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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 0.80
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Transcription factors associated with MAZ_ZNF281_GTF2F1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000103495.9 | MYC associated zinc finger protein | |
| ENSG00000162702.7 | zinc finger protein 281 | |
| ENSG00000125651.9 | general transcription factor IIF subunit 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg19_v2_chr19_-_6393465_6393479 | -0.46 | 1.0e-12 | Click! |
| MAZ | hg19_v2_chr16_+_29818857_29819023 | -0.41 | 1.9e-10 | Click! |
| ZNF281 | hg19_v2_chr1_-_200379180_200379191, hg19_v2_chr1_-_200379129_200379174, hg19_v2_chr1_-_200379104_200379128 | -0.20 | 3.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_20812690 Show fit | 84.93 |
ENST00000375078.3
|
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
| chr8_+_80523962 Show fit | 78.37 |
ENST00000518491.1
|
stathmin-like 2 |
|
| chr6_-_29600832 Show fit | 76.66 |
ENST00000377016.4
ENST00000376977.3 ENST00000377034.4 |
gamma-aminobutyric acid (GABA) B receptor, 1 |
|
| chr11_-_64410787 Show fit | 71.08 |
ENST00000301894.2
|
neurexin 2 |
|
| chr11_-_111783595 Show fit | 65.20 |
ENST00000528628.1
|
crystallin, alpha B |
|
| chr19_-_49149553 Show fit | 59.16 |
ENST00000084798.4
|
carbonic anhydrase XI |
|
| chr11_-_111782696 Show fit | 53.23 |
ENST00000227251.3
ENST00000526180.1 |
crystallin, alpha B |
|
| chr12_-_6798616 Show fit | 51.70 |
ENST00000355772.4
ENST00000417772.3 ENST00000396801.3 ENST00000396799.2 |
zinc finger protein 384 |
|
| chr9_-_122131696 Show fit | 50.14 |
ENST00000373964.2
ENST00000265922.3 |
bone morphogenetic protein/retinoic acid inducible neural-specific 1 |
|
| chr11_-_64490634 Show fit | 48.87 |
ENST00000377559.3
ENST00000265459.6 |
neurexin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 251.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 13.3 | 239.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 14.5 | 232.7 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 22.5 | 180.3 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 2.2 | 159.2 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 2.3 | 152.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 3.6 | 127.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 12.5 | 124.7 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 5.9 | 117.4 | GO:0022010 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 4.0 | 111.3 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 657.3 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 3.1 | 538.4 | GO:0030426 | growth cone(GO:0030426) |
| 2.8 | 293.6 | GO:0043204 | perikaryon(GO:0043204) |
| 4.0 | 276.8 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 15.9 | 254.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 2.7 | 209.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 3.9 | 196.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 3.7 | 194.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.2 | 188.1 | GO:0098793 | presynapse(GO:0098793) |
| 0.1 | 175.9 | GO:0016021 | integral component of membrane(GO:0016021) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 231.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 14.4 | 230.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 195.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.9 | 186.8 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.5 | 149.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 2.9 | 144.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 4.7 | 135.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 6.3 | 126.7 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 9.2 | 110.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 8.3 | 107.8 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 193.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.4 | 190.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.5 | 127.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 2.1 | 109.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 1.3 | 97.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 2.1 | 74.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 1.3 | 73.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.1 | 66.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 1.4 | 64.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 1.7 | 63.3 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.5 | 189.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 5.1 | 174.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 5.2 | 162.0 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 5.7 | 154.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 1.4 | 148.5 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 2.2 | 145.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 3.2 | 138.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 6.9 | 125.1 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.8 | 122.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 2.6 | 121.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |