulator activity(GO:0019888)
9.9	29.8	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1	26.7	GO:0003924	GTPase activity(GO:0003924)
0.7	21.4	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
3.5	21.1	GO:1903135	cupric ion binding(GO:1903135)
1.9	21.1	GO:0031681	G-protein beta-subunit binding(GO:0031681)
1.6	19.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
1.6	18.8	GO:0004971	AMPA glutamate receptor activity(GO:0004971)

Showing 1 to 10 of 325 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	95.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.5	33.7	PID ATR PATHWAY	ATR signaling pathway
0.6	31.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.7	29.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	25.3	PID AURORA A PATHWAY	Aurora A signaling
1.0	20.4	PID S1P S1P4 PATHWAY	S1P4 pathway
0.4	19.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	18.5	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.3	16.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.4	12.4	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Showing 1 to 10 of 56 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	75.8	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
1.1	63.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	39.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3	34.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
1.1	31.9	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5	29.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.6	26.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.8	23.6	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.6	19.1	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.6	18.7	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling

Showing 1 to 10 of 114 entries

Results for MAFB

Z-value: 0.04

Motif logo

Transcription factors associated with MAFB

Activity-expression correlation:

Activity profile of MAFB motif

Sorted Z-values of MAFB motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: