ISMARA results: MIXL1_GSX1_BSX_MEOX2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MIXL1_GSX1_BSX_MEOX2_LHX4

Z-value: 0.93

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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4

Gene Symbol	Gene ID	Gene Info
MIXL1 Ensembl NCBI GeneCards UniProt	ENSG00000185155.7	Mix paired-like homeobox
GSX1 Ensembl NCBI GeneCards UniProt	ENSG00000169840.4	GS homeobox 1
BSX Ensembl NCBI GeneCards UniProt	ENSG00000188909.4	brain specific homeobox
MEOX2 Ensembl NCBI GeneCards UniProt	ENSG00000106511.5	mesenchyme homeobox 2
LHX4 Ensembl NCBI GeneCards UniProt	ENSG00000121454.4	LIM homeobox 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MIXL1	hg19_v2_chr1_+_226411319_226411366	0.16	1.7e-02	Click!
MEOX2	hg19_v2_chr7_-_15726296_15726437	0.05	4.9e-01	Click!

Activity profile of MIXL1_GSX1_BSX_MEOX2_LHX4 motif

Sorted Z-values of MIXL1_GSX1_BSX_MEOX2_LHX4 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_-_13835147 Show fit	34.84	ENST00000493677.1 ENST00000355135.2	GPM6B Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6B
chr11_-_117748138 Show fit	34.05	ENST00000527717.1	FXYD6 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 6
chr11_-_117747607 Show fit	32.29	ENST00000540359.1 ENST00000539526.1	FXYD6 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 6
chr11_-_117747434 Show fit	31.51	ENST00000529335.2 ENST00000530956.1 ENST00000260282.4	FXYD6 Ensembl NCBI GeneCards UniProt Show fit	FXYD domain containing ion transport regulator 6
chr2_+_90248739 Show fit	22.24	ENST00000468879.1	IGKV1D-43 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1D-43
chr2_+_68962014 Show fit	17.73	ENST00000467265.1	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr16_-_4852915 Show fit	16.49	ENST00000322048.7	ROGDI Ensembl NCBI GeneCards UniProt Show fit	rogdi homolog (Drosophila)
chr5_+_66300446 Show fit	16.06	ENST00000261569.7	MAST4 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated serine/threonine kinase family member 4
chr18_+_32556892 Show fit	15.56	ENST00000591734.1 ENST00000413393.1 ENST00000589180.1 ENST00000587359.1	MAPRE2 Ensembl NCBI GeneCards UniProt Show fit	microtubule-associated protein, RP/EB family, member 2
chr3_-_18480260 Show fit	15.50	ENST00000454909.2	SATB1 Ensembl NCBI GeneCards UniProt Show fit	SATB homeobox 1
chr2_+_68961934 Show fit	15.41	ENST00000409202.3	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr13_-_46716969 Show fit	15.14	ENST00000435666.2	LCP1 Ensembl NCBI GeneCards UniProt Show fit	lymphocyte cytosolic protein 1 (L-plastin)
chr11_-_111794446 Show fit	15.12	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt Show fit	crystallin, alpha B
chr2_+_68961905 Show fit	15.06	ENST00000295381.3	ARHGAP25 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 25
chr12_-_6233828 Show fit	14.88	ENST00000572068.1 ENST00000261405.5	VWF Ensembl NCBI GeneCards UniProt Show fit	von Willebrand factor
chr4_+_40198527 Show fit	14.01	ENST00000381799.5	RHOH Ensembl NCBI GeneCards UniProt Show fit	ras homolog family member H
chr6_-_32908765 Show fit	13.94	ENST00000416244.2	HLA-DMB Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DM beta
chr6_-_32908792 Show fit	13.78	ENST00000418107.2	HLA-DMB Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DM beta
chr2_-_158300556 Show fit	12.38	ENST00000264192.3	CYTIP Ensembl NCBI GeneCards UniProt Show fit	cytohesin 1 interacting protein
chr11_-_33913708 Show fit	12.38	ENST00000257818.2	LMO2 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 2 (rhombotin-like 1)
chr12_+_81110684 Show fit	12.15	ENST00000228644.3	MYF5 Ensembl NCBI GeneCards UniProt Show fit	myogenic factor 5
chr2_-_89340242 Show fit	11.85	ENST00000480492.1	IGKV1-12 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-12
chr3_+_111718036 Show fit	11.47	ENST00000455401.2	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr18_+_71815743 Show fit	10.67	ENST00000169551.6 ENST00000580087.1	TIMM21 Ensembl NCBI GeneCards UniProt Show fit	translocase of inner mitochondrial membrane 21 homolog (yeast)
chr3_+_111717600 Show fit	10.60	ENST00000273368.4	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr3_+_111718173 Show fit	10.51	ENST00000494932.1	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr5_+_156696362 Show fit	10.45	ENST00000377576.3	CYFIP2 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic FMR1 interacting protein 2
chrX_+_13671225 Show fit	10.39	ENST00000545566.1 ENST00000544987.1 ENST00000314720.4	TCEANC Ensembl NCBI GeneCards UniProt Show fit	transcription elongation factor A (SII) N-terminal and central domain containing
chr2_+_90273679 Show fit	10.28	ENST00000423080.2	IGKV3D-7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-7
chr3_-_39321512 Show fit	10.14	ENST00000399220.2	CX3CR1 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-X3-C motif) receptor 1
chr2_-_136288113 Show fit	10.05	ENST00000401392.1	ZRANB3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger, RAN-binding domain containing 3
chr13_-_88323218 Show fit	10.01	ENST00000436290.2 ENST00000453832.2 ENST00000606590.1	MIR4500HG Ensembl NCBI GeneCards UniProt Show fit	MIR4500 host gene (non-protein coding)
chr3_+_35722487 Show fit	9.95	ENST00000441454.1	ARPP21 Ensembl NCBI GeneCards UniProt Show fit	cAMP-regulated phosphoprotein, 21kDa
chr3_+_111717511 Show fit	9.91	ENST00000478951.1 ENST00000393917.2	TAGLN3 Ensembl NCBI GeneCards UniProt Show fit	transgelin 3
chr1_+_111415757 Show fit	9.89	ENST00000429072.2 ENST00000271324.5	CD53 Ensembl NCBI GeneCards UniProt Show fit	CD53 molecule
chr2_+_90211643 Show fit	9.81	ENST00000390277.2	IGKV3D-11 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-11
chr8_-_27468842 Show fit	9.58	ENST00000523500.1	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr5_-_24645078 Show fit	9.51	ENST00000264463.4	CDH10 Ensembl NCBI GeneCards UniProt Show fit	cadherin 10, type 2 (T2-cadherin)
chr11_-_129062093 Show fit	9.35	ENST00000310343.9	ARHGAP32 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 32
chr6_+_151042224 Show fit	9.16	ENST00000358517.2	PLEKHG1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_+_174844645 Show fit	9.14	ENST00000486220.1	RABGAP1L Ensembl NCBI GeneCards UniProt Show fit	RAB GTPase activating protein 1-like
chr4_-_46911248 Show fit	8.90	ENST00000355591.3 ENST00000505102.1	COX7B2 Ensembl NCBI GeneCards UniProt Show fit	cytochrome c oxidase subunit VIIb2
chr6_-_152639479 Show fit	8.76	ENST00000356820.4	SYNE1 Ensembl NCBI GeneCards UniProt Show fit	spectrin repeat containing, nuclear envelope 1
chr19_+_50016610 Show fit	8.60	ENST00000596975.1	FCGRT Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG, receptor, transporter, alpha
chr1_-_92952433 Show fit	8.57	ENST00000294702.5	GFI1 Ensembl NCBI GeneCards UniProt Show fit	growth factor independent 1 transcription repressor
chr4_-_87028478 Show fit	8.56	ENST00000515400.1 ENST00000395157.3	MAPK10 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase 10
chr8_+_28748765 Show fit	8.51	ENST00000355231.5	HMBOX1 Ensembl NCBI GeneCards UniProt Show fit	homeobox containing 1
chr3_+_115342349 Show fit	8.35	ENST00000393780.3	GAP43 Ensembl NCBI GeneCards UniProt Show fit	growth associated protein 43
chr1_-_150738261 Show fit	8.33	ENST00000448301.2 ENST00000368985.3	CTSS Ensembl NCBI GeneCards UniProt Show fit	cathepsin S
chr11_+_121447469 Show fit	8.27	ENST00000532694.1 ENST00000534286.1	SORL1 Ensembl NCBI GeneCards UniProt Show fit	sortilin-related receptor, L(DLR class) A repeats containing
chr3_+_108541545 Show fit	8.22	ENST00000295756.6	TRAT1 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor associated transmembrane adaptor 1
chr5_+_36608422 Show fit	8.21	ENST00000381918.3	SLC1A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_208031943 Show fit	8.19	ENST00000421199.1 ENST00000457962.1	KLF7 Ensembl NCBI GeneCards UniProt Show fit	Kruppel-like factor 7 (ubiquitous)
chr2_+_196313239 Show fit	8.12	ENST00000413290.1	AC064834.1 Ensembl NCBI GeneCards UniProt Show fit	AC064834.1
chr11_-_5255861 Show fit	8.11	ENST00000380299.3	HBD Ensembl NCBI GeneCards UniProt Show fit	hemoglobin, delta
chr3_+_108541608 Show fit	8.06	ENST00000426646.1	TRAT1 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor associated transmembrane adaptor 1
chrX_-_19988382 Show fit	7.97	ENST00000356980.3 ENST00000379687.3 ENST00000379682.4	CXorf23 Ensembl NCBI GeneCards UniProt Show fit	chromosome X open reading frame 23
chr4_-_120243545 Show fit	7.90	ENST00000274024.3	FABP2 Ensembl NCBI GeneCards UniProt Show fit	fatty acid binding protein 2, intestinal
chr11_-_104972158 Show fit	7.80	ENST00000598974.1 ENST00000593315.1 ENST00000594519.1 ENST00000415981.2 ENST00000525374.1 ENST00000375707.1	CASP1 Ensembl NCBI GeneCards UniProt Show fit CARD16 Ensembl NCBI GeneCards UniProt Show fit CARD17 Ensembl NCBI GeneCards UniProt Show fit	caspase 1, apoptosis-related cysteine peptidase caspase recruitment domain family, member 16 caspase recruitment domain family, member 17
chr12_-_16761007 Show fit	7.64	ENST00000354662.1 ENST00000441439.2	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr10_-_71169031 Show fit	7.63	ENST00000373307.1	TACR2 Ensembl NCBI GeneCards UniProt Show fit	tachykinin receptor 2
chr4_-_170897045 Show fit	7.61	ENST00000508313.1	RP11-205M3.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-205M3.3
chr1_-_152386732 Show fit	7.52	ENST00000271835.3	CRNN Ensembl NCBI GeneCards UniProt Show fit	cornulin
chr6_+_31583761 Show fit	7.42	ENST00000376049.4	AIF1 Ensembl NCBI GeneCards UniProt Show fit	allograft inflammatory factor 1
chr12_-_112123524 Show fit	7.41	ENST00000327551.6	BRAP Ensembl NCBI GeneCards UniProt Show fit	BRCA1 associated protein
chr2_+_103035102 Show fit	7.26	ENST00000264260.2	IL18RAP Ensembl NCBI GeneCards UniProt Show fit	interleukin 18 receptor accessory protein
chr13_-_99910673 Show fit	7.25	ENST00000397473.2 ENST00000397470.2	GPR18 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 18
chr18_+_32558208 Show fit	7.06	ENST00000436190.2	MAPRE2 Ensembl NCBI GeneCards UniProt Show fit	microtubule-associated protein, RP/EB family, member 2
chr14_-_101295407 Show fit	7.04	ENST00000596284.1	AL117190.2 Ensembl NCBI GeneCards UniProt Show fit	AL117190.2
chr3_+_35721106 Show fit	7.00	ENST00000474696.1 ENST00000412048.1 ENST00000396482.2 ENST00000432682.1	ARPP21 Ensembl NCBI GeneCards UniProt Show fit	cAMP-regulated phosphoprotein, 21kDa
chr1_+_198608146 Show fit	6.86	ENST00000367376.2 ENST00000352140.3 ENST00000594404.1 ENST00000598951.1 ENST00000530727.1 ENST00000442510.2 ENST00000367367.4 ENST00000348564.6 ENST00000367364.1 ENST00000413409.2	PTPRC Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase, receptor type, C
chr7_+_50348268 Show fit	6.79	ENST00000438033.1 ENST00000439701.1	IKZF1 Ensembl NCBI GeneCards UniProt Show fit	IKAROS family zinc finger 1 (Ikaros)
chr11_-_108093329 Show fit	6.73	ENST00000278612.8	NPAT Ensembl NCBI GeneCards UniProt Show fit	nuclear protein, ataxia-telangiectasia locus
chr2_+_169926047 Show fit	6.70	ENST00000428522.1 ENST00000450153.1 ENST00000421653.1	DHRS9 Ensembl NCBI GeneCards UniProt Show fit	dehydrogenase/reductase (SDR family) member 9
chr21_-_42219065 Show fit	6.55	ENST00000400454.1	DSCAM Ensembl NCBI GeneCards UniProt Show fit	Down syndrome cell adhesion molecule
chr12_-_16759711 Show fit	6.47	ENST00000447609.1	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr12_+_26348246 Show fit	6.45	ENST00000422622.2	SSPN Ensembl NCBI GeneCards UniProt Show fit	sarcospan
chr2_-_89292422 Show fit	6.43	ENST00000495489.1	IGKV1-8 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-8
chr2_-_89399845 Show fit	6.35	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-16
chrX_-_13835461 Show fit	6.35	ENST00000316715.4 ENST00000356942.5	GPM6B Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6B
chr12_-_91546926 Show fit	6.35	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr20_+_45947246 Show fit	6.33	ENST00000599904.1	AL031666.2 Ensembl NCBI GeneCards UniProt Show fit	HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr16_+_8768422 Show fit	6.32	ENST00000268251.8 ENST00000564714.1	ABAT Ensembl NCBI GeneCards UniProt Show fit	4-aminobutyrate aminotransferase
chr1_+_101003687 Show fit	6.28	ENST00000315033.4	GPR88 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 88
chrX_-_73512411 Show fit	6.25	ENST00000602576.1 ENST00000429124.1	FTX Ensembl NCBI GeneCards UniProt Show fit	FTX transcript, XIST regulator (non-protein coding)
chr14_+_61654271 Show fit	6.17	ENST00000555185.1 ENST00000557294.1 ENST00000556778.1	PRKCH Ensembl NCBI GeneCards UniProt Show fit	protein kinase C, eta
chr8_+_117950422 Show fit	6.11	ENST00000378279.3	AARD Ensembl NCBI GeneCards UniProt Show fit	alanine and arginine rich domain containing protein
chr12_-_114841703 Show fit	6.01	ENST00000526441.1	TBX5 Ensembl NCBI GeneCards UniProt Show fit	T-box 5
chr8_-_90769422 Show fit	5.93	ENST00000524190.1 ENST00000523859.1	RP11-37B2.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-37B2.1
chrX_-_92928557 Show fit	5.91	ENST00000373079.3 ENST00000475430.2	NAP1L3 Ensembl NCBI GeneCards UniProt Show fit	nucleosome assembly protein 1-like 3
chr4_+_88754113 Show fit	5.89	ENST00000560249.1 ENST00000540395.1 ENST00000511670.1 ENST00000361056.3	MEPE Ensembl NCBI GeneCards UniProt Show fit	matrix extracellular phosphoglycoprotein
chr6_-_39693111 Show fit	5.84	ENST00000373215.3 ENST00000538893.1 ENST00000287152.7 ENST00000373216.3	KIF6 Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 6
chr12_-_15103621 Show fit	5.76	ENST00000536592.1	ARHGDIB Ensembl NCBI GeneCards UniProt Show fit	Rho GDP dissociation inhibitor (GDI) beta
chr11_+_28129795 Show fit	5.68	ENST00000406787.3 ENST00000342303.5 ENST00000403099.1 ENST00000407364.3	METTL15 Ensembl NCBI GeneCards UniProt Show fit	methyltransferase like 15
chr2_-_89327228 Show fit	5.68	ENST00000483158.1	IGKV3-11 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3-11
chr14_+_22977587 Show fit	5.65	ENST00000390504.1	TRAJ33 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha joining 33
chr18_+_29027696 Show fit	5.59	ENST00000257189.4	DSG3 Ensembl NCBI GeneCards UniProt Show fit	desmoglein 3
chr18_-_5396271 Show fit	5.58	ENST00000579951.1	EPB41L3 Ensembl NCBI GeneCards UniProt Show fit	erythrocyte membrane protein band 4.1-like 3
chr10_+_18549645 Show fit	5.53	ENST00000396576.2	CACNB2 Ensembl NCBI GeneCards UniProt Show fit	calcium channel, voltage-dependent, beta 2 subunit
chr16_+_22501658 Show fit	5.49	ENST00000415833.2	NPIPB5 Ensembl NCBI GeneCards UniProt Show fit	nuclear pore complex interacting protein family, member B5
chr13_-_41593425 Show fit	5.48	ENST00000239882.3	ELF1 Ensembl NCBI GeneCards UniProt Show fit	E74-like factor 1 (ets domain transcription factor)
chr6_-_52705641 Show fit	5.45	ENST00000370989.2	GSTA5 Ensembl NCBI GeneCards UniProt Show fit	glutathione S-transferase alpha 5
chrX_+_55478538 Show fit	5.37	ENST00000342972.1	MAGEH1 Ensembl NCBI GeneCards UniProt Show fit	melanoma antigen family H, 1
chr5_-_39219641 Show fit	5.37	ENST00000509072.1 ENST00000504542.1 ENST00000505428.1 ENST00000506557.1	FYB Ensembl NCBI GeneCards UniProt Show fit	FYN binding protein
chr1_+_180601139 Show fit	5.35	ENST00000367590.4 ENST00000367589.3	XPR1 Ensembl NCBI GeneCards UniProt Show fit	xenotropic and polytropic retrovirus receptor 1
chr7_+_97361218 Show fit	5.33	ENST00000319273.5	TAC1 Ensembl NCBI GeneCards UniProt Show fit	tachykinin, precursor 1
chr8_-_86253888 Show fit	5.27	ENST00000522389.1 ENST00000432364.2 ENST00000517618.1	CA1 Ensembl NCBI GeneCards UniProt Show fit	carbonic anhydrase I
chr13_-_36788718 Show fit	5.26	ENST00000317764.6 ENST00000379881.3	SOHLH2 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr14_+_22337014 Show fit	5.19	ENST00000390436.2	TRAV13-1 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha variable 13-1
chr2_+_113763031 Show fit	5.09	ENST00000259211.6	IL36A Ensembl NCBI GeneCards UniProt Show fit	interleukin 36, alpha
chr1_+_84609944 Show fit	5.09	ENST00000370685.3	PRKACB Ensembl NCBI GeneCards UniProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr11_-_128894053 Show fit	5.02	ENST00000392657.3	ARHGAP32 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 32
chr7_+_149535455 Show fit	4.95	ENST00000223210.4 ENST00000460379.1	ZNF862 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 862
chr8_-_27469196 Show fit	4.92	ENST00000546343.1 ENST00000560566.1	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chrM_+_12331 Show fit	4.92	ENST00000361567.2	MT-ND5 Ensembl NCBI GeneCards UniProt Show fit	mitochondrially encoded NADH dehydrogenase 5
chrX_-_73512177 Show fit	4.89	ENST00000603672.1 ENST00000418855.1	FTX Ensembl NCBI GeneCards UniProt Show fit	FTX transcript, XIST regulator (non-protein coding)
chr12_+_25205568 Show fit	4.84	ENST00000548766.1 ENST00000556887.1	LRMP Ensembl NCBI GeneCards UniProt Show fit	lymphoid-restricted membrane protein
chr6_-_25042231 Show fit	4.83	ENST00000510784.2	FAM65B Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 65, member B
chr19_-_7968427 Show fit	4.81	ENST00000539278.1	AC010336.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chrX_-_138724994 Show fit	4.79	ENST00000536274.1	MCF2 Ensembl NCBI GeneCards UniProt Show fit	MCF.2 cell line derived transforming sequence
chr1_-_25291475 Show fit	4.69	ENST00000338888.3 ENST00000399916.1	RUNX3 Ensembl NCBI GeneCards UniProt Show fit	runt-related transcription factor 3
chr4_-_89205879 Show fit	4.67	ENST00000608933.1 ENST00000315194.4 ENST00000514204.1	PPM1K Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr10_-_50970322 Show fit	4.66	ENST00000374103.4	OGDHL Ensembl NCBI GeneCards UniProt Show fit	oxoglutarate dehydrogenase-like
chr16_-_66584059 Show fit	4.62	ENST00000417693.3 ENST00000544898.1 ENST00000569718.1 ENST00000527284.1 ENST00000299697.7 ENST00000451102.2	TK2 Ensembl NCBI GeneCards UniProt Show fit	thymidine kinase 2, mitochondrial
chr1_+_117963209 Show fit	4.61	ENST00000449370.2	MAN1A2 Ensembl NCBI GeneCards UniProt Show fit	mannosidase, alpha, class 1A, member 2
chr17_+_45000483 Show fit	4.59	ENST00000576910.2 ENST00000439730.2 ENST00000393456.2 ENST00000415811.2 ENST00000575949.1 ENST00000225567.4 ENST00000572403.1 ENST00000570879.1	GOSR2 Ensembl NCBI GeneCards UniProt Show fit	golgi SNAP receptor complex member 2
chr7_+_100136811 Show fit	4.56	ENST00000300176.4 ENST00000262935.4	AGFG2 Ensembl NCBI GeneCards UniProt Show fit	ArfGAP with FG repeats 2
chr1_+_84630645 Show fit	4.53	ENST00000394839.2	PRKACB Ensembl NCBI GeneCards UniProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr4_-_57547870 Show fit	4.52	ENST00000381260.3 ENST00000420433.1 ENST00000554144.1 ENST00000557328.1	HOPX Ensembl NCBI GeneCards UniProt Show fit	HOP homeobox
chr1_+_36789335 Show fit	4.46	ENST00000373137.2	RP11-268J15.5 Ensembl NCBI GeneCards UniProt Show fit	RP11-268J15.5
chr6_-_32557610 Show fit	4.45	ENST00000360004.5	HLA-DRB1 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DR beta 1
chr14_-_106926724 Show fit	4.44	ENST00000434710.1	IGHV3-43 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-43
chr4_-_57524061 Show fit	4.41	ENST00000508121.1	HOPX Ensembl NCBI GeneCards UniProt Show fit	HOP homeobox
chr14_+_22931924 Show fit	4.41	ENST00000390477.2	TRDC Ensembl NCBI GeneCards UniProt Show fit	T cell receptor delta constant
chrX_+_37639264 Show fit	4.38	ENST00000378588.4	CYBB Ensembl NCBI GeneCards UniProt Show fit	cytochrome b-245, beta polypeptide
chr12_+_56325812 Show fit	4.31	ENST00000394147.1 ENST00000551156.1 ENST00000553783.1 ENST00000557080.1 ENST00000432422.3 ENST00000556001.1	DGKA Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol kinase, alpha 80kDa
chr2_+_90077680 Show fit	4.29	ENST00000390270.2	IGKV3D-20 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-20
chr6_-_170101749 Show fit	4.28	ENST00000448612.1	WDR27 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 27
chr2_-_50574856 Show fit	4.22	ENST00000342183.5	NRXN1 Ensembl NCBI GeneCards UniProt Show fit	neurexin 1
chr9_-_95166841 Show fit	4.21	ENST00000262551.4	OGN Ensembl NCBI GeneCards UniProt Show fit	osteoglycin
chr6_+_72926145 Show fit	4.20	ENST00000425662.2 ENST00000453976.2	RIMS1 Ensembl NCBI GeneCards UniProt Show fit	regulating synaptic membrane exocytosis 1
chr4_-_57547454 Show fit	4.16	ENST00000556376.2	HOPX Ensembl NCBI GeneCards UniProt Show fit	HOP homeobox
chr19_-_53758094 Show fit	4.15	ENST00000601828.1 ENST00000598513.1 ENST00000599012.1 ENST00000333952.4 ENST00000598806.1	ZNF677 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 677
chr7_-_73038822 Show fit	4.14	ENST00000414749.2 ENST00000429400.2 ENST00000434326.1	MLXIPL Ensembl NCBI GeneCards UniProt Show fit	MLX interacting protein-like
chr11_-_104905840 Show fit	4.08	ENST00000526568.1 ENST00000393136.4 ENST00000531166.1 ENST00000534497.1 ENST00000527979.1 ENST00000446369.1 ENST00000353247.5 ENST00000528974.1 ENST00000533400.1 ENST00000525825.1 ENST00000436863.3	CASP1 Ensembl NCBI GeneCards UniProt Show fit	caspase 1, apoptosis-related cysteine peptidase
chr13_+_49551020 Show fit	4.08	ENST00000541916.1	FNDC3A Ensembl NCBI GeneCards UniProt Show fit	fibronectin type III domain containing 3A
chr8_-_102803163 Show fit	4.06	ENST00000523645.1 ENST00000520346.1 ENST00000220931.6 ENST00000522448.1 ENST00000522951.1 ENST00000522252.1 ENST00000519098.1	NCALD Ensembl NCBI GeneCards UniProt Show fit	neurocalcin delta
chr18_-_53177984 Show fit	4.04	ENST00000543082.1	TCF4 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 4
chr5_+_54398463 Show fit	3.99	ENST00000274306.6	GZMA Ensembl NCBI GeneCards UniProt Show fit	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr6_+_26365443 Show fit	3.93	ENST00000527422.1 ENST00000356386.2 ENST00000396934.3 ENST00000377708.2 ENST00000396948.1 ENST00000508906.2	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A2
chr5_+_176853702 Show fit	3.92	ENST00000507633.1 ENST00000393576.3 ENST00000355958.5 ENST00000528793.1 ENST00000512684.1	GRK6 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor kinase 6
chr6_-_32784687 Show fit	3.92	ENST00000447394.1 ENST00000438763.2	HLA-DOB Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DO beta
chr1_-_48937821 Show fit	3.92	ENST00000396199.3	SPATA6 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated 6
chr12_-_23737534 Show fit	3.91	ENST00000396007.2	SOX5 Ensembl NCBI GeneCards UniProt Show fit	SRY (sex determining region Y)-box 5
chr4_-_176733897 Show fit	3.90	ENST00000393658.2	GPM6A Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6A
chr2_-_89442621 Show fit	3.90	ENST00000492167.1	IGKV3-20 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3-20
chr18_+_32173276 Show fit	3.90	ENST00000591816.1 ENST00000588125.1 ENST00000598334.1 ENST00000588684.1 ENST00000554864.3 ENST00000399121.5 ENST00000595022.1 ENST00000269190.7 ENST00000399097.3	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin, alpha
chr1_-_45956822 Show fit	3.89	ENST00000372086.3 ENST00000341771.6	TESK2 Ensembl NCBI GeneCards UniProt Show fit	testis-specific kinase 2
chr14_-_104181771 Show fit	3.87	ENST00000554913.1 ENST00000554974.1 ENST00000553361.1 ENST00000555055.1 ENST00000555964.1 ENST00000556682.1 ENST00000445556.1 ENST00000553332.1 ENST00000352127.7	XRCC3 Ensembl NCBI GeneCards UniProt Show fit	X-ray repair complementing defective repair in Chinese hamster cells 3
chr7_-_73038867 Show fit	3.85	ENST00000313375.3 ENST00000354613.1 ENST00000395189.1 ENST00000453275.1	MLXIPL Ensembl NCBI GeneCards UniProt Show fit	MLX interacting protein-like
chr17_-_9929581 Show fit	3.84	ENST00000437099.2 ENST00000396115.2	GAS7 Ensembl NCBI GeneCards UniProt Show fit	growth arrest-specific 7
chr8_+_38585704 Show fit	3.84	ENST00000519416.1 ENST00000520615.1	TACC1 Ensembl NCBI GeneCards UniProt Show fit	transforming, acidic coiled-coil containing protein 1
chr10_+_18629628 Show fit	3.79	ENST00000377329.4	CACNB2 Ensembl NCBI GeneCards UniProt Show fit	calcium channel, voltage-dependent, beta 2 subunit
chr13_-_41706864 Show fit	3.76	ENST00000379485.1 ENST00000499385.2	KBTBD6 Ensembl NCBI GeneCards UniProt Show fit	kelch repeat and BTB (POZ) domain containing 6
chr8_-_101571964 Show fit	3.75	ENST00000520552.1 ENST00000521345.1 ENST00000523000.1 ENST00000335659.3 ENST00000358990.3 ENST00000519597.1	ANKRD46 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat domain 46
chr13_+_31309645 Show fit	3.75	ENST00000380490.3	ALOX5AP Ensembl NCBI GeneCards UniProt Show fit	arachidonate 5-lipoxygenase-activating protein
chr7_-_37488834 Show fit	3.74	ENST00000310758.4	ELMO1 Ensembl NCBI GeneCards UniProt Show fit	engulfment and cell motility 1
chr12_-_118796910 Show fit	3.72	ENST00000541186.1 ENST00000539872.1	TAOK3 Ensembl NCBI GeneCards UniProt Show fit	TAO kinase 3
chr1_+_183774240 Show fit	3.71	ENST00000360851.3	RGL1 Ensembl NCBI GeneCards UniProt Show fit	ral guanine nucleotide dissociation stimulator-like 1
chr3_-_98241358 Show fit	3.71	ENST00000503004.1 ENST00000506575.1 ENST00000513452.1 ENST00000515620.1	CLDND1 Ensembl NCBI GeneCards UniProt Show fit	claudin domain containing 1
chr12_-_30887948 Show fit	3.70	ENST00000433722.2	CAPRIN2 Ensembl NCBI GeneCards UniProt Show fit	caprin family member 2
chr7_+_97361388 Show fit	3.69	ENST00000350485.4 ENST00000346867.4	TAC1 Ensembl NCBI GeneCards UniProt Show fit	tachykinin, precursor 1
chr1_-_48937838 Show fit	3.69	ENST00000371847.3	SPATA6 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated 6
chr12_-_10282836 Show fit	3.68	ENST00000304084.8 ENST00000353231.5 ENST00000525605.1	CLEC7A Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 7, member A
chr6_-_22297730 Show fit	3.68	ENST00000306482.1	PRL Ensembl NCBI GeneCards UniProt Show fit	prolactin
chrX_+_77166172 Show fit	3.68	ENST00000343533.5 ENST00000350425.4 ENST00000341514.6	ATP7A Ensembl NCBI GeneCards UniProt Show fit	ATPase, Cu++ transporting, alpha polypeptide
chr6_+_26402517 Show fit	3.67	ENST00000414912.2	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin, subfamily 3, member A1
chr8_+_119294456 Show fit	3.67	ENST00000366457.2	AC023590.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr12_-_22063787 Show fit	3.66	ENST00000544039.1	ABCC9 Ensembl NCBI GeneCards UniProt Show fit	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr10_+_13142075 Show fit	3.63	ENST00000378757.2 ENST00000430081.1 ENST00000378752.3 ENST00000378748.3	OPTN Ensembl NCBI GeneCards UniProt Show fit	optineurin
chr8_-_87755878 Show fit	3.63	ENST00000320005.5	CNGB3 Ensembl NCBI GeneCards UniProt Show fit	cyclic nucleotide gated channel beta 3
chr10_-_115904361 Show fit	3.63	ENST00000428953.1 ENST00000543782.1	C10orf118 Ensembl NCBI GeneCards UniProt Show fit	chromosome 10 open reading frame 118
chrX_+_37639302 Show fit	3.62	ENST00000545017.1 ENST00000536160.1	CYBB Ensembl NCBI GeneCards UniProt Show fit	cytochrome b-245, beta polypeptide
chr4_+_3388057 Show fit	3.59	ENST00000538395.1	RGS12 Ensembl NCBI GeneCards UniProt Show fit	regulator of G-protein signaling 12
chrX_+_15808569 Show fit	3.59	ENST00000380308.3 ENST00000307771.7	ZRSR2 Ensembl NCBI GeneCards UniProt Show fit	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr9_-_95166884 Show fit	3.58	ENST00000375561.5	OGN Ensembl NCBI GeneCards UniProt Show fit	osteoglycin
chr6_-_32157947 Show fit	3.58	ENST00000375050.4	PBX2 Ensembl NCBI GeneCards UniProt Show fit	pre-B-cell leukemia homeobox 2
chr4_+_88754069 Show fit	3.55	ENST00000395102.4 ENST00000497649.2	MEPE Ensembl NCBI GeneCards UniProt Show fit	matrix extracellular phosphoglycoprotein
chr9_-_21368075 Show fit	3.54	ENST00000449498.1	IFNA13 Ensembl NCBI GeneCards UniProt Show fit	interferon, alpha 13
chr7_-_137028534 Show fit	3.53	ENST00000348225.2	PTN Ensembl NCBI GeneCards UniProt Show fit	pleiotrophin
chr1_-_160681593 Show fit	3.50	ENST00000368045.3 ENST00000368046.3	CD48 Ensembl NCBI GeneCards UniProt Show fit	CD48 molecule
chr4_-_89205705 Show fit	3.48	ENST00000295908.7 ENST00000510548.2 ENST00000508256.1	PPM1K Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr18_-_21977748 Show fit	3.47	ENST00000399441.4 ENST00000319481.3	OSBPL1A Ensembl NCBI GeneCards UniProt Show fit	oxysterol binding protein-like 1A
chr6_+_28317685 Show fit	3.45	ENST00000252211.2 ENST00000341464.5 ENST00000377255.3	ZKSCAN3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger with KRAB and SCAN domains 3
chr13_-_46626847 Show fit	3.42	ENST00000242848.4 ENST00000282007.3	ZC3H13 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing 13
chr7_-_105029812 Show fit	3.41	ENST00000482897.1	SRPK2 Ensembl NCBI GeneCards UniProt Show fit	SRSF protein kinase 2
chr12_+_7014064 Show fit	3.39	ENST00000443597.2	LRRC23 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 23
chr12_-_9760482 Show fit	3.39	ENST00000229402.3	KLRB1 Ensembl NCBI GeneCards UniProt Show fit	killer cell lectin-like receptor subfamily B, member 1
chr7_-_87342564 Show fit	3.38	ENST00000265724.3 ENST00000416177.1	ABCB1 Ensembl NCBI GeneCards UniProt Show fit	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_-_137028498 Show fit	3.36	ENST00000393083.2	PTN Ensembl NCBI GeneCards UniProt Show fit	pleiotrophin

Network of associatons between targets according to the STRING database.

First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.2	27.7	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
4.3	42.7	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
3.4	10.1	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
3.0	9.0	GO:2000854	positive regulation of corticosterone secretion(GO:2000854)
3.0	11.9	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
2.9	22.9	GO:0001920	negative regulation of receptor recycling(GO:0001920)
2.9	8.6	GO:0070105	positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
2.8	8.3	GO:1902997	regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
2.5	7.6	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
2.4	14.5	GO:1902996	regulation of neurofibrillary tangle assembly(GO:1902996)
2.4	14.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.3	6.9	GO:1904395	retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
2.1	14.5	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.0	10.1	GO:0048478	replication fork protection(GO:0048478)
2.0	6.0	GO:0003218	cardiac left ventricle formation(GO:0003218)
1.9	9.6	GO:0097338	response to clozapine(GO:0097338)
1.7	13.4	GO:0007258	JUN phosphorylation(GO:0007258)
1.6	4.9	GO:0000294	nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
1.6	11.3	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
1.6	6.4	GO:0046104	thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.6	8.0	GO:1904844	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.6	6.3	GO:0061743	motor learning(GO:0061743)
1.6	9.3	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.5	7.4	GO:0014738	regulation of muscle hyperplasia(GO:0014738)
1.5	4.4	GO:0002399	MHC class II protein complex assembly(GO:0002399)
1.4	5.8	GO:0071461	cellular response to redox state(GO:0071461)
1.4	22.8	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.4	6.9	GO:0048539	immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
1.3	9.3	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
1.3	3.9	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
1.3	10.5	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.3	6.5	GO:0035063	nuclear speck organization(GO:0035063)
1.3	3.9	GO:0071139	resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
1.3	98.1	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.3	2.5	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
1.2	3.7	GO:0071284	cellular response to lead ion(GO:0071284)
1.2	1.2	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
1.1	4.6	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.1	8.0	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
1.1	3.3	GO:0002384	hepatic immune response(GO:0002384)
1.1	3.2	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.0	3.1	GO:0051697	protein delipidation(GO:0051697)
1.0	10.2	GO:0016198	axon choice point recognition(GO:0016198)
1.0	7.1	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
1.0	12.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.0	3.0	GO:0048382	mesendoderm development(GO:0048382)
1.0	6.9	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.9	17.1	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.9	13.1	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.9	4.6	GO:0035934	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.9	9.3	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.9	2.6	GO:1904647	response to rotenone(GO:1904647)
0.9	1.7	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.9	6.8	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.8	15.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.8	1.7	GO:0090090	negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.8	10.7	GO:0033617	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.8	3.2	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.8	20.7	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.8	4.0	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.8	6.2	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.8	4.6	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)
0.8	2.3	GO:1902956	neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of cellular respiration(GO:1901857) regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.8	2.3	GO:0019417	sulfur oxidation(GO:0019417)
0.7	2.2	GO:0015888	thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.7	5.7	GO:0070475	rRNA base methylation(GO:0070475)
0.7	4.8	GO:0072501	cellular divalent inorganic anion homeostasis(GO:0072501)
0.7	2.0	GO:0006258	UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
0.7	2.0	GO:0032641	negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.7	12.8	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
0.7	3.9	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.6	1.9	GO:1904897	regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.6	1.9	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.6	6.7	GO:0042908	xenobiotic transport(GO:0042908)
0.6	0.6	GO:0070662	mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.6	1.2	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186)
0.6	6.7	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.6	1.8	GO:0000354	cis assembly of pre-catalytic spliceosome(GO:0000354)
0.6	13.7	GO:0072643	interferon-gamma secretion(GO:0072643)
0.6	2.3	GO:1990418	response to insulin-like growth factor stimulus(GO:1990418)
0.6	2.8	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.6	2.8	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.6	1.7	GO:0001694	histamine biosynthetic process(GO:0001694)
0.6	2.2	GO:0072166	posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.6	2.8	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.6	1.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.5	8.1	GO:0015671	oxygen transport(GO:0015671)
0.5	2.6	GO:0010958	regulation of amino acid import(GO:0010958) L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.5	1.1	GO:0030199	collagen fibril organization(GO:0030199)
0.5	2.1	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.5	1.6	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
0.5	6.5	GO:0048842	positive regulation of axon extension involved in axon guidance(GO:0048842)
0.5	1.5	GO:0044771	meiotic cell cycle phase transition(GO:0044771) establishment of meiotic spindle localization(GO:0051295) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.5	5.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.5	1.0	GO:1904252	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.5	3.9	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.5	0.5	GO:0007356	thorax and anterior abdomen determination(GO:0007356)
0.5	1.9	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.5	2.4	GO:1904823	pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.5	2.3	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5	1.4	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.5	2.3	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.5	0.9	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.5	9.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.5	10.0	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.5	4.1	GO:0019722	calcium-mediated signaling(GO:0019722)
0.4	2.2	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.4	1.3	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4	1.3	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.4	3.4	GO:2000773	negative regulation of cellular senescence(GO:2000773)
0.4	8.5	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.4	13.1	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.4	3.7	GO:2001300	lipoxin metabolic process(GO:2001300)
0.4	59.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	1.2	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.4	7.7	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.4	1.6	GO:0060023	soft palate development(GO:0060023)
0.4	1.2	GO:1901876	regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.4	3.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4	0.4	GO:0018262	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.4	0.7	GO:0015074	DNA integration(GO:0015074)
0.4	3.0	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.4	0.4	GO:0003404	optic vesicle morphogenesis(GO:0003404)
0.4	2.5	GO:1903232	melanosome assembly(GO:1903232)
0.4	1.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.4	5.4	GO:0016024	CDP-diacylglycerol biosynthetic process(GO:0016024)
0.4	2.5	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.4	9.6	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.4	0.7	GO:0043524	negative regulation of neuron apoptotic process(GO:0043524)
0.3	0.3	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.3	2.4	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.3	0.7	GO:0033364	mast cell secretory granule organization(GO:0033364)
0.3	2.3	GO:0071896	protein localization to adherens junction(GO:0071896)
0.3	1.3	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.3	1.0	GO:1901859	negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.3	6.9	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.3	1.6	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.3	1.3	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.3	3.9	GO:1902260	diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3	1.6	GO:0050955	thermoception(GO:0050955)
0.3	1.3	GO:0033123	positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.3	5.9	GO:2000353	positive regulation of endothelial cell apoptotic process(GO:2000353)
0.3	5.7	GO:0035493	SNARE complex assembly(GO:0035493)
0.3	3.3	GO:0048251	elastic fiber assembly(GO:0048251)
0.3	2.4	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.3	2.4	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3	1.2	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.3	2.1	GO:1902947	regulation of tau-protein kinase activity(GO:1902947)
0.3	2.4	GO:0034587	piRNA metabolic process(GO:0034587)
0.3	1.5	GO:0099538	synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.3	1.2	GO:0045872	positive regulation of rhodopsin gene expression(GO:0045872)
0.3	4.6	GO:0042832	defense response to protozoan(GO:0042832)
0.3	2.0	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.3	0.6	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.3	1.4	GO:0072023	thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.3	2.0	GO:0016098	monoterpenoid metabolic process(GO:0016098)
0.3	1.1	GO:0036269	swimming behavior(GO:0036269)
0.3	1.4	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.3	3.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3	1.9	GO:0039663	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.3	0.8	GO:0014807	regulation of somitogenesis(GO:0014807)
0.3	14.0	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.3	1.6	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
0.3	1.1	GO:0038155	interleukin-23-mediated signaling pathway(GO:0038155)
0.3	4.8	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.3	1.6	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.3	0.8	GO:0019605	benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.3	3.0	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.3	2.0	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.2	5.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.2	1.2	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2	0.7	GO:0097056	seryl-tRNA aminoacylation(GO:0006434) selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.2	0.7	GO:0090341	negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.2	2.9	GO:1901898	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2	1.7	GO:0046849	bone remodeling(GO:0046849)
0.2	1.4	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.2	6.5	GO:0044458	motile cilium assembly(GO:0044458)
0.2	0.7	GO:0001764	neuron migration(GO:0001764)
0.2	2.4	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.2	1.2	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.2	2.3	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2	0.5	GO:0010966	regulation of phosphate transport(GO:0010966)
0.2	1.4	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2	2.7	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2	1.1	GO:0006265	DNA topological change(GO:0006265)
0.2	4.1	GO:0060009	Sertoli cell development(GO:0060009)
0.2	1.8	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.2	0.7	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.2	7.1	GO:0016601	Rac protein signal transduction(GO:0016601)
0.2	1.6	GO:0034505	tooth mineralization(GO:0034505)
0.2	0.4	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2	2.2	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.2	1.7	GO:0048263	determination of dorsal identity(GO:0048263)
0.2	2.4	GO:0003351	epithelial cilium movement(GO:0003351)
0.2	0.8	GO:0035425	autocrine signaling(GO:0035425)
0.2	0.6	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2	0.8	GO:0033133	positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.2	1.2	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.2	72.5	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)
0.2	3.8	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.2	0.6	GO:0021764	amygdala development(GO:0021764)
0.2	1.2	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.2	1.3	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2	0.4	GO:0051799	negative regulation of hair follicle development(GO:0051799)
0.2	27.5	GO:0002377	immunoglobulin production(GO:0002377)
0.2	5.7	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.2	2.9	GO:0002819	regulation of adaptive immune response(GO:0002819)
0.2	1.3	GO:0044245	polysaccharide digestion(GO:0044245)
0.2	0.9	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.2	0.5	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.2	0.9	GO:0046618	drug export(GO:0046618)
0.2	9.0	GO:0015701	bicarbonate transport(GO:0015701)
0.2	0.9	GO:0006776	vitamin A metabolic process(GO:0006776)
0.2	0.3	GO:0061113	pancreas morphogenesis(GO:0061113)
0.2	1.9	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.2	5.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.2	2.7	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.2	0.5	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.2	0.7	GO:0010519	negative regulation of phospholipase activity(GO:0010519)
0.2	11.8	GO:0042475	odontogenesis of dentin-containing tooth(GO:0042475)
0.2	0.6	GO:0003185	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2	0.9	GO:1990253	cellular response to leucine starvation(GO:1990253)
0.2	6.3	GO:0019433	triglyceride catabolic process(GO:0019433)
0.2	0.5	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.2	1.2	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.2	0.5	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.1	1.8	GO:0001823	mesonephros development(GO:0001823)
0.1	0.6	GO:0016045	detection of bacterium(GO:0016045) detection of other organism(GO:0098543)
0.1	3.7	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1	0.6	GO:0007525	somatic muscle development(GO:0007525)
0.1	0.9	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.1	0.6	GO:0003183	mitral valve morphogenesis(GO:0003183)
0.1	2.0	GO:0021702	cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1	5.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.1	0.6	GO:2000253	positive regulation of feeding behavior(GO:2000253)
0.1	1.5	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.1	1.7	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.1	1.4	GO:0098719	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1	4.4	GO:0009081	branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083)
0.1	21.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	1.3	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.1	0.5	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1	0.4	GO:0072144	renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.1	1.0	GO:0045919	positive regulation of cytolysis(GO:0045919)
0.1	2.6	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1	1.7	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.1	0.8	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.1	0.8	GO:0014043	negative regulation of neuron maturation(GO:0014043)
0.1	1.9	GO:0051354	negative regulation of oxidoreductase activity(GO:0051354)
0.1	2.4	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1	0.4	GO:0006014	D-ribose metabolic process(GO:0006014)
0.1	1.6	GO:0051382	kinetochore assembly(GO:0051382)
0.1	0.5	GO:0048738	cardiac muscle tissue development(GO:0048738)
0.1	16.8	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1	0.7	GO:0015012	heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.1	2.9	GO:0039694	viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1	0.7	GO:0015811	L-cystine transport(GO:0015811)
0.1	1.4	GO:0048012	hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1	0.6	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1	1.0	GO:2000467	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1	2.7	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1	1.9	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.1	3.1	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.1	0.7	GO:0030324	lung development(GO:0030324)
0.1	2.4	GO:0000042	protein targeting to Golgi(GO:0000042)
0.1	0.2	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.1	3.5	GO:0006699	bile acid biosynthetic process(GO:0006699)
0.1	3.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.1	2.1	GO:0006749	glutathione metabolic process(GO:0006749)
0.1	0.5	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1	0.5	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.1	1.8	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.1	1.9	GO:0051412	response to corticosterone(GO:0051412)
0.1	0.2	GO:0042746	regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.1	0.9	GO:0045766	positive regulation of angiogenesis(GO:0045766)
0.1	0.4	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1	2.7	GO:0070207	protein homotrimerization(GO:0070207)
0.1	0.3	GO:0072709	cellular response to sorbitol(GO:0072709)
0.1	1.9	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.1	1.6	GO:0006955	immune response(GO:0006955)
0.1	0.5	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.1	0.6	GO:0000160	phosphorelay signal transduction system(GO:0000160)
0.1	0.4	GO:1905097	regulation of guanyl-nucleotide exchange factor activity(GO:1905097)
0.1	0.6	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.1	1.1	GO:0046600	negative regulation of centriole replication(GO:0046600)
0.1	0.3	GO:0072488	carnitine shuttle(GO:0006853) ammonium transmembrane transport(GO:0072488) carnitine transmembrane transport(GO:1902603)
0.1	0.4	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.1	0.3	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1	1.0	GO:0031167	rRNA methylation(GO:0031167)
0.1	0.3	GO:0032900	negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of neurotrophin production(GO:0032900) negative regulation of transforming growth factor beta1 production(GO:0032911) negative regulation of transforming growth factor beta production(GO:0071635)
0.1	0.3	GO:0046013	T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.1	2.6	GO:0018149	peptide cross-linking(GO:0018149)
0.1	2.3	GO:0006458	'de novo' protein folding(GO:0006458)
0.1	1.8	GO:2000249	regulation of actin cytoskeleton reorganization(GO:2000249)
0.1	0.6	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.1	10.9	GO:0034605	cellular response to heat(GO:0034605)
0.1	2.5	GO:1901687	glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1	0.2	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1	1.6	GO:0036119	response to platelet-derived growth factor(GO:0036119) cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.1	0.2	GO:0048840	otolith development(GO:0048840)
0.1	1.6	GO:0097120	receptor localization to synapse(GO:0097120)
0.1	1.2	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1	0.5	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	1.2	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1	0.4	GO:0046606	negative regulation of centrosome cycle(GO:0046606)
0.1	0.4	GO:0010927	cellular component assembly involved in morphogenesis(GO:0010927)
0.1	7.5	GO:0006903	vesicle targeting(GO:0006903)
0.1	0.8	GO:0032196	transposition(GO:0032196)
0.1	4.0	GO:0070301	cellular response to hydrogen peroxide(GO:0070301)
0.1	0.8	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.1	0.6	GO:0097190	apoptotic signaling pathway(GO:0097190)
0.1	0.5	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.1	0.2	GO:0038001	paracrine signaling(GO:0038001)
0.1	1.4	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.1	1.4	GO:0097421	liver regeneration(GO:0097421)
0.1	0.1	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541) Peyer's patch morphogenesis(GO:0061146)
0.1	1.6	GO:0097503	sialylation(GO:0097503)
0.1	0.8	GO:0050890	cognition(GO:0050890)
0.1	0.8	GO:0007625	grooming behavior(GO:0007625)
0.1	2.4	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	0.3	GO:0015692	lead ion transport(GO:0015692)
0.1	5.5	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.1	0.8	GO:0070233	negative regulation of T cell apoptotic process(GO:0070233)
0.1	1.2	GO:0005513	detection of calcium ion(GO:0005513)
0.1	0.4	GO:0018344	protein geranylgeranylation(GO:0018344)
0.1	0.1	GO:2000354	regulation of ovarian follicle development(GO:2000354)
0.1	0.8	GO:0034391	smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1	6.4	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.1	0.5	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.1	0.4	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1	0.4	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.3	GO:0045176	apical protein localization(GO:0045176)
0.1	0.6	GO:0006491	N-glycan processing(GO:0006491)
0.1	2.1	GO:0003407	neural retina development(GO:0003407)
0.1	0.5	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.1	2.6	GO:0001578	microtubule bundle formation(GO:0001578)
0.1	0.3	GO:0001554	luteolysis(GO:0001554)
0.1	0.6	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.1	1.6	GO:0010107	potassium ion import(GO:0010107)
0.1	0.9	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.1	0.4	GO:0060789	hair follicle placode formation(GO:0060789)
0.1	1.4	GO:0000226	microtubule cytoskeleton organization(GO:0000226)
0.1	1.0	GO:0007520	myoblast fusion(GO:0007520)
0.1	1.8	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1	0.7	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.1	0.5	GO:0010818	T cell chemotaxis(GO:0010818)
0.0	2.6	GO:0048477	oogenesis(GO:0048477)
0.0	0.6	GO:0030202	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	1.2	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0	2.0	GO:0009408	response to heat(GO:0009408)
0.0	0.9	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.0	0.7	GO:0006833	water transport(GO:0006833)
0.0	0.6	GO:0048568	embryonic organ development(GO:0048568)
0.0	0.3	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	3.8	GO:1990830	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0	1.0	GO:2000785	regulation of autophagosome assembly(GO:2000785)
0.0	0.5	GO:1904896	ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0	0.6	GO:0044804	nucleophagy(GO:0044804)
0.0	4.9	GO:0007265	Ras protein signal transduction(GO:0007265)
0.0	0.2	GO:2001023	regulation of response to drug(GO:2001023)
0.0	1.5	GO:0080171	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0	1.2	GO:0007595	lactation(GO:0007595)
0.0	0.6	GO:0007616	long-term memory(GO:0007616)
0.0	0.2	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0	0.2	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.2	GO:0006824	cobalt ion transport(GO:0006824)
0.0	1.9	GO:0042100	B cell proliferation(GO:0042100)
0.0	2.2	GO:0030282	bone mineralization(GO:0030282)
0.0	0.8	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0	1.4	GO:1903146	regulation of mitophagy(GO:1903146)
0.0	0.8	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.1	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.2	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0	0.1	GO:0045852	pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0	0.8	GO:0050901	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	3.0	GO:0048813	dendrite morphogenesis(GO:0048813)
0.0	0.5	GO:0035418	protein localization to synapse(GO:0035418)
0.0	0.2	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.0	1.4	GO:0007368	determination of left/right symmetry(GO:0007368)
0.0	0.2	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0	3.3	GO:0006334	nucleosome assembly(GO:0006334)
0.0	1.2	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
0.0	1.2	GO:0035914	skeletal muscle cell differentiation(GO:0035914)
0.0	0.6	GO:0042108	positive regulation of cytokine biosynthetic process(GO:0042108)
0.0	1.2	GO:0060349	bone morphogenesis(GO:0060349)
0.0	0.5	GO:0015695	organic cation transport(GO:0015695)
0.0	0.1	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.5	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	1.3	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	1.9	GO:0006096	glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0	0.6	GO:0032411	positive regulation of transporter activity(GO:0032411)
0.0	1.9	GO:0030218	erythrocyte differentiation(GO:0030218)
0.0	0.7	GO:0051437	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition(GO:0051437) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.0	0.4	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.0	0.0	GO:0061196	branch elongation involved in ureteric bud branching(GO:0060681) fungiform papilla development(GO:0061196) negative regulation of mesonephros development(GO:0061218) cranial ganglion development(GO:0061550) trigeminal ganglion development(GO:0061551) regulation of branch elongation involved in ureteric bud branching(GO:0072095) ureter development(GO:0072189) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193) mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199) negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0	2.7	GO:0007601	visual perception(GO:0007601)
0.0	0.3	GO:0006295	nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.6	GO:0035196	production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0	0.1	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0	0.8	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0	0.3	GO:0001682	tRNA 5'-leader removal(GO:0001682)
0.0	0.6	GO:0035690	cellular response to drug(GO:0035690)
0.0	0.0	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.7	GO:0035308	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	0.4	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.5	GO:0006898	receptor-mediated endocytosis(GO:0006898)
0.0	0.1	GO:0001676	long-chain fatty acid metabolic process(GO:0001676)
0.0	0.8	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.0	0.2	GO:1901652	response to peptide(GO:1901652)
0.0	0.5	GO:0006813	potassium ion transport(GO:0006813)
0.0	0.1	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	0.1	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.0	0.4	GO:0016486	peptide hormone processing(GO:0016486)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	11.6	GO:0097179	protease inhibitor complex(GO:0097179)
1.9	7.6	GO:0097224	sperm connecting piece(GO:0097224)
1.7	36.1	GO:0042613	MHC class II protein complex(GO:0042613)
1.6	6.3	GO:0032144	4-aminobutyrate transaminase complex(GO:0032144)
1.5	10.2	GO:0032584	growth cone membrane(GO:0032584)
1.3	3.9	GO:0071749	IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
1.2	3.7	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
1.2	8.3	GO:0036021	endolysosome lumen(GO:0036021)
1.1	22.6	GO:0001891	phagocytic cup(GO:0001891)
1.0	5.1	GO:0005602	complement component C1 complex(GO:0005602)
1.0	4.9	GO:0044530	supraspliceosomal complex(GO:0044530)
0.9	15.1	GO:0097512	cardiac myofibril(GO:0097512)
0.9	14.5	GO:0097418	neurofibrillary tangle(GO:0097418)
0.9	10.7	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.9	6.0	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.8	3.3	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.8	4.8	GO:0033063	DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.7	23.6	GO:0035371	microtubule plus-end(GO:0035371)
0.7	3.6	GO:0089701	U2AF(GO:0089701)
0.7	9.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.7	9.3	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.7	5.5	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.7	4.6	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.6	9.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.6	19.0	GO:0042101	T cell receptor complex(GO:0042101)
0.6	10.0	GO:0045277	respiratory chain complex IV(GO:0045277)
0.6	8.1	GO:0005833	hemoglobin complex(GO:0005833)
0.6	2.3	GO:0097449	astrocyte projection(GO:0097449)
0.6	6.9	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.6	1.7	GO:0002945	cyclin K-CDK13 complex(GO:0002945)
0.6	9.6	GO:0033270	paranode region of axon(GO:0033270)
0.6	7.9	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6	3.9	GO:1990635	proximal dendrite(GO:1990635)
0.5	1.6	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.5	8.3	GO:0043020	NADPH oxidase complex(GO:0043020)
0.5	2.4	GO:0071546	pi-body(GO:0071546)
0.4	3.9	GO:0005721	pericentric heterochromatin(GO:0005721)
0.4	2.5	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.4	3.7	GO:0016013	syntrophin complex(GO:0016013)
0.4	19.5	GO:0001772	immunological synapse(GO:0001772)
0.4	2.8	GO:0014802	terminal cisterna(GO:0014802)
0.4	6.0	GO:0005641	nuclear envelope lumen(GO:0005641)
0.4	6.3	GO:0043194	axon initial segment(GO:0043194)
0.4	3.1	GO:0045180	basal cortex(GO:0045180)
0.4	2.3	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.4	1.9	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.3	10.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.3	1.4	GO:1990246	uniplex complex(GO:1990246)
0.3	13.6	GO:0005720	nuclear heterochromatin(GO:0005720)
0.3	0.6	GO:0043159	acrosomal matrix(GO:0043159)
0.3	13.6	GO:0048786	presynaptic active zone(GO:0048786)
0.3	0.8	GO:0005879	axonemal microtubule(GO:0005879)
0.3	4.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3	1.1	GO:0072536	interleukin-23 receptor complex(GO:0072536)
0.3	12.4	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.3	3.6	GO:0001673	male germ cell nucleus(GO:0001673)
0.2	1.2	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.2	1.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.2	2.2	GO:0034399	nuclear periphery(GO:0034399)
0.2	5.0	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2	2.5	GO:0030008	TRAPP complex(GO:0030008)
0.2	9.7	GO:0043596	nuclear replication fork(GO:0043596)
0.2	3.9	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.2	2.1	GO:0071953	elastic fiber(GO:0071953)
0.2	0.6	GO:0097342	ripoptosome(GO:0097342)
0.2	1.2	GO:1990357	terminal web(GO:1990357)
0.2	4.9	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.2	3.9	GO:0044295	axonal growth cone(GO:0044295)
0.2	1.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2	2.3	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2	1.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.2	37.8	GO:0043209	myelin sheath(GO:0043209)
0.2	10.3	GO:0031201	SNARE complex(GO:0031201)
0.2	2.4	GO:0031045	dense core granule(GO:0031045)
0.2	0.9	GO:0034448	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2	1.5	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	1.3	GO:0000125	PCAF complex(GO:0000125)
0.1	50.8	GO:0045121	membrane raft(GO:0045121)
0.1	2.9	GO:0034451	centriolar satellite(GO:0034451)
0.1	7.1	GO:0001533	cornified envelope(GO:0001533)
0.1	1.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	14.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	0.7	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1	0.5	GO:0002177	manchette(GO:0002177)
0.1	6.9	GO:0042734	presynaptic membrane(GO:0042734)
0.1	0.4	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1	1.0	GO:0005579	membrane attack complex(GO:0005579)
0.1	4.9	GO:0016235	aggresome(GO:0016235)
0.1	4.1	GO:0001669	acrosomal vesicle(GO:0001669)
0.1	2.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	0.4	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1	5.7	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	1.7	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	1.0	GO:0030914	STAGA complex(GO:0030914)
0.1	0.4	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.1	0.3	GO:0060077	inhibitory synapse(GO:0060077)
0.1	0.6	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	0.5	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	23.4	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	5.3	GO:0043235	receptor complex(GO:0043235)
0.1	3.1	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	1.9	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	2.9	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	0.8	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	3.7	GO:0031904	endosome lumen(GO:0031904)
0.1	9.2	GO:0016363	nuclear matrix(GO:0016363)
0.1	1.3	GO:0071437	invadopodium(GO:0071437)
0.1	3.5	GO:0005801	cis-Golgi network(GO:0005801)
0.1	1.8	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	1.8	GO:0005682	U5 snRNP(GO:0005682)
0.1	0.3	GO:0070826	paraferritin complex(GO:0070826)
0.1	0.4	GO:0097452	GAIT complex(GO:0097452)
0.1	0.8	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	10.4	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.1	4.6	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.1	23.6	GO:0005635	nuclear envelope(GO:0005635)
0.1	1.5	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1	2.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	3.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	2.2	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	0.2	GO:0060198	clathrin-sculpted vesicle(GO:0060198) clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	5.6	GO:0072562	blood microparticle(GO:0072562)
0.0	0.3	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	6.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	3.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	0.1	GO:0031213	RSF complex(GO:0031213)
0.0	4.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.6	GO:0034707	chloride channel complex(GO:0034707)
0.0	0.6	GO:0097225	sperm midpiece(GO:0097225)
0.0	1.6	GO:0043195	terminal bouton(GO:0043195)
0.0	0.5	GO:0014704	intercalated disc(GO:0014704)
0.0	1.8	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.7	GO:0071564	SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.0	0.1	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0	0.6	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.3	GO:0032420	stereocilium(GO:0032420)
0.0	0.2	GO:0090544	BAF-type complex(GO:0090544)
0.0	0.0	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.8	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	46.3	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.0	0.3	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	2.2	GO:0005814	centriole(GO:0005814)
0.0	0.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.4	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.2	GO:0070069	cytochrome complex(GO:0070069)
0.0	0.2	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	21.6	GO:0005615	extracellular space(GO:0005615)
0.0	0.2	GO:0031526	brush border membrane(GO:0031526)
0.0	3.7	GO:0009986	cell surface(GO:0009986)
0.0	0.1	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.9	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	1.0	GO:0055037	recycling endosome(GO:0055037)
0.0	0.6	GO:1990391	DNA repair complex(GO:1990391)
0.0	0.5	GO:0043204	perikaryon(GO:0043204)
0.0	0.9	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.5	GO:0031225	anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.4	10.1	GO:0016495	C-X3-C chemokine receptor activity(GO:0016495)
2.8	11.3	GO:0019770	IgG receptor activity(GO:0019770)
2.4	7.3	GO:0047696	beta-adrenergic receptor kinase activity(GO:0047696)
2.2	13.4	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.1	6.4	GO:0004797	deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
2.0	5.9	GO:0005174	CD40 receptor binding(GO:0005174)
1.9	5.7	GO:0016434	rRNA (cytosine) methyltransferase activity(GO:0016434)
1.8	100.7	GO:0017080	sodium channel regulator activity(GO:0017080)
1.7	6.9	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
1.6	8.2	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
1.6	6.3	GO:0003867	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
1.5	7.6	GO:0004995	tachykinin receptor activity(GO:0004995)
1.4	6.9	GO:1990430	extracellular matrix protein binding(GO:1990430)
1.3	5.3	GO:0000822	inositol hexakisphosphate binding(GO:0000822)
1.2	3.7	GO:0004464	leukotriene-C4 synthase activity(GO:0004464)
1.2	38.5	GO:0023026	MHC class II protein complex binding(GO:0023026)
1.2	3.7	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.2	6.2	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
1.2	3.7	GO:0005148	prolactin receptor binding(GO:0005148)
1.2	3.7	GO:0032767	copper-dependent protein binding(GO:0032767)
1.2	6.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.2	8.2	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
1.2	9.3	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.2	4.6	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
1.1	3.3	GO:0019981	interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
1.1	3.2	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
1.1	8.6	GO:0004064	arylesterase activity(GO:0004064)
1.0	10.1	GO:0036310	annealing helicase activity(GO:0036310)
1.0	9.8	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.9	16.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.9	8.5	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.8	5.7	GO:0030021	extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.8	2.4	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.8	11.1	GO:0050700	CARD domain binding(GO:0050700)
0.7	2.2	GO:0015234	thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.7	7.4	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.7	2.2	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.7	14.5	GO:0051787	misfolded protein binding(GO:0051787)
0.7	3.6	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.7	2.1	GO:0005549	odorant binding(GO:0005549)
0.7	2.1	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.7	3.4	GO:0090554	phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.7	2.0	GO:0005137	interleukin-5 receptor binding(GO:0005137)
0.6	18.0	GO:0019865	immunoglobulin binding(GO:0019865)
0.6	14.0	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.6	7.6	GO:0032027	myosin light chain binding(GO:0032027)
0.6	8.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.6	1.9	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.6	9.6	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.6	2.4	GO:0015265	glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.6	2.3	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.6	4.6	GO:0034711	inhibin binding(GO:0034711)
0.6	5.8	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6	7.4	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5	110.6	GO:0003823	antigen binding(GO:0003823)
0.5	3.6	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
0.5	8.3	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.5	3.9	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5	14.5	GO:0005212	structural constituent of eye lens(GO:0005212)
0.4	2.2	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.4	3.5	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4	14.5	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.4	6.8	GO:0097109	neuroligin family protein binding(GO:0097109)
0.4	1.3	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.4	8.3	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.4	19.4	GO:0070888	E-box binding(GO:0070888)
0.4	2.9	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4	8.0	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.4	1.2	GO:0032093	SAM domain binding(GO:0032093)
0.4	1.6	GO:0052798	beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.4	2.3	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.4	3.8	GO:0019957	C-C chemokine binding(GO:0019957)
0.4	12.3	GO:0071889	14-3-3 protein binding(GO:0071889)
0.4	2.3	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.4	2.2	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.4	8.4	GO:0001968	fibronectin binding(GO:0001968)
0.4	2.2	GO:0039552	RIG-I binding(GO:0039552)
0.4	1.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.4	1.1	GO:0030107	HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.3	6.6	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.3	1.0	GO:0016435	rRNA (guanine) methyltransferase activity(GO:0016435)
0.3	1.3	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.3	6.7	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.3	9.3	GO:0005521	lamin binding(GO:0005521)
0.3	1.7	GO:0002046	opsin binding(GO:0002046)
0.3	0.3	GO:0008094	DNA helicase activity(GO:0003678) DNA-dependent ATPase activity(GO:0008094)
0.3	5.9	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3	1.6	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.3	10.6	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.3	3.1	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
0.3	3.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3	2.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.3	1.8	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.3	1.2	GO:0031685	adenosine receptor binding(GO:0031685)
0.3	1.5	GO:0060175	brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.3	2.0	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3	1.4	GO:0043422	protein kinase B binding(GO:0043422)
0.3	5.1	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.3	1.4	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.3	20.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3	1.9	GO:0001515	opioid peptide activity(GO:0001515)
0.3	1.1	GO:0042020	interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.3	6.3	GO:0002162	dystroglycan binding(GO:0002162)
0.3	1.3	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3	1.6	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3	7.4	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3	6.6	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3	0.8	GO:0098640	integrin binding involved in cell-matrix adhesion(GO:0098640)
0.2	5.4	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.2	0.7	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.2	0.7	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2	87.8	GO:0030695	GTPase regulator activity(GO:0030695)
0.2	11.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.2	10.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.2	3.4	GO:0005522	profilin binding(GO:0005522)
0.2	1.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.2	0.4	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.2	2.3	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.2	7.0	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.2	1.4	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.2	2.7	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2	0.6	GO:0070697	activin receptor binding(GO:0070697)
0.2	0.8	GO:0004803	transposase activity(GO:0004803)
0.2	1.9	GO:0001851	complement component C3b binding(GO:0001851)
0.2	0.8	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.2	1.9	GO:0032794	GTPase activating protein binding(GO:0032794)
0.2	2.6	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2	1.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.2	43.5	GO:0051015	actin filament binding(GO:0051015)
0.2	0.7	GO:0032810	sterol response element binding(GO:0032810)
0.2	1.8	GO:0031701	angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.2	1.9	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2	4.1	GO:0043014	alpha-tubulin binding(GO:0043014)
0.2	3.5	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.2	1.0	GO:0003910	DNA ligase (ATP) activity(GO:0003910)
0.2	0.7	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.2	0.8	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.2	4.6	GO:0042287	MHC protein binding(GO:0042287)
0.2	0.8	GO:0004359	glutaminase activity(GO:0004359)
0.2	0.6	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.2	3.2	GO:0050321	tau-protein kinase activity(GO:0050321)
0.2	2.0	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
0.2	3.5	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	0.7	GO:0008420	CTD phosphatase activity(GO:0008420)
0.1	1.0	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.1	1.4	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.1	0.4	GO:0032184	SUMO polymer binding(GO:0032184)
0.1	1.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	1.5	GO:0070569	uridylyltransferase activity(GO:0070569)
0.1	2.7	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.1	2.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	0.5	GO:0008422	beta-glucosidase activity(GO:0008422)
0.1	1.9	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	1.4	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1	0.6	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1	0.6	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.1	2.1	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993)
0.1	4.4	GO:0030507	spectrin binding(GO:0030507)
0.1	2.7	GO:0001056	RNA polymerase III activity(GO:0001056)
0.1	1.4	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	12.6	GO:0003774	motor activity(GO:0003774)
0.1	3.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1	2.4	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.1	0.8	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1	1.6	GO:0016018	cyclosporin A binding(GO:0016018)
0.1	1.2	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	0.8	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.1	0.5	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	3.3	GO:0015248	sterol transporter activity(GO:0015248)
0.1	0.5	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.1	1.2	GO:0042056	chemoattractant activity(GO:0042056)
0.1	1.3	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	0.9	GO:0000150	recombinase activity(GO:0000150)
0.1	0.5	GO:0016300	tRNA (uracil) methyltransferase activity(GO:0016300)
0.1	1.0	GO:0017049	GTP-Rho binding(GO:0017049)
0.1	0.6	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	2.3	GO:0071949	FAD binding(GO:0071949)
0.1	0.8	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.1	1.4	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	0.4	GO:0051373	FATZ binding(GO:0051373)
0.1	2.3	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1	1.9	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	0.4	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.1	0.3	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.1	2.9	GO:0005109	frizzled binding(GO:0005109)
0.1	1.8	GO:0042609	CD4 receptor binding(GO:0042609)
0.1	6.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.1	13.9	GO:0008017	microtubule binding(GO:0008017)
0.1	0.5	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1	3.6	GO:0004364	glutathione transferase activity(GO:0004364)
0.1	20.6	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1	0.7	GO:0015250	water transmembrane transporter activity(GO:0005372) water channel activity(GO:0015250)
0.1	1.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	1.7	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1	2.4	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.1	0.5	GO:0032393	MHC class I receptor activity(GO:0032393)
0.1	7.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	2.2	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.1	0.9	GO:0019841	retinol binding(GO:0019841)
0.1	0.9	GO:0008201	heparin binding(GO:0008201)
0.1	1.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	2.2	GO:0030246	carbohydrate binding(GO:0030246)
0.1	11.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	0.2	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.1	0.3	GO:0015087	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1	2.5	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	2.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	0.7	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.1	1.8	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	1.4	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	0.5	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1	3.3	GO:0015459	potassium channel regulator activity(GO:0015459)
0.1	0.8	GO:0005243	gap junction channel activity(GO:0005243)
0.1	2.7	GO:0005178	integrin binding(GO:0005178)
0.1	0.9	GO:0043522	leucine zipper domain binding(GO:0043522)
0.1	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.1	0.8	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	0.3	GO:0045029	UDP-activated nucleotide receptor activity(GO:0045029)
0.1	0.5	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.1	1.2	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups(GO:0016747)
0.1	0.2	GO:0016499	orexin receptor activity(GO:0016499)
0.0	0.9	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.2	GO:0005477	pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0	2.3	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	1.5	GO:0005504	fatty acid binding(GO:0005504)
0.0	1.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	1.3	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	1.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.7	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	1.8	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.6	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	0.6	GO:0071837	HMG box domain binding(GO:0071837)
0.0	1.5	GO:0019902	phosphatase binding(GO:0019902)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	3.8	GO:0017124	SH3 domain binding(GO:0017124)
0.0	1.0	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	2.0	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	0.1	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	3.8	GO:0005262	calcium channel activity(GO:0005262)
0.0	0.3	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.2	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.5	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.8	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	2.6	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	0.5	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	1.3	GO:0003924	GTPase activity(GO:0003924)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	1.9	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.1	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.0	1.7	GO:0098531	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0	0.2	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	1.2	GO:0051117	ATPase binding(GO:0051117)
0.0	0.3	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	2.3	GO:0005516	calmodulin binding(GO:0005516)
0.0	0.2	GO:0008061	chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.0	0.4	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.2	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	9.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.5	12.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.4	19.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.3	13.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.3	10.8	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	3.3	ST STAT3 PATHWAY	STAT3 Pathway
0.3	22.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	7.1	PID ARF 3PATHWAY	Arf1 pathway
0.3	14.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	18.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.3	12.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	15.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	2.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	4.2	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.2	3.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	5.9	PID IL12 2PATHWAY	IL12-mediated signaling events
0.2	4.8	PID IL3 PATHWAY	IL3-mediated signaling events
0.2	6.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	4.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.2	2.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.2	3.9	PID IL23 PATHWAY	IL23-mediated signaling events
0.2	4.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	14.6	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	11.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	15.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	1.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	6.2	PID ENDOTHELIN PATHWAY	Endothelins
0.1	1.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	1.8	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	1.5	PID IFNG PATHWAY	IFN-gamma pathway
0.1	1.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	3.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	1.9	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	0.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	4.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	1.0	PID MYC PATHWAY	C-MYC pathway
0.1	1.5	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.1	25.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	2.1	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	15.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.7	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.7	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	3.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.1	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	2.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	1.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.0	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	4.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.6	PID BMP PATHWAY	BMP receptor signaling
0.0	0.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.2	PID ATR PATHWAY	ATR signaling pathway
0.0	0.2	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.4	PID SHP2 PATHWAY	SHP2 signaling
0.0	0.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.1	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.6	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	0.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	0.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	14.9	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.8	8.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.7	14.9	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.6	6.9	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.6	11.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.6	8.6	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.6	2.8	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.6	10.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5	13.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.5	23.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.5	1.9	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.4	77.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	7.7	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.4	19.2	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	5.8	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.4	6.5	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.3	20.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	9.6	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3	11.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.3	10.5	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.3	6.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.3	6.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	3.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.3	3.9	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3	34.8	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.3	8.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	4.8	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.2	5.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2	2.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.2	3.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.2	4.8	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.2	6.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.2	6.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	1.2	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.2	6.5	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.2	3.5	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.2	8.0	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2	6.4	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.2	2.8	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	23.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.2	0.8	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.2	9.9	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.1	1.9	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	8.9	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	3.9	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.1	2.3	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	9.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	2.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	4.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.5	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	11.5	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	2.7	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.1	1.3	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	0.4	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.1	5.0	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	0.5	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	2.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	2.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.2	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	0.7	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.9	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	2.0	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	1.8	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	5.5	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	1.9	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.1	0.6	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.1	2.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	1.8	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	6.6	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.1	0.7	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1	8.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	5.5	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	1.2	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.0	3.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.8	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	1.3	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	2.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	0.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.7	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	1.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.5	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.4	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	1.3	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.0	1.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.5	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.7	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.5	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.7	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.5	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	1.0	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases

Results for MIXL1_GSX1_BSX_MEOX2_LHX4

Z-value: 0.93

Motif logo

Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4

Activity-expression correlation:

Activity profile of MIXL1_GSX1_BSX_MEOX2_LHX4 motif

Sorted Z-values of MIXL1_GSX1_BSX_MEOX2_LHX4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: