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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MIXL1_GSX1_BSX_MEOX2_LHX4
Z-value: 0.93
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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000185155.7 | Mix paired-like homeobox | |
| ENSG00000169840.4 | GS homeobox 1 | |
| ENSG00000188909.4 | brain specific homeobox | |
| ENSG00000106511.5 | mesenchyme homeobox 2 | |
| ENSG00000121454.4 | LIM homeobox 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MIXL1 | hg19_v2_chr1_+_226411319_226411366 | 0.16 | 1.7e-02 | Click! |
| MEOX2 | hg19_v2_chr7_-_15726296_15726437 | 0.05 | 4.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_13835147 Show fit | 34.84 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr11_-_117748138 Show fit | 34.05 |
ENST00000527717.1
|
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117747607 Show fit | 32.29 |
ENST00000540359.1
ENST00000539526.1 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117747434 Show fit | 31.51 |
ENST00000529335.2
ENST00000530956.1 ENST00000260282.4 |
FXYD domain containing ion transport regulator 6 |
|
| chr2_+_90248739 Show fit | 22.24 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr2_+_68962014 Show fit | 17.73 |
ENST00000467265.1
|
Rho GTPase activating protein 25 |
|
| chr16_-_4852915 Show fit | 16.49 |
ENST00000322048.7
|
rogdi homolog (Drosophila) |
|
| chr5_+_66300446 Show fit | 16.06 |
ENST00000261569.7
|
microtubule associated serine/threonine kinase family member 4 |
|
| chr18_+_32556892 Show fit | 15.56 |
ENST00000591734.1
ENST00000413393.1 ENST00000589180.1 ENST00000587359.1 |
microtubule-associated protein, RP/EB family, member 2 |
|
| chr3_-_18480260 Show fit | 15.50 |
ENST00000454909.2
|
SATB homeobox 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 98.1 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.2 | 72.5 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.4 | 59.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 4.3 | 42.7 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 9.2 | 27.7 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.2 | 27.5 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.9 | 22.9 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 1.4 | 22.8 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 21.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.8 | 20.7 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 50.8 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 46.3 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 37.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.7 | 36.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.7 | 23.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 23.6 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.1 | 23.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 1.1 | 22.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 21.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 19.5 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 110.6 | GO:0003823 | antigen binding(GO:0003823) |
| 1.8 | 100.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 87.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.2 | 43.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.2 | 38.5 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 20.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.3 | 20.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.4 | 19.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.6 | 18.0 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.9 | 16.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 22.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 19.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.3 | 18.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 15.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 15.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 15.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 14.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 14.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 13.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 77.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 34.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.5 | 23.5 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.2 | 23.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 20.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 19.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.9 | 14.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.7 | 14.9 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.5 | 13.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.6 | 11.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |