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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MSX2
Z-value: 1.00
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Transcription factors associated with MSX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MSX2 | hg19_v2_chr5_+_174151536_174151610 | -0.16 | 1.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MSX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.4 | GO:0051307 | meiotic chromosome separation(GO:0051307) |
| 1.0 | 13.4 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 3.2 | 12.7 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 2.4 | 11.8 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 0.1 | 11.6 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.6 | 10.6 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 3.2 | 9.5 | GO:1900195 | spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195) |
| 1.8 | 9.2 | GO:0042816 | vitamin B6 metabolic process(GO:0042816) |
| 0.1 | 9.2 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.7 | 8.2 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 21.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 1.2 | 12.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 12.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.4 | 10.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.6 | 9.2 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 2.6 | 7.8 | GO:0009330 | DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330) |
| 0.0 | 7.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 7.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.9 | 7.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.3 | 6.3 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 13.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.9 | 12.7 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 12.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.1 | 9.5 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.0 | 9.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 9.2 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 8.4 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 2.6 | 7.8 | GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.1 | 7.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 2.1 | 6.3 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 11.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 9.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 7.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 6.3 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 6.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 5.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.1 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 3.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.7 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.4 | 12.7 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.3 | 9.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 7.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 6.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 5.9 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.2 | 5.8 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 5.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 4.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |