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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MSX1

Z-value: 1.22

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Transcription factors associated with MSX1

Gene Symbol Gene ID Gene Info
MSX1
ENSG00000163132.6 msh homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX1hg19_v2_chr4_+_4861385_4861398-0.082.6e-01Click!

Activity profile of MSX1 motif

Sorted Z-values of MSX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_196313239 32.31 ENST00000413290.1
AC064834.1
AC064834.1
chr13_-_88323218 26.68 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr5_+_150404904 17.51 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chrX_+_1710484 14.78 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr6_-_32095968 14.50 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr2_-_136288113 13.48 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chrX_+_73164149 11.94 ENST00000602938.1
ENST00000602294.1
ENST00000602920.1
ENST00000602737.1
ENST00000602772.1
JPX
JPX transcript, XIST activator (non-protein coding)
chr6_-_32557610 11.88 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr18_-_5396271 10.68 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr6_-_84419101 10.60 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
SNAP91
synaptosomal-associated protein, 91kDa
chr13_-_38172863 10.56 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr22_+_51176624 10.54 ENST00000216139.5
ENST00000529621.1
ACR
acrosin
chr19_-_53757941 10.44 ENST00000594517.1
ENST00000601413.1
ENST00000594681.1
ZNF677
zinc finger protein 677
chr1_-_160492994 10.42 ENST00000368055.1
ENST00000368057.3
ENST00000368059.3
SLAMF6
SLAM family member 6
chr3_-_123339418 10.25 ENST00000583087.1
MYLK
myosin light chain kinase
chr5_-_11588907 10.18 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr11_-_85376121 10.04 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr3_-_123339343 9.84 ENST00000578202.1
MYLK
myosin light chain kinase
chr11_+_92085262 9.83 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr4_-_57547454 9.63 ENST00000556376.2
HOPX
HOP homeobox
chr6_-_52705641 9.34 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr19_-_53758094 9.11 ENST00000601828.1
ENST00000598513.1
ENST00000599012.1
ENST00000333952.4
ENST00000598806.1
ZNF677
zinc finger protein 677
chr5_+_121647386 8.58 ENST00000542191.1
ENST00000506272.1
ENST00000508681.1
ENST00000509154.2
SNCAIP
synuclein, alpha interacting protein
chr13_-_52733980 8.43 ENST00000339406.3
NEK3
NIMA-related kinase 3
chr6_-_32908765 8.12 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr3_-_21792838 7.86 ENST00000281523.2
ZNF385D
zinc finger protein 385D
chr7_-_36634181 7.76 ENST00000538464.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr11_-_128894053 7.56 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr5_+_67586465 7.51 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_+_22964877 7.40 ENST00000390494.1
TRAJ43
T cell receptor alpha joining 43
chr16_-_66584059 7.27 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr10_-_101380121 7.14 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr14_-_75389975 6.93 ENST00000555647.1
ENST00000557413.1
RPS6KL1
ribosomal protein S6 kinase-like 1
chr1_+_158985457 6.93 ENST00000567661.1
ENST00000474473.1
IFI16
interferon, gamma-inducible protein 16
chr12_+_9980069 6.83 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr3_-_123512688 6.79 ENST00000475616.1
MYLK
myosin light chain kinase
chr13_+_49551020 6.30 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr5_-_75919253 6.00 ENST00000296641.4
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr15_-_77712477 5.99 ENST00000560626.2
PEAK1
pseudopodium-enriched atypical kinase 1
chr5_-_177207634 5.90 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr6_+_6588316 5.89 ENST00000379953.2
LY86
lymphocyte antigen 86
chr6_+_134758827 5.88 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr6_+_131894284 5.83 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr2_-_88927092 5.65 ENST00000303236.3
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr14_-_75389925 5.41 ENST00000556776.1
RPS6KL1
ribosomal protein S6 kinase-like 1
chr11_+_12132117 5.34 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr3_+_108308513 5.27 ENST00000361582.3
DZIP3
DAZ interacting zinc finger protein 3
chr22_-_32766972 5.17 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr2_-_158345462 5.13 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr11_+_101785727 4.98 ENST00000263468.8
KIAA1377
KIAA1377
chr3_-_93781750 4.94 ENST00000314636.2
DHFRL1
dihydrofolate reductase-like 1
chr5_+_175490540 4.94 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr3_+_171561127 4.90 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr14_+_22293618 4.82 ENST00000390432.2
TRAV10
T cell receptor alpha variable 10
chr1_+_158815588 4.77 ENST00000438394.1
MNDA
myeloid cell nuclear differentiation antigen
chr6_+_26020672 4.57 ENST00000357647.3
HIST1H3A
histone cluster 1, H3a
chr8_+_28748765 4.45 ENST00000355231.5
HMBOX1
homeobox containing 1
chr22_-_32767017 4.39 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr16_-_66583701 4.38 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr18_+_61637159 4.36 ENST00000397985.2
ENST00000353706.2
ENST00000542677.1
ENST00000397988.3
ENST00000448851.1
SERPINB8
serpin peptidase inhibitor, clade B (ovalbumin), member 8
chr14_+_50291993 4.22 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr2_+_32502952 4.08 ENST00000238831.4
YIPF4
Yip1 domain family, member 4
chr2_-_209028300 4.05 ENST00000304502.4
CRYGA
crystallin, gamma A
chr4_-_120243545 4.02 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr10_+_13142225 3.89 ENST00000378747.3
OPTN
optineurin
chr12_+_56324756 3.80 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr5_-_75919217 3.78 ENST00000504899.1
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr14_+_55595762 3.50 ENST00000254301.9
LGALS3
lectin, galactoside-binding, soluble, 3
chr1_+_111415757 3.37 ENST00000429072.2
ENST00000271324.5
CD53
CD53 molecule
chr19_-_7812397 3.35 ENST00000593660.1
ENST00000354397.6
ENST00000593821.1
ENST00000602261.1
ENST00000315591.8
ENST00000394161.5
ENST00000204801.8
ENST00000601256.1
ENST00000601951.1
ENST00000315599.7
CD209
CD209 molecule
chr10_-_29923893 3.32 ENST00000355867.4
SVIL
supervillin
chr11_-_66964638 3.25 ENST00000444002.2
AP001885.1
AP001885.1
chr3_-_190040223 3.22 ENST00000295522.3
CLDN1
claudin 1
chr4_+_5527117 3.21 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr9_+_115913222 3.17 ENST00000259392.3
SLC31A2
solute carrier family 31 (copper transporter), member 2
chrX_+_11311533 3.12 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr12_+_122688090 3.08 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr5_-_137475071 3.08 ENST00000265191.2
NME5
NME/NM23 family member 5
chr14_-_101295407 3.06 ENST00000596284.1
AL117190.2
AL117190.2
chr15_-_42500351 2.99 ENST00000348544.4
ENST00000318006.5
VPS39
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr2_-_109605663 2.96 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr3_+_93781728 2.93 ENST00000314622.4
NSUN3
NOP2/Sun domain family, member 3
chr10_+_17270214 2.90 ENST00000544301.1
VIM
vimentin
chr5_+_82767487 2.89 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr5_+_140762268 2.89 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr19_-_7812446 2.87 ENST00000394173.4
ENST00000301357.8
CD209
CD209 molecule
chr5_+_140220769 2.86 ENST00000531613.1
ENST00000378123.3
PCDHA8
protocadherin alpha 8
chr19_-_53662257 2.85 ENST00000599096.1
ENST00000334197.7
ENST00000597183.1
ENST00000601804.1
ENST00000601469.2
ENST00000452676.2
ZNF347
zinc finger protein 347
chr7_+_2636522 2.81 ENST00000423196.1
IQCE
IQ motif containing E
chr21_+_43619796 2.79 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr10_+_135050908 2.78 ENST00000325980.9
VENTX
VENT homeobox
chr7_-_32338917 2.76 ENST00000396193.1
PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
chr6_+_118869452 2.71 ENST00000357525.5
PLN
phospholamban
chr5_+_82767583 2.62 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr8_+_1993152 2.54 ENST00000262113.4
MYOM2
myomesin 2
chr8_-_121824374 2.53 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr11_+_62037622 2.47 ENST00000227918.2
ENST00000525380.1
SCGB2A2
secretoglobin, family 2A, member 2
chr2_+_168675182 2.45 ENST00000305861.1
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr9_+_79074068 2.42 ENST00000444201.2
ENST00000376730.4
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr19_+_55043977 2.36 ENST00000335056.3
KIR3DX1
killer cell immunoglobulin-like receptor, three domains, X1
chr4_+_5526883 2.34 ENST00000195455.2
C4orf6
chromosome 4 open reading frame 6
chr1_+_160160283 2.31 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr18_+_29598335 2.23 ENST00000217740.3
RNF125
ring finger protein 125, E3 ubiquitin protein ligase
chr13_-_47471155 2.18 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr14_+_68086515 2.06 ENST00000261783.3
ARG2
arginase 2
chr1_-_167487808 2.05 ENST00000392122.3
CD247
CD247 molecule
chr1_-_167487758 1.99 ENST00000362089.5
CD247
CD247 molecule
chr12_+_56324933 1.95 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr7_+_99425633 1.88 ENST00000354829.2
ENST00000421837.2
ENST00000417625.1
ENST00000342499.4
ENST00000444905.1
ENST00000415413.1
ENST00000312017.5
ENST00000222382.5
CYP3A43
cytochrome P450, family 3, subfamily A, polypeptide 43
chr8_-_72274095 1.84 ENST00000303824.7
EYA1
eyes absent homolog 1 (Drosophila)
chr4_-_100140331 1.81 ENST00000407820.2
ENST00000394897.1
ENST00000508558.1
ENST00000394899.2
ADH6
alcohol dehydrogenase 6 (class V)
chr12_+_106751436 1.72 ENST00000228347.4
POLR3B
polymerase (RNA) III (DNA directed) polypeptide B
chr6_+_136172820 1.69 ENST00000308191.6
PDE7B
phosphodiesterase 7B
chrY_-_2655644 1.69 ENST00000525526.2
ENST00000534739.2
ENST00000383070.1
SRY
sex determining region Y
chr9_+_90112117 1.57 ENST00000358077.5
DAPK1
death-associated protein kinase 1
chr8_+_1993173 1.54 ENST00000523438.1
MYOM2
myomesin 2
chr1_+_160160346 1.51 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr19_-_20150014 1.37 ENST00000358523.5
ENST00000397162.1
ENST00000601100.1
ZNF682
zinc finger protein 682
chr6_-_32784687 1.35 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr10_+_32873190 1.30 ENST00000375025.4
C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr2_-_219031709 1.28 ENST00000295683.2
CXCR1
chemokine (C-X-C motif) receptor 1
chr8_-_17555164 1.25 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr2_-_77749474 1.24 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr10_+_13141585 1.20 ENST00000378764.2
OPTN
optineurin
chr9_+_133539981 1.16 ENST00000253008.2
PRDM12
PR domain containing 12
chr13_+_50570019 1.14 ENST00000442421.1
TRIM13
tripartite motif containing 13
chr11_-_102401469 1.06 ENST00000260227.4
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr7_-_20256965 1.03 ENST00000400331.5
ENST00000332878.4
MACC1
metastasis associated in colon cancer 1
chr6_+_29141311 1.00 ENST00000377167.2
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr5_+_82767284 0.96 ENST00000265077.3
VCAN
versican
chr14_+_55595960 0.92 ENST00000554715.1
LGALS3
lectin, galactoside-binding, soluble, 3
chr6_+_28092338 0.91 ENST00000340487.4
ZSCAN16
zinc finger and SCAN domain containing 16
chr6_-_109777128 0.91 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr2_-_31361543 0.84 ENST00000349752.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr22_+_41697520 0.69 ENST00000352645.4
ZC3H7B
zinc finger CCCH-type containing 7B
chr11_-_102496063 0.65 ENST00000260228.2
MMP20
matrix metallopeptidase 20
chr12_+_9980113 0.54 ENST00000537723.1
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr9_-_15510287 0.53 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chr18_-_3874271 0.44 ENST00000400149.3
ENST00000400155.1
ENST00000400150.3
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr4_-_186696425 0.29 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr1_-_149908217 0.21 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr8_-_25281747 0.15 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr20_+_56964169 0.11 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr8_+_24241969 0.08 ENST00000522298.1
ADAMDEC1
ADAM-like, decysin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
4.0 20.0 GO:0002399 MHC class II protein complex assembly(GO:0002399)
3.5 10.6 GO:1990523 bone regeneration(GO:1990523)
3.4 26.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.9 11.6 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
2.7 13.5 GO:0048478 replication fork protection(GO:0048478)
2.4 7.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
2.1 6.2 GO:0019417 sulfur oxidation(GO:0019417)
1.9 5.7 GO:1990737 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
1.5 10.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
1.5 10.5 GO:0007341 penetration of zona pellucida(GO:0007341)
1.5 4.4 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
1.2 6.2 GO:0046968 peptide antigen transport(GO:0046968)
1.2 14.5 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
1.2 5.8 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
1.1 3.2 GO:1903348 cellular response to lead ion(GO:0071284) positive regulation of bicellular tight junction assembly(GO:1903348)
1.1 8.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
1.0 3.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.0 2.9 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.9 2.8 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.9 2.7 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.7 5.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.6 5.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.6 10.4 GO:0001787 natural killer cell proliferation(GO:0001787)
0.6 3.0 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.5 3.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.5 4.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.5 4.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 1.3 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.4 9.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.4 7.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.4 2.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.4 1.3 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.4 9.6 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.4 3.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.4 10.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.4 3.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.3 2.4 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 1.2 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.3 6.3 GO:0060009 Sertoli cell development(GO:0060009)
0.3 4.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.3 3.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.3 2.9 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.3 8.6 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.3 6.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 3.1 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.3 5.8 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 2.1 GO:0000050 urea cycle(GO:0000050)
0.2 1.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 2.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.2 4.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.2 2.4 GO:0060352 cell adhesion molecule production(GO:0060352)
0.2 3.4 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.2 4.8 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.2 1.8 GO:0006069 ethanol oxidation(GO:0006069)
0.2 2.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 1.7 GO:2000020 positive regulation of male gonad development(GO:2000020)
0.1 10.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 4.0 GO:0070207 protein homotrimerization(GO:0070207)
0.1 6.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.7 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.1 9.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 4.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 15.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 6.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 1.1 GO:0044849 estrous cycle(GO:0044849)
0.0 6.0 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 1.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 10.9 GO:0042113 B cell activation(GO:0042113)
0.0 1.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 10.0 GO:0009615 response to virus(GO:0009615)
0.0 3.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 4.1 GO:0007601 visual perception(GO:0007601)
0.0 0.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0043159 acrosomal matrix(GO:0043159)
1.9 7.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
1.1 5.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
1.0 21.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 10.7 GO:0033270 paranode region of axon(GO:0033270)
0.5 3.8 GO:0014802 terminal cisterna(GO:0014802)
0.5 3.3 GO:0036449 microtubule minus-end(GO:0036449)
0.4 4.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.4 26.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 4.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 2.2 GO:0070852 cell body fiber(GO:0070852)
0.3 13.5 GO:0043596 nuclear replication fork(GO:0043596)
0.3 3.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 4.1 GO:0032982 myosin filament(GO:0032982)
0.2 2.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 20.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 7.8 GO:0001772 immunological synapse(GO:0001772)
0.1 10.6 GO:0031594 neuromuscular junction(GO:0031594)
0.1 4.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 2.7 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 10.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 5.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.5 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 8.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 8.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 6.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 10.3 GO:0043204 perikaryon(GO:0043204)
0.1 2.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 6.2 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.1 6.0 GO:0055037 recycling endosome(GO:0055037)
0.1 7.6 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1 6.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 3.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 12.1 GO:0005840 ribosome(GO:0005840)
0.0 3.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 13.0 GO:0045177 apical part of cell(GO:0045177)
0.0 8.4 GO:0030424 axon(GO:0030424)
0.0 12.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.4 GO:0031985 Golgi cisterna(GO:0031985)
0.0 7.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.1 GO:0005938 cell cortex(GO:0005938)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.9 GO:0043195 terminal bouton(GO:0043195)
0.0 7.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 23.4 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 26.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
3.9 11.6 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
3.5 10.5 GO:0004040 amidase activity(GO:0004040) fucose binding(GO:0042806)
2.6 7.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
1.9 5.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.6 9.8 GO:0015057 thrombin receptor activity(GO:0015057)
1.6 17.5 GO:0008430 selenium binding(GO:0008430)
1.3 13.5 GO:0036310 annealing helicase activity(GO:0036310)
1.0 3.1 GO:0046848 hydroxyapatite binding(GO:0046848)
1.0 3.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.9 7.5 GO:0043559 insulin binding(GO:0043559)
0.9 2.8 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.8 2.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8 2.4 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.7 14.5 GO:0035497 cAMP response element binding(GO:0035497)
0.7 21.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.7 2.7 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.6 3.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.6 2.9 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.6 7.4 GO:0032393 MHC class I receptor activity(GO:0032393)
0.6 6.2 GO:0046790 virion binding(GO:0046790)
0.6 7.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 4.4 GO:0019863 IgE binding(GO:0019863)
0.5 6.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.5 2.9 GO:1990254 keratin filament binding(GO:1990254)
0.5 10.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.4 7.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.4 4.5 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.4 1.3 GO:0019959 interleukin-8 binding(GO:0019959)
0.3 5.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 1.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 2.8 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.3 5.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 6.2 GO:0071949 FAD binding(GO:0071949)
0.2 6.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 9.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 2.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2 4.1 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.2 1.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 10.4 GO:0051018 protein kinase A binding(GO:0051018)
0.1 3.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 4.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.9 GO:0070330 aromatase activity(GO:0070330)
0.1 4.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 10.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 4.0 GO:0005504 fatty acid binding(GO:0005504)
0.1 6.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 11.6 GO:0008201 heparin binding(GO:0008201)
0.1 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 4.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.0 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 6.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 6.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.2 GO:0001618 virus receptor activity(GO:0001618)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 7.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.3 GO:0051015 actin filament binding(GO:0051015)
0.0 1.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 10.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.5 26.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 7.5 PID IL5 PATHWAY IL5-mediated signaling events
0.3 15.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 6.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.4 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 7.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 5.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 13.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 3.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 5.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 15.9 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4 26.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 11.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 7.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.3 9.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 6.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 1.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 9.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 2.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 4.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 5.7 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.1 6.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 5.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 9.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 0.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 5.9 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 5.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.7 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events