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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MECOM

Z-value: 1.00

Motif logo

Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
ENSG00000085276.13 MDS1 and EVI1 complex locus

Activity-expression correlation:

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_88450244 33.21 ENST00000503414.1
SPARC-like 1 (hevin)
chr12_-_16758059 19.10 ENST00000261169.6
LIM domain only 3 (rhombotin-like 2)
chr12_-_16758304 18.74 ENST00000320122.6
LIM domain only 3 (rhombotin-like 2)
chr6_-_31514516 16.95 ENST00000303892.5
ENST00000483251.1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr17_-_66951474 16.25 ENST00000269080.2
ATP-binding cassette, sub-family A (ABC1), member 8
chr8_-_27115931 15.13 ENST00000523048.1
stathmin-like 4
chr6_-_52860171 13.61 ENST00000370963.4
glutathione S-transferase alpha 4
chr12_-_15038779 13.15 ENST00000228938.5
ENST00000539261.1
matrix Gla protein
chr6_-_52859968 12.97 ENST00000370959.1
glutathione S-transferase alpha 4
chr10_+_106034884 12.43 ENST00000369707.2
ENST00000429569.2
glutathione S-transferase omega 2
chr8_-_27115903 12.19 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
stathmin-like 4
chr2_-_224467093 11.94 ENST00000305409.2
secretogranin II
chr3_-_145968923 11.28 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
phospholipid scramblase 4
chr17_-_37308824 11.10 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
plexin domain containing 1
chr17_+_53344945 11.08 ENST00000575345.1
hepatic leukemia factor
chr3_-_145968857 10.61 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
phospholipid scramblase 4
chr5_+_140739537 10.32 ENST00000522605.1
protocadherin gamma subfamily B, 2
chrX_-_43741594 10.17 ENST00000536181.1
ENST00000378069.4
monoamine oxidase B
chr11_-_18656028 10.03 ENST00000336349.5
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr17_+_73750699 9.38 ENST00000584939.1
integrin, beta 4
chr6_+_69942298 9.18 ENST00000238918.8
brain-specific angiogenesis inhibitor 3
chr5_-_64920115 8.72 ENST00000381018.3
ENST00000274327.7
tripartite motif containing 23
chr8_-_38008783 8.53 ENST00000276449.4
steroidogenic acute regulatory protein
chr12_-_8218997 8.38 ENST00000307637.4
complement component 3a receptor 1
chr22_+_29138013 8.23 ENST00000216027.3
ENST00000398941.2
HscB mitochondrial iron-sulfur cluster co-chaperone
chr18_-_21891460 8.17 ENST00000357041.4
oxysterol binding protein-like 1A
chr7_+_97361388 8.17 ENST00000350485.4
ENST00000346867.4
tachykinin, precursor 1
chr3_-_45883558 8.03 ENST00000445698.1
ENST00000296135.6
leucine zipper transcription factor-like 1
chr2_+_189839046 7.92 ENST00000304636.3
ENST00000317840.5
collagen, type III, alpha 1
chr2_+_55746746 7.01 ENST00000406691.3
ENST00000349456.4
ENST00000407816.3
ENST00000403007.3
coiled-coil domain containing 104
chr7_-_100844193 6.95 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
monoacylglycerol O-acyltransferase 3
chr4_-_76944621 6.91 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr3_+_147127142 6.87 ENST00000282928.4
Zic family member 1
chr14_-_76447494 6.75 ENST00000238682.3
transforming growth factor, beta 3
chr2_-_237416181 6.70 ENST00000409907.3
IQ motif containing with AAA domain 1
chr5_+_140165876 6.68 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
protocadherin alpha 1
chr2_-_237416071 6.52 ENST00000309507.5
ENST00000431676.2
IQ motif containing with AAA domain 1
chr14_-_24584138 6.20 ENST00000558280.1
ENST00000561028.1
neural retina leucine zipper
chr5_+_64920543 6.20 ENST00000399438.3
ENST00000510585.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr9_+_82186682 6.15 ENST00000376552.2
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_-_56150910 5.96 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EGF containing fibulin-like extracellular matrix protein 1
chr17_-_43138357 5.95 ENST00000342350.5
dephospho-CoA kinase domain containing
chr9_+_134378289 5.92 ENST00000423007.1
ENST00000404875.2
ENST00000441334.1
ENST00000341012.7
ENST00000372228.3
ENST00000402686.3
ENST00000419118.2
ENST00000541219.1
ENST00000354713.4
ENST00000418774.1
ENST00000415075.1
ENST00000448212.1
ENST00000430619.1
protein-O-mannosyltransferase 1
chr12_+_57522258 5.90 ENST00000553277.1
ENST00000243077.3
low density lipoprotein receptor-related protein 1
chr8_-_39695719 5.87 ENST00000347580.4
ENST00000379853.2
ENST00000521880.1
ADAM metallopeptidase domain 2
chr14_+_29236269 5.87 ENST00000313071.4
forkhead box G1
chr12_+_20848486 5.78 ENST00000545102.1
solute carrier organic anion transporter family, member 1C1
chr6_+_31515337 5.67 ENST00000376148.4
ENST00000376145.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr8_-_39695764 5.63 ENST00000265708.4
ADAM metallopeptidase domain 2
chr5_+_74807886 5.60 ENST00000514296.1
polymerase (DNA directed) kappa
chr5_-_115910091 5.58 ENST00000257414.8
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr6_-_87804815 5.56 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chr5_+_102201722 5.52 ENST00000274392.9
ENST00000455264.2
peptidylglycine alpha-amidating monooxygenase
chr2_-_145275228 5.38 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
zinc finger E-box binding homeobox 2
chr4_+_155484155 5.32 ENST00000509493.1
fibrinogen beta chain
chr4_+_74275057 5.26 ENST00000511370.1
albumin
chr5_+_125695805 5.17 ENST00000513040.1
GRAM domain containing 3
chr19_+_22235279 5.16 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
zinc finger protein 257
chr6_+_29624898 5.09 ENST00000396704.3
ENST00000483013.1
ENST00000490427.1
ENST00000416766.2
ENST00000376891.4
ENST00000376898.3
ENST00000396701.2
ENST00000494692.1
ENST00000431798.2
myelin oligodendrocyte glycoprotein
chr17_-_37309480 5.07 ENST00000539608.1
plexin domain containing 1
chr6_-_22297730 4.96 ENST00000306482.1
prolactin
chrX_-_62974941 4.95 ENST00000374872.1
ENST00000253401.6
ENST00000374870.4
Cdc42 guanine nucleotide exchange factor (GEF) 9
chrX_-_85302531 4.95 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
choroideremia (Rab escort protein 1)
chr5_+_64920826 4.86 ENST00000438419.2
ENST00000231526.4
ENST00000505553.1
ENST00000545191.1
trafficking protein particle complex 13
chr3_+_148583043 4.86 ENST00000296046.3
carboxypeptidase A3 (mast cell)
chr6_-_154831779 4.84 ENST00000607772.1
CNKSR family member 3
chr9_+_82186872 4.78 ENST00000376544.3
ENST00000376520.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_37392086 4.64 ENST00000561208.1
Meis homeobox 2
chr1_+_209859510 4.60 ENST00000367028.2
ENST00000261465.1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_+_102201509 4.57 ENST00000348126.2
ENST00000379787.4
peptidylglycine alpha-amidating monooxygenase
chr12_+_20848282 4.56 ENST00000545604.1
solute carrier organic anion transporter family, member 1C1
chr11_+_12115543 4.47 ENST00000537344.1
ENST00000532179.1
ENST00000526065.1
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr12_+_20848377 4.43 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
solute carrier organic anion transporter family, member 1C1
chr12_+_72079842 4.32 ENST00000266673.5
ENST00000550524.1
transmembrane protein 19
chr11_+_61008514 4.24 ENST00000312403.5
pepsinogen 5, group I (pepsinogen A)
chr1_+_206223941 4.18 ENST00000367126.4
arginine vasopressin receptor 1B
chr15_-_79103757 4.12 ENST00000388820.4
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr7_-_8302164 3.99 ENST00000447326.1
ENST00000406470.2
islet cell autoantigen 1, 69kDa
chr8_+_42552533 3.89 ENST00000289957.2
cholinergic receptor, nicotinic, beta 3 (neuronal)
chr13_+_49280951 3.87 ENST00000282018.3
cysteinyl leukotriene receptor 2
chr15_+_71185148 3.87 ENST00000443425.2
ENST00000560755.1
leucine rich repeat containing 49
chr14_-_24551195 3.81 ENST00000560550.1
neural retina leucine zipper
chr12_+_72080253 3.73 ENST00000549735.1
transmembrane protein 19
chr14_-_24551137 3.69 ENST00000396995.1
neural retina leucine zipper
chrX_+_102883620 3.67 ENST00000372626.3
transcription elongation factor A (SII)-like 1
chr7_-_8302207 3.67 ENST00000407906.1
islet cell autoantigen 1, 69kDa
chr2_+_172543967 3.66 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
dynein, cytoplasmic 1, intermediate chain 2
chr13_+_111855414 3.66 ENST00000375737.5
Rho guanine nucleotide exchange factor (GEF) 7
chrX_-_101694853 3.63 ENST00000372749.1
nuclear RNA export factor 2B
chr8_+_134203303 3.57 ENST00000519433.1
ENST00000517423.1
ENST00000377863.2
ENST00000220856.6
WNT1 inducible signaling pathway protein 1
chr5_+_102201430 3.57 ENST00000438793.3
ENST00000346918.2
peptidylglycine alpha-amidating monooxygenase
chr14_-_82089405 3.52 ENST00000554211.1
RP11-799P8.1
chr2_-_157189180 3.52 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
nuclear receptor subfamily 4, group A, member 2
chr13_-_46626847 3.48 ENST00000242848.4
ENST00000282007.3
zinc finger CCCH-type containing 13
chr7_-_15601595 3.35 ENST00000342526.3
alkylglycerol monooxygenase
chr3_+_152552685 3.24 ENST00000305097.3
purinergic receptor P2Y, G-protein coupled, 1
chr19_-_46366392 3.16 ENST00000598059.1
ENST00000594293.1
ENST00000245934.7
symplekin
chr9_+_33240157 3.16 ENST00000379721.3
serine peptidase inhibitor, Kazal type 4
chr3_-_184971853 3.15 ENST00000231887.3
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr1_+_50569575 3.14 ENST00000371827.1
ELAV like neuron-specific RNA binding protein 4
chr11_-_5207612 3.13 ENST00000380367.1
olfactory receptor, family 52, subfamily A, member 1
chr15_-_48470558 3.09 ENST00000324324.7
myelin expression factor 2
chrX_+_15525426 3.06 ENST00000342014.6
BMX non-receptor tyrosine kinase
chrX_+_101502170 3.02 ENST00000372757.1
nuclear RNA export factor 2
chr2_+_172544011 2.99 ENST00000508530.1
dynein, cytoplasmic 1, intermediate chain 2
chr16_+_33204156 2.90 ENST00000398667.4
TP53 target 3C
chr3_+_4344988 2.80 ENST00000358065.4
SET domain and mariner transposase fusion gene
chr12_+_96588279 2.74 ENST00000552142.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr1_+_160160283 2.74 ENST00000368079.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr13_-_113242439 2.72 ENST00000375669.3
ENST00000261965.3
tubulin, gamma complex associated protein 3
chr19_-_14316980 2.71 ENST00000361434.3
ENST00000340736.6
latrophilin 1
chr14_+_22458631 2.70 ENST00000390444.1
T cell receptor alpha variable 16
chr12_-_371994 2.65 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
solute carrier family 6 (neurotransmitter transporter), member 13
chr2_+_172543919 2.62 ENST00000452242.1
ENST00000340296.4
dynein, cytoplasmic 1, intermediate chain 2
chr12_+_12202774 2.56 ENST00000589718.1
BCL2-like 14 (apoptosis facilitator)
chr4_+_96012614 2.45 ENST00000264568.4
bone morphogenetic protein receptor, type IB
chr8_+_22857048 2.44 ENST00000251822.6
Rho-related BTB domain containing 2
chr8_-_133637624 2.36 ENST00000522789.1
leucine rich repeat containing 6
chr14_-_69261310 2.31 ENST00000336440.3
ZFP36 ring finger protein-like 1
chr11_+_30252549 2.28 ENST00000254122.3
ENST00000417547.1
follicle stimulating hormone, beta polypeptide
chr12_-_102872317 2.26 ENST00000424202.2
insulin-like growth factor 1 (somatomedin C)
chr10_+_57358750 2.25 ENST00000512524.2
MT-RNR2-like 5
chr19_-_41388657 2.23 ENST00000301146.4
ENST00000291764.3
cytochrome P450, family 2, subfamily A, polypeptide 7
chr17_-_32484313 2.21 ENST00000359872.6
acid-sensing (proton-gated) ion channel 2
chr1_-_146696901 2.16 ENST00000369272.3
ENST00000441068.2
flavin containing monooxygenase 5
chrX_+_66764375 2.12 ENST00000374690.3
androgen receptor
chr12_+_12202785 2.11 ENST00000586576.1
ENST00000464885.2
BCL2-like 14 (apoptosis facilitator)
chr4_+_164415785 2.09 ENST00000513272.1
ENST00000513134.1
translation machinery associated 16 homolog (S. cerevisiae)
chr1_+_160160346 2.05 ENST00000368078.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_+_108145913 2.02 ENST00000443205.1
AC096669.3
chr5_-_160973649 2.00 ENST00000393959.1
ENST00000517547.1
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr3_-_119379427 1.98 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
popeye domain containing 2
chr6_+_153019069 1.96 ENST00000532295.1
myc target 1
chr19_-_20844368 1.95 ENST00000595094.1
ENST00000601440.1
ENST00000291750.6
CTC-513N18.7
zinc finger protein 626
chr22_+_36113919 1.95 ENST00000249044.2
apolipoprotein L, 5
chr8_+_39759794 1.95 ENST00000518804.1
ENST00000519154.1
ENST00000522495.1
ENST00000522840.1
indoleamine 2,3-dioxygenase 1
chr4_+_155484103 1.95 ENST00000302068.4
fibrinogen beta chain
chr16_-_90096309 1.88 ENST00000408886.2
chromosome 16 open reading frame 3
chrX_+_2959512 1.88 ENST00000381127.1
arylsulfatase F
chr9_-_13175823 1.85 ENST00000545857.1
multiple PDZ domain protein
chr11_+_30253410 1.78 ENST00000533718.1
follicle stimulating hormone, beta polypeptide
chr1_+_15802594 1.75 ENST00000375910.3
chymotrypsin-like elastase family, member 2B
chr19_+_47538560 1.69 ENST00000439365.2
ENST00000594670.1
neuronal PAS domain protein 1
chr16_-_69419871 1.66 ENST00000603068.1
ENST00000254942.3
ENST00000567296.2
telomeric repeat binding factor 2
chr1_+_171060018 1.66 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
flavin containing monooxygenase 3
chr2_+_172544182 1.60 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
dynein, cytoplasmic 1, intermediate chain 2
chr12_-_81763127 1.60 ENST00000541017.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr5_-_127674883 1.55 ENST00000507835.1
fibrillin 2
chr17_-_46691990 1.53 ENST00000576562.1
homeobox B8
chr1_+_172422026 1.50 ENST00000367725.4
chromosome 1 open reading frame 105
chr12_-_8815299 1.49 ENST00000535336.1
microfibrillar associated protein 5
chr11_+_60989688 1.48 ENST00000378149.3
ENST00000422676.2
pepsinogen 4, group I (pepsinogen A)
chr20_+_36012051 1.46 ENST00000373567.2
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr1_-_208084729 1.40 ENST00000310833.7
ENST00000356522.4
CD34 molecule
chr3_+_44916098 1.39 ENST00000296125.4
transglutaminase 4
chr3_-_178984759 1.35 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr20_+_36932521 1.31 ENST00000262865.4
bactericidal/permeability-increasing protein
chr12_-_81763184 1.30 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr18_-_67624160 1.21 ENST00000581982.1
ENST00000280200.4
CD226 molecule
chr9_+_39355699 1.20 ENST00000377647.3
SPATA31 subfamily A, member 1
chr10_-_29923893 1.15 ENST00000355867.4
supervillin
chr5_+_54320078 1.12 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr2_+_172544294 1.04 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
dynein, cytoplasmic 1, intermediate chain 2
chr4_-_40859132 1.01 ENST00000543538.1
ENST00000502841.1
ENST00000504305.1
ENST00000513516.1
ENST00000510670.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr6_-_10882174 1.01 ENST00000379491.4
glial cells missing homolog 2 (Drosophila)
chr12_+_15699286 0.99 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chr16_-_3930724 0.98 ENST00000262367.5
CREB binding protein
chr19_-_9785743 0.96 ENST00000537617.1
ENST00000589542.1
ENST00000590155.1
ENST00000541032.1
ENST00000588653.1
ENST00000448622.1
ENST00000453792.2
zinc finger protein 562
chr3_-_38992052 0.87 ENST00000302328.3
ENST00000450244.1
ENST00000444237.2
sodium channel, voltage-gated, type XI, alpha subunit
chr10_-_48806939 0.87 ENST00000374233.3
ENST00000507417.1
ENST00000512321.1
ENST00000395660.2
ENST00000374235.2
ENST00000395661.3
protein tyrosine phosphatase, non-receptor type 20B
chr11_+_22696314 0.85 ENST00000532398.1
ENST00000433790.1
growth arrest-specific 2
chr21_-_28338732 0.80 ENST00000284987.5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chrX_-_49965663 0.79 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
A kinase (PRKA) anchor protein 4
chrX_+_30261847 0.79 ENST00000378981.3
ENST00000397550.1
melanoma antigen family B, 1
chr8_-_95274536 0.78 ENST00000297596.2
ENST00000396194.2
GTP binding protein overexpressed in skeletal muscle
chr16_+_31225337 0.75 ENST00000322122.3
tripartite motif containing 72
chr9_-_95244781 0.73 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
asporin
chrX_+_155227246 0.69 ENST00000244174.5
ENST00000424344.3
interleukin 9 receptor
chr13_+_60971080 0.67 ENST00000377894.2
tudor domain containing 3
chr11_-_8964580 0.67 ENST00000325884.1
achaete-scute family bHLH transcription factor 3
chrX_+_129473916 0.66 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_+_86934526 0.60 ENST00000394711.1
chloride channel accessory 1
chr12_-_47219733 0.58 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
solute carrier family 38, member 4
chr8_-_93029865 0.57 ENST00000422361.2
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr19_-_47735918 0.57 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BCL2 binding component 3
chr1_+_47901689 0.53 ENST00000334793.5
forkhead box D2
chr5_+_92919043 0.53 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr12_+_41831485 0.47 ENST00000539469.2
ENST00000298919.7
PDZ domain containing ring finger 4
chr4_+_74301880 0.45 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein
chr3_+_121311966 0.44 ENST00000338040.4
F-box protein 40
chr6_+_29141311 0.44 ENST00000377167.2
olfactory receptor, family 2, subfamily J, member 2
chr10_-_69455873 0.34 ENST00000433211.2
catenin (cadherin-associated protein), alpha 3
chr5_+_140787600 0.32 ENST00000520790.1
protocadherin gamma subfamily B, 6
chr1_+_82266053 0.25 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr9_-_107690420 0.22 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ATP-binding cassette, sub-family A (ABC1), member 1
chrX_+_135730373 0.19 ENST00000370628.2
CD40 ligand
chr12_+_21168630 0.16 ENST00000421593.2
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr16_+_2867228 0.12 ENST00000005995.3
ENST00000574813.1
protease, serine, 21 (testisin)
chr13_-_103053946 0.04 ENST00000376131.4
fibroblast growth factor 14
chrX_-_10588595 0.04 ENST00000423614.1
ENST00000317552.4
midline 1 (Opitz/BBB syndrome)

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 37.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
3.4 13.7 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
3.4 13.7 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
2.8 8.5 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
2.7 8.2 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
2.0 5.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.8 12.4 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
1.8 5.3 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
1.7 6.7 GO:1905073 ossification involved in bone remodeling(GO:0043932) frontal suture morphogenesis(GO:0060364) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
1.7 21.9 GO:0017121 phospholipid scrambling(GO:0017121)
1.6 8.0 GO:1903564 regulation of protein localization to cilium(GO:1903564)
1.5 4.5 GO:0019417 sulfur oxidation(GO:0019417)
1.5 16.2 GO:0042908 xenobiotic transport(GO:0042908)
1.5 10.2 GO:0010269 response to selenium ion(GO:0010269)
1.4 6.9 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
1.4 8.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
1.3 5.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
1.2 5.9 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
1.2 3.5 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.2 2.3 GO:0003342 proepicardium development(GO:0003342) septum transversum development(GO:0003343)
1.1 14.8 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 10.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
1.1 11.9 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.0 7.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.9 2.8 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.9 26.6 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.8 3.2 GO:0060406 positive regulation of penile erection(GO:0060406)
0.8 11.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.7 7.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.7 9.4 GO:0035878 nail development(GO:0035878)
0.7 2.1 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
0.7 4.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.7 4.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.7 6.0 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.6 3.9 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.6 11.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.6 15.6 GO:0001502 cartilage condensation(GO:0001502)
0.6 4.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.6 8.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.6 1.7 GO:0031627 telomeric loop formation(GO:0031627) negative regulation of t-circle formation(GO:1904430)
0.5 4.9 GO:0018344 protein geranylgeranylation(GO:0018344)
0.5 26.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.5 17.0 GO:0090383 phagosome acidification(GO:0090383)
0.5 4.9 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.5 1.9 GO:0036269 swimming behavior(GO:0036269)
0.5 3.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.5 5.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.5 2.3 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.4 6.9 GO:0006071 glycerol metabolic process(GO:0006071)
0.4 1.2 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.4 2.7 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.4 2.2 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.4 3.7 GO:1904424 regulation of GTP binding(GO:1904424)
0.4 1.5 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.3 1.4 GO:1900168 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.3 5.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.3 1.0 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.3 2.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.3 3.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.3 2.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.3 4.9 GO:0002003 angiotensin maturation(GO:0002003)
0.3 5.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.3 0.8 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 1.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.2 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 24.6 GO:0021510 spinal cord development(GO:0021510)
0.2 2.4 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.2 1.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 4.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.2 3.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 4.8 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.2 5.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.2 8.2 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.2 5.6 GO:0016486 peptide hormone processing(GO:0016486)
0.2 5.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 2.6 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 1.0 GO:0060017 parathyroid gland development(GO:0060017)
0.2 11.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 3.0 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 1.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.1 0.7 GO:0071104 response to interleukin-9(GO:0071104)
0.1 2.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 17.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.5 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 2.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 3.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 1.7 GO:0060746 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.1 0.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 3.9 GO:0008542 visual learning(GO:0008542)
0.1 1.4 GO:0005513 detection of calcium ion(GO:0005513)
0.1 3.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 3.2 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.1 28.7 GO:0043687 post-translational protein modification(GO:0043687)
0.1 0.3 GO:0086073 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 0.2 GO:0032489 aminophospholipid transport(GO:0015917) regulation of Cdc42 protein signal transduction(GO:0032489) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.0 0.8 GO:0044458 motile cilium assembly(GO:0044458)
0.0 2.9 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.9 GO:0044764 viral process(GO:0016032) multi-organism cellular process(GO:0044764)
0.0 1.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 5.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 3.1 GO:0014902 myotube differentiation(GO:0014902)
0.0 5.7 GO:0007586 digestion(GO:0007586)
0.0 7.7 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 1.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.9 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 2.0 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.0 GO:1902803 regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle recycling(GO:1903421)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 2.4 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 3.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.2 8.5 GO:0030061 mitochondrial crista(GO:0030061)
0.7 17.0 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.7 7.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 11.9 GO:0031045 dense core granule(GO:0031045)
0.6 3.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.6 4.8 GO:0014802 terminal cisterna(GO:0014802)
0.6 5.7 GO:0097486 multivesicular body lumen(GO:0097486)
0.6 7.3 GO:0005577 fibrinogen complex(GO:0005577)
0.5 2.7 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.5 1.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.5 3.7 GO:0000322 storage vacuole(GO:0000322)
0.5 3.2 GO:0097165 nuclear stress granule(GO:0097165)
0.4 9.4 GO:0030056 hemidesmosome(GO:0030056)
0.4 11.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 2.3 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.2 1.7 GO:0030870 Mre11 complex(GO:0030870)
0.2 2.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 1.2 GO:0036449 microtubule minus-end(GO:0036449)
0.2 3.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 62.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 29.3 GO:0030426 growth cone(GO:0030426)
0.1 5.0 GO:0031904 endosome lumen(GO:0031904)
0.1 18.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 11.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 8.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 2.8 GO:0035861 site of double-strand break(GO:0035861)
0.1 13.7 GO:0043204 perikaryon(GO:0043204)
0.1 5.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 5.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 5.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 4.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 13.7 GO:0030424 axon(GO:0030424)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 3.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 36.4 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 GO:0045174 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
3.4 13.7 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
2.3 6.9 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
2.2 6.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
2.0 16.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
2.0 21.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.8 14.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.7 5.0 GO:0005148 prolactin receptor binding(GO:0005148)
1.5 4.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
1.5 6.1 GO:0030226 apolipoprotein receptor activity(GO:0030226)
1.5 5.9 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
1.3 6.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.3 10.2 GO:0008131 primary amine oxidase activity(GO:0008131)
1.2 6.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
1.0 4.9 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
1.0 5.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.9 2.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.9 10.0 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.8 3.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.8 3.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.8 3.9 GO:0004974 leukotriene receptor activity(GO:0004974)
0.8 13.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.7 9.4 GO:0038132 neuregulin binding(GO:0038132)
0.6 1.9 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.6 8.4 GO:0004875 complement receptor activity(GO:0004875)
0.6 11.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.6 7.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 16.4 GO:0015248 sterol transporter activity(GO:0015248)
0.5 34.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 3.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.5 2.8 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.5 4.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.4 2.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.4 2.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.4 2.1 GO:0005497 androgen binding(GO:0005497)
0.4 3.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3 11.9 GO:0042056 chemoattractant activity(GO:0042056)
0.3 5.3 GO:0015643 toxic substance binding(GO:0015643)
0.3 14.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 2.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.3 2.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.3 5.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 8.2 GO:0001671 ATPase activator activity(GO:0001671)
0.2 1.6 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 8.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 2.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.2 11.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 5.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 3.9 GO:0042166 acetylcholine binding(GO:0042166)
0.2 1.5 GO:0071253 connexin binding(GO:0071253)
0.2 14.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 1.7 GO:0034061 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) DNA polymerase activity(GO:0034061)
0.2 2.0 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.2 4.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 4.5 GO:0071949 FAD binding(GO:0071949)
0.2 5.5 GO:0017091 AU-rich element binding(GO:0017091)
0.1 16.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.4 GO:0043199 sulfate binding(GO:0043199)
0.1 1.9 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 2.2 GO:0070330 aromatase activity(GO:0070330)
0.1 17.0 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.1 5.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 11.9 GO:0005179 hormone activity(GO:0005179)
0.1 1.0 GO:0043426 MRF binding(GO:0043426)
0.1 2.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 3.7 GO:0050699 WW domain binding(GO:0050699)
0.1 8.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.3 GO:0051087 chaperone binding(GO:0051087)
0.1 27.2 GO:0015631 tubulin binding(GO:0015631)
0.1 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 3.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 15.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.9 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.4 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 13.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 60.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 6.7 PID ALK1 PATHWAY ALK1 signaling events
0.1 7.9 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 8.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 21.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 9.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 5.0 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 12.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 3.1 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.9 PID ENDOTHELIN PATHWAY Endothelins
0.1 2.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 2.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 3.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.4 PID BMP PATHWAY BMP receptor signaling
0.0 5.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 8.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 39.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.9 20.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.7 9.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.6 17.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.4 16.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.4 6.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 13.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 5.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 3.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 7.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 3.9 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 5.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 3.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 10.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 2.7 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 11.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 1.9 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 27.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 18.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 7.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 10.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 6.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 6.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport