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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MEF2D_MEF2A

Z-value: 1.27

Motif logo

Transcription factors associated with MEF2D_MEF2A

Gene Symbol Gene ID Gene Info
ENSG00000116604.13 myocyte enhancer factor 2D
ENSG00000068305.13 myocyte enhancer factor 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Dhg19_v2_chr1_-_156470515_1564705420.534.7e-17Click!
MEF2Ahg19_v2_chr15_+_100106155_1001062430.211.4e-03Click!

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_21493884 40.13 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG family member 2
chr12_-_45269430 39.39 ENST00000395487.2
NEL-like 2 (chicken)
chr14_-_21493649 36.59 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG family member 2
chr14_-_21493123 36.03 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG family member 2
chr2_+_233497931 32.11 ENST00000264059.3
EF-hand domain family, member D1
chr3_+_127634312 29.46 ENST00000407609.3
kelch repeat and BTB (POZ) domain containing 12
chr3_+_127634069 26.95 ENST00000405109.1
kelch repeat and BTB (POZ) domain containing 12
chr12_-_111358372 26.92 ENST00000548438.1
ENST00000228841.8
myosin, light chain 2, regulatory, cardiac, slow
chr11_-_19223523 25.43 ENST00000265968.3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr11_+_1860200 25.15 ENST00000381911.1
troponin I type 2 (skeletal, fast)
chr2_-_211168332 24.47 ENST00000341685.4
myosin, light chain 1, alkali; skeletal, fast
chr6_-_6007200 24.29 ENST00000244766.2
neuritin 1
chr1_+_160085501 22.75 ENST00000361216.3
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_+_138067521 20.65 ENST00000494949.1
muscle RAS oncogene homolog
chr10_+_95517660 20.61 ENST00000371413.3
leucine-rich, glioma inactivated 1
chr16_-_31439735 19.91 ENST00000287490.4
cytochrome c oxidase subunit VIa polypeptide 2
chr19_+_35629702 19.75 ENST00000351325.4
FXYD domain containing ion transport regulator 1
chr20_+_44657845 19.50 ENST00000243964.3
solute carrier family 12 (potassium/chloride transporter), member 5
chr9_+_139871948 19.42 ENST00000224167.2
ENST00000457950.1
ENST00000371625.3
ENST00000371623.3
prostaglandin D2 synthase 21kDa (brain)
chr13_-_67802549 19.15 ENST00000328454.5
ENST00000377865.2
protocadherin 9
chr19_+_35630022 18.74 ENST00000589209.1
FXYD domain containing ion transport regulator 1
chr3_+_138067314 17.70 ENST00000423968.2
muscle RAS oncogene homolog
chr12_-_91539918 17.68 ENST00000548218.1
decorin
chr22_-_36013368 17.67 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
myoglobin
chr8_-_27115931 17.44 ENST00000523048.1
stathmin-like 4
chrX_-_21776281 16.35 ENST00000379494.3
small muscle protein, X-linked
chr15_+_42651691 16.33 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
calpain 3, (p94)
chr10_+_88428370 16.19 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LIM domain binding 3
chr10_+_88428206 16.10 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LIM domain binding 3
chr2_-_211179883 15.99 ENST00000352451.3
myosin, light chain 1, alkali; skeletal, fast
chr12_+_119616447 15.56 ENST00000281938.2
heat shock 22kDa protein 8
chr8_+_1993152 15.34 ENST00000262113.4
myomesin 2
chr17_+_37821593 15.28 ENST00000578283.1
titin-cap
chr7_+_30951461 15.27 ENST00000311813.4
aquaporin 1 (Colton blood group)
chr10_-_75415825 15.10 ENST00000394810.2
synaptopodin 2-like
chr10_+_95517616 15.09 ENST00000371418.4
leucine-rich, glioma inactivated 1
chr19_-_47164386 15.00 ENST00000391916.2
ENST00000410105.2
dishevelled-binding antagonist of beta-catenin 3
chr8_-_27115903 14.96 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
stathmin-like 4
chr12_-_16759711 14.86 ENST00000447609.1
LIM domain only 3 (rhombotin-like 2)
chr3_+_138067666 14.85 ENST00000475711.1
ENST00000464896.1
muscle RAS oncogene homolog
chr5_-_42812143 14.60 ENST00000514985.1
selenoprotein P, plasma, 1
chr11_+_1860832 14.47 ENST00000252898.7
troponin I type 2 (skeletal, fast)
chr5_-_42811986 14.47 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
selenoprotein P, plasma, 1
chr20_+_44035847 14.28 ENST00000372712.2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_-_21491477 14.13 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG family member 2
chr7_-_37488834 13.98 ENST00000310758.4
engulfment and cell motility 1
chr11_+_1860682 13.96 ENST00000381906.1
troponin I type 2 (skeletal, fast)
chr9_+_100263912 13.94 ENST00000259365.4
tropomodulin 1
chr4_+_41362796 13.67 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIM and calponin homology domains 1
chr8_+_27631903 13.63 ENST00000305188.8
establishment of sister chromatid cohesion N-acetyltransferase 2
chr12_-_49393092 13.50 ENST00000421952.2
dendrin
chr12_-_9268707 13.31 ENST00000318602.7
alpha-2-macroglobulin
chr1_-_201391149 13.26 ENST00000555948.1
ENST00000556362.1
troponin I type 1 (skeletal, slow)
chr22_-_36018569 13.18 ENST00000419229.1
ENST00000406324.1
myoglobin
chr16_+_7382745 13.08 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RNA binding protein, fox-1 homolog (C. elegans) 1
chr7_-_44105158 12.52 ENST00000297283.3
phosphoglycerate mutase 2 (muscle)
chr17_+_7184986 12.42 ENST00000317370.8
ENST00000571308.1
solute carrier family 2 (facilitated glucose transporter), member 4
chr10_+_95517566 12.40 ENST00000542308.1
leucine-rich, glioma inactivated 1
chr17_+_4855053 12.17 ENST00000518175.1
enolase 3 (beta, muscle)
chr8_+_1993173 12.12 ENST00000523438.1
myomesin 2
chr16_+_8768422 12.03 ENST00000268251.8
ENST00000564714.1
4-aminobutyrate aminotransferase
chr5_+_53751445 11.51 ENST00000302005.1
heat shock 27kDa protein 3
chr11_+_1940925 11.43 ENST00000453458.1
ENST00000381557.2
ENST00000381589.3
ENST00000381579.3
ENST00000381563.4
ENST00000344578.4
troponin T type 3 (skeletal, fast)
chr4_+_186064395 11.39 ENST00000281456.6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr9_+_129677039 11.21 ENST00000259351.5
ENST00000424082.2
ENST00000394022.3
ENST00000394011.3
ENST00000319107.4
Ral GEF with PH domain and SH3 binding motif 1
chr12_+_52445191 10.86 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
nuclear receptor subfamily 4, group A, member 1
chr12_+_101988627 10.64 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
myosin binding protein C, slow type
chr4_+_113970772 10.57 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr1_-_154164534 10.40 ENST00000271850.7
ENST00000368530.2
tropomyosin 3
chr10_-_115423792 10.37 ENST00000369360.3
ENST00000360478.3
ENST00000359988.3
ENST00000369358.4
nebulin-related anchoring protein
chr22_+_32340481 10.36 ENST00000397492.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr14_-_23877474 10.28 ENST00000405093.3
myosin, heavy chain 6, cardiac muscle, alpha
chr3_-_52486841 10.11 ENST00000496590.1
troponin C type 1 (slow)
chr11_+_1942580 10.11 ENST00000381558.1
troponin T type 3 (skeletal, fast)
chr11_-_47374246 9.93 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
myosin binding protein C, cardiac
chr11_+_112832202 9.83 ENST00000534015.1
neural cell adhesion molecule 1
chr2_+_220283091 9.63 ENST00000373960.3
desmin
chr1_-_31845914 9.52 ENST00000373713.2
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr4_+_120056939 9.34 ENST00000307128.5
myozenin 2
chr14_+_100150622 9.26 ENST00000261835.3
cytochrome P450, family 46, subfamily A, polypeptide 1
chr11_+_112832090 9.20 ENST00000533760.1
neural cell adhesion molecule 1
chr5_+_67584174 9.18 ENST00000320694.8
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_66300446 9.14 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr1_-_116311402 9.02 ENST00000261448.5
calsequestrin 2 (cardiac muscle)
chr1_-_115238207 8.87 ENST00000520113.2
ENST00000369538.3
ENST00000353928.6
adenosine monophosphate deaminase 1
chr1_+_92632542 8.79 ENST00000409154.4
ENST00000370378.4
KIAA1107
chr11_-_18034701 8.64 ENST00000265965.5
secretion regulating guanine nucleotide exchange factor
chr9_-_97356075 8.61 ENST00000375337.3
fructose-1,6-bisphosphatase 2
chr6_+_7108210 8.58 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
ras responsive element binding protein 1
chr5_+_161274940 8.55 ENST00000393943.4
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_-_45270151 8.52 ENST00000429094.2
NEL-like 2 (chicken)
chr16_+_6069072 8.49 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr22_+_32340447 8.36 ENST00000248975.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr11_-_62477041 8.33 ENST00000433053.1
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr12_-_45270077 8.30 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NEL-like 2 (chicken)
chr5_-_88179302 8.26 ENST00000504921.2
myocyte enhancer factor 2C
chr7_-_150946015 8.22 ENST00000262188.8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_+_160160283 8.22 ENST00000368079.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr19_+_37998031 8.22 ENST00000586138.1
ENST00000588578.1
ENST00000587986.1
zinc finger protein 793
chr4_-_57547870 8.21 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOP homeobox
chr19_+_3933579 8.18 ENST00000593949.1
nicotinamide riboside kinase 2
chr5_+_161274685 8.16 ENST00000428797.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr16_+_84328252 8.13 ENST00000219454.5
WAP four-disulfide core domain 1
chr17_+_42264322 8.07 ENST00000446571.3
ENST00000357984.3
ENST00000538716.2
transmembrane and ubiquitin-like domain containing 2
chr19_+_35630344 8.05 ENST00000455515.2
FXYD domain containing ion transport regulator 1
chr4_-_57547454 7.79 ENST00000556376.2
HOP homeobox
chr16_+_84328429 7.73 ENST00000568638.1
WAP four-disulfide core domain 1
chr19_-_47975417 7.60 ENST00000236877.6
solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_+_33661382 7.59 ENST00000402538.3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_+_220143989 7.52 ENST00000336576.5
DnaJ (Hsp40) homolog, subfamily B, member 2
chr8_-_17533838 7.52 ENST00000400046.1
microtubule associated tumor suppressor 1
chr4_-_186697044 7.40 ENST00000437304.2
sorbin and SH3 domain containing 2
chr19_+_3933085 7.40 ENST00000168977.2
ENST00000599576.1
nicotinamide riboside kinase 2
chr7_+_47694842 7.32 ENST00000408988.2
chromosome 7 open reading frame 65
chr1_+_160160346 7.30 ENST00000368078.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr6_-_169654139 7.22 ENST00000366787.3
thrombospondin 2
chr7_+_99775520 7.15 ENST00000317296.5
ENST00000422690.1
ENST00000439782.1
stromal antigen 3
chr18_-_53070913 6.97 ENST00000568186.1
ENST00000564228.1
transcription factor 4
chr7_+_99775366 6.70 ENST00000394018.2
ENST00000416412.1
stromal antigen 3
chr1_-_201390846 6.65 ENST00000367312.1
ENST00000555340.2
ENST00000361379.4
troponin I type 1 (skeletal, slow)
chr2_+_170366203 6.56 ENST00000284669.1
kelch-like family member 41
chr7_+_154002189 6.49 ENST00000332007.3
dipeptidyl-peptidase 6
chr2_+_173686303 6.37 ENST00000397087.3
Rap guanine nucleotide exchange factor (GEF) 4
chrX_+_153046456 6.36 ENST00000393786.3
ENST00000370104.1
ENST00000370108.3
ENST00000370101.3
ENST00000430541.1
ENST00000370100.1
SRSF protein kinase 3
chr17_-_1389228 6.24 ENST00000438665.2
myosin IC
chr7_-_134143841 6.15 ENST00000285930.4
aldo-keto reductase family 1, member B1 (aldose reductase)
chr12_+_12938541 6.00 ENST00000356591.4
apolipoprotein L domain containing 1
chr22_+_31742875 5.96 ENST00000504184.2
CDNA FLJ20464 fis, clone KAT06158; HCG1777549; Uncharacterized protein
chr6_-_27806117 5.95 ENST00000330180.2
histone cluster 1, H2ak
chr5_-_115910630 5.94 ENST00000343348.6
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_-_117753540 5.92 ENST00000328189.3
ENST00000369458.3
V-set domain containing T cell activation inhibitor 1
chr18_-_3220106 5.91 ENST00000356443.4
ENST00000400569.3
myomesin 1
chr22_-_37215523 5.78 ENST00000216200.5
parvalbumin
chr11_+_1940786 5.77 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
troponin T type 3 (skeletal, fast)
chr17_-_9929581 5.75 ENST00000437099.2
ENST00000396115.2
growth arrest-specific 7
chr5_-_137475071 5.74 ENST00000265191.2
NME/NM23 family member 5
chr15_+_73976715 5.73 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276 molecule
chr3_-_38071122 5.63 ENST00000334661.4
phospholipase C, delta 1
chr7_-_113559104 5.63 ENST00000284601.3
protein phosphatase 1, regulatory subunit 3A
chr12_+_69201923 5.61 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2 oncogene, E3 ubiquitin protein ligase
chr9_+_33290491 5.60 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
nuclear transcription factor, X-box binding 1
chr5_-_16509101 5.47 ENST00000399793.2
family with sequence similarity 134, member B
chr1_+_95583479 5.44 ENST00000455656.1
ENST00000604534.1
transmembrane protein 56
TMEM56-RWDD3 readthrough
chr1_+_150229554 5.34 ENST00000369111.4
carbonic anhydrase XIV
chr17_-_10421853 5.27 ENST00000226207.5
myosin, heavy chain 1, skeletal muscle, adult
chr3_-_46904918 5.19 ENST00000395869.1
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr8_+_104831472 5.16 ENST00000262231.10
ENST00000507740.1
regulating synaptic membrane exocytosis 2
chr3_-_192445289 5.15 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
fibroblast growth factor 12
chr2_+_30569506 5.14 ENST00000421976.2
AC109642.1
chr3_-_46904946 4.98 ENST00000292327.4
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr12_-_371994 4.97 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
solute carrier family 6 (neurotransmitter transporter), member 13
chr9_-_130639997 4.94 ENST00000373176.1
adenylate kinase 1
chr1_-_201346761 4.93 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
troponin T type 2 (cardiac)
chr7_+_143013198 4.74 ENST00000343257.2
chloride channel, voltage-sensitive 1
chr4_-_186696425 4.69 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr1_-_156460391 4.68 ENST00000360595.3
myocyte enhancer factor 2D
chr5_+_140552218 4.67 ENST00000231137.3
protocadherin beta 7
chr15_+_91446157 4.63 ENST00000559717.1
mannosidase, alpha, class 2A, member 2
chr10_-_45474237 4.61 ENST00000448778.1
ENST00000298295.3
chromosome 10 open reading frame 10
chr20_+_1875110 4.59 ENST00000400068.3
signal-regulatory protein alpha
chr1_-_25756638 4.55 ENST00000349320.3
Rh blood group, CcEe antigens
chr18_+_13611431 4.54 ENST00000587757.1
low density lipoprotein receptor class A domain containing 4
chr11_+_45918092 4.53 ENST00000395629.2
mitogen-activated protein kinase 8 interacting protein 1
chr10_-_6104253 4.50 ENST00000256876.6
ENST00000379954.1
ENST00000379959.3
interleukin 2 receptor, alpha
chr10_-_74114714 4.36 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DnaJ (Hsp40) homolog, subfamily B, member 12
chr2_+_220144052 4.29 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DnaJ (Hsp40) homolog, subfamily B, member 2
chr8_+_95565947 4.22 ENST00000523011.1
RP11-267M23.4
chrX_-_11284095 4.19 ENST00000303025.6
ENST00000534860.1
Rho GTPase activating protein 6
chr5_-_131347501 4.16 ENST00000543479.1
acyl-CoA synthetase long-chain family member 6
chr17_+_68165657 4.16 ENST00000243457.3
potassium inwardly-rectifying channel, subfamily J, member 2
chr7_-_151217001 4.13 ENST00000262187.5
Ras homolog enriched in brain
chr6_+_41021027 4.13 ENST00000244669.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr3_+_35721106 4.09 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
cAMP-regulated phosphoprotein, 21kDa
chr6_+_26020672 3.93 ENST00000357647.3
histone cluster 1, H3a
chr10_-_72141330 3.91 ENST00000395011.1
ENST00000395010.1
leucine rich repeat containing 20
chr11_-_35440796 3.87 ENST00000278379.3
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_104179682 3.86 ENST00000406432.1
pleckstrin and Sec7 domain containing
chr17_+_42264556 3.84 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
transmembrane and ubiquitin-like domain containing 2
chrX_+_9217932 3.81 ENST00000432442.1
GS1-519E5.1
chr11_-_35440579 3.76 ENST00000606205.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_-_215744 3.73 ENST00000382387.2
chromosome 9 open reading frame 66
chr2_-_166060552 3.71 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chr2_+_113816685 3.70 ENST00000393200.2
interleukin 36 receptor antagonist
chr22_-_31742218 3.68 ENST00000266269.5
ENST00000405309.3
ENST00000351933.4
POZ (BTB) and AT hook containing zinc finger 1
chr9_-_136344197 3.62 ENST00000414172.1
ENST00000371897.4
solute carrier family 2 (facilitated glucose transporter), member 6
chr3_-_114343039 3.55 ENST00000481632.1
zinc finger and BTB domain containing 20
chr10_-_75410771 3.49 ENST00000372873.4
synaptopodin 2-like
chr3_+_8543561 3.46 ENST00000397386.3
LIM and cysteine-rich domains 1
chr21_-_42219065 3.46 ENST00000400454.1
Down syndrome cell adhesion molecule
chr1_+_25757376 3.41 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
transmembrane protein 57
chr9_-_15472730 3.33 ENST00000481862.1
PC4 and SFRS1 interacting protein 1
chr9_-_136344237 3.31 ENST00000432868.1
ENST00000371899.4
solute carrier family 2 (facilitated glucose transporter), member 6
chr2_-_157198860 3.30 ENST00000409572.1
nuclear receptor subfamily 4, group A, member 2
chr12_+_81101277 3.28 ENST00000228641.3
myogenic factor 6 (herculin)
chr8_+_27183033 3.26 ENST00000420218.2
protein tyrosine kinase 2 beta
chr3_+_159570722 3.25 ENST00000482804.1
schwannomin interacting protein 1
chr16_-_71610985 3.22 ENST00000355962.4
tyrosine aminotransferase
chr10_-_104178857 3.18 ENST00000020673.5
pleckstrin and Sec7 domain containing
chr16_+_30075783 3.16 ENST00000412304.2
aldolase A, fructose-bisphosphate
chrX_+_119384607 3.11 ENST00000326624.2
ENST00000557385.1
zinc finger and BTB domain containing 33

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.2 40.7 GO:0035995 detection of muscle stretch(GO:0035995)
7.9 126.9 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
7.8 46.5 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
5.6 5.6 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
5.1 15.3 GO:0072229 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
5.0 25.0 GO:0032971 regulation of muscle filament sliding(GO:0032971)
4.9 19.5 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
4.5 22.7 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
4.0 56.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
3.9 30.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
3.8 30.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
3.5 10.6 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.4 26.9 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
3.2 9.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
3.1 12.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
3.1 15.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
3.0 12.0 GO:0061528 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
2.7 208.4 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
2.7 16.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
2.5 14.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.2 8.6 GO:0005986 sucrose biosynthetic process(GO:0005986)
2.1 8.6 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
2.1 8.3 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
2.1 6.2 GO:0006059 hexitol metabolic process(GO:0006059) response to methylglyoxal(GO:0051595)
1.9 11.4 GO:0015853 adenine transport(GO:0015853)
1.9 5.6 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
1.7 19.9 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.6 8.2 GO:0003219 cardiac right ventricle formation(GO:0003219)
1.6 14.7 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.6 6.4 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
1.5 6.1 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
1.5 5.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.5 8.8 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
1.3 46.4 GO:0045214 sarcomere organization(GO:0045214)
1.3 10.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.1 19.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.1 4.5 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
1.0 4.2 GO:0090076 relaxation of skeletal muscle(GO:0090076)
1.0 13.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.9 19.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.9 2.8 GO:0032900 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.9 28.0 GO:0006706 steroid catabolic process(GO:0006706)
0.9 8.9 GO:0032264 IMP salvage(GO:0032264)
0.8 0.8 GO:0071288 cellular response to mercury ion(GO:0071288)
0.8 16.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.8 16.7 GO:0071420 cellular response to histamine(GO:0071420)
0.8 13.9 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.8 2.4 GO:0048867 stem cell fate determination(GO:0048867)
0.7 5.7 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.7 2.1 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.7 19.4 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.7 4.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.7 15.6 GO:0009435 NAD biosynthetic process(GO:0009435)
0.7 32.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.6 7.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 3.7 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.6 2.4 GO:0001757 somite specification(GO:0001757)
0.6 2.9 GO:0015793 glycerol transport(GO:0015793)
0.6 4.7 GO:0007512 adult heart development(GO:0007512)
0.6 2.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.6 4.6 GO:0006013 mannose metabolic process(GO:0006013)
0.6 9.2 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.6 4.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 5.1 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.5 5.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.5 5.7 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.5 11.7 GO:0071168 protein localization to chromatin(GO:0071168)
0.5 3.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 5.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.4 4.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.4 5.5 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.4 1.6 GO:0060023 soft palate development(GO:0060023)
0.4 3.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 2.0 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.4 2.3 GO:1990822 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.4 7.9 GO:0006986 response to unfolded protein(GO:0006986)
0.4 3.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 14.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.4 49.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.4 1.8 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.4 4.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.4 8.3 GO:0034389 lipid particle organization(GO:0034389)
0.4 1.4 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.4 21.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4 2.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.4 7.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 1.0 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.3 7.8 GO:0030239 myofibril assembly(GO:0030239)
0.3 24.3 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.3 14.1 GO:0006735 NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 3.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 3.5 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.2 7.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.7 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 18.6 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 3.3 GO:0042693 muscle cell fate commitment(GO:0042693)
0.2 3.9 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.2 2.3 GO:0008343 adult feeding behavior(GO:0008343)
0.2 67.7 GO:0007411 axon guidance(GO:0007411)
0.2 2.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.8 GO:0051971 negative regulation of transmission of nerve impulse(GO:0051970) positive regulation of transmission of nerve impulse(GO:0051971)
0.2 6.0 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.2 3.4 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.2 14.9 GO:0061045 negative regulation of wound healing(GO:0061045)
0.2 1.8 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 26.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.5 GO:0097026 myeloid dendritic cell chemotaxis(GO:0002408) dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
0.2 7.6 GO:0007265 Ras protein signal transduction(GO:0007265)
0.2 1.1 GO:0097396 eosinophil differentiation(GO:0030222) response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.2 6.7 GO:0019228 neuronal action potential(GO:0019228)
0.2 13.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 9.2 GO:0003300 cardiac muscle hypertrophy(GO:0003300)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.0 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 7.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 15.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 2.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.4 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 4.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.1 3.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 2.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 0.7 GO:0042760 positive regulation of fatty acid beta-oxidation(GO:0032000) very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 3.0 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 6.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 1.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 9.8 GO:0006941 striated muscle contraction(GO:0006941)
0.1 1.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 6.5 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 4.4 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 6.5 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 0.4 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.1 3.4 GO:0007420 brain development(GO:0007420)
0.1 2.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 2.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.2 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.1 3.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.3 GO:0001502 cartilage condensation(GO:0001502)
0.1 3.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.8 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 1.0 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1 0.5 GO:0009642 response to light intensity(GO:0009642)
0.1 3.7 GO:0005977 glycogen metabolic process(GO:0005977)
0.1 6.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 3.0 GO:0061053 somite development(GO:0061053)
0.1 1.9 GO:2000273 positive regulation of receptor activity(GO:2000273)
0.1 1.7 GO:0048265 response to pain(GO:0048265)
0.0 2.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.9 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.4 GO:0019530 taurine metabolic process(GO:0019530)
0.0 6.6 GO:0046578 regulation of Ras protein signal transduction(GO:0046578)
0.0 32.5 GO:0016567 protein ubiquitination(GO:0016567)
0.0 7.0 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.5 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 7.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 2.0 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 1.4 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 2.1 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 1.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
4.8 115.8 GO:0005861 troponin complex(GO:0005861)
4.5 26.7 GO:0005927 muscle tendon junction(GO:0005927)
3.9 46.5 GO:0097512 cardiac myofibril(GO:0097512)
3.5 69.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
3.0 109.0 GO:0005859 muscle myosin complex(GO:0005859)
3.0 12.0 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
2.5 27.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.3 13.9 GO:0030893 meiotic cohesin complex(GO:0030893)
2.3 9.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
2.2 8.8 GO:0045160 myosin I complex(GO:0045160)
2.0 12.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.8 21.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.5 6.2 GO:0097454 Schwann cell microvillus(GO:0097454)
1.4 11.4 GO:0032593 insulin-responsive compartment(GO:0032593)
1.4 19.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.4 38.9 GO:0031143 pseudopodium(GO:0031143)
1.3 17.7 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.0 13.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.0 6.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.9 189.9 GO:0030426 growth cone(GO:0030426)
0.9 24.3 GO:0036379 myofilament(GO:0036379)
0.8 56.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.6 101.8 GO:0030018 Z disc(GO:0030018)
0.6 13.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.6 1.8 GO:0032437 cuticular plate(GO:0032437)
0.6 2.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.6 23.1 GO:0014704 intercalated disc(GO:0014704)
0.6 13.0 GO:0030673 axolemma(GO:0030673)
0.6 19.5 GO:0043198 dendritic shaft(GO:0043198)
0.5 16.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 1.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 3.9 GO:0031430 M band(GO:0031430)
0.3 8.2 GO:0071564 npBAF complex(GO:0071564)
0.3 3.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 46.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.2 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.2 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.2 4.2 GO:0005884 actin filament(GO:0005884)
0.2 15.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 8.6 GO:0016235 aggresome(GO:0016235)
0.2 3.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 14.3 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 2.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.7 GO:0005922 connexon complex(GO:0005922)
0.1 3.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 7.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 2.5 GO:0030315 T-tubule(GO:0030315)
0.1 14.2 GO:0031091 platelet alpha granule(GO:0031091)
0.1 8.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 9.2 GO:0044306 neuron projection terminus(GO:0044306)
0.1 3.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 10.3 GO:0043204 perikaryon(GO:0043204)
0.1 6.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 17.8 GO:0005802 trans-Golgi network(GO:0005802)
0.1 19.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.8 GO:0016528 sarcoplasm(GO:0016528)
0.1 4.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 32.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.8 GO:0010008 endosome membrane(GO:0010008)
0.1 4.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 23.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.5 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.1 1.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.9 GO:0016592 mediator complex(GO:0016592)
0.1 1.2 GO:0012505 endomembrane system(GO:0012505)
0.0 3.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0042383 sarcolemma(GO:0042383)
0.0 5.9 GO:0030424 axon(GO:0030424)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.8 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 6.4 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.3 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
5.1 15.3 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
4.9 24.6 GO:0051373 FATZ binding(GO:0051373)
4.9 19.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
4.5 63.7 GO:0031014 troponin T binding(GO:0031014)
4.4 13.3 GO:0019959 interleukin-8 binding(GO:0019959)
4.2 25.4 GO:0031433 telethonin binding(GO:0031433)
3.9 89.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
3.9 15.6 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
3.7 11.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
3.2 9.5 GO:0070538 oleic acid binding(GO:0070538)
3.1 12.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
3.1 46.0 GO:0032036 myosin heavy chain binding(GO:0032036)
3.0 12.0 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
3.0 15.0 GO:0070097 delta-catenin binding(GO:0070097)
2.8 11.4 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
2.6 13.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
2.5 4.9 GO:0030172 troponin C binding(GO:0030172)
2.4 30.8 GO:0005344 oxygen transporter activity(GO:0005344)
2.2 8.6 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
2.1 16.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.0 12.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.0 6.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.9 5.6 GO:0061663 NEDD8 ligase activity(GO:0061663)
1.8 16.3 GO:0031432 titin binding(GO:0031432)
1.8 19.5 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.8 10.6 GO:0017018 myosin phosphatase activity(GO:0017018)
1.6 22.7 GO:1990239 steroid hormone binding(GO:1990239)
1.5 51.3 GO:0030742 GTP-dependent protein binding(GO:0030742)
1.5 10.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.4 8.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.4 19.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
1.4 5.5 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
1.3 70.4 GO:0017080 sodium channel regulator activity(GO:0017080)
1.1 9.2 GO:0043559 insulin binding(GO:0043559)
1.1 4.5 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
1.1 3.2 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.9 4.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.9 13.9 GO:0005523 tropomyosin binding(GO:0005523)
0.8 5.0 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.8 7.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.7 52.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.7 3.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.7 2.9 GO:0015254 glycerol channel activity(GO:0015254)
0.7 2.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.7 19.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 6.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.6 1.9 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.6 3.0 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.6 4.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.6 2.9 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.6 2.3 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.6 2.8 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.5 7.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 8.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.5 2.6 GO:0002046 opsin binding(GO:0002046)
0.5 10.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.5 2.4 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.4 7.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.4 3.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.4 7.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.4 2.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 2.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.4 4.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 8.3 GO:0035198 miRNA binding(GO:0035198)
0.4 1.4 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.4 11.8 GO:0001671 ATPase activator activity(GO:0001671)
0.4 4.6 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.4 3.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 6.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 5.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 2.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.3 3.3 GO:0097100 supercoiled DNA binding(GO:0097100)
0.3 6.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 5.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.3 5.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 9.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.3 7.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 1.0 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.3 1.8 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 3.5 GO:0070412 R-SMAD binding(GO:0070412)
0.2 17.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.6 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 10.6 GO:0030507 spectrin binding(GO:0030507)
0.2 4.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 17.7 GO:0001618 virus receptor activity(GO:0001618)
0.2 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 4.7 GO:0046965 retinoid X receptor binding(GO:0046965)
0.2 0.8 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.2 4.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 15.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 4.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 6.4 GO:0030552 cAMP binding(GO:0030552)
0.1 2.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 57.5 GO:0003779 actin binding(GO:0003779)
0.1 59.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.5 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 0.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 2.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 93.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 9.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 8.2 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.2 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.1 3.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 3.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 6.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 9.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.5 GO:0019003 GDP binding(GO:0019003)
0.0 12.2 GO:0015631 tubulin binding(GO:0015631)
0.0 8.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 5.9 GO:0016874 ligase activity(GO:0016874)
0.0 0.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 4.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 9.6 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.1 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.7 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 26.9 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.9 35.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.7 98.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.7 23.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.6 6.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 109.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 58.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.4 5.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 17.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 11.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.6 PID RAS PATHWAY Regulation of Ras family activation
0.2 7.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 9.6 PID AURORA B PATHWAY Aurora B signaling
0.2 10.9 PID FGF PATHWAY FGF signaling pathway
0.2 5.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 5.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 8.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 3.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.3 PID IL27 PATHWAY IL27-mediated signaling events
0.1 2.6 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 4.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 2.0 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 4.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 ST ADRENERGIC Adrenergic Pathway
0.0 3.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 2.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 236.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.3 18.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.9 9.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.9 19.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.8 7.2 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.7 13.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.7 17.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.5 35.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 16.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 7.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.4 9.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 21.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 3.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4 5.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.4 8.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 12.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 17.7 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.3 3.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.3 10.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 16.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.3 14.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 5.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 7.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.3 5.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.3 11.4 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 2.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 12.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 4.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 2.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 6.4 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.2 6.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 5.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 4.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.4 REACTOME DEFENSINS Genes involved in Defensins
0.1 4.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 5.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 7.6 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.1 3.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 3.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 1.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 4.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production