ISMARA results: MAFK

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MAFK

Z-value: 0.43

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Transcription factors associated with MAFK

Gene Symbol	Gene ID	Gene Info
MAFK Ensembl NCBI GeneCards UniProt NextProt	ENSG00000198517.5	MAF bZIP transcription factor K

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MAFK	hg19_v2_chr7_+_1570322_1570360	0.29	1.2e-05	Click!

Activity profile of MAFK motif

Sorted Z-values of MAFK motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_89459813 Show fit	34.31	ENST00000390256.2	IGKV6-21 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 6-21 (non-functional)
chr6_+_33043703 Show fit	25.13	ENST00000418931.2 ENST00000535465.1	HLA-DPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP beta 1
chr2_+_90060377 Show fit	17.51	ENST00000436451.2	IGKV6D-21 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 6D-21 (non-functional)
chr6_+_32709119 Show fit	15.00	ENST00000374940.3	HLA-DQA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DQ alpha 2
chr12_-_15103621 Show fit	14.55	ENST00000536592.1	ARHGDIB Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GDP dissociation inhibitor (GDI) beta
chr10_+_5135981 Show fit	13.83	ENST00000380554.3	AKR1C3 Ensembl NCBI GeneCards UniProt NextProt Show fit	aldo-keto reductase family 1, member C3
chr3_-_121379739 Show fit	13.62	ENST00000428394.2 ENST00000314583.3	HCLS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hematopoietic cell-specific Lyn substrate 1
chr22_+_23237555 Show fit	12.93	ENST00000390321.2	IGLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 1 (Mcg marker)
chr1_+_158801095 Show fit	12.47	ENST00000368141.4	MNDA Ensembl NCBI GeneCards UniProt NextProt Show fit	myeloid cell nuclear differentiation antigen
chr12_+_69742121 Show fit	12.34	ENST00000261267.2 ENST00000549690.1 ENST00000548839.1	LYZ Ensembl NCBI GeneCards UniProt NextProt Show fit	lysozyme

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFK

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	222.1	GO:0006958	complement activation, classical pathway(GO:0006958)
0.6	87.4	GO:0002377	immunoglobulin production(GO:0002377)
6.0	42.2	GO:0071395	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.4	40.4	GO:0031295	T cell costimulation(GO:0031295)
1.2	26.5	GO:0052695	cellular glucuronidation(GO:0052695)
0.4	24.6	GO:0018149	peptide cross-linking(GO:0018149)
0.2	24.0	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
1.0	16.7	GO:0051639	actin filament network formation(GO:0051639)
0.6	14.6	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
3.6	14.5	GO:0071461	cellular response to redox state(GO:0071461)

Showing 1 to 10 of 371 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	134.4	GO:0072562	blood microparticle(GO:0072562)
0.1	104.7	GO:0005615	extracellular space(GO:0005615)
1.5	71.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
2.0	42.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.4	41.9	GO:0035578	azurophil granule lumen(GO:0035578)
0.1	37.1	GO:0009897	external side of plasma membrane(GO:0009897)
1.1	20.8	GO:0001891	phagocytic cup(GO:0001891)
0.3	20.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.3	16.1	GO:0001533	cornified envelope(GO:0001533)
0.8	14.8	GO:0031089	platelet dense granule lumen(GO:0031089)

Showing 1 to 10 of 131 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	227.3	GO:0003823	antigen binding(GO:0003823)
1.5	81.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
6.8	40.6	GO:0047086	phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.9	33.0	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.3	25.6	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	21.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.3	18.2	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	16.2	GO:0051015	actin filament binding(GO:0051015)
1.5	14.5	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	14.3	GO:0004866	endopeptidase inhibitor activity(GO:0004866)

Showing 1 to 10 of 275 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	17.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	17.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	11.7	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	11.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.2	11.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	10.2	PID CMYB PATHWAY	C-MYB transcription factor network
0.3	9.9	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	8.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	7.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events

Showing 1 to 10 of 56 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	53.8	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.7	44.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.4	34.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	19.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.2	18.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	17.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	17.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	17.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	11.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	11.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport

Showing 1 to 10 of 96 entries

Results for MAFK

Z-value: 0.43

Motif logo

Transcription factors associated with MAFK

Activity-expression correlation:

Activity profile of MAFK motif

Sorted Z-values of MAFK motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFK

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: