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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MEF2D_MEF2A
Z-value: 1.27
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Transcription factors associated with MEF2D_MEF2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2D | hg19_v2_chr1_-_156470515_156470542 | 0.53 | 4.7e-17 | Click! |
| MEF2A | hg19_v2_chr15_+_100106155_100106243 | 0.21 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2D_MEF2A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 208.4 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 7.9 | 126.9 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.2 | 67.7 | GO:0007411 | axon guidance(GO:0007411) |
| 4.0 | 56.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.4 | 49.4 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 7.8 | 46.5 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 1.3 | 46.4 | GO:0045214 | sarcomere organization(GO:0045214) |
| 10.2 | 40.7 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.0 | 32.5 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.7 | 32.4 | GO:0007019 | microtubule depolymerization(GO:0007019) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 189.9 | GO:0030426 | growth cone(GO:0030426) |
| 4.8 | 115.8 | GO:0005861 | troponin complex(GO:0005861) |
| 3.0 | 109.0 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.6 | 101.8 | GO:0030018 | Z disc(GO:0030018) |
| 3.5 | 69.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.8 | 56.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 3.9 | 46.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 46.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.4 | 38.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 32.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 93.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.9 | 89.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 1.3 | 70.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 4.5 | 63.7 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 59.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 57.5 | GO:0003779 | actin binding(GO:0003779) |
| 0.7 | 52.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.5 | 51.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 3.1 | 46.0 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 2.4 | 30.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 109.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 98.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 58.2 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.9 | 35.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.5 | 26.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.7 | 23.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.3 | 17.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 11.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 10.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 9.6 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 236.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 35.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 21.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.9 | 19.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 1.3 | 18.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.7 | 17.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 17.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.5 | 16.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 16.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 14.0 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |