ISMARA results: MZF1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MZF1

Z-value: 0.07

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Transcription factors associated with MZF1

Gene Symbol	Gene ID	Gene Info
MZF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000099326.4	myeloid zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MZF1	hg19_v2_chr19_-_59084647_59084721	0.42	9.6e-11	Click!

Activity profile of MZF1 motif

Sorted Z-values of MZF1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_61765315 Show fit	24.96	ENST00000406957.1 ENST00000401558.2	XPO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	exportin 1 (CRM1 homolog, yeast)
chr17_+_4618734 Show fit	24.50	ENST00000571206.1	ARRB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	arrestin, beta 2
chr4_-_84035905 Show fit	20.71	ENST00000311507.4	PLAC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	placenta-specific 8
chr4_-_84035868 Show fit	19.47	ENST00000426923.2 ENST00000509973.1	PLAC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	placenta-specific 8
chr17_-_47841485 Show fit	19.23	ENST00000506156.1 ENST00000240364.2	FAM117A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 117, member A
chr16_+_69958887 Show fit	19.20	ENST00000568684.1	WWP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	WW domain containing E3 ubiquitin protein ligase 2
chr11_-_46142615 Show fit	17.57	ENST00000529734.1 ENST00000323180.6	PHF21A Ensembl NCBI GeneCards UniProt NextProt Show fit	PHD finger protein 21A
chr12_-_15114603 Show fit	15.95	ENST00000228945.4	ARHGDIB Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GDP dissociation inhibitor (GDI) beta
chr11_-_46142948 Show fit	15.85	ENST00000257821.4	PHF21A Ensembl NCBI GeneCards UniProt NextProt Show fit	PHD finger protein 21A
chr1_-_153518270 Show fit	15.11	ENST00000354332.4 ENST00000368716.4	S100A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MZF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.4	52.2	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.5	47.3	GO:0006334	nucleosome assembly(GO:0006334)
0.9	45.9	GO:0043486	histone exchange(GO:0043486)
2.5	40.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
7.3	29.4	GO:0071461	cellular response to redox state(GO:0071461)
0.1	28.8	GO:0038093	Fc receptor signaling pathway(GO:0038093)
3.6	25.0	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
3.0	23.9	GO:0001661	conditioned taste aversion(GO:0001661)
1.0	23.8	GO:0000185	activation of MAPKKK activity(GO:0000185)
6.8	20.3	GO:0046586	regulation of calcium-dependent cell-cell adhesion(GO:0046586)

Showing 1 to 10 of 277 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	50.1	GO:0005642	annulate lamellae(GO:0005642)
0.4	47.4	GO:0035578	azurophil granule lumen(GO:0035578)
0.4	44.5	GO:0005905	clathrin-coated pit(GO:0005905)
0.2	43.9	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
1.8	37.3	GO:0000812	Swr1 complex(GO:0000812)
0.3	34.2	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.6	33.4	GO:1990391	DNA repair complex(GO:1990391)
1.6	25.2	GO:0097346	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) INO80-type complex(GO:0097346)
3.6	25.0	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.1	23.1	GO:0000151	ubiquitin ligase complex(GO:0000151)

Showing 1 to 10 of 136 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.4	52.2	GO:0031859	platelet activating factor receptor binding(GO:0031859)
1.3	51.5	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.4	46.2	GO:0003697	single-stranded DNA binding(GO:0003697)
0.8	44.9	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.6	33.8	GO:0004407	histone deacetylase activity(GO:0004407)
2.9	29.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.5	28.8	GO:0070063	RNA polymerase binding(GO:0070063)
0.5	28.6	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
1.7	25.0	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
2.2	23.9	GO:0005049	nuclear export signal receptor activity(GO:0005049)

Showing 1 to 10 of 190 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	55.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
1.7	51.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.5	36.2	PID P53 REGULATION PATHWAY	p53 pathway
1.4	35.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.5	32.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.9	28.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
1.7	25.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	22.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
1.0	19.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	19.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Showing 1 to 10 of 53 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	55.0	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3	44.4	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.2	38.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.9	25.0	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.5	24.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.3	24.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.1	22.8	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.4	21.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.0	17.9	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.4	17.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 84 entries

Results for MZF1

Z-value: 0.07

Motif logo

Transcription factors associated with MZF1

Activity-expression correlation:

Activity profile of MZF1 motif

Sorted Z-values of MZF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MZF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: