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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MEF2B
Z-value: 0.64
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Transcription factors associated with MEF2B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2B | hg19_v2_chr19_-_19302931_19302974 | 0.28 | 3.1e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 63.9 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.7 | 36.4 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 22.7 | GO:0031175 | neuron projection development(GO:0031175) |
| 4.2 | 21.0 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.2 | 17.1 | GO:0061045 | negative regulation of wound healing(GO:0061045) |
| 0.1 | 17.1 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 1.1 | 15.8 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 12.3 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.6 | 11.3 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 2.4 | 9.8 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 105.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 21.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 5.2 | 21.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 1.2 | 13.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.6 | 13.6 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 13.5 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 10.5 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.3 | 9.8 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 7.4 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 7.3 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 21.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.7 | 21.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.7 | 17.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.5 | 17.1 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.2 | 17.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 9.8 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 9.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.6 | 8.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 8.4 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 65.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 19.7 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 16.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 16.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 9.3 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 8.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 5.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 5.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 4.2 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 21.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 9.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 9.3 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.2 | 8.8 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.2 | 8.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 7.3 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 7.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 5.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 5.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 4.8 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |