Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for MLXIPL
Z-value: 0.45
Motif logo
Transcription factors associated with MLXIPL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLXIPL | hg19_v2_chr7_-_73038867_73038878, hg19_v2_chr7_-_73038822_73038862 | 0.45 | 2.1e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLXIPL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 107.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.7 | 61.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 42.9 | GO:0006968 | cellular defense response(GO:0006968) |
| 2.9 | 42.8 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.9 | 37.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.5 | 33.6 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 1.8 | 30.4 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 2.9 | 28.7 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 1.6 | 26.5 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 2.9 | 26.3 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 98.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 49.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 10.7 | 42.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.4 | 28.9 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.4 | 28.5 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 9.1 | 27.3 | GO:0071748 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 0.2 | 27.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.2 | 25.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.8 | 22.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 4.2 | 21.1 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 210.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 2.4 | 131.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 3.3 | 42.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.3 | 42.2 | GO:0003823 | antigen binding(GO:0003823) |
| 2.1 | 38.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.7 | 36.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.4 | 34.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 30.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 9.5 | 28.6 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.2 | 26.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 60.8 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.0 | 54.8 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.4 | 37.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 36.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 32.2 | PID ATM PATHWAY | ATM pathway |
| 0.7 | 28.3 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.8 | 23.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.4 | 19.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.5 | 17.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 17.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 161.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.9 | 78.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.1 | 48.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.5 | 32.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.2 | 24.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.0 | 24.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.5 | 22.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 21.5 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 1.0 | 20.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.4 | 20.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |