Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for MYBL2
Z-value: 1.77
Motif logo
Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg19_v2_chr20_+_42295745_42295797 | 0.56 | 3.7e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 373.7 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 1.9 | 97.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 1.0 | 95.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.4 | 94.6 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 6.7 | 93.4 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 3.3 | 90.2 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 8.1 | 80.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 8.5 | 76.4 | GO:0043570 | maintenance of DNA repeat elements(GO:0043570) |
| 3.5 | 65.8 | GO:0000022 | mitotic spindle elongation(GO:0000022) |
| 16.3 | 65.3 | GO:0090579 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 214.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.0 | 197.5 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 4.1 | 124.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 3.3 | 117.2 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 5.9 | 82.2 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 79.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 19.1 | 76.4 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 1.3 | 75.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 9.2 | 73.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.6 | 71.1 | GO:0035371 | microtubule plus-end(GO:0035371) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 244.2 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 1.3 | 104.1 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 21.5 | 86.0 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 10.1 | 80.9 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 19.1 | 76.4 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.1 | 75.2 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 74.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.7 | 70.4 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 1.5 | 67.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 10.9 | 65.3 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 216.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.3 | 140.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.2 | 138.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.0 | 102.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 47.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 47.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.2 | 41.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.6 | 36.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 22.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 18.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 204.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 5.0 | 130.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.9 | 126.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.6 | 106.5 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.4 | 77.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.7 | 75.0 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 1.7 | 65.3 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.5 | 60.4 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 5.8 | 51.9 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.6 | 49.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |