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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MSX1
Z-value: 1.22
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Transcription factors associated with MSX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MSX1 | hg19_v2_chr4_+_4861385_4861398 | -0.08 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MSX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 26.9 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 4.0 | 20.0 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 5.8 | 17.5 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.1 | 15.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.2 | 14.5 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 2.7 | 13.5 | GO:0048478 | replication fork protection(GO:0048478) |
| 2.9 | 11.6 | GO:0046104 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 0.0 | 10.9 | GO:0042113 | B cell activation(GO:0042113) |
| 1.5 | 10.7 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 3.5 | 10.6 | GO:1990523 | bone regeneration(GO:1990523) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.9 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 23.4 | GO:0005615 | extracellular space(GO:0005615) |
| 1.0 | 21.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 20.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.3 | 13.5 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 13.0 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 12.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 12.1 | GO:0005840 | ribosome(GO:0005840) |
| 0.6 | 10.7 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 10.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 26.9 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.7 | 21.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 1.6 | 17.5 | GO:0008430 | selenium binding(GO:0008430) |
| 0.7 | 14.5 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 1.3 | 13.5 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 3.9 | 11.6 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.1 | 11.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.5 | 10.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 3.5 | 10.5 | GO:0004040 | amidase activity(GO:0004040) fucose binding(GO:0042806) |
| 0.2 | 10.4 | GO:0051018 | protein kinase A binding(GO:0051018) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 26.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 15.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 13.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 9.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 7.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 7.5 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.2 | 6.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 5.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.8 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 5.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.7 | 15.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 11.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 9.8 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 9.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 9.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.4 | 7.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 6.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 6.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 5.9 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |