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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NANOG
Z-value: 0.07
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Transcription factors associated with NANOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NANOG | hg19_v2_chr12_+_7941989_7942014 | -0.04 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NANOG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.6 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 10.6 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 1.0 | 10.4 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 1.7 | 10.1 | GO:0061517 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.1 | 9.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.3 | 7.3 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.1 | 7.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.3 | 5.3 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 1.3 | 5.2 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.2 | 5.0 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.6 | 10.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 9.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 8.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 8.1 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.6 | 7.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.4 | 5.5 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.2 | 5.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 4.6 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.5 | 3.4 | GO:0019815 | B cell receptor complex(GO:0019815) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.5 | 10.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.6 | 9.5 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 1.8 | 8.9 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.8 | 8.3 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 7.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 6.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.4 | 5.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.4 | 5.0 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 4.7 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 10.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 10.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 5.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 2.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 2.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.2 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 9.5 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 8.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 7.1 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 5.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 4.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 4.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 3.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.5 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 2.4 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |